Toxicology of Nanomaterials With a Special Focus on the Nervous System DOI
Bancha Yingngam

Advances in medical diagnosis, treatment, and care (AMDTC) book series, Journal Year: 2024, Volume and Issue: unknown, P. 27 - 64

Published: Oct. 11, 2024

Nanomaterials possess different properties that make them suitable for application in numerous fields. Nonetheless, their toxicity, especially neurotoxic propensity, is a considerable area of investigation. In this chapter, nanomaterial neurotoxicity reviewed detail, with an emphasis on assessing levels exposure or routes entry to brain cells, mechanisms by which they cause damage, and specific types damage. addition, vitro, ex vivo, vivo models used measure are described. This chapter provides discussion matter considering challenges terms characterization, risk assessment, regulatory aspects. concludes underscoring the importance toxicological prediction safe-by-design solutions. Future research should address long-term effects using nanomaterials means preventing neurotoxicity.

Language: Английский

Research Progress in 3D Printed Biobased and Biodegradable Polyester/Ceramic Composite Materials: Applications and Challenges in Bone Tissue Engineering DOI

Shunshun Zhu,

Hongnan Sun, Taihua Mu

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: 17(2), P. 2791 - 2813

Published: Jan. 6, 2025

Transplantation of bone implants is currently recognized as one the most effective means treating defects. Biobased and biodegradable polyester composites combine good mechanical degradable properties polyester, thereby providing an alternative for implant materials. Bone tissue engineering (BTE) accelerates defect repair by simulating microenvironment. Composite scaffolds support formation further accelerate process repair. The introduction 3D printing technology enables preparation to be more precise, reproducible, flexible, which a very promising development. This review presents physical BTE summarizes strategies adopted domestic international scholars improve based on biobased polyester/ceramic in recent years. In addition, future development prospects field challenges expanding production clinical applications are presented.

Language: Английский

Citations

1
CoFe2O4-BaTiO3 Core-Shell-Embedded Flexible Polymer Composite as an Efficient Magnetoelectric Energy Harvester DOI

Bitna Bae,

Nagamalleswara Rao Alluri, Cheol Min Kim

et al.

Materials Today Physics, Journal Year: 2024, Volume and Issue: 48, P. 101567 - 101567

Published: Oct. 10, 2024

Language: Английский

Citations

4
Electro-spun piezoelectric PLLA smart composites as a scaffold on bone fracture: A review DOI Creative Commons

Melika Mirghaffari,

Asal Mahmoodiyan,

Shahram Mahboubizadeh

et al.

Regenerative Therapy, Journal Year: 2025, Volume and Issue: 28, P. 591 - 605

Published: Feb. 20, 2025

Language: Английский

Citations

0
Piezoelectric Biomaterials for Use in Bone Tissue Engineering—A Narrative Review DOI Open Access
Sandeep Choudhury, Debaprasad Das, Sandipan Roy

et al.

Journal of Biomedical Materials Research Part B Applied Biomaterials, Journal Year: 2025, Volume and Issue: 113(4)

Published: March 17, 2025

ABSTRACT To examine natural bone's bioelectrical traits, notably its piezoelectricity, and to look into how these characteristics influence bone growth repair. In the context of exploring potential piezoelectric biomaterials, such as biopolymers bio‐ceramics, towards orthopedic regeneration applications, research seeks evaluate significance piezoelectricity‐driven osteogenesis. The paper reviews recent on electrical dielectric properties, surface polarization/electrical stimulation effects interacting with cell activity effectiveness biomaterials support tissues' regenerative process. study includes a number materials, collagen, polyvinylidene fluoride (PVDF) barium titanate. applications organic polymers, polymers are particularly highlighted. Piezoelectric being shown in studies enhance cellular metabolism vitro well promote tissues vivo, especially when paired electric field or interface polarization. bio‐ceramics like magnesium silicate titanate, collagen PVDF, have possibilities for applications. However, there several challenges regarding manufacturing specific compositions having desired properties. This review highlighted special emphasis bioceramics. Therefore, types materials huge because they can mimic properties allow better advances tissue engineering medicine. date, little is known about their mechanism action, modifications needed improve efficacy clinical uptake.

Language: Английский

Citations

0
Implanted Magnetoelectric Bionic Cartilage Hydrogel DOI Open Access
Jiachen Liang, Xinyue Huang,

Kaiqi Qin

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Enhancing defective cartilage repair by creating a bionic hydrogel supplemented with in situ electromagnetic stimulation, replicating endogenous effects, remains challenging. To achieve this, unique three-phase solvent system is designed to prepare magnetoelectric incorporating piezoelectric poly(3-hydroxybutyric acid-3-hydroxyvaleric acid) (PHBV) and magnetostrictive triiron tetraoxide nanoparticles (Fe3O4 NPs) into sodium alginate (SA) form dual-network, semi-crosslinked chain entanglement structure. The synthesized features similar composition, structure, mechanical properties natural cartilage. In addition, after the implantation of cartilage, motion-driven magnetoelectric-coupled cyclic transformation model triggered gentle joint forces, initiating response that leads transformation. freely excitable cyclically enhanced stimulation it can provide, simulating amplifying obtains induced efficacy superior or magnetic alone.

Language: Английский

Citations

0
Piezoelectric properties of collagen films: Insights into their potential for electroactive biomedical applications DOI
Mireia Andonegi, Ander García Díez, Carlos M. Costa

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142799 - 142799

Published: April 1, 2025

Language: Английский

Citations

0
Stimuli-responsive microcarriers and their application in tissue repair: A review of magnetic and electroactive microcarrier DOI Creative Commons
Liyang Zhang,

Mengjiao Ma,

Junfei Li

et al.

Bioactive Materials, Journal Year: 2024, Volume and Issue: 39, P. 147 - 162

Published: May 19, 2024

Microcarrier applications have made great advances in tissue engineering recent years, which can load cells, drugs, and bioactive factors. These microcarriers be minimally injected into the defect to help reconstruct a good microenvironment for repair. In order achieve more ideal performance face complex damage, an increasing amount of effort has been focused on that actively respond external stimuli. functions directional movement, targeted enrichment, material release control, providing signals conducive Given high controllability designability magnetic electroactive microcarriers, research progress these is highlighted this review. Their structure, function applications, potential repair mechanisms, challenges are discussed. summary, through design with clinical translation ability, meaningful comprehensive experimental characterization, in-depth study application stimuli-responsive

Language: Английский

Citations

3
Lipid Priming of Adipose Mesenchymal Stromal Cells with Docosahexaenoic Acid: Impact on Cell Differentiation, Senescence and the Secretome Neuroregulatory Profile DOI Creative Commons
Jonas Campos, Belém Sampaio‐Marques, Diogo J. Santos

et al.

Tissue Engineering and Regenerative Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 4, 2024

Priming strategies that improve the functionality of MSCs may be required to address issues limiting successful clinical translation MSC therapies. For conditions requiring high trophic support such as brain and spinal cord injuries, priming produce higher levels factors instrumental facilitate current We developed tested a novel molecular paradigm using docosahexaenoic acid (DHA) prime adipose tissue-derived mesenchymal stromal cells (ASCs) enhance secretome neuroregulatory potential.

Language: Английский

Citations

2
Research trends of piezoelectric biomaterials in osteochondral tissue engineering DOI
Yubao Liu, Jun Lu

Materials Today Communications, Journal Year: 2024, Volume and Issue: 41, P. 110264 - 110264

Published: Aug. 29, 2024

Language: Английский

Citations

2
Toxicology of Nanomaterials With a Special Focus on the Nervous System DOI
Bancha Yingngam

Advances in medical diagnosis, treatment, and care (AMDTC) book series, Journal Year: 2024, Volume and Issue: unknown, P. 27 - 64

Published: Oct. 11, 2024

Nanomaterials possess different properties that make them suitable for application in numerous fields. Nonetheless, their toxicity, especially neurotoxic propensity, is a considerable area of investigation. In this chapter, nanomaterial neurotoxicity reviewed detail, with an emphasis on assessing levels exposure or routes entry to brain cells, mechanisms by which they cause damage, and specific types damage. addition, vitro, ex vivo, vivo models used measure are described. This chapter provides discussion matter considering challenges terms characterization, risk assessment, regulatory aspects. concludes underscoring the importance toxicological prediction safe-by-design solutions. Future research should address long-term effects using nanomaterials means preventing neurotoxicity.

Language: Английский

Citations

0