Expert Opinion on Drug Delivery,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 24, 2025
Hepatocellularcarcinoma
(HCC),
the
primary
form
of
liver
cancer,
is
second
leading
causeof
cancer-related
deaths
worldwide.
Current
therapies
have
limited
effectiveness,particularly
in
advanced
stages
disease,
highlighting
need
forinnovative
treatment
options.
Small-interfering
RNA(siRNA)
molecules
show
great
promise
as
a
therapeutic
solution
since
they
caninhibit
expression
genes
promoting
HCC
growth.
Their
cost-effective
synthesis
has
further
encouraged
their
potentialuse
novel
drugs.
However,
siRNAs
are
vulnerable
to
degradation
biologicalenvironments,
necessitating
protective
delivery
systems.
Additionally,
targeteddelivery
critical
for
optimal
efficacy
and
minimal
undesired
sideeffects.
This
review
addresses
challenges
associated
with
siRNA
toHCC,
discussing
focusing
on
systems
based
lipid
polymeric
nanoparticlesin
publications
from
past
five
years.
Futurenanoparticles
will
effectively
cross
vessel
wall,
migrate
throughthe
extracellular
matrix
finally
cell
membrane.
may
beachieved
by
optimizing
nanoparticle
size,
equipment
nanoparticles
withHCC
targeting
moieties
loading
againstHCC-specific
oncogenes.
Bioactive Materials,
Journal Year:
2023,
Volume and Issue:
27, P. 1 - 14
Published: March 23, 2023
Intracerebral
hemorrhage
(ICH),
as
a
type
of
life-threatening
and
highly
disabled
disease,
has
limited
therapeutic
approaches.
Here,
we
show
that
exosomes
derived
from
young
healthy
human
plasma
exhibiting
typical
features
could
facilitate
functional
recovery
ICH
mice.
When
these
are
intraventricularly
delivered
into
the
brain
after
ICH,
they
mainly
distribute
around
hematoma
be
internalized
by
neuronal
cells.
Strikingly,
administration
markedly
enhanced
behavioral
mice
through
reducing
injury
cell
ferroptosis.
MiRNA
sequencing
revealed
microRNA-25-3p
(miR-25-3p)
was
differentially
expressed
miRNA
in
plasma,
compared
with
old
control.
Importantly,
miR-25-3p
mimicked
treatment
effect
on
improvement,
mediated
neuroprotective
against
ferroptosis
ICH.
Furthermore,
luciferase
assay
western
blotting
data
illustrated
P53
assumed
role
downstream
effector
miR-25-3p,
thereby
regulating
SLC7A11/GPX4
pathway
to
counteract
Taken
together,
findings
firstly
reveal
improve
counteracting
ferroptotic
P53/SLC7A11/GPX4
axis
Given
easy
availability
exosomes,
our
study
provides
potent
strategy
for
patients
quick
clinical
translation
near
future.
Advanced Science,
Journal Year:
2023,
Volume and Issue:
10(15)
Published: March 26, 2023
Abstract
The
regulation
of
tumor
immunosuppressive
microenvironments
via
precise
drug
delivery
is
a
promising
strategy
for
preventing
recurrence
and
metastasis.
Inspired
by
the
stealth
strategy,
stealthy
nanovehicle
based
on
neutrophil
camouflage
developed
to
achieve
immunotherapy
triggering
pyroptosis.
comprises
anti‐CD11b‐
IR820‐conjugated
bovine
serum
albumin
nanoparticles
loaded
with
decitabine.
Camouflaged
neutrophils,
nanovehicles
efficient
hitchhiking
owing
biotropism
neutrophils
tumors.
fluorescent
signal
molecule,
IR820,
acts
as
navigation
monitor
track
nanovehicle.
released
decitabine
upregulates
gasdermin
E,
laser
irradiation
activates
caspase‐3,
thereby
resulting
in
pyroptosis,
which
improves
system's
adaptive
immune
response.
In
triple‐negative
breast
cancer
animal
model,
it
regulates
microenvironment
effective
induces
long‐lasting
strong
memory
prevent
lung
Chemical Reviews,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 27, 2025
Nanozymes
have
shown
significant
potential
in
cancer
catalytic
therapy
by
strategically
catalyzing
tumor-associated
substances
and
metabolites
into
toxic
reactive
oxygen
species
(ROS)
situ,
thereby
inducing
oxidative
stress
promoting
cell
death.
However,
within
the
complex
tumor
microenvironment
(TME),
rational
design
of
nanozymes
factors
like
activity,
reaction
substrates,
TME
itself
significantly
influence
efficiency
ROS
generation.
To
address
these
limitations,
recent
research
has
focused
on
exploring
that
affect
activity
developing
nanozyme-based
cascade
systems,
which
can
trigger
two
or
more
processes
tumors,
producing
therapeutic
achieving
efficient
stable
with
minimal
side
effects.
This
area
remarkable
progress.
Perspective
provides
a
comprehensive
overview
nanozymes,
covering
their
classification
fundamentals.
The
regulation
nanozyme
strategies
are
discussed
detail.
Furthermore,
representative
paradigms
for
successful
construction
systems
treatment
summarized
focus
revealing
underlying
mechanisms.
Finally,
we
current
challenges
future
prospects
development
biomedical
applications.
Pharmaceutics,
Journal Year:
2022,
Volume and Issue:
14(10), P. 1990 - 1990
Published: Sept. 21, 2022
Cancer
immunotherapy
has
shown
impressive
anti-tumor
activity
in
patients
with
advanced
and
early-stage
malignant
tumors,
thus
improving
long-term
survival.
However,
current
cancer
is
limited
by
barriers
such
as
low
tumor
specificity,
poor
response
rate,
systemic
toxicities,
which
result
the
development
of
primary,
adaptive,
or
acquired
resistance.
Immunotherapy
resistance
complex
mechanisms
that
depend
on
interaction
between
cells
microenvironment
(TME).
Therefore,
targeting
TME
recently
received
attention
a
feasibility
strategy
for
re-sensitizing
resistant
neoplastic
niches
to
existing
immunotherapy.
With
nanotechnology,
nanoplatforms
possess
outstanding
features,
including
high
loading
capacity,
tunable
porosity,
specific
desired
locus.
can
significantly
improve
effectiveness
while
reducing
its
toxic
side
effects
non-target
receive
intense
This
review
explores
reprogramming
resistance,
TAMs,
CAFs,
vasculature,
hypoxia.
We
also
examined
whether
application
nano-drugs
combined
regimens
clinical
outcomes
solid
tumors.
Immunological Reviews,
Journal Year:
2023,
Volume and Issue:
321(1), P. 94 - 114
Published: Aug. 7, 2023
Immunogenic
cell
death
(ICD)
is
a
unique
mode
of
death,
which
can
release
immunogenic
damage-associated
molecular
patterns
(DAMPs)
and
tumor-associated
antigens
to
trigger
long-term
protective
antitumor
immune
responses.
Thus,
amplifying
"eat
me
signal"
during
tumor
ICD
cascade
critical
for
cancer
immunotherapy.
Some
therapies
(radiotherapy,
photodynamic
therapy
(PDT),
photothermal
(PTT),
etc.)
inducers
(chemotherapeutic
agents,
have
enabled
initiate
and/or
facilitate
activate
Recently,
nanostructure-based
drug
delivery
systems
been
synthesized
inducing
through
combining
treatment
chemotherapeutic
photosensitizers
PDT,
transformation
agents
PTT,
radiosensitizers
radiotherapy,
etc.,
loaded
at
an
appropriate
dosage
in
the
designated
place
time,
contributing
higher
efficiency
lower
toxicity.
Also,
immunotherapeutic
combination
with
produce
synergetic
effects,
thus
potentiating
Overall,
our
review
outlines
emerging
inducers,
nanostructure
loading
diverse
evoke
chemoradiotherapy,
PTT
or
agents.
Moreover,
we
discuss
prospects
challenges
harnessing
induction-based
immunotherapy,
highlight
significance
multidisciplinary
interprofessional
collaboration
promote
optimal
translation
this
strategy.
Ultrasonics Sonochemistry,
Journal Year:
2023,
Volume and Issue:
100, P. 106617 - 106617
Published: Sept. 23, 2023
The
rapid
spread
and
uncontrollable
evolution
of
antibiotic-resistant
bacteria
have
already
become
urgent
global
to
treat
bacterial
infections.
Sonodynamic
therapy
(SDT),
a
noninvasive
effective
therapeutic
strategy,
has
broadened
the
way
toward
dealing
with
biofilms,
which
base
on
ultrasound
(US)
sonosensitizer.
Sonosensitizer,
based
small
organic
molecules
or
inorganic
nanoparticles,
is
essential
SDT
process.
Thus,
it
meaningful
design
sonosensitizer-loaded
nanoplatform
synthesize
an
efficient
effect.
In
this
review,
we
initially
summarize
probable
SDT-based
antibacterial
mechanisms
systematically
discuss
current
advancement
in
different
(including
for
small-molecule
sonosensitizer
delivery
as
sonosensitizer)
infection
therapy.
addition,
biomedical
applications
SDT-involved
multifunctional
nanoplatforms
are
also
discussed.
We
believe
innovative
would
highly
next-generation
tool
combating
infection.
