The wonders of X-PDT: an advance route to cancer theranostics DOI Creative Commons
Asim Mushtaq, M. Zubair Iqbal,

Jianbin Tang

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Oct. 25, 2024

Global mortality data indicates cancer as the second-leading cause of death worldwide. Therefore, there's a pressing need to innovate effective treatments address this significant medical and societal challenge. In recent years, X-ray-induced photodynamic therapy (X-PDT) has emerged promising advancement, revolutionizing traditional (PDT) for deeply entrenched malignancies by harnessing penetrating X-rays external stimuli. Recent developments in X-ray have shown trend toward minimizing radiation doses remarkably low levels after proof-of-concept demonstration. Early detection real-time monitoring are crucial aspects treatment. Sophisticated imaging techniques been enhanced introduction luminescence nano-agents, alongside contrast nanomaterials based on attenuation. luminescence-based vivo offers excellent sensitivity superior image quality deep tissues at reasonable cost, due unhindered penetration unimpeded auto-fluorescence X-rays. This review emphasizes significance responsive theranostics, exploring their mechanism action, feasibility, biocompatibility, prospects imaging-guided deep-seated tumors. Additionally, it discusses applications X-PDT treating breast cancer, liver lung skin colorectal cancer.

Language: Английский

Colorectal liver metastasis: molecular mechanism and interventional therapy DOI Creative Commons
Hui Zhou, Zhongtao Liu,

Yongxiang Wang

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2022, Volume and Issue: 7(1)

Published: March 4, 2022

Abstract Colorectal cancer (CRC) is one of the most frequently occurring malignancy tumors with a high morbidity additionally, CRC patients may develop liver metastasis, which major cause death. Despite significant advances in diagnostic and therapeutic techniques, survival rate colorectal metastasis (CRLM) remains very low. CRLM, as complex cascade reaction process involving multiple factors procedures, has diverse molecular mechanisms. In this review, we summarize mechanisms/pathophysiology, diagnosis, treatment CRLM. We also focus on an overview recent understanding basis CRLM special emphasis tumor microenvironment promise newer targeted therapies for further improving prognosis patients.

Language: Английский

Citations

178
Recent advances and trends in nanoparticles based photothermal and photodynamic therapy DOI
Jamileh Kadkhoda, Ali Tarighatnia, Jaleh Barar

et al.

Photodiagnosis and Photodynamic Therapy, Journal Year: 2021, Volume and Issue: 37, P. 102697 - 102697

Published: Dec. 20, 2021

Language: Английский

Citations

111
Recent Advances in Cancer Therapeutic Copper-Based Nanomaterials for Antitumor Therapy DOI Creative Commons
Reyida Aishajiang, Zhongshan Liu, Tiejun Wang

et al.

Molecules, Journal Year: 2023, Volume and Issue: 28(5), P. 2303 - 2303

Published: March 1, 2023

Copper serves as a vital microelement which is widely present in the biosystem, functioning multi-enzyme active site, including oxidative stress, lipid oxidation and energy metabolism, where reduction characteristics are both beneficial lethal to cells. Since tumor tissue has higher demand for copper more susceptible homeostasis, may modulate cancer cell survival through reactive oxygen species (ROS) excessive accumulation, proteasome inhibition anti-angiogenesis. Therefore, intracellular attracted great interest that multifunctional copper-based nanomaterials can be exploited diagnostics antitumor therapy. this review explains potential mechanisms of copper-associated death investigates effectiveness biomaterials field

Language: Английский

Citations

45
Unveiling the promising anticancer effect of copper-based compounds: a comprehensive review DOI Creative Commons

Sara Abdolmaleki,

Alireza Aliabadi, Samad Khaksar

et al.

Journal of Cancer Research and Clinical Oncology, Journal Year: 2024, Volume and Issue: 150(4)

Published: April 25, 2024

Abstract Copper is a necessary micronutrient for maintaining the well-being of human body. The biological activity organic ligands, especially their anticancer activity, often enhanced when they coordinate with copper(I) and (II) ions. its compounds are capable inducing tumor cell death through various mechanisms action, including activation apoptosis signaling pathways by reactive oxygen species (ROS), inhibition angiogenesis, induction cuproptosis, paraptosis. Some copper complexes currently being evaluated in clinical trials ability to map hypoxia cancers, locally advanced rectal cancer bulky tumors. Several studies have shown that nanoparticles can be used as effective agents chemodynamic therapy, phototherapy, hyperthermia, immunotherapy. Despite promising copper-based compounds, use subject certain limitations. Elevated concentrations may promote growth, metastasis affecting cellular processes.

Language: Английский

Citations

26
Hydrogen‐Bonded Organic Framework Nanoscintillators for X‐Ray‐Induced Photodynamic Therapy in Hepatocellular Carcinoma DOI Open Access

Lihui Gu,

Han Wu, Xu Li

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Abstract X‐ray induced photodynamic therapy (X‐PDT) leverages penetrating to generate singlet oxygen ( 1 O 2 ) for treating deep‐seated tumors. However, conventional X‐PDT typically relies on heavy metal inorganic scintillators and organic photosensitizers produce , which presents challenges related toxicity energy conversion efficiency. In this study, highly biocompatible phosphorescent nanoscintillators based hydrogen‐bonded frameworks (HOF) are designed engineered, termed BPT‐HOF@PEG, enhance in hepatocellular carcinoma (HCC) treatment. BPT‐HOF@PEG functions simultaneously as both scintillator photosensitizer, effectively absorbing transferring abundant . Both vitro vivo investigations demonstrate that internalized efficiently produces significant quantities of upon irradiation. Additionally, exposure directly inflicts DNA damage, the synergistic effects these mechanisms result pronounced cell death substantial tumor growth inhibition, with a inhibition rate up 90.4% assessments. RNA sequencing analyses reveal induces apoptosis Hepa1‐6 cells while inhibiting proliferation, culminating death. Therefore, work highlights considerable potential efficient HOF nanoscintillators‐based promising therapeutic approach HCC, providing effective alternative negligible patients unresectable

Language: Английский

Citations

2
Copper‐based nanomaterials for cancer theranostics DOI
Xiaoyan Zhong, Xingliang Dai, Yan Wang

et al.

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2022, Volume and Issue: 14(4)

Published: April 13, 2022

Abstract Copper‐based nanomaterials (Cu‐based NMs) with favorable biocompatibility and unique properties have attracted the attention of many biomedical researchers. Cu‐based NMs are one most widely studied materials in cancer treatment. In recent years, great progress has been made field biomedicine, especially treatment diagnosis tumors. This review begins classification synthetic strategies NMs. Then, according to abundant special NMs, their application biomedicine is summarized detail. For imaging, such as photoacoustic positron emission tomography multimodal imaging based on summarized, well improve diagnostic effectiveness. Moreover, a series structures functions underlying property activity relationship were shown highlight promising therapeutic performance. used monotherapies, photothermal therapy (PTT) chemodynamic (CDT). sophisticated design composition, structure, surface fabrication can endow these more modalities therapy. To further efficiency treatment, combined was introduced Finally, challenges, critical factors, future prospects for clinical translation multifunctional theranostic agents also considered discussed. The aim this provide better understanding key consideration rational increasingly important new paradigm agents. article categorized under: Therapeutic Approaches Drug Discovery > Nanomedicine Oncologic Disease Diagnostic Tools Vivo Nanodiagnostics Imaging

Language: Английский

Citations

68
Oxygen self-supplied enzyme nanogels for tumor targeting with amplified synergistic starvation and photodynamic therapy DOI
Xiaotong Fan, Zheng Luo, Ying Chen

et al.

Acta Biomaterialia, Journal Year: 2022, Volume and Issue: 142, P. 274 - 283

Published: Jan. 31, 2022

Language: Английский

Citations

57
Copper-cysteamine nanoparticle-mediated microwave dynamic therapy improves cancer treatment with induction of ferroptosis DOI Creative Commons
Hui Zhou, Zhongtao Liu, Zijian Zhang

et al.

Bioactive Materials, Journal Year: 2022, Volume and Issue: 24, P. 322 - 330

Published: Dec. 28, 2022

Photodynamic Therapy (PDT) holds a great promise for cancer patients, however, due to the hypoxic characteristics of most solid tumors and limited penetration depth light in tissues, extensive clinical application PDT is limited. Herein, we report microwave induced copper-cysteamine (Cu-Cy) nanoparticles-based as promising treatment overcome resistance combination with ferroptosis. The efficiency Cu-Cy-mediated dynamic therapy (MWDT) tested on HCT15 colorectal (CRC) cells via cell titer-blue viability assay live/dead reveal that Cu-Cy upon MW irradiation can effectively destroy CRC average IC-50 values 20 μg/mL. cytotoxicity tumor after stimulation be alleviated by ferroptosis inhibitor. Furthermore, mediated MWDT could deplete glutathione peroxide 4 (GPX4) enhance lipid peroxides (LPO) malondialdehyde (MDA). Our findings demonstrate MW-activated killed inducing superior vivo antitumor efficacy was corroborated tumor-bearing mice model. Immunohistochemical experiments showed GPX4 expression level + group significantly lower than other groups. Overall, these nanoparticles have safe prospect deep-seated inhibit proliferation ferroptosis, which provides potential solution resistance.

Language: Английский

Citations

48
Phototherapy Using a Fluoroquinolone Antibiotic Drug to Suppress Tumor Migration and Proliferation and to Enhance Apoptosis DOI

Zhaoyou Chu,

Hao Chen, Peisan Wang

et al.

ACS Nano, Journal Year: 2022, Volume and Issue: 16(3), P. 4917 - 4929

Published: March 11, 2022

In this work, a fluoroquinolone antibiotic drug (sparfloxacin (SP)) was selected as chemotherapy and photosensitizer for combined therapy. A facile chemical process developed to incorporate SP upconversion nanoparticles (UCNPs) into the thermally sensitive amphiphilic polymer polyethylene glycol-poly(2-hexoxy-2-oxo-1,3,2-dioxaphospholane). vitro in vivo experiments showed that 60% of molecules can be released from micelles thermal-sensitive polymers using 1 W cm-2 980 nm laser, successfully inhibits cell migration metastasis by inhibiting type II topoisomerases nuclei. Additionally, intracellular metal ions were chelated induce cancer apoptosis decreasing activity superoxide dismutase catalase. particular, produced singlet oxygen (1O2) kill cells, triggered UCNPs when irradiation performed with laser. Overall, retained weak chemotherapeutic effect, achieved enhanced photosensitizer-like effects, able repurpose old drugs elevate therapeutic efficacy against cancer, increase specificity suppressing tumor proliferation, enhance apoptosis.

Language: Английский

Citations

40
Prospects of nanoparticle-based radioenhancement for radiotherapy DOI Creative Commons
Lukas R. H. Gerken,

Maren E. Gerdes,

Martin Pruschy

et al.

Materials Horizons, Journal Year: 2023, Volume and Issue: 10(10), P. 4059 - 4082

Published: Jan. 1, 2023

Radiotherapy is a key pillar of solid cancer treatment. Despite high level conformal dose deposition, radiotherapy limited due to co-irradiation organs at risk and subsequent normal tissue toxicities. Nanotechnology offers an attractive opportunity for increasing the efficacy safety radiotherapy. Leveraging freedom design growing synthetic capabilities nanomaterial-community, variety engineered nanomaterials have been designed investigated as radiosensitizers or radioenhancers. While research so far has primarily focused on gold nanoparticles other atomic number materials increase absorption cross section tumor tissue, recent studies are challenging traditional concept high-

Language: Английский

Citations

39