International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(10), P. 5249 - 5249
Published: May 11, 2024
In
clinical
practice,
tissue
adhesives
have
emerged
as
an
alternative
tool
for
wound
treatments
due
to
their
advantages
in
ease
of
use,
rapid
application,
less
pain,
and
minimal
damage.
Since
most
are
designed
internal
use
or
treatments,
the
biodegradation
is
important.
To
endow
with
biodegradability,
past
few
decades,
various
biodegradable
polymers,
either
natural
polymers
(such
chitosan,
hyaluronic
acid,
gelatin,
chondroitin
sulfate,
starch,
sodium
alginate,
glucans,
pectin,
functional
proteins,
peptides)
synthetic
poly(lactic
acid),
polyurethanes,
polycaprolactone,
poly(lactic-co-glycolic
acid)),
been
utilized
develop
novel
adhesives.
Incorporated
degraded
vivo
time
under
specific
conditions,
leading
destruction
structure
further
degradation
this
review,
we
first
summarize
strategies
utilizing
Furthermore,
provide
a
symmetric
overview
used
adhesives,
focus
on
degradability
applications
these
Additionally,
challenges
perspectives
polymer-based
discussed.
We
expect
that
review
can
new
inspirations
design
biomedical
applications.
Small,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 10, 2025
Abstract
Diabetic
ulcers
(DUs)
are
characterized
by
a
microenvironment
with
high
oxidative
stress,
blood
glucose
levels,
and
recalcitrant
bacterial
infections.
This
is
accompanied
long‐term
suppression
of
endogenous
antioxidant
systems,
which
makes
their
clinical
management
extremely
challenging.
To
address
this
issue,
hybridized
novel
gold‐palladium
(AuPd)
nanoshell
the
injectable/injectable
hydrogel
system
UiO/AuPd
shells
/BNN6/PEG@Gel
(UAPsBP@Gel)
developed.
The
capable
acting
as
nitric
oxide
(NO)
reactor
utilizing
synergistic
therapy
that
harnesses
NIR‐II
light‐triggered
photothermal
effects
controlled
release
NO
gas
for
treatment
to
eradicate
biofilm
infections
at
different
depths.
AuPd
nanoshells
exhibits
superoxide
dismutase
(SOD)‐,
oxidase
(GOx)‐,
catalase
(CAT)‐like
activities,
enabling
self‐cascade
process
scavenging
both
reactive
oxygen
species
(ROS)
glucose.
activity
reshapes
DUs
microenvironment,
switches
on
Nrf2/HO‐1
pathway
inhibits
NF‐κB
pathway,
promotes
macrophage
polarization
toward
anti‐inflammatory
M2
phenotype,
reduces
resulting
in
efficient
immunomodulation.
In
vitro
/
vivo
results
demonstrate
UAPsBP@Gel
can
multifacetedly
enhance
epithelial
rejuvenation
through
wound
hemostasis,
pro‐cellular
migration
vascularization.
These
highlight
programmed
therapeutic
based
UBAPsP@Gel
tailored
stages
infected
meet
complex
needs.
Journal of Materials Chemistry B,
Journal Year:
2022,
Volume and Issue:
11(4), P. 837 - 851
Published: Dec. 5, 2022
The
delayed
healing
of
diabetic
wounds
is
directly
affected
by
the
disturbance
wound
microenvironment,
resulting
from
persistent
inflammation,
insufficient
angiogenesis,
and
impaired
cell
functions.
Mesenchymal
stem
cell-derived
extracellular
vesicles
(MSC-EVs)
showed
considerable
therapeutic
potential
in
healing.
However,
low
retention
rate
MSC-EVs
at
sites
hampers
their
efficacy.
For
skin
exposed
to
outer
environment,
using
a
hydrogel
with
tissue
adhesiveness
under
moist
condition
promising
strategy
for
In
this
study,
we
modified
methacryloyl-modified
gelatin
(GelMA)
catechol
motifs
dopamine
fabricate
GelMA-dopamine
hydrogel.
EVs
isolated
MSCs
were
applied
synthesized
prepare
GelMA-dopamine-EV
results
demonstrated
that
newly
formed
possessed
improved
properties
softness,
adhesiveness,
absorptive
capacity,
as
well
high
biocompatibility
working
concentration
(15%
w/v).
addition,
verified
promote
migration
angiogenesis
vitro.
model
rats,
exerted
prominent
efficacy
estimated
collagen
deposition,
appendage
regeneration,
expression
IL-6,
CD31,
TGF-β.
conclusion,
combination
not
only
accelerates
closure
but
also
promotes
structure
normalization
rescuing
homeostasis
microenvironment
wounds,
which
provides
approach
treatment
wounds.
Burns & Trauma,
Journal Year:
2023,
Volume and Issue:
11
Published: Jan. 1, 2023
Abstract
Wound
healing
is
a
long-term,
multi-stage
biological
process
that
mainly
includes
haemostatic,
inflammatory,
proliferative
and
tissue
remodelling
phases.
Controlling
infection
inflammation
promoting
regeneration
can
contribute
well
to
wound
healing.
Smart
biomaterials
offer
significant
advantages
in
because
of
their
ability
control
time
space.
Understanding
how
are
designed
for
different
stages
will
facilitate
future
personalized
material
tailoring
wounds,
making
them
beneficial
therapy.
This
review
summarizes
the
design
approaches
field
anti-inflammatory,
antimicrobial
regeneration,
highlights
advanced
precise
achieved
by
outlines
clinical
practical
applications
