Microenvironment-responsive nanoparticles functionalized titanium implants mediate redox balance and immunomodulation for enhanced osseointegration DOI Creative Commons
Wei Chen,

Yifei Pan,

Catherine Huihan Chu

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101628 - 101628

Published: March 2, 2025

Various pathological conditions (e.g., diabetes, osteoporosis) are accompanied by persistent oxidative stress, which compromises the immune microenvironment and poses substantial challenges for osseointegration. Reactive oxygen species (ROS) play a "double-edged sword" role in bone tissue. Therefore, developing responsive biomaterials to maintain redox balance dynamically is crucial enhanced Herein, microenvironment-responsive coordination nanoparticles (C-Ca-SalB NPs) composed of salvianolic acid B (SalB), catechol-conjugated chitosan (CS-C), Ca2+ constructed further covalently immobilized onto titanium implant surfaces. The resulting implants achieve on-demand antioxidant immunomodulatory effects manner, thus facilitating regeneration under both normal conditions. Under physiological conditions, functionalized display modest properties without affecting balance, while C-Ca-SalB NPs remain relatively stable. However, modified enable rapid decomposition acidic displaying robust ROS-scavenging, anti-inflammatory, osteoinductive capacities, ultimately remodeling into regenerative one. Overall, smart with controlled bioactive agent release this study present comprehensive solution enhancing bone-implant integration, particularly challenging context stress.

Language: Английский

Natural Products from Herbal Medicine Self‐Assemble into Advanced Bioactive Materials DOI Creative Commons
Xiaohang Guo, Weikang Luo,

Lingyu Wu

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: July 21, 2024

Novel biomaterials are becoming more crucial in treating human diseases. However, many materials require complex artificial modifications and synthesis, leading to potential difficulties preparation, side effects, clinical translation. Recently, significant progress has been achieved terms of direct self-assembly natural products from herbal medicine (NPHM), an important source for novel medications, resulting a wide range bioactive supramolecular including gels, nanoparticles. The NPHM-based produced renewable resources, simple prepare, have demonstrated multi-functionality slow-release, smart-responsive release, especially possess powerful biological effects treat various In this review, revealed as emerging, revolutionary, promising strategy. development, advantages, limitations NPHM, well the advantageous position materials, first reviewed. Subsequently, systematic comprehensive analysis strategies specific seven major classes NPHM is highlighted. Insights into influence structural features on formation also provided. Finally, drivers preparations summarized, emphasizing biomedical applications, future scientific challenges, opportunities, with hope igniting inspiration research applications.

Language: Английский

Citations

37
Cellular Trojan Horse initiates bimetallic Fe-Cu MOF-mediated synergistic cuproptosis and ferroptosis against malignancies DOI Creative Commons
Kerong Chen, Anwei Zhou, X Zhou

et al.

Science Advances, Journal Year: 2024, Volume and Issue: 10(15)

Published: April 10, 2024

Disruptions in metal balance can trigger a synergistic interplay of cuproptosis and ferroptosis, offering promising solutions to enduring challenges oncology. Here, we have engineered Cellular Trojan Horse, named MetaCell, which uses live neutrophils stably internalize thermosensitive liposomal bimetallic Fe-Cu MOFs (Lip@Fe-Cu-MOFs). MetaCell instigate thereby enhancing treatment efficacy. Mirroring the characteristics neutrophils, evade immune system not only infiltrate tumors but also respond inflammation by releasing therapeutic components, surmounting traditional barriers. Notably, Lip@Fe-Cu-MOFs demonstrate notable photothermal effects, inciting targeted release Fe-Cu-MOFs within cancer cells amplifying action ferroptosis. has demonstrated outcomes tumor-bearing mice, effectively eliminating solid forestalling recurrence, leading extended survival. This research provides great insights into complex between copper iron homeostasis malignancies, potentially paving way for innovative approaches treatment.

Language: Английский

Citations

28
Metal–Drug Coordination Nanoparticles and Hydrogels for Enhanced Delivery DOI Creative Commons
Ka‐Ying Wong, Zhenyu Nie, Man‐Sau Wong

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(26)

Published: April 11, 2024

Drug delivery is a key component of nanomedicine, and conventional relies on the adsorption or encapsulation drug molecules to nanomaterial. Many vehicles contain metal ions, such as metal-organic frameworks, oxides, transition dichalcogenides, MXene, noble nanoparticles. These materials have high content pose potential long-term toxicity concerns leading difficulties for clinical approval. In this review, recent developments are summarized in use ligands coordination forming various nanomaterials soft materials. these cases, drug-to-metal ratio much higher than adsorption-based strategies. The divided into small-molecule drugs, nucleic acids, proteins. formed hybrid mainly include nanoparticles hydrogels, upon which targeting can be grafted improve efficacy further decrease toxicity. application addressing cancer, viral infection, bacterial infection inflammatory bowel disease, bone diseases reviewed. end, some future directions discussed from fundamental research, science, medicine.

Language: Английский

Citations

24
Natural Glycyrrhizic Acid‐Tailored Nanoparticles toward the Enhancement of Pesticide Bioavailability DOI

Kailun Wei,

Zilu Li,

Zhiran Zheng

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(28)

Published: March 13, 2024

Abstract Pesticide spraying serves as a prevalent segment in crop production for substantial economic and ecological benefits. Nevertheless, the existing pesticide formulations are often plagued by droplets rebounding during process, controlled‐release, photolysis protection, non‐targeted bio‐friendliness not inadequately considered. Herein, combining spinosad (SSD, model pesticide) with glycyrrhizic acid (GL) an attractive building block, supramolecular co‐assembly strategy is employed to elaborate (GL‐SSD) simultaneously featuring high deposition, environmental friendliness. The resulting spherical GL‐SSD nanoparticles (NPs) have average diameter of 207 nm show improved 5.2‐fold photostability compared commercial suspension (SSD SC). Upon impacting on hydrophobic surfaces polytetrafluoroethylene film cabbage leaf, NPs exhibit superior affinity micro/nano structure surface. Consequently, droplet inhibited effectively, ensuring deposition efficiency surfaces. In addition, release SSD from can be controlled pH variation. Indoor toxicity pot experiments demonstrate that possess good control efficacy against Plutella xylostella . work offers alternative approach development multi‐functional sustainable promising potentials actual agriculture production.

Language: Английский

Citations

21
Cuproptosis: Advances in Stimulus‐Responsive Nanomaterials for Cancer Therapy DOI

Jiacheng Lu,

Yuqing Miao, Yuhao Li

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(19)

Published: April 15, 2024

Abstract Cuproptosis, a recently identified non‐apoptotic programmed cell death modality, attracts considerable attention in the realm of cancer therapeutics owing to its unique cellular demise mechanisms. Since initial report 2022, strategies inducing or amplifying cuproptosis for treatment emerge. The engineering nano‐systems elicit effectively circumvents constraints associated with conventional small‐molecule pharmaceutical interventions, presenting novel prospects oncological therapy. Stimulus‐responsive nanomaterials, leveraging their distinctive spatiotemporal control attributes, are investigated role modulating induction augmentation cuproptosis. In this comprehensive review, physiological characteristics cuproptosis, encompassing facets such as copper overload and depletion, coupled regulatory factors intrinsic expounded upon. Subsequently, design methodologies stimulus‐responsive enhancement employing stimuli light, ultrasound, X‐ray, tumor microenvironment, systematically delineated. This review encompasses intricacies nanomaterial design, insights into therapeutic processes, advantages. Finally, challenges inherent induction/enhancement deliberated upon prospective future trajectory copper‐mediated therapy provided.

Language: Английский

Citations

15
Dye-augmented bandgap engineering of a degradable cascade nanoreactor for tumor immune microenvironment-enhanced dynamic phototherapy of breast cancer DOI Open Access

Zongyan He,

Jun Du, Qian Wang

et al.

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 176, P. 390 - 404

Published: Jan. 18, 2024

Language: Английский

Citations

9
Copper-Based Biomaterials for Anti-Tumor Therapy: Recent Advances and Perspectives DOI
Shufang Zhang, Shuping Peng

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

1
Metal-organic coordinated self-assembled nanomedicine for enhanced cuproptosis-mediated chemo-photo-chemodynamic synergistic therapy of non-small cell lung cancer DOI
R.P. Liu,

Ruirui Zhao,

Zi-Wei Yu

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161305 - 161305

Published: March 1, 2025

Language: Английский

Citations

1
A Multifunctional Hydrogel Fabricated by Direct Self-Assembly of Natural Herbal Small Molecule Mangiferin for Treating Diabetic Wounds DOI

Mengke Hao,

Simin Wei,

Siqi Su

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(19), P. 24221 - 24234

Published: May 6, 2024

Clinical studies have continually referred to the involvement of drug carrier having dramatic negative influences on biocompatibility, biodegradability, and loading efficacy hydrogel. To overcome this deficiency, researchers proposed directly self-assemble natural herbal small molecules into a hydrogel without any structural modification. However, it is still formidable challenge due high requirements structure molecules, leading rarity type Mangiferin (MF) polyphenol C-glucoside xanthone with various positive health benefits, including treatment diabetic wounds, but its poor hydrosolubility low bioavailability significantly restrict clinical application. Inspired by these, heating/cooling treatment, carrier-free (MF-gel) developed assembling molecule mangiferin, which mainly governed through hydrogen bonds intermolecular π–π stacking interactions. The as-prepared has injectable self-healing properties shows excellent continuous release ability, reversible stimuli-responsive performances. All superiorities enable MF-based serve as potential wound dressing for treating was further confirmed both vitro vivo studies. In vitro, MF-gel could promote migration healing-related cells from peripheral well angiogenesis displays capacity mediating inflammation response scavenging intracellular ROS. vivo, accelerates contraction healing via inflammatory adjustment, collagen deposition, angiogenesis. This study provides facile effective method management emphasizes direct self-assembly molecule.

Language: Английский

Citations

8
Orchestrated Metal-coordinated Carrier-free Celastrol Hydrogel Intensifies T Cell Activation and Regulates Response to Immune Checkpoint Blockade for Synergistic Chemo-immunotherapy DOI
Linying Wu,

Wenmin Pi,

Huang Xuemei

et al.

Biomaterials, Journal Year: 2024, Volume and Issue: 312, P. 122723 - 122723

Published: July 31, 2024

Language: Английский

Citations

8