Green Starch-Based Hydrogels with Excellent Injectability, Self-Healing, Adhesion, Photothermal Effect, and Antibacterial Activity for Promoting Wound Healing DOI
Ke Xu, Xinyu Sun,

Chuanyu Chong

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(2), P. 2027 - 2040

Published: Jan. 6, 2024

Hydrogel materials have proven valuable in wound healing, but improving the safety of these hydrogels is still challenging. Therefore, designing multifunctional natural polymeric-based with excellent mechanical properties to replace toxic or potentially risky, refractory chemical polymer-based such as polyacrylamide and polyethylene glycol particular significance. Here, a green starch-based hydrogel (Starch@Ca/CGC hydrogel) injectability, self-healing, instant adhesion was constructed by coordination interaction, electrostatic intramolecular intermolecular hydrogen bonds. Therein, bioactive small molecules gallic acid (GA) carvacrol (CA) were coordinated metal ions ultrasonic-triggered self-assembly ionic cross-linking codriven strategy prepare Cu-gallic acid-carvacrol nanospheres (CGC NPs), which conferred near-infrared light (NIR)-controlled CA release photothermal synergistic sterilization properties, well antioxidant anti-infection capabilities. More importantly, platforms could completely cover an irregular shape prevent secondary injury significantly accelerate healing under NIR more skin appendages like hair follicles blood vessels appearing. it expected that this serve competitive dressing biomedical field, including bacteria-derived infection other tissue repair.

Language: Английский

Recent advances in conductive hydrogels: classifications, properties, and applications DOI

Tianxue Zhu,

Yimeng Ni,

Gill M. Biesold

et al.

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 52(2), P. 473 - 509

Published: Dec. 9, 2022

Hydrogel-based conductive materials for smart wearable devices have attracted increasing attention due to their excellent flexibility, versatility, and outstanding biocompatibility. This review presents the recent advances in multifunctional hydrogels electronic devices. First, with different components are discussed, including pure single network based on polymers, additional additives (i.e., nanoparticles, nanowires, nanosheets), double additives. Second, a variety of functionalities, self-healing, super toughness, self-growing, adhesive, anti-swelling, antibacterial, structural color, hydrophobic, anti-freezing, shape memory external stimulus responsiveness introduced detail. Third, applications flexible illustrated strain sensors, supercapacitors, touch panels, triboelectric nanogenerator, bioelectronic devices, robot). Next, current challenges facing summarized. Finally, an imaginative but reasonable outlook is given, which aims drive further development future.

Language: Английский

Citations

379
Recent progress of antibacterial hydrogels in wound dressings DOI Creative Commons
Ben Jia,

Guowei Li,

Ertai Cao

et al.

Materials Today Bio, Journal Year: 2023, Volume and Issue: 19, P. 100582 - 100582

Published: Feb. 16, 2023

Hydrogels are essential biomaterials due to their favorable biocompatibility, mechanical properties similar human soft tissue extracellular matrix, and repair properties. In skin wound repair, hydrogels with antibacterial functions especially suitable for dressing applications, so novel hydrogel dressings have attracted widespread attention, including the design of components, optimization preparation methods, strategies reduce bacterial resistance, etc. this review, we discuss fabrication challenges associated crosslinking methods chemistry materials. We investigated advantages limitations (antibacterial effects mechanisms) different components in achieve good properties, response stimuli such as light, sound, electricity resistance. Conclusively, provide a systematic summary findings (crosslinking methods) an outlook on long-lasting effects, broader spectrum, diversified forms, future development prospects field.

Language: Английский

Citations

192
Recent advances in carboxymethyl chitosan-based materials for biomedical applications DOI

Yongtao Geng,

Hang Xue, Zhenhe Zhang

et al.

Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 305, P. 120555 - 120555

Published: Jan. 6, 2023

Language: Английский

Citations

153
Versatile Hydrogel Dressing with Skin Adaptiveness and Mild Photothermal Antibacterial Activity for Methicillin‐Resistant Staphylococcus Aureus‐Infected Dynamic Wound Healing DOI Creative Commons
Peng Zhao, Yu Zhang,

Xiaoai Chen

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 10(11)

Published: Feb. 12, 2023

Bacterial infection often induces chronic repair of wound healing owing to aggravated inflammation. Hydrogel dressing exhibiting intrinsic antibacterial activity may substantially reduce the use antibiotics for infected management. Hence, a versatile hydrogel (rGB/QCS/PDA-PAM) skin adaptiveness on dynamic wounds and mild photothermal is developed safe efficient treatment. Phenylboronic acid-functionalized graphene (rGB) oxadiazole-decorated quaternary carboxymethyl chitosan (QCS) are incorporated into polydopamine-polyacrylamide (PDA-PAM) network with multiple covalent noncovalent bonds, which conferred flexible mechanical properties, strong tissue adhesion excellent self-healing ability wounds. Moreover, glycocalyx-mimicking phenylboronic acid surface rGB enables specifically capture bacteria. The enhanced membrane permeability QCS bacterial vulnerability therapy（PTT）, demonstrated by PTT antibacteria against methicillin-resistant Staphylococcus aureus in vitro vivo at temperatures <49.6 °C. Consequently, demonstrate accelerated regeneration MRSA-infected vivo, an intact epidermis, abundant collagen deposition prominent angiogenesis. Therefore, rGB/QCS/PDA-PAM inherent has considerable potential treating drug-resistant

Language: Английский

Citations

133
Recent advances in the medical applications of hemostatic materials DOI Creative Commons
Yu Guo, Min Wang, Qi Liu

et al.

Theranostics, Journal Year: 2022, Volume and Issue: 13(1), P. 161 - 196

Published: Nov. 29, 2022

Bleeding caused by trauma or surgery is a serious health problem, and uncontrollable bleeding can result in death.Therefore, developing safe, effective, convenient hemostatic materials important.Active agents currently used to investigate the field of hemostasis are divided into four broad categories: natural polymers, synthetic inorganic materials, metal-containing materials.Hemostatic prepared various forms for wound care applications based on active ingredients used.These include nanofibers, gels, sponges, nanoparticles.Hemostatic find their care, they also during malignant tumor surgery.Prompt effective reduce possibility spread cells with blood.This review discusses outcomes current research conducted problems persisting materials.The presents platform further development materials.Bleeding materials.

Language: Английский

Citations

101
Multi-crosslinked hydrogels with strong wet adhesion, self-healing, antibacterial property, reactive oxygen species scavenging activity, and on-demand removability for seawater-immersed wound healing DOI
Yuancai Lv,

Fengying Cai,

Yuxiang He

et al.

Acta Biomaterialia, Journal Year: 2023, Volume and Issue: 159, P. 95 - 110

Published: Feb. 2, 2023

Language: Английский

Citations

94
Self-Healing Hydrogels: From Synthesis to Multiple Applications DOI

Hongyan Yin,

Fangfei Liu, Tursun Abdiryim

et al.

ACS Materials Letters, Journal Year: 2023, Volume and Issue: 5(7), P. 1787 - 1830

Published: May 26, 2023

Due to the good reliability and long-term stability, self-healing hydrogels have emerged as promising soft materials for tissue engineering, smart wearable sensors, bioelectronics, energy storage devices. The mechanism depends on reversible chemical or physical cross-linking interactions. Self-healing with fascinating features (including mechanical performances, biocompatibility, conductivity, antibacterial ability, responsiveness, etc.) are being designed developed according practical application requirements. In this review, recent progress in their synthesis strategies multiple applications is summarized. Their involve processes a combination of two. include flexible strain supercapacitors, actuators, adhesives, wound healing, drug delivery, tumor treatment, 3D printing, etc. Finally, current challenges, future development, opportunities discussed.

Language: Английский

Citations

86
Harnessing the potential of hydrogels for advanced therapeutic applications: current achievements and future directions DOI Creative Commons

Peilin Lu,

Dongxue Ruan,

Meiqi Huang

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: July 1, 2024

The applications of hydrogels have expanded significantly due to their versatile, highly tunable properties and breakthroughs in biomaterial technologies. In this review, we cover the major achievements potential therapeutic applications, focusing primarily on two areas: emerging cell-based therapies promising non-cell modalities. Within context cell therapy, discuss capacity overcome existing translational challenges faced by mainstream therapy paradigms, provide a detailed discussion advantages principal design considerations for boosting efficacy as well list specific examples different disease scenarios. We then explore drug delivery, physical intervention therapies, other areas (e.g., bioadhesives, artificial tissues, biosensors), emphasizing utility beyond mere delivery vehicles. Additionally, complement our latest progress clinical application outline future research directions, particularly terms integration with advanced biomanufacturing This review aims present comprehensive view critical insights into selection both tailored meet requirements diverse diseases situations.

Language: Английский

Citations

83
Injectable, self-healing, transparent, and antibacterial hydrogels based on chitosan and dextran for wound dressings DOI
Lei Nie,

Qianqian Wei,

Meng Sun

et al.

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 233, P. 123494 - 123494

Published: Feb. 1, 2023

Language: Английский

Citations

78
Polysaccharide-Based Multifunctional Hydrogel Bio-Adhesives for Wound Healing: A Review DOI Creative Commons
Jiahao Yang, Shige Wang

Gels, Journal Year: 2023, Volume and Issue: 9(2), P. 138 - 138

Published: Feb. 6, 2023

Wound healing is a long-term and complex biological process that involves multiple hemostasis, inflammation, proliferation, remodeling stages. In order to realize comprehensive systematic wound management, appropriate treatment bio-adhesives are urgently needed. Hydrogel have excellent properties show unique remarkable advantages in the field of management. This review begins with detailed description design criteria functionalities ideal hydrogel for healing. Then, recent advances polysaccharide-based multifunctional bio-adhesives, which involve chitosan, hyaluronic acid, alginate, cellulose, dextran, konjac glucomannan, chondroitin sulfate, other polysaccharides, comprehensively discussed. Finally, current challenges future research directions proposed stimulate further exploration by researchers.

Language: Английский

Citations

78