Journal of Child Psychology and Psychiatry,
Journal Year:
2017,
Volume and Issue:
59(2), P. 129 - 139
Published: Sept. 11, 2017
During
adolescence,
peer
victimization
is
a
potent
type
of
social
stressor
that
can
confer
enduring
risk
for
poor
mental
and
physical
health.
Given
recent
research
implicating
inflammation
in
promoting
variety
serious
health
problems,
this
study
examined
the
role
cognitive
vulnerability
(i.e.
negative
styles
hopelessness)
play
shaping
adolescents'
pro-inflammatory
cytokine
responses
to
an
acute
stressor.
Journal of Neuroscience Research,
Journal Year:
2019,
Volume and Issue:
97(10), P. 1223 - 1241
Published: May 29, 2019
Abstract
The
study
of
the
gut
microbiome
has
increasingly
revealed
an
important
role
in
modulating
brain
function
and
mental
health.
In
this
review,
we
underscore
specific
pathways
mechanisms
by
which
can
promote
development
disorders
such
as
depression
anxiety.
First,
review
involvement
stress
response
immune
system
activation
Then,
examine
germ‐free
murine
models
used
to
uncover
developing
pertinent
activity
system.
We
also
document
multiple
stress‐induced
inflammation
harms
ultimately
affects
health,
how
probiotic
prebiotic
treatments
have
shown
be
beneficial.
Lastly,
provide
overview
microbiome‐derived
compounds
(short‐chain
fatty
acids,
tryptophan
catabolites,
microbial
pattern
recognition)
related
(vagal
nerve
fecal
microbiota
transplants)
involved
mediating
influence
Overall,
a
picture
playing
facilitating
between
response,
inflammation,
depression,
anxiety
is
emerging.
Future
research
needed
firmly
establish
microbiome's
causal
role,
further
elucidate
microbes
possibly
develop
that
improve
health
through
microbiotic
targets.
Annual Review of Psychology,
Journal Year:
2019,
Volume and Issue:
71(1), P. 49 - 78
Published: Sept. 30, 2019
Depression
remains
one
of
the
most
prevalent
psychiatric
disorders,
with
many
patients
not
responding
adequately
to
available
treatments.
Chronic
or
early-life
stress
is
key
risk
factors
for
depression.
In
addition,
a
growing
body
data
implicates
chronic
inflammation
as
major
player
in
depression
pathogenesis.
More
recently,
gut
microbiota
has
emerged
an
important
regulator
brain
and
behavior
also
been
linked
However,
how
this
holy
trinity
interact
maintain
physiological
homeostasis
fully
understood.
review,
we
integrate
from
animal
human
studies
on
these
three
etiology
progression
We
focus
processes
by
which
microbiota-immune-stress
matrix
may
influence
centrally
mediated
events
possible
therapeutic
interventions
correct
imbalances
triune.
Frontiers in Neuroscience,
Journal Year:
2022,
Volume and Issue:
16
Published: Aug. 10, 2022
The
circadian
rhythm
is
crucial
for
physiological
and
behavioral
functions.
Chronotype,
which
represents
individual
preferences
activity
performance,
associated
with
human
health
issues,
particularly
psychiatric
disorders.
This
narrative
review,
focuses
on
the
relationship
between
chronotype
mental
disorders,
provides
an
insight
into
potential
mechanism.
Recent
evidence
indicates
that
(1)
evening
a
risk
factor
depressive
disorders
substance
use
whereas
morning
protective
factor.
(2)
Evening
individuals
bipolar
disorder
tend
to
have
more
severe
symptoms
comorbidities.
(3)
only
related
anxiety
symptoms.
(4)
schizophrenia
remains
unclear,
despite
increasing
their
link.
(5)
significantly
eating
majority
of
studies
focused
binge
Furthermore,
underlying
mechanisms
or
influence
factors
are
described
in
detail,
including
clock
genes,
brain
characteristics,
neuroendocrinology,
light/dark
cycle,
social
factors,
psychological
sleep
These
findings
provide
latest
chronotypes
serve
as
valuable
reference
researchers.
Neuronal Signaling,
Journal Year:
2023,
Volume and Issue:
7(2)
Published: June 26, 2023
Abstract
There
are
several
hypotheses
concerning
the
underlying
pathophysiological
mechanisms
of
major
depression,
which
centre
largely
around
adaptive
changes
in
neuronal
transmission
and
plasticity,
neurogenesis,
circuit
regional
connectivity.
The
immune
endocrine
systems
commonly
implicated
driving
these
changes.
An
intricate
interaction
stress
hormones,
innate
cells
actions
soluble
mediators
immunity
within
nervous
system
is
described
as
being
associated
with
symptoms
depression.
Bridging
processes
to
neurotransmission
signalling
key
cortical
limbic
brain
circuits
critical
understanding
depression
a
disorder
neuroimmune
origins.
Emergent
areas
research
include
growing
recognition
system,
advances
neuroimaging
techniques
mechanistic
insights
gained
from
transgenic
animals.
Elucidation
glial–neuronal
interactions
providing
additional
avenues
into
promising
research,
development
clinically
relevant
disease
models
discovery
novel
therapies.
This
narrative
review
focuses
on
molecular
cellular
that
influenced
by
inflammation
stress.
aim
this
provide
an
overview
our
current
origin,
focusing
neuroendocrine
dysregulation
pathophysiology.
Advances
lie
pursuit
biomarkers,
potential
biomarker
signatures
improve
clinical
outcomes
yet
be
fully
realised.
Further
investigations
expand
panels
including
integration
neuroimaging,
utilising
individual
stratify
patients
more
homogenous
subpopulations
targeting
for
new
treatment
approaches
will
help
address
unmet
need.
Complex & Intelligent Systems,
Journal Year:
2024,
Volume and Issue:
10(4), P. 5883 - 5915
Published: April 4, 2024
Abstract
Depression
is
a
multifactorial
disease
with
unknown
etiology
affecting
globally.
It’s
the
second
most
significant
reason
for
infirmity
in
2020,
about
50
million
people
worldwide,
80%
living
developing
nations.
Recently,
surge
depression
research
has
been
witnessed,
resulting
multitude
of
emerging
techniques
developed
prediction,
evaluation,
detection,
classification,
localization,
and
treatment.
The
main
purpose
this
study
to
determine
volume
conducted
on
different
aspects
such
as
genetics,
proteins,
hormones,
oxidative
stress,
inflammation,
mitochondrial
dysfunction,
associations
other
mental
disorders
like
anxiety
stress
using
traditional
medical
intelligence
(medical
AI).
In
addition,
it
also
designs
comprehensive
survey
treatment
planning,
genetic
predisposition,
along
future
recommendations.
This
work
designed
through
methods,
including
systematic
mapping
process,
literature
review,
network
visualization.
we
used
VOSviewer
software
some
authentic
databases
Google
Scholar,
Scopus,
PubMed,
Web
Science
data
collection,
analysis,
designing
picture
study.
We
analyzed
60
articles
related
intelligence,
47
from
machine
learning
513,767
subjects
(mean
±
SD
=
10,931.212
35,624.372)
13
deep
37,917
3159.75
6285.57).
Additionally,
found
that
stressors
impact
brain's
cognitive
autonomic
functioning,
increased
production
catecholamine,
decreased
cholinergic
glucocorticoid
activity,
cortisol.
These
factors
lead
chronic
inflammation
hinder
normal
leading
depression,
anxiety,
cardiovascular
disorders.
brain,
reactive
oxygen
species
(ROS)
by
IL-6
stimulation
cytochrome
c
oxidase
inhibited
nitric
oxide,
potent
inhibitor.
Proteins,
lipids,
phosphorylation
enzymes,
mtDNA
are
further
disposed
impairment
mitochondria.
Consequently,
dysfunction
exacerbates
impairs
DNA
(mtDNA)
or
deletions
mtDNA,
increases
intracellular
Ca
2+
levels,
changes
fission/fusion
morphology,
lastly
leads
neuronal
death.
highlights
multidisciplinary
approaches
intelligence.
It
will
open
new
way
technologies.
Nutrition Reviews,
Journal Year:
2019,
Volume and Issue:
78(5), P. 394 - 411
Published: Aug. 15, 2019
Abstract
Dietary
fiber
is
a
crucial
component
of
healthy
diet,
with
benefits
that
can
be
attributed
to
processes
in
the
gut
microbiota
and
resulting
by-products.
Observational
studies
support
associations
between
dietary
intake
depression
inflammation,
but
potential
mechanisms
are
poorly
understood.
This
review
examines
evidence
effects
on
inflammation
considers
plausible
linking
depression,
including
microbiota-driven
modification
gene
expression
increased
production
neurotransmitters.
Additionally,
may
mediate
relationship
depression.
A
high-fiber
diet
potentially
lowers
by
modifying
both
pH
permeability
gut.
The
resultant
reduction
inflammatory
compounds
alter
neurotransmitter
concentrations
reduce
symptoms
Further
research
into
link
essential,
as
findings
could
provide
guidance
for
improvement
or
prevention
depressive
disorders.