Exploring the impact of ketogenic diet on multiple sclerosis: obesity, anxiety, depression, and the glutamate system DOI Creative Commons
José Enrique de la Rubia Ortí, María Cuerda‐Ballester, Claudia Emmanuela Sanchis-Sanchis

et al.

Frontiers in Nutrition, Journal Year: 2023, Volume and Issue: 10

Published: Aug. 25, 2023

Multiple sclerosis (MS) is a neurodegenerative disorder. Individuals with MS frequently present symptoms such as functional disability, obesity, and anxiety depression. Axonal demyelination can be observed implies alterations in mitochondrial activity increased inflammation associated disruptions glutamate neurotransmitter activity. In this context, the ketogenic diet (KD), which promotes production of ketone bodies blood [mainly β-hydroxybutyrate (βHB)], non-pharmacological therapeutic alternative that has shown promising results peripheral obesity reduction central reduction. However, association type emotional through modulation individuals remains unknown.To provide an update on topic discuss potential impact KD depression subjects MS.The main findings suggest KD, source blood, improves by reducing insulin resistance dyslipidemia, promoting (particularly increase interleukins IL-1β, IL-6, IL-17). This improvement would imply decrease extrasynaptic activity, been linked to disability presence disorders

Language: Английский

The influence of depression and anxiety on cognition in people with multiple sclerosis: a cross-sectional analysis DOI
David Freedman, Jiwon Oh,

Alex Kiss

et al.

Journal of Neurology, Journal Year: 2024, Volume and Issue: 271(8), P. 4885 - 4896

Published: May 11, 2024

Language: Английский

Citations

9
Managing multiple sclerosis in individuals aged 55 and above: a comprehensive review DOI Creative Commons
Óscar Fernández, Per Soelberg Sørensen, Gıancarlo Comı

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: April 5, 2024

Multiple Sclerosis (MS) management in individuals aged 55 and above presents unique challenges due to the complex interaction between aging, comorbidities, immunosenescence, MS pathophysiology. This comprehensive review explores evolving landscape of older adults, including increased incidence prevalence this age group, shift disease phenotypes from relapsing-remitting progressive forms, presence multimorbidity polypharmacy. We aim provide an updated available evidence disease-modifying treatments (DMTs) patients, efficacy safety existing therapies, emerging such as Bruton tyrosine kinase (BTKs) inhibitors those targeting remyelination neuroprotection, critical decisions surrounding initiation, de-escalation, discontinuation DMTs. Non-pharmacologic approaches, physical therapy, neuromodulation cognitive rehabilitation, psychotherapy, are also examined for their role holistic care. The importance Care Units advance care planning explored a cornerstone providing patient-centric care, ensuring alignment with patient preferences trajectory. Finally, emphasizes need personalized continuous monitoring alongside advocating inclusive study designs clinical research improve growing demographic.

Language: Английский

Citations

8
The association between tobacco smoking and depression and anxiety in people with multiple sclerosis: A systematic review DOI Creative Commons

Vincent Vong,

Steve Simpson,

Spreeha Phaiju

et al.

Multiple Sclerosis and Related Disorders, Journal Year: 2023, Volume and Issue: 70, P. 104501 - 104501

Published: Jan. 4, 2023

Language: Английский

Citations

15
Associations between diet and disease progression and symptomatology in multiple sclerosis: A systematic review of observational studies DOI
E. Solsona, Thanasis G. Tektonidis, Jeanette C. Reece

et al.

Multiple Sclerosis and Related Disorders, Journal Year: 2024, Volume and Issue: 87, P. 105636 - 105636

Published: April 17, 2024

Language: Английский

Citations

5
Prevalence, treatment and correlates of depression in multiple sclerosis DOI Creative Commons
Carolyn Young, Dawn Langdon, David Rog

et al.

Multiple Sclerosis and Related Disorders, Journal Year: 2024, Volume and Issue: 87, P. 105648 - 105648

Published: April 26, 2024

Background The prevalence of depression in Multiple Sclerosis (MS) is often assessed by administering patient reported outcome measures (PROMs) examining depressive symptomatology to population cohorts; a recent review summarised 12 such studies, eight which used the Hospital Anxiety and Depression Scale-Depression (HADS-D). In clinical practice, diagnosed an individual structured interview; diagnosis leads treatment options including antidepressant medication. It follows that MS will include those whose current symptoms meet threshold for diagnosis, plus who previously met diagnostic criteria have been treated improved below threshold. We examined large establish multi-attribute estimate depression, taking into account probable on HADS-D, as well anti-depressant medication use co-morbidity data reporting depression. then studied associations with demographic health status trajectories over time. Methods Participants were recruited UK-wide Trajectories Outcome Neurological Conditions-MS (TONiC-MS) study, disease from records, PROMs collected at intervals least 9 months, co-morbidities Interval level conversions PROM followed Rasch analysis. Logistic regression characteristics Finally, group-based trajectory model was applied Results Baseline 5633 participants showed be 25.3% (CI: 24.2-26.5). There significant differences subtype: relapsing 23.2% 21.8- 24.5), primary progressive 25.8% 22.5-29.3), secondary 31.5% 29.0-34.0); disability: EDSS 0-4 19.2% 17.8-20.6), ≥4.5 31.9% 30.2-33.6); age: 42-57 years 27.7% 26.0-29.3), above or this range 23.1% 21.6-24.7). Fatigue, disability, self-efficacy self esteem correlated effect size (>.8) whereas sleep, spasticity pain, vision bladder had >.5. logistic (N=4938) correctly classified 80% 93% specificity: risk increased fatigue, anxiety, more comorbidities smoking. Higher marriage reduced Trajectory analysis 40 months (N=1096) three groups: 19.1% low symptoms, 49.2% greater between possible 31.7% high symptoms. 29.9% 27.6-32.3) depressed subjects untreated, conversely treated, 26.1% still symptom consistent case 23.5-28.9). Conclusion A essential because using only screening questionnaires, diagnoses all under-estimate true prevalence. affects MS, almost half either untreated indicating despite treatment. Services must pro-active flexible, recognising heterogeneity outcomes reaching out ongoing

Language: Английский

Citations

5
Depression and anxiety in multiple sclerosis. Review of a fatal combination DOI
K. A. Jellinger

Journal of Neural Transmission, Journal Year: 2024, Volume and Issue: 131(8), P. 847 - 869

Published: June 13, 2024

Language: Английский

Citations

5
A systematic review and meta-analysis exploring the efficacy of mindfulness-based interventions on quality of life in people with multiple sclerosis DOI Creative Commons
Robert Simpson, Stephanie Posa, Laura Langer

et al.

Journal of Neurology, Journal Year: 2022, Volume and Issue: 270(2), P. 726 - 745

Published: Nov. 9, 2022

Abstract Background Quality of life (QoL) is commonly impaired among people with multiple sclerosis (PwMS). The aim this study was to evaluate via meta-analysis the efficacy Mindfulness-based interventions (MBIs) for improving QoL in PwMS. Methods Eligible randomized controlled trials (RCTs) were identified searching six major electronic databases (MEDLINE, EMBASE, CINAHL, Cochrane Central Register Controlled Trials, AMED, and PsycINFO) April 2022. primary outcome QoL. Study quality determined using Collaboration risk bias tool. Meta-analysis a random effects model undertaken. Effect sizes are reported as Standardized Mean Difference (SMD). Prospero ID: 139835. Results From total 1312 individual studies, 14 RCTs eligible inclusion meta-analysis, participant n = 937. Most studies included PwMS who remained ambulatory. Cognitively largely excluded. Comorbidities inconsistently reported. MBIs delivered face-to face group format, but five online. Eight ( 8) measured MS-specific In overall effect size (SMD) any measure 14) 0.40 (0.18–0.61), p 0.0003, I 2 52%. SMD measures 0.39 (0.21–0.57), < 0.0001, 0%. MBI largest on subscale mental 8), 0.70 (0.33–1.06), 0.0002, 63%. Adverse events infrequently Conclusions effectively improve greatest benefits health-related However, more research needed characterize optimal formatting, mechanisms action, diverse social, educational, clinical backgrounds.

Language: Английский

Citations

20
Cognition and psychological well-being in adults with post COVID-19 condition and analyses of symptom sequelae DOI

V. Lynn Ashton Rennison,

Cathy J. Chovaz,

Sandra Zirul

et al.

The Clinical Neuropsychologist, Journal Year: 2023, Volume and Issue: 38(2), P. 326 - 353

Published: June 23, 2023

Objective As the coronavirus disease 2019 (COVID-19) pandemic moves into its fourth year, gaining a better clinical understanding of individuals with post COVID-19 condition is paramount. The current study examined neurocognitive and psychological status adults condition, as well explored impact high burden on objective functioning relationship between subjective cognitive concerns findings.Method Valid neuropsychological assessments were completed 51 symptomatic who 297.55 days, average, following confirmed severe acute respiratory syndrome 2 (SARS-CoV-2) infection. Participants brief self-report depression, anxiety, PTSD questionnaires, questionnaire ratings abilities, standardized tests that performance validity, attention, processing speed, verbal learning memory, naming, visual construction, executive functioning.Results participants mostly Caucasian (80.39%), middle-aged (average 47.37 years), women (82.35%), never hospitalized (86.27%). Despite all reporting problems in daily life, mean performances testing did not reveal any deficits (at or below 8th percentile) at group level. Approximately half (49.02%) reported co-occurring mental health symptoms considered clinically elevated based results. High symptom was associated greater difficulties but result dysfunction testing.Conclusions This contributes to literature regarding including symptoms. Results are summarized key points.

Language: Английский

Citations

12
A systematic review and meta-analysis of neuropathic pain in multiple sclerosis: Prevalence, clinical types, sex dimorphism, and increased depression and anxiety symptoms DOI
Patrícia Rodrigues, Brenda da Silva, Gabriela Trevisan

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2023, Volume and Issue: 154, P. 105401 - 105401

Published: Sept. 28, 2023

Language: Английский

Citations

11
Predictive Model of Anxiety and Depression Perception in Multiple Sclerosis Patients: Possible Implications for Clinical Treatment DOI Creative Commons
María Cuerda‐Ballester,

Antonio Bustos,

David Sancho-Cantus

et al.

Bioengineering, Journal Year: 2024, Volume and Issue: 11(1), P. 100 - 100

Published: Jan. 22, 2024

Multiple Sclerosis (MS) is a neurodegenerative disease characterized by motor and non-motor symptoms, including emotional distress, anxiety, depression. These symptoms currently have pharmacological treatment with limited effectiveness; therefore, it necessary to delve into their relationship other psychological, functional, or prefrontal alterations. Additionally, exploring non-pharmacological therapeutic alternatives that shown benefits in addressing distress MS patients essential. Aim: To establish predictive model for the presence of anxiety depression patients, based on variables such as psychological well-being, functional activity, symptoms. this study aimed propose model. Materials Methods: A descriptive, observational, cross-sectional was conducted sample 64 diagnosed who underwent cognitive assessments using following questionnaires scales: Functional Activities Questionnaire (FAQ), Acceptance Action (AAQ-II), Experiences (EQ), Self-Compassion Scale Short Form (SCS-SF), Beck Depression Inventory II (BDI-II), State-Trait Anxiety (STAI), Prefrontal Symptoms (PSI). Results: The showed an excellent fit data indicated well-being most significant predictor criteria (β = −0.83), followed activity −0.18) 0.15). latter two are negatively related −0.16 β −0.75, respectively). Conclusions: Low variable significantly predicts Interventions mindfulness acceptance recommended, along nutritional interventions antioxidant-enriched ketogenic diets moderate group physical exercise.

Language: Английский

Citations

4