ACS Chemical Neuroscience,
Journal Year:
2025,
Volume and Issue:
16(5), P. 826 - 843
Published: Feb. 20, 2025
Gold
nanoparticles
(AuNPs)
are
valuable
tools
in
pharmacological
and
biological
research,
offering
unique
properties
for
drug
delivery
the
treatment
of
neurodegenerative
diseases.
This
study
investigates
potential
gold
loaded
with
afzelin,
a
natural
chemical
extracted
from
Ribes
fasciculatum,
to
enhance
its
therapeutic
effects
overcome
limitations
using
compounds
regarding
low
productivity.
We
hypothesized
that
combined
AuNPs
afzelin
(AuNP-afzelin)
would
remarkably
enforce
neuroprotective
compared
single
afzelin.
Central
administration
AuNP-afzelin
(10
ng
afzelin)
indicated
improvements
cognition
memory-involved
assessments
behavioral
tests,
comparing
treatments
or
100
scopolamine-induced
AD
mice.
also
performed
superior
rescuing
mature
neuronal
cells
recovered
cholinergic
dysfunction
alone,
according
further
investigations
BDNF-pCREB-pAkt
signaling,
long-term
potentiation,
doublecortin
(DCX)
expression
hippocampus.
highlights
as
promising
approach
mitigating
cognitive
impairments
associated
diseases
offers
new
avenue
future
research
development.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(12), P. 8885 - 8905
Published: March 11, 2024
As
intervertebral
disc
degeneration
(IVDD)
proceeds,
the
dysfunctional
mitochondria
disrupt
viability
of
nucleus
pulposus
cells,
initiating
degradation
extracellular
matrix.
To
date,
there
is
a
lack
effective
therapies
targeting
cells.
Here,
we
synthesized
polygallic
acid-manganese
(PGA-Mn)
nanoparticles
via
self-assembly
polymerization
gallic
acid
in
an
aqueous
medium
and
introduced
mitochondrial
peptide
(TP04)
onto
using
Schiff
base
linkage,
resulting
PGA-Mn-TP04
nanoparticles.
With
size
smaller
than
50
nm,
possesses
pH-buffering
capacity,
avoiding
lysosomal
confinement
selectively
accumulating
within
through
electrostatic
interactions.
The
rapid
electron
exchange
between
manganese
ions
enhances
redox
capability
PGA-Mn-TP04,
effectively
reducing
damage
caused
by
reactive
oxygen
species.
Moreover,
restores
function
facilitating
fusion
minimizing
their
fission,
thereby
sustaining
vitality
In
rat
IVDD
model,
maintained
height
tissue
hydration.
It
offers
nonoperative
treatment
approach
for
other
skeletal
muscle
diseases
from
dysfunction,
presenting
alternative
to
traditional
surgical
interventions.
Ageing Research Reviews,
Journal Year:
2024,
Volume and Issue:
98, P. 102323 - 102323
Published: May 9, 2024
Oxidative
stress
is
one
of
the
main
driving
mechanisms
intervertebral
disc
degeneration(IDD).
has
been
associated
with
inflammation
in
disc,
cellular
senescence,
autophagy,
and
epigenetics
cells.
It
above
pathological
are
closely
linked
through
common
hub
reactive
oxygen
species(ROS),
promote
each
other
process
degeneration
development
disease.
This
reveals
important
role
oxidative
IDD,
importance
great
potential
IDD
therapy
targeting
stress.
The
efficacy
traditional
unstable
or
cannot
be
maintained.
In
recent
years,
due
to
rise
materials
science,
many
bioactive
functional
have
applied
treatment
combination
drugs,
satisfactory
achieved.
At
present,
research
review
antioxidant
not
complete.
Based
on
existing
studies,
mechanism
were
summarized
this
paper,
strategies
based
emerging
reviewed.
Journal of Orthopaedic Translation,
Journal Year:
2025,
Volume and Issue:
50, P. 111 - 128
Published: Jan. 1, 2025
The
treatment
of
orthopaedic
diseases,
such
as
fractures
and
osteoarthritis,
remains
a
significant
challenge
due
to
the
complex
requirements
for
mechanical
strength
tissue
repair.
Hydrogels
based
on
hyaluronic
acid
methacrylate
(HAMA)
show
promise
engineering
materials
these
conditions.
Hyaluronic
(HA)
is
natural
component
extracellular
matrix,
known
its
good
compatibility.
HAMA-based
hydrogels
can
be
adjusted
through
crosslinking
by
combining
them
with
other
materials.
This
review
provides
an
overview
recent
research
applications
in
diseases.
First,
we
summarize
techniques
preparation
characterization
HAMA
hydrogels.
Next,
offer
detailed
use
treating
conditions
cartilage
injuries,
bone
defects,
meniscus
injuries.
Additionally,
discuss
diseases
related
orthopaedics.
Finally,
point
out
challenges
propose
future
directions
clinical
translation
strong
translational
potential
orthopaedics
their
biocompatibility,
adjustable
properties,
regenerative
capabilities.
With
ongoing
research,
are
well-positioned
applications,
particularly
repair,
osteoarthritis
treatment.
Journal of Nanobiotechnology,
Journal Year:
2023,
Volume and Issue:
21(1)
Published: Oct. 18, 2023
Brain-derived
neurotrophic
factor
(BDNF)
with
neuronic
development
and
function
is
a
promising
therapeutic
agent
for
treating
depressive
disorder,
according
to
the
neurotrophin
hypothesis.
However,
delivery
of
BDNF
into
brain
not
easy
as
these
large
protein
molecules
cannot
efficiently
cross
blood-brain
barrier
(BBB)
easily
suffer
oxidative
damage
in
vivo.
Therefore,
quercetin-based
alginate
nanogels
(quercetin
nanogels)
loaded
have
been
developed,
which
could
bypass
BBB
via
nose-to-brain
pathway
protect
from
damage,
providing
an
effective
route
therapy
disorders
by
intranasal
delivery.Quercetin
exhibited
uniform
size
distribution,
excellent
biocompatibility,
potent
antioxidant
anti-inflammatory
activities.
Quercetin
thermosensitive
gel
achieved
sustained
controlled
release
non-Fick's
diffusion,
rapid
nearly
50-fold
enhanced
bioavailability
compared
oral
quercetin.
drug
carrier
exerted
antidepressant
effects
on
reserpine-induced
rats,
effectively
delivered
reverse
despair
behavior
stress-induced
mice,
chronic
mild
unpredictable
stimulation
(CUMS)
rats.
These
BDNF-Quercetin
CUMS
rats
are
associated
regulation
glutamatergic
system,
PI3K-Akt,
BDNF-TrkB
signaling
pathway.In
this
study,
we
provide
strategy
disorders,
through
combining
quercetin
administration.
Molecular Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 22, 2024
Intervertebral
disc
degeneration
(IVDD)
is
commonly
associated
with
many
spinal
problems,
such
as
low
back
pain,
and
significantly
impacts
a
patient's
quality
of
life.
However,
current
treatments
for
IVDD,
which
include
conservative
surgical
methods,
are
limited
in
their
ability
to
fully
address
degeneration.
To
combat
delivery-system-based
therapy
has
received
extensive
attention
from
researchers.
These
delivery
systems
can
effectively
deliver
therapeutic
agents
overcoming
the
limitations
these
agents,
reducing
leakage
increasing
local
concentration
inhibit
IVDD
or
promote
intervertebral
(IVD)
regeneration.
This
review
first
briefly
introduces
structure
function
IVD,
related
pathophysiology
IVDD.
Subsequently,
roles
drug-based
bioactive-substance-based
highlighted.
The
former
includes
natural
source
drugs,
nonsteroidal
anti-inflammatory
steroid
medications,
other
small
molecular
drugs.
latter
chemokines,
growth
factors,
interleukin,
platelet-rich
plasma.
Additionally,
gene-based
cell-based
involved.
Finally,
future
development
combination
treatment
discussed,
providing
insights
research.
