State-of-the-art review of advanced electrospun nanofiber yarn-based textiles for biomedical applications

Applied Materials Today, Journal Year: 2022, Volume and Issue: 27, P. 101473 - 101473

Published: April 10, 2022

Language: Английский

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Review of advances in electrospinning-based strategies for spinal cord regeneration

Materials Today Chemistry, Journal Year: 2022, Volume and Issue: 24, P. 100944 - 100944

Published: May 13, 2022

Language: Английский

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Biomaterials to enhance stem cell transplantation

Cell stem cell, Journal Year: 2022, Volume and Issue: 29(5), P. 692 - 721

Published: April 27, 2022

Language: Английский

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3D Printed Conductive Multiscale Nerve Guidance Conduit with Hierarchical Fibers for Peripheral Nerve Regeneration

Advanced Science, Journal Year: 2023, Volume and Issue: 10(12)

Published: Feb. 17, 2023

Nerve guidance conduits (NGCs) have become a promising alternative for peripheral nerve regeneration; however, the outcome of regeneration and functional recovery is greatly affected by physical, chemical, electrical properties NGCs. In this study, conductive multiscale filled NGC (MF-NGC) consisting electrospun poly(lactide-co-caprolactone) (PCL)/collagen nanofibers as sheath, reduced graphene oxide /PCL microfibers backbone, PCL internal structure developed. The printed MF-NGCs presented good permeability, mechanical stability, conductivity, which further promoted elongation growth Schwann cells neurite outgrowth PC12 neuronal cells. Animal studies using rat sciatic injury model reveal that promote neovascularization M2 transition through rapid recruitment vascular macrophages. Histological assessments regenerated nerves confirm significantly enhance regeneration, indicated improved axon myelination, muscle weight increase, function index. This study demonstrates feasibility 3D-printed with hierarchically oriented fibers can regeneration.

Language: Английский

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ROS‐Scavenging Hydrogels Synergize with Neural Stem Cells to Enhance Spinal Cord Injury Repair via Regulating Microenvironment and Facilitating Nerve Regeneration

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(18)

Published: March 29, 2023

Abstract Although stem cell‐based therapy is recognized as a promising therapeutic strategy for spinal cord injury (SCI), its efficacy greatly limited by local reactive oxygen species (ROS)‐abundant and hyper‐inflammatory microenvironments. It still challenge to develop bioactive scaffolds with outstanding antioxidant capacity neural cells (NSCs) transplantation. In this study, albumin biomimetic cerium oxide nanoparticles (CeO 2 @BSA nanoparticles, CeNPs) are prepared in simple efficient manner dispersed gelatin methacryloyl obtain the ROS‐scavenging hydrogel (CeNP‐Gel). CeNP‐Gel synergistically promotes neurogenesis via alleviating oxidative stress microenvironments improving viability of encapsulated NSCs. More interestingly, presence CeNP‐Gel, microglial polarization anti‐inflammatory M2 subtype obviously facilitated, which further verified be associated phosphoinositide 3‐kinase/protein kinase B pathway activation. Additionally, injectable confirmed induce integration differentiation transplanted Compared blank‐gel group, survival rate NSCs group about 3.5 times higher, efficiency 2.1 higher. Therefore, NSCs‐laden represents comprehensive great application prospect treatment SCI through comprehensively modulating adverse microenvironment.

Language: Английский

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Polydopamine‐Decorated PLCL Conduit to Induce Synergetic Effect of Electrical Stimulation and Topological Morphology for Peripheral Nerve Regeneration

Small Methods, Journal Year: 2023, Volume and Issue: 7(2)

Published: Jan. 3, 2023

Due to the limited self-repairing capacity after peripheral nerve injuries (PNI), artificial conduits are widely applied facilitate neural regeneration. Exogenous electrical stimulation (ES) that is carried out by conductive conduit regulates biological behavior of Schwann cells (SCs). Meanwhile, a longitudinal surface structure counts guide axonal growth accelerate end-to-end connection. Currently, there no equipped with both conduction and axon-guiding structure. Herein, biodegradable, poly(l-lactide-co-caprolactone)/graphene (PLCL/GN) composite designed. The 20.96 ± 1.26 MPa tensile strength has micropatterned 20 µm groove fabricated microimprint technology self-assembled polydopamine (PDA). In vitro evaluation shows ES effectively stimulate directional cell migration, adhesion, elongation, enhance neuronal expression SCs. rat sciatic crush model demonstrates promotes myelin sheath, faster regeneration, 20-fold functional recovery in vivo. These discoveries prove PLCL(G)/PDA/GN promising tool for PNI treatment providing integration physical guidance, biomimetic regulation, bioelectrical stimulation, which inspires novel therapeutic approach regeneration future.

Language: Английский

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Recent advances of electrospun nanofiber-enhanced hydrogel composite scaffolds in tissue engineering

Journal of Manufacturing Processes, Journal Year: 2024, Volume and Issue: 123, P. 112 - 127

Published: June 5, 2024

Language: Английский

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Revealing an important role of piezoelectric polymers in nervous-tissue regeneration: A review

Materials Today Bio, Journal Year: 2024, Volume and Issue: 25, P. 100950 - 100950

Published: Jan. 11, 2024

Nerve injuries pose a drastic threat to nerve mobility and sensitivity lead permanent dysfunction due low regenerative capacity of mature neurons. The electrical stimuli that can be provided by electroactive materials are some the most effective tools for formation soft tissues, including nerves. Electric output provide distinctly favorable bioelectrical microenvironment, which is especially relevant nervous system. Piezoelectric biomaterials have attracted attention in field neural tissue engineering owing their biocompatibility ability generate piezoelectric surface charges. In this review, an outlook recent achievements described with emphasis on polymers engineering. First, general recommendations design optimal scaffold discussed. Then, specific mechanisms determining regeneration via stimulation considered. Activation responses natural body movements, ultrasound, magnetic fillers also examined. use magnetoelectric combination alternating fields thought promising controllable reproducible cyclic deformations deep permeation without heating.

Language: Английский

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Progress in chitin/chitosan and their derivatives for biomedical applications: Where we stand

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 343, P. 122233 - 122233

Published: May 4, 2024

Language: Английский

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Axon-like aligned conductive CNT/GelMA hydrogel fibers combined with electrical stimulation for spinal cord injury recovery

Bioactive Materials, Journal Year: 2024, Volume and Issue: 35, P. 534 - 548

Published: Feb. 22, 2024

Rehabilitation and regenerative medicine are two promising approaches for spinal cord injury (SCI) recovery, but their combination has been limited. Conductive biomaterials could bridge scaffolds with electrical stimulation by inducing axon regeneration supporting physiological signal transmission. Here, we developed aligned conductive hydrogel fibers incorporating carbon nanotubes (CNTs) into methacrylate acylated gelatin (GelMA) via rotating liquid bath electrospinning. The electrospun CNT/GelMA mimicked the micro-scale structure, conductivity, soft mechanical properties of neural axons. For

Language: Английский

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