Polychlorinated Biphenyls (PCBs) in the Environment: Occupational and Exposure Events, Effects on Human Health and Fertility

Toxics, Journal Year: 2022, Volume and Issue: 10(7), P. 365 - 365

Published: July 1, 2022

In the last decade or so, polychlorinated biphenyls (PCBs) garnered renewed attention in scientific community due to new evidence pointing at their continued presence environment and workplaces potential human risks related presence. PCBs move from humans through different routes; dominant pathway is ingestion of contaminated foods (fish, seafood dairy products), followed by inhalation (both indoor outdoor air), and, a lesser extent, dust dermal contact. Numerous studies reported environmental occupational exposure these pollutants, deriving building materials (flame-retardants, plasticizers, paints, caulking compounds, sealants, fluorescent light ballasts, etc.) electrical equipment. The highest contaminations were detected e-waste recycling sites, suggesting need for implementation remediation strategies such polluted areas safeguard health workers local populations. Furthermore, significant correlation between PCB increased blood concentrations was observed people working PCB-contaminated workplaces. Several epidemiological suggest that high associated with outcomes, as neuropsychological neurobehavioral deficits, dementia, immune system dysfunctions, cardiovascular diseases cancer. addition, recent indicate bioaccumulation can reduce fertility, harmful effects on reproductive be passed offspring. near future, further are needed assess real low prolonged specific environments.

Language: Английский

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The adverse role of endocrine disrupting chemicals in the reproductive system

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 17, 2024

Reproductive system diseases pose prominent threats to human physical and mental well-being. Besides being influenced by genetic material regulation changes in lifestyle, the occurrence of these is closely connected exposure harmful substances environment. Endocrine disrupting chemicals (EDCs), characterized hormone-like effects, have a wide range influences on reproductive system. EDCs are ubiquitous natural environment present industrial everyday products. Currently, thousands been reported exhibit endocrine this number likely increase as testing for potential has not consistently required, obtaining data limited, partly due long latency many diseases. The ability avoid EDCs, especially those artificially synthesized origin, increasingly challenging. While can be divided into persistent non-persistent depending their degree degradation, recent uptick research studies area, we chosen focus pertaining detrimental effects health several that widely encountered daily life over past six years, specifically bisphenol A (BPA), phthalates (PAEs), polychlorinated biphenyls (PCBs), parabens, pesticides, heavy metals, so on. By focusing impact hypothalamic-pituitary-gonadal (HPG) axis, which leads development diseases, review aims provide new insights molecular mechanisms EDCs’ damage encourage further in-depth clarify potentially EDC through various other mechanisms. Ultimately, it offers scientific basis enhance risk management, an endeavor significant societal importance safeguarding health.

Language: Английский

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From Oxidative Stress to Male Infertility: Review of the Associations of Endocrine-Disrupting Chemicals (Bisphenols, Phthalates, and Parabens) with Human Semen Quality

Antioxidants, Journal Year: 2022, Volume and Issue: 11(8), P. 1617 - 1617

Published: Aug. 20, 2022

Exposure to endocrine-disrupting chemicals (EDCs) may result in oxidative stress and endocrine system disturbance, which can have an impact on human reproduction development. In male reproductive health, EDCs been related impaired function infertility, altered fetal development, testicular germ-cell, prostate, breast cancers. We conducted electronic search using PubMed disruptors evaluated their association with (bisphenols, phthalates, parabens) 25 articles. Higher levels of urinary bisphenols showed correlation semen quality increased DNA damage. Considering phthalates metabolites, all studies found a positive between at least one parameter indicative low quality; some also revealed sperm The parabens less often concentrations decrease count, as well motility Moreover, elevate ROS production lipid peroxidation, increase apoptosis, induce epigenetic modifications, change the Y:X chromosome ratio protein composition. Our review detrimental effects integrity—especially BPA but parabens.

Language: Английский

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Endocrine disrupting chemicals and their effects on the reproductive health in men

Environmental Research, Journal Year: 2023, Volume and Issue: 236, P. 116825 - 116825

Published: Aug. 5, 2023

Language: Английский

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Bisphenol A induces apoptosis and disrupts testosterone synthesis in TM3 cells via reactive oxygen species-mediated mitochondrial pathway and autophagic flux inhibition

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 289, P. 117691 - 117691

Published: Jan. 1, 2025

Bisphenol A (BPA) is a common endocrine disruptor chemical that widely used in the production of food plastic packaging, and it has been shown to potentially harm reproductive system. However, specific mechanism by which BPA induces apoptosis Leydig cells (LCs) inhibits testosterone synthesis these unclear. In present study, TM3 were as an experimental model combination with reactive oxygen species (ROS) scavenger (N-acetylcysteine), Caspase-3 inhibitor (Ac-DEVD-CHO), autophagy activator (Torin2), (Chloroquine) investigate potential mechanisms causes cell damage vitro. treatment increased ROS production, led marked decrease antioxidant enzyme activity expression levels antioxidant-related genes proteins cells. Upregulated cause excessive opening mitochondrial permeability transition pore significantly related membrane function The release cytochrome C from damaged mitochondria into cytoplasm activated Caspase cascade reaction. addition, impaired autophagic degradation inhibiting fusion autophagosomes lysosomes. These abnormalities eventually induced inhibited collective findings suggest interferes upregulating thereby activating apoptotic pathway flux. provide novel mechanistic insights male toxicity caused exposure.

Language: Английский

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Using alternative test methods to predict endocrine disruption and reproductive adverse outcomes: do we have enough knowledge?

Environmental Pollution, Journal Year: 2022, Volume and Issue: 304, P. 119242 - 119242

Published: April 1, 2022

Language: Английский

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Lack of association between endocrine disrupting chemicals and male fertility: A systematic review and meta-analysis

Environmental Research, Journal Year: 2022, Volume and Issue: 217, P. 114942 - 114942

Published: Nov. 24, 2022

The incidence of infertility currently affects about 15% the world's population. Male factors are estimated to be responsible for up 40–50% these cases. While cause reproductive disorders is still unclear, exposure a family ubiquitous compounds in our daily life, named endocrine disrupting chemicals (EDCs) could involved. This paper was aimed at performing systematic review and meta-analysis population studies exploring whether human male EDCs fertility. Clinical observational assessing along with sperm quality, most common disorders, DNA damage, oxidative stress, fertilization rate, implantation clinical pregnancy live birth miscarriage rate were included. quality assessment tool from NHLBI-NIH used assure that met standardized criteria. Sensitivity analysis heterogeneity among assessed. Overall, 32 selected articles, including 7825 individuals review, explored 12 families EDCs. results revealed high relation association between endpoints analyzed. Meta-analyses performed data 7 articles 479 individuals, 4 BPA urine 3 evaluating PCB153 serum quality. In meta-analysis, we identified an unpredicted significant positive concentration. However, it would not clinically relevant. No or inverse associations found neither BPA, nor rest parameters disparity made difficult draw conclusions on potential harmful effects Consequently, delineate relationship can have fertility, important condition stressing health system, further investigations required.

Language: Английский

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Using Experimental Models to Decipher the Effects of Acetaminophen and NSAIDs on Reproductive Development and Health

Frontiers in Toxicology, Journal Year: 2022, Volume and Issue: 4

Published: March 8, 2022

Nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin (acetylsalicylic acid), diclofenac and ibuprofen (IBU), analgesic drugs, acetaminophen (APAP, or paracetamol), are widely used to treat inflammation pain. APAP IBU over-the-counter among the most commonly taken in first trimester of pregnancy, even combination. Furthermore, these their metabolites released environment, can be frequently detected wastewater, surface water, importantly drinking water. Although environmental concentrations much lower than therapeutics doses, this suggests an uncontrolled low-dose exposure general population, including pregnant women young children, two particularly at risk populations. Epidemiological studies show that molecules second gestation favor genital malformations new-born boys. To investigate cellular, molecular mechanistic effects molecules, ex vivo with human rodent gonadal explants experiments rodents have been performed past years. This review recapitulates recent data obtained models after utero postnatal drugs. The part discusses mechanisms by which NSAIDs analgesics may impair development maturation, puberty development, sex hormone production, maturation function adult organs, ultimately fertility exposed animals offspring. Like other endocrine disruptors, interfere gland inter/transgenerational adverse effects. Particularly, they target germ cells, resulting reduced quality male female gametes, decreased individuals descendants. Then, a single drug aspirin, IBU) combinations during early embryogenesis, consequences on reproductive health. Altogether, increase medical public awareness about health concerns, childbearing age, women, parents children.

Language: Английский

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Genistein prevents the production of hypospadias induced by Di-(2-ethylhexyl) phthalate through androgen signaling and antioxidant response in rats

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 466, P. 133537 - 133537

Published: Jan. 17, 2024

Language: Английский

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Therapeutic potential of virgin coconut oil in mitigating sodium benzoate- model of male infertility: Role of Nrf2/Hmox-1/NF-kB signaling pathway.

PubMed, Journal Year: 2024, Volume and Issue: 27(5), P. 543 - 551

Published: Jan. 1, 2024

Male infertility is a major public health issue due to increased prevalence, so there an urgent need for therapeutic solution. The search natural dietary substance that could modulate redox balance and inflammation protect testicular function in demand. Virgin Coconut Oil (VCO) has found use the treatment of diabetes, cancer owing presence polyphenols. However, dearth information on its effect toxicity. present study investigated VCO as possible toxicity Sodium Benzoate (SB) model male by evaluating oxidative inflammatory status, circulating hormonal levels, key sperm indices.

Language: Английский

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