Journal of Neural Engineering,
Journal Year:
2024,
Volume and Issue:
21(4), P. 041001 - 041001
Published: July 23, 2024
Abstract
Peripheral
nerve
injury
(PNI)
represents
a
serious
clinical
and
public
health
problem
due
to
its
high
incurrence
poor
spontaneous
recovery.
Compared
autograft,
which
is
still
the
best
current
practice
for
long-gap
peripheral
defects
in
clinics,
use
of
polymer-based
biodegradable
guidance
conduits
(NGCs)
has
been
gaining
momentum
as
an
alternative
guide
repair
severe
PNI
without
need
secondary
surgery
donor
tissue.
However,
simple
hollow
cylindrical
tubes
can
barely
outperform
autograft
terms
regenerative
efficiency
especially
critical
sized
PNI.
With
rapid
development
tissue
engineering
technology
materials
science,
various
functionalized
NGCs
have
emerged
enhance
regeneration
over
past
decades.
From
aspect
scaffold
design
considerations,
with
specific
focus
on
polymers,
this
review
aims
summarize
recent
advances
by
addressing
onerous
demands
biomaterial
selections,
structural
designs,
manufacturing
techniques
that
contributes
biocompatibility,
degradation
rate,
mechanical
properties,
drug
encapsulation
release
efficiency,
immunomodulation,
angiogenesis,
overall
potential
NGCs.
In
addition,
several
commercially
available
along
their
regulation
pathways
applications
are
compared
discussed.
Lastly,
we
discuss
challenges
future
directions
attempting
provide
inspiration
ideal
completely
cure
defects.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: May 12, 2024
Abstract
Biomaterials
can
modulate
the
local
immune
microenvironments
to
promote
peripheral
nerve
regeneration.
Inspired
by
spatial
orderly
distribution
and
endogenous
electric
field
of
fibers,
we
aimed
investigate
synergistic
effects
electrical
topological
cues
on
Nerve
guidance
conduits
(NGCs)
with
aligned
electrospun
nanofibers
were
fabricated
using
a
polyurethane
copolymer
containing
conductive
aniline
trimer
degradable
L
-lysine
(PUAT).
In
vitro
experiments
showed
that
PUAT
(A-PUAT)
membranes
promoted
recruitment
macrophages
induced
their
polarization
towards
pro-healing
M2
phenotype,
which
subsequently
facilitated
migration
myelination
Schwann
cells.
Furthermore,
NGCs
from
A-PUAT
increased
proportion
improved
regeneration
in
rat
model
sciatic
injury.
conclusion,
this
study
demonstrated
potential
application
an
immunomodulatory
perspective
revealed
as
clinically-actionable
strategy
for
Materials & Design,
Journal Year:
2024,
Volume and Issue:
238, P. 112646 - 112646
Published: Jan. 6, 2024
Polyetheretherketone
(PEEK)
is
a
frequently
utilized
orthopedic
implant
material
in
clinical
settings.
However,
the
adverse
inflammatory
and
immunological
reactions
due
to
PEEK
surface
after
implantation
often
cause
poor
osseointegration
thereby
hinder
its
utility.
To
improve
enhance
success
rate
of
implants,
can
be
biofunctionalized
immunomodulatory.
Consequently,
this
study,
lithium-doped
bioglass
nanospheres
(Li/BGs)
was
coated
on
sulfonated
surface.
Furthermore,
we
assessed
anti-inflammatory
potential
implants
their
impact
osteogenesis.
In
our
it
observed
that
vitro
exhibited
enhanced
osteogenesis
immunomodulatory
properties,
while
also
effectively
suppressing
acute
response
initiated
by
macrophages.
vivo
experiments
demonstrated
contributed
improved
properties
mitigated
formation
fibrous
capsules.
Therefore,
results
modification
with
Li/BGs
not
only
changed
disadvantage
being
bioinert
but
endowed
osteoimmunomodulatory
regulation
bone-promoting
properties.
Thus,
may
promising
candidate
for
use
as
an
National Science Review,
Journal Year:
2024,
Volume and Issue:
11(4)
Published: Jan. 25, 2024
Tissue
regeneration
is
a
complicated
process
that
relies
on
the
coordinated
effort
of
nervous,
vascular
and
immune
systems.
While
nervous
system
plays
crucial
role
in
tissue
regeneration,
current
engineering
approaches
mainly
focus
restoring
function
injury-related
cells,
neglecting
guidance
provided
by
nerves.
This
has
led
to
unsatisfactory
therapeutic
outcomes.
Herein,
we
propose
new
generation
engineered
neural
constructs
from
perspective
induction,
which
offers
versatile
platform
for
promoting
multiple
regeneration.
Specifically,
consist
inorganic
biomaterials
stem
cells
(NSCs),
where
endows
NSCs
with
enhanced
biological
activities
including
proliferation
differentiation.
Through
animal
experiments,
show
effectiveness
repairing
central
injuries
recovery.
More
importantly,
also
stimulate
osteogenesis,
angiogenesis
neuromuscular
junction
formation,
thus
bone
skeletal
muscle,
exhibiting
its
performance.
These
findings
suggest
inorganic-biomaterial/NSC-based
represents
promising
avenue
inducing
recovery
varying
tissues
organs.
Journal of Materials Chemistry B,
Journal Year:
2024,
Volume and Issue:
12(9), P. 2217 - 2235
Published: Jan. 1, 2024
Effective
immune
response
is
an
indispensable
process
for
peripheral
nerve
regeneration
and
the
tissue
engineering
strategies
provide
approach
regulating
cells
that
promote
repair.
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 27, 2025
Tissue
engineering
aims
to
repair
damaged
tissues
with
physiological
functions
recovery.
Although
several
therapeutic
strategies
are
there
for
tissue
regeneration,
the
functional
recovery
of
regenerated
still
poses
significant
challenges
due
lack
concerns
innervation.
Design
rationale
multifunctional
biomaterials
both
tissue-induction
and
neural
induction
activities
shows
great
potential
regeneration.
Recently,
research
application
inorganic
attracts
increasing
attention
in
innervated
multi-tissue
such
as
central
nerves,
bone,
skin,
because
its
superior
tunable
chemical
composition,
topographical
structures,
physiochemical
properties.
More
importantly,
easily
combined
other
organic
materials,
biological
factors,
external
stimuli
enhance
their
effects.
This
review
presents
a
comprehensive
overview
recent
advancements
It
begins
introducing
classification
properties
typical
design
inorganic-based
material
composites.
Then,
progresses
regenerating
various
nerves
nerve-innervated
systematically
reviewed.
Finally,
existing
future
perspectives
proposed.
may
pave
way
direction
offers
new
strategy
regeneration
combination
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(31)
Published: June 17, 2024
Abstract
Advanced
artificial
nerve
conduits
offer
a
promising
alternative
for
injury
repair.
Current
research
focuses
on
improving
the
therapeutic
effectiveness
of
by
optimizing
scaffold
materials
and
functional
components.
In
this
study,
novel
poly(3,4‐ethylenedioxythiophene)
(PEDOT)‐integrated
fish
swim
bladder
(FSB)
is
presented
as
conductive
conduit
with
ordered
topology
electrical
stimulation
to
promote
regeneration.
PEDOT
nanomaterials
adhesive
peptides
(IKVAV)
are
successfully
incorporated
onto
decellularized
FSB
substrate
through
pre‐coating
polydopamine.
The
obtained
PEDOT/IKVAV‐integrated
exhibits
outstanding
mechanical
properties,
high
conductivity,
stability,
well
excellent
biocompatibility
bioadhesive
properties.
vitro
studies
confirm
that
can
effectively
facilitate
growth
directional
extension
pheochromocytoma
12
cells
dorsal
root
ganglion
neurites.
addition,
in
vivo
experiments
demonstrate
proposed
accelerate
defective
repair
restoration.
findings
indicate
FSB‐derived
multiple
regenerative
inducing
signals
integration
provide
conducive
milieu
regeneration,
exhibiting
great
potential
repairing
long‐segment
neural
defects.
Acta Biomaterialia,
Journal Year:
2024,
Volume and Issue:
178, P. 307 - 319
Published: Feb. 20, 2024
Lithium
(Li),
a
widely
used
drug
for
bipolar
disorder
management,
is
associated
with
many
side
effects
due
to
systemic
exposure.
The
localized
delivery
of
lithium
through
implants
could
be
an
approach
overcome
this
challenge,
which
biodegradable
magnesium
(Mg)-based
materials
are
promising
choice.
In
study,
we
focus
on
Mg-Li
thin
film
alloys
as
potential
Li-releasing
implants.
Therefore,
investigated
the
in
vitro
short-term
corrosion
behavior
and
cytocompatibility
two
alloys,
Mg-1.6wt%Li
Mg-9.5wt%Li.
As
glial
cells
key
players
foreign
body
responses
implants,
human
cell
lines
studies,
murine
brain
slice
model
more
holistic
view
at
neuroinflammatory
response.
We
found
that
corrodes
approximately
six
times
slower
than
Microscopic
analysis
showed
material
surface
(Mg-1.6wt%Li)
suitable
adhesion.
test
Mg-9.5wt%Li
alloy
extracts
revealed
both
types
proliferated
well
up
10
mM
Mg
concentration,
irrespective
Li
concentration.
model,
did
not
provoke
significant
upregulation
inflammatory/
reactivity
markers
(IL-1β,
IL-6,
FN1,
TNC)
after
24
h
Furthermore,
gene
expression
IL-1β
(up
3-fold)
IL-6
16-fold)
were
significantly
downregulated
96
h,
downregulation
concentration
dependency.
Together,
these
results
indicate
acute
provide
basis
future
studies
explore
applications
material.
propose
idea
via
reduce
therapy
other
neurological
applications.
This
first
study
investigating
Mg-xLi
degradation
under
physiological
conditions
its
influence
cellular
such
proliferation,
viability,
morphology
inflammation.
Utilizing
brain-derived
lines,
normal
attachment.
Using
slices,
comprise
multicellular
network,
demonstrated
elicit
pro-inflammatory
These
substantiate
degradable
biocompatible
support
further
investigation
their
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(18), P. 14132 - 14132
Published: Sept. 15, 2023
Porous
structure
is
an
important
three-dimensional
morphological
feature
of
the
peripheral
nerve
guidance
conduit
(NGC),
which
permits
infiltration
cells,
nutrients,
and
molecular
signals
discharge
metabolic
waste.
structures
with
precisely
customized
pore
sizes,
porosities,
connectivities
are
being
used
to
construct
fully
permeable,
semi-permeable,
asymmetric
NGCs
for
replacement
traditional
autografts
in
treatment
long-segment
injury.
In
this
review,
features
porous
classification
based
on
these
characteristics
discussed.
Common
methods
constructing
3D
current
research
described,
as
well
parameters
tune
pores.
The
effects
physical
properties
NGCs,
including
biodegradation,
mechanical
performance,
permeability,
were
analyzed.
Pore
affects
biological
behavior
Schwann
macrophages,
fibroblasts,
vascular
endothelial
cells
during
regeneration.
construction
ideal
a
significant
advancement
regeneration
tissue
engineering
materials.
purpose
review
generalize,
summarize,
analyze
preparation
their
functions
promoting
guide
development
medical
repair
