Recent advances in 3D-printed polylactide and polycaprolactone-based biomaterials for tissue engineering applications

International Journal of Biological Macromolecules, Journal Year: 2022, Volume and Issue: 218, P. 930 - 968

Published: July 24, 2022

Language: Английский

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3D printing of magneto-active smart materials for advanced actuators and soft robotics applications

European Polymer Journal, Journal Year: 2024, Volume and Issue: 205, P. 112718 - 112718

Published: Jan. 2, 2024

In the contemporary era, novel manufacturing technologies like additive (AM) have revolutionized different engineering sectors including biomedical, aerospace, electronics, etc. Four-dimensional (4D) printing aka AM of smart materials is gaining popularity among scientific community, which has excellent ability to make soft structures such as robots, actuators, and grippers. These are developed by applying various stimuli pH, temperature, magnetic field, many combinations onto materials. Stimuli in 3D permit shape-morphing behaviors bending, twisting, folding, swelling, rolling, shrinking, origami, or locomotion. A wide variety can be fabricated through incorporation hard particles into resulting magneto-active (MASMs). With this integration, magneto-thermal coupling actuation allows diverse magneto-deformations, facilitating development personalized devices that capable enhanced deformation. review, guidelines provided on for MASMs polymers (MAPs), composites, hydrogels (MAHs) booming flexible wearable biomimetic devices. Moreover, 3D-printed robotics an outstanding capacity adapt complicated situations advanced actuating applications. Finally, some current challenges emerging areas exciting technology been proposed. Lastly, it anticipated technological advancements developing intelligent will a significant impact design real-world

Language: Английский

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3D/4D printing of cellulose nanocrystals-based biomaterials: Additives for sustainable applications

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 251, P. 126287 - 126287

Published: Aug. 11, 2023

Cellulose nanocrystals (CNCs) have gained significant attraction from both industrial and academic sectors, thanks to their biodegradability, non-toxicity, renewability with remarkable mechanical characteristics. Desirable characteristics of CNCs include high stiffness, strength, excellent flexibility, large surface-to-volume ratio. Additionally, the properties can be tailored through chemical modifications for high-end applications including tissue engineering, actuating, biomedical. Modern manufacturing methods 3D/4D printing are highly advantageous developing sophisticated intricate geometries. This review highlights major developments additive manufactured CNCs, which promote sustainable solutions across a wide range applications. this contribution also presents current challenges future research directions CNC-based composites developed techniques myriad engineering sectors wound healing, wearable electronics, robotics, anti-counterfeiting Overall, will greatly help scientists chemistry, materials, biomedicine, other disciplines comprehend underlying principles, properties, additively structures.

Language: Английский

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3D printing of stimuli-responsive hydrogel materials: Literature review and emerging applications

Giant, Journal Year: 2023, Volume and Issue: 17, P. 100209 - 100209

Published: Nov. 15, 2023

Additive manufacturing (AM) aka three-dimensional (3D) printing has been a well-established and unparalleled technology, which is expanding the boundaries of materials science exhibiting an enormous potential to fabricate intricate geometries for healthcare, electronics, construction sectors. In contemporary era, combination AM technology stimuli-responsive hydrogels (SRHs) helps create dynamic functional structures with extreme accuracy, are capable changing their shape, functional, or mechanical properties in response environmental cues such as humidity, heat, light, pH, magnetic field, electric etc. 3D SRHs permits creation on-demand dynamically controllable shapes excellent control over various self-repair, self-assembly, multi-functionality, These accelerate researchers think unthinkable applications. Additively manufactured objects have shown applications like tissue engineering, drug delivery, soft robots, sensors, other biomedical devices. The current review provides recent progress SRHs, more focus on techniques, stimuli mechanisms, shape morphing behaviors, Finally, trends future roadmap additively smart different also presented, will be helpful research. This holds great promise providing fundamental knowledge about diverse

Language: Английский

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Nanocellulose derived from agricultural biowaste by-products–Sustainable synthesis, biocompatibility, biomedical applications, and future perspectives: A review

Carbohydrate Polymer Technologies and Applications, Journal Year: 2024, Volume and Issue: 8, P. 100529 - 100529

Published: June 20, 2024

Cellulose, a natural linear biopolymer composed of hierarchically arranged cellulose nanofibrils, presents compelling avenue for sustainable nanocellulose synthesis from agricultural by-products. This innovative approach both mitigates organic waste and landfill disposal unlocks the latent potential nanocellulose, transforming residue into valuable resources. paradigm shift towards sustainability resonates across diverse industrial sectors, particularly in biomedical research development. In recent years, remarkable attributes including its biocompatibility, low cytotoxicity, exceptional water-holding capacity cell immobilization, have propelled adoption various medical applications. From drug delivery systems to wound healing, tissue engineering, antimicrobial treatments, has emerged as versatile biomaterial. Moreover, strategic integration composites structural functionalization enable customizing properties specific functions, further expanding utility. comprehensive review explores prominent types nanocellulose—including nanocrystals, microbial or bacterial cellulose—elucidating their underscores principles underpinning utilization by exploring sources derived biowaste processes production. As crucial component wide array materials, drives innovation propels advancement biomedicine toward sustainability.

Language: Английский

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Biomimetic Scaffolds—A Novel Approach to Three Dimensional Cell Culture Techniques for Potential Implementation in Tissue Engineering

Nanomaterials, Journal Year: 2024, Volume and Issue: 14(6), P. 531 - 531

Published: March 16, 2024

Biomimetic scaffolds imitate native tissue and can take a multidimensional form. They are biocompatible influence cellular metabolism, making them attractive bioengineering platforms. The use of biomimetic adds complexity to traditional cell cultivation methods. most commonly used technique involves cultivating cells on flat surface in two-dimensional format due its simplicity. A three-dimensional (3D) provide microenvironment for surrounding cells. There two main techniques obtaining 3D structures based the presence scaffolding. Scaffold-free consist spheroid technologies. Meanwhile, scaffold contain organoids all constructs that various types scaffolds, ranging from decellularized extracellular matrix (dECM) through hydrogels one extensively studied forms potential culture up 4D bioprinted biomaterials. bioprinting is important create scaffolds. versatility this allows many different inks, mainly hydrogels, as well inorganic substances. Increasing amounts data evidence vast usage engineering personalized medicine, with area application being regeneration skin musculoskeletal systems. Recent papers also indicate increasing vivo tests products which further strengthen importance branch emphasize need extensive research safe humansbiomimetic tissues organs. In review article, we recent advancements field preceded by an overview technologies led development complex type culture.

Language: Английский

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Near-field electrospun PCL fibers/GelMA hydrogel composite dressing with controlled deferoxamine-release ability and retiform surface for diabetic wound healing

Nano Research, Journal Year: 2022, Volume and Issue: 16(1), P. 599 - 612

Published: Sept. 3, 2022

Language: Английский

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Simvastatin-hydroxyapatite coatings prevent biofilm formation and improve bone formation in implant-associated infections

Bioactive Materials, Journal Year: 2022, Volume and Issue: 21, P. 44 - 56

Published: Aug. 13, 2022

Implant-associated infections (IAIs) caused by biofilm formation are the most devastating complications of orthopedic surgery. Statins have been commonly and safely used drugs for hypercholesterolemia many years. Here, we report that simvastatin-hydroxyapatite-coated titanium alloy prevents biofilm-associated infections. The antibacterial properties simvastatin against Staphylococcus aureus epidermidis biofilms in vitro was confirmed crystal violet staining live-dead bacterial staining. We developed a simvastatin-and hydroxyapatite (Sim-HA)-coated via electrochemical deposition. Sim-HA coatings inhibited improved biocompatibility alloy. effectively prevented IAI rat femurs, as radiological assessment histological examination. effects were attributed to their inhibitory on formation, verified scanning electron microscopic observations spread plate analysis. In addition, enhanced osteogenesis osteointegration, micro-CT, evaluation, biomechanical pull-out tests. summary, promising implant materials protection

Language: Английский

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Convergence of 3D Bioprinting and Nanotechnology in Tissue Engineering Scaffolds

Biomimetics, Journal Year: 2023, Volume and Issue: 8(1), P. 94 - 94

Published: Feb. 26, 2023

Three-dimensional (3D) bioprinting has emerged as a promising scaffold fabrication strategy for tissue engineering with excellent control over geometry and microstructure. Nanobiomaterials bioinks play key role in manipulating the cellular microenvironment to alter its growth development. This review first introduces commonly used nanomaterials scaffolds, including natural polymers, synthetic polymer derivatives, reveals improvement of on performance. Second, 3D technologies inkjet-based bioprinting, extrusion-based laser-assisted stereolithography are comprehensively itemized, advantages underlying mechanisms revealed. Then convergence nanotechnology applications such bone, nerve, blood vessel, tendon, internal organs, discussed. Finally, challenges perspectives proposed. will provide scientific guidance develop scaffolds by nanotechnology.

Language: Английский

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Droplet-Based Microfluidics: Applications in Pharmaceuticals

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(7), P. 937 - 937

Published: June 28, 2023

Droplet-based microfluidics offer great opportunities for applications in various fields, such as diagnostics, food sciences, and drug discovery. A droplet provides an isolated environment performing a single reaction within microscale-volume sample, allowing fast with high sensitivity, throughput, low risk of cross-contamination. Owing to several remarkable features, droplet-based microfluidic techniques have been intensively studied. In this review, we discuss the impact microfluidics, particularly focusing on screening development. addition, surveyed methods device fabrication generation/manipulation. We further highlight some promising studies covering synthesis delivery that were updated last 5 years. This review researchers quick guide includes most up-to-date relevant information latest scientific findings development pharmaceutical field.

Language: Английский

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