Influenza and Other Respiratory Viruses,
Journal Year:
2023,
Volume and Issue:
17(4)
Published: April 1, 2023
SARS-CoV-2
genomic
surveillance
is
necessary
for
the
detection,
monitoring,
and
evaluation
of
virus
variants,
which
can
have
increased
transmissibility,
disease
severity,
or
other
adverse
effects.
We
sequenced
330
genomes
during
sixth
wave
COVID
pandemic
in
Iran
compared
them
with
five
previous
waves,
identifying
behavior
virus,
understanding
its
characteristics.After
viral
RNA
extraction
from
clinical
samples
collected
COVID-19
pandemic,
next
generation
sequencing
was
performed
using
Nextseq
Nanopore
platforms.
The
data
were
analyzed
reference
sequences.In
first
wave,
V
L
clades
detected.
second
recognized
by
G,
GH,
GR
clades.
Circulating
third
GH
GR.
In
fourth
GRY
(alpha
variant),
GK
(delta
one
clade
(beta
variant)
All
viruses
fifth
variant).
Omicron
variant
(GRA
clade)
circulating.Genome
sequencing,
a
key
strategy
systems,
helps
to
detect
monitor
prevalence
evolution
SARS-CoV-2,
identify
new
variants
prevention,
control,
treatment,
also
provide
information
conduct
public
health
measures
this
area.
With
system,
could
be
ready
respiratory
diseases
besides
influenza
SARS-CoV-2.
The Brazilian Journal of Infectious Diseases,
Journal Year:
2021,
Volume and Issue:
25(4), P. 101606 - 101606
Published: July 1, 2021
Since
the
first
described
human
infection
with
SARS-CoV-2
in
December
of
2019
many
subunit
protein
vaccines
have
been
proposed
for
use
humans.
Subunit
one
or
more
antigens
suitable
eliciting
a
robust
immune
response.
However,
major
concern
is
efficacy
and
elicited
antibodies
to
neutralize
variants
like
B.1.1.7
(Alpha),
B.1.351
(Beta)
P1
(Gamma),
B.1.617
(Delta)
C.37
(Lambda).
The
Spike
(S)
potential
fragment
as
an
antigen
vaccine
development.
This
plays
crucial
role
step
process,
it
binds
Angiotensin-Converting
Enzyme
2
(ACE2)
receptor
enters
host
cell
after
binding.
Immunization-induced
specific
against
binding
domain
(RBD)
may
block
effectively
prevent
virus
invasion.
focus
this
review
impact
spike
mutated
SARS-CoV2
(Alpha,
Beta,
Gamma,
Delta,
Lambda)
on
recombinant
vaccines.
To
date,
low
no
significant
Alpha
Delta
has
reported.
Such
Lambda
be
even
greater
compared
variant.
Nonetheless,
comprehensive
analyses
are
needed
assess
real
brought
about
by
variants.
The Journal of Physical Chemistry B,
Journal Year:
2021,
Volume and Issue:
125(3), P. 850 - 873
Published: Jan. 15, 2021
The
rapidly
growing
body
of
structural
and
biochemical
studies
the
SARS-CoV-2
spike
glycoprotein
has
revealed
a
variety
distinct
functional
states
with
radically
different
arrangements
receptor-binding
domain,
highlighting
remarkable
function-driven
conformational
plasticity
adaptability
proteins.
In
this
study,
we
examined
molecular
mechanisms
underlying
dynamic
changes
in
mutant
trimers
through
lens
analysis
allosteric
interaction
networks
atomistic
modeling
signal
transmission.
Using
an
integrated
approach
that
combined
coarse-grained
simulations,
protein
stability
analysis,
perturbation-based
residue
networks,
how
mutations
regulatory
regions
can
differentially
affect
dynamics
signaling
states.
results
study
key
centers
govern
collective
dynamics,
interactions,
control
transmission
We
found
experimentally
confirmed
hotspots
dictate
switching
between
correspond
to
hinge
sites
global
mediating
networks.
provide
novel
insight
into
proteins
showing
at
positions
modulate
distribution
determine
topography
communication
pathways
operating
state-specific
cascades
switch
points.
This
provides
plausible
strategy
for
probing
equilibrium
therapeutic
intervention
by
targeting
specific
interactions
communications
International Journal of Biological Sciences,
Journal Year:
2022,
Volume and Issue:
18(2), P. 889 - 900
Published: Jan. 1, 2022
Vaccines
are
proving
to
be
highly
effective
in
controlling
hospitalization
and
deaths
associated
with
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
infection,
as
shown
by
clinical
trials
real-world
evidence.
However,
a
deadly
second
wave
of
disease
2019
(COVID-19),
infected
SARS-CoV-2
variants,
especially
the
Delta
(B.1.617.2)
variant,
an
increased
number
post-vaccination
breakthrough
infections
were
reported
world
recently.
Actually,
variant
not
only
resulted
surge
vaccine
which
was
accompanied
high
viral
load
transmissibility,
but
also
challenged
development
vaccines.
Therefore,
biological
characteristics
epidemiological
profile
current
status
mechanism
discussed
this
article.
In
addition,
significant
role
spike
(S)
protein
immune
escape
highlighted
particular,
we
further
key
points
on
future
research
development,
hoping
make
contribution
early,
accurate
rapid
control
COVID-19
epidemic.
ACS Chemical Neuroscience,
Journal Year:
2021,
Volume and Issue:
12(19), P. 3535 - 3549
Published: Sept. 17, 2021
The
prevalence
of
chemosensory
dysfunction
in
patients
with
COVID-19
varies
greatly
between
populations.
It
is
unclear
whether
such
differences
are
due
to
factors
at
the
level
human
host,
or
coronavirus,
both.
At
host
level,
entry
proteins
which
allow
virus
binding
and
have
variants
distinct
properties,
frequency
differs
ethnicities.
virus,
D614G
mutation
enhances
cell.
Since
two
strains
(D614
G614)
coexisted
first
six
months
pandemic
most
populations,
it
has
been
difficult
distinguish
contributions
for
anosmia.
To
answer
this
question,
we
conducted
a
systematic
review
meta-analysis
studies
South
Asian
populations
when
either
D614
G614
was
dominant.
We
show
that
infected
predominantly
had
much
higher
anosmia
(pooled
31.8%)
compared
same
ethnic
mostly
strain
5.3%).
conclude
major
contributing
factor
increases
COVID-19,
enhanced
effect
on
olfaction
constitutes
previously
unrecognized
phenotype
mutation.
new
additional
mutations
background
can
be
expected
cause
similarly
increased
dysfunctions.
