Polysaccharide-Based Multifunctional Hydrogel Bio-Adhesives for Wound Healing: A Review

Gels, Journal Year: 2023, Volume and Issue: 9(2), P. 138 - 138

Published: Feb. 6, 2023

Wound healing is a long-term and complex biological process that involves multiple hemostasis, inflammation, proliferation, remodeling stages. In order to realize comprehensive systematic wound management, appropriate treatment bio-adhesives are urgently needed. Hydrogel have excellent properties show unique remarkable advantages in the field of management. This review begins with detailed description design criteria functionalities ideal hydrogel for healing. Then, recent advances polysaccharide-based multifunctional bio-adhesives, which involve chitosan, hyaluronic acid, alginate, cellulose, dextran, konjac glucomannan, chondroitin sulfate, other polysaccharides, comprehensively discussed. Finally, current challenges future research directions proposed stimulate further exploration by researchers.

Language: Английский

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Chitosan-Based Biomaterials for Hemostatic Applications: A Review of Recent Advances

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(13), P. 10540 - 10540

Published: June 23, 2023

Hemorrhage is a detrimental event present in traumatic injury, surgery, and disorders of bleeding that can become life-threatening if not properly managed. Moreover, uncontrolled complicate surgical interventions, altering the outcome procedures. Therefore, to reduce risk complications decrease morbidity mortality associated with hemorrhage, it necessary use an effective hemostatic agent ensures immediate control bleeding. In recent years, there have been increasingly rapid advances developing novel generation biomaterials properties. Nowadays, wide array topical agents available, including chitosan-based shown outstanding properties such as antibacterial, antifungal, hemostatic, analgesic activity addition their biocompatibility, biodegradability, wound-healing effects. This review provides analysis discusses progress made performance, mechanism action, efficacy, cost, safety years.

Language: Английский

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Hydrogel-based dressings designed to facilitate wound healing

Materials Advances, Journal Year: 2023, Volume and Issue: 5(4), P. 1364 - 1394

Published: Dec. 20, 2023

This review provides an overview of the functionalities hydrogel-based dressings and their role in promoting wound healing.

Language: Английский

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Prospects and challenges for the application of tissue engineering technologies in the treatment of bone infections

Bone Research, Journal Year: 2024, Volume and Issue: 12(1)

Published: May 14, 2024

Osteomyelitis is a devastating disease caused by microbial infection in deep bone tissue. Its high recurrence rate and impaired restoration of deficiencies are major challenges treatment. Microbes have evolved numerous mechanisms to effectively evade host intrinsic adaptive immune attacks persistently localize the host, such as drug-resistant bacteria, biofilms, persister cells, intracellular small colony variants (SCVs). Moreover, microbial-mediated dysregulation microenvironment impedes regeneration process, leading defect repair. Despite advances surgical strategies drug applications for treatment infections within last decade, remain clinical management. The development application tissue engineering materials provided new infections, but comprehensive review their research progress lacking. This discusses critical pathogenic microbes skeletal system immunomodulatory effects on regeneration, highlights prospects technologies infections. It will inform translation antimicrobial repair management

Language: Английский

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Multifunctional hydrogels-based therapies for chronic diabetic wound healing

European Polymer Journal, Journal Year: 2024, Volume and Issue: 211, P. 113026 - 113026

Published: April 8, 2024

Chronic diabetic wounds persist as a healthcare challenge and therefore require the use of innovative therapeutic approaches. Among emerging solutions, hydrogels stand out promising avenue for wound healing due to their unique properties versatile applications, capable addressing complex challenging microenvironment that characterizes such wounds. In this work, through detailed analysis relevant experimental studies, we highlight multifunctionality hydrogels, namely ability promote tissue attachment, prevent scarring, fight infection, attenuate inflammation, facilitate electrical signaling, control bleeding, repair damage autonomously, exhibit responses tailored specific characteristics. The collective findings from these studies emphasize attributes in challenges. By elucidating crucial insights, work seeks lay groundwork both academics industries development implementation effective hydrogel-based strategies can significantly improve outcomes, offering new hope patients suffering chronic

Language: Английский

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Hydro‐Sensitive, In Situ Ultrafast Physical Self‐Gelatinizing, and Red Blood Cells Strengthened Hemostatic Adhesive Powder with Antibiosis and Immunoregulation for Wound Repair

Advanced Science, Journal Year: 2023, Volume and Issue: 11(4)

Published: Nov. 30, 2023

Immediate and effective hemostatic treatments for complex bleeding wounds are an urgent clinical demand. Hemostatic materials with characteristics of adhesion, sealing, anti-infection, concrescence promotion have drawn growing concerns. However, pure natural multifunctional in situ ultrafast self-gelation rarely reported. In this study, a hydro-sensitive collagen/tannic acid (ColTA) powder is developed that can self-gel to form adhesive by the non-covalent crosslinking between tannic (TA) collagen (Col) liquids. The physical interactions endow ColTA instantaneous formation high adhesion at various substrate surfaces. Crucially, shows enhanced performance presence blood due electrostatic red cells, conducive sealing rapid hemostasis. biocompatible hemocompatible effectively control seal caudal vein, liver, heart, femoral arteries rats. Furthermore, low-cost ready-to-use also possesses good antibacterial inhibiting biofilm ability, efficiently regulate immune response NF-κB pathway promote wound repair, making it highly promising material great potential biomedical applications.

Language: Английский

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Chitosan/starch based unoxidized tannic acid modified microparticles for rapid hemostasis with broad spectrum antibacterial activity

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 336, P. 122111 - 122111

Published: April 5, 2024

Language: Английский

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Chitosan Hemostatic Dressings: Properties and Surgical Applications

Polymers, Journal Year: 2024, Volume and Issue: 16(13), P. 1770 - 1770

Published: June 22, 2024

Wounds caused by trauma and/or surgery represent a significant challenge in contemporary medical practice, requiring innovative approaches to promote optimal healing and reduce the risk of bleeding complications resulting from it. In this context, chitosan, natural polysaccharide derived chitin, represents an ideal material for study application devices, form dressings, wound management pre- post-operative wounds due its ability induce hemostasis high biocompatibility with biological tissues. The aim work was discuss structural characteristics, properties chitosan-based hemostatic dressings processes or post-surgical approaches.

Language: Английский

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Shape memory and hemostatic silk-laponite scaffold for alveolar bone regeneration after tooth extraction trauma

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 260, P. 129454 - 129454

Published: Jan. 16, 2024

Persistent bleeding and the absence of alveolar bone stress following tooth loss can hinder socket healing, complicating future dental implant procedures, potentially leading to neighboring instability. Therefore, developing materials that promote regeneration possess both hemostatic osteogenic properties is crucial for preserving extraction sites. This study introduces a silk-based laponite composite scaffold material with proficient functions, excellent shape-memory efficient extraction- site filling. In vitro studies research demonstrated scaffold's inherent negative charge significantly enhanced blood coagulation thrombin generation. Moreover, its porous structure slightly rough inner surface promoted cell adhesion and, improved performance. Furthermore, facilitated stem differentiation by activating TRPM7 channel through released magnesium ions. vivo tests using rat models confirmed effectiveness in promoting mandibular regeneration. Thus, this proposes promising approach post-extraction regenerative repair. The material, capabilities features, enhance success overall oral health.

Language: Английский

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Adhesive transparent antimicrobial quaternized chitosan/oxidized dextran/polydopamine nanoparticle hydrogels for accelerated wound healing

Biomaterials Advances, Journal Year: 2025, Volume and Issue: 169, P. 214176 - 214176

Published: Jan. 9, 2025

Language: Английский

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