Cancer associated-fibroblast-derived exosomes in cancer progression

Molecular Cancer, Journal Year: 2021, Volume and Issue: 20(1)

Published: Dec. 1, 2021

To identify novel cancer therapies, the tumor microenvironment (TME) has received a lot of attention in recent years particular with advent clinical successes achieved by targeting immune checkpoint inhibitors (ICIs). The TME consists multiple cell types that are embedded extracellular matrix (ECM), including cells, endothelial cells and associated fibroblasts (CAFs), which communicate each other during progression. CAFs dominant heterogeneous type within pivotal role controlling invasion metastasis, evasion, angiogenesis chemotherapy resistance. mediate their effects part remodeling ECM secreting soluble factors vesicles. Exosomes subtype vesicles (EVs), contain various biomolecules such as nucleic acids, lipids, proteins. exosomes can be transmitted from one to another cell, thereby affect behavior receiving cell. As also present circulation, contents explored biomarkers for diagnosis prognosis patients. In this review, we concentrate on CAFs-derived communication between TME. First, introduce roles tumorigenesis. Thereafter, discuss ways interplay TME, focus exosomes. Then, elaborate mechanisms contribute progression, well impact We conclude discussing aspects deserve further investigation, emerging insights into making treatment inhibitor blockade more efficient.

Language: Английский

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Engineered exosomes from different sources for cancer-targeted therapy

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: March 15, 2023

Exosome is a subgroup of extracellular vesicles, which has been serving as an efficient therapeutic tool for various diseases. Engineered exosomes are the sort modified with surface decoration and internal molecules. After appropriate modification, engineered able to deliver antitumor drugs tumor sites efficiently precisely fewer treatment-related adverse effects. However, there still exist many challenges clinical translation exosomes. For instance, what sources modification strategies could endow most activity poorly understood. Additionally, how choose appropriately in different therapies another unresolved problem. In this review, we summarized characteristics exosomes, especially spatial temporal properties. concluded recent advances cancer fields, including sources, isolation technologies, strategies, labeling imaging methods Furthermore, applications were summarized, such photodynamic therapy, gene immunotherapy. Consequently, above provides researchers community latest ideas on exosome new direction drug development, prospective accelerate cancer-targeted therapy.

Language: Английский

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Thermal immuno-nanomedicine in cancer

Nature Reviews Clinical Oncology, Journal Year: 2023, Volume and Issue: 20(2), P. 116 - 134

Published: Jan. 5, 2023

Language: Английский

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Nanoparticles in tumor microenvironment remodeling and cancer immunotherapy

Journal of Hematology & Oncology, Journal Year: 2024, Volume and Issue: 17(1)

Published: April 2, 2024

Abstract Cancer immunotherapy and vaccine development have significantly improved the fight against cancers. Despite these advancements, challenges remain, particularly in clinical delivery of immunomodulatory compounds. The tumor microenvironment (TME), comprising macrophages, fibroblasts, immune cells, plays a crucial role response modulation. Nanoparticles, engineered to reshape TME, shown promising results enhancing by facilitating targeted These nanoparticles can suppress fibroblast activation, promote M1 macrophage polarization, aid dendritic cell maturation, encourage T infiltration. Biomimetic further enhance increasing internalization agents cells such as cells. Moreover, exosomes, whether naturally secreted body or bioengineered, been explored regulate TME immune-related affect cancer immunotherapy. Stimuli-responsive nanocarriers, activated pH, redox, light conditions, exhibit potential accelerate co-application with checkpoint inhibitors is an emerging strategy boost anti-tumor immunity. With their ability induce long-term immunity, nanoarchitectures are structures development. This review underscores critical overcoming current driving advancement modification.

Language: Английский

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Exosome-liposome hybrid nanoparticle codelivery of TP and miR497 conspicuously overcomes chemoresistant ovarian cancer

Journal of Nanobiotechnology, Journal Year: 2022, Volume and Issue: 20(1)

Published: Jan. 25, 2022

Although cisplatin-based chemotherapy has been used as the first-line treatment for ovarian cancer (OC), tumor cells develop resistance to cisplatin during treatment, causing poor prognosis in OC patients. Studies have demonstrated that overactivation of phosphatidylinositol 3-kinase/protein kinase B/mammalian target rapamycin (PI3K/AKT/mTOR) pathway is involved chemoresistance and overexpression microRNA-497 (miR497) may overcome by inhibiting mTOR pathway. However, low transcriptional efficiency unstable chemical properties miR497 limit its clinical application. Additionally, triptolide (TP) was confirmed possess a superior killing effect on cisplatin-resistant cell lines, partially through Even so, applications TP are restricted serious systemic toxicity weak water solubility.Herein, whether combined application could further synergically suppressing signaling investigated. Bioinspired hybrid nanoparticles formed fusion CD47-expressing exosomes cRGD-modified liposomes (miR497/TP-HENPs) were prepared codeliver TP. In vitro results indicated efficiently taken up cells, thus significantly enhancing apoptosis. Similarly, effectively enriched areas exerted significant anticancer activity without any negative effects vivo. Mechanistically, they promoted dephosphorylation overactivated PI3K/AKT/mTOR pathway, boosted reactive oxygen species (ROS) generation upregulated polarization macrophages from M2 M1 macrophages.Overall, our findings provide translational strategy offer potential solution other tumors.

Language: Английский

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Nanomaterials in tumor immunotherapy: new strategies and challenges

Molecular Cancer, Journal Year: 2023, Volume and Issue: 22(1)

Published: June 13, 2023

Abstract Tumor immunotherapy exerts its anti-tumor effects by stimulating and enhancing immune responses of the body. It has become another important modality therapy with significant clinical efficacy advantages compared to chemotherapy, radiotherapy targeted therapy. Although various kinds tumor immunotherapeutic drugs have emerged, challenges faced in delivery these drugs, such as poor permeability low cell uptake rate, had prevented their widespread application. Recently, nanomaterials emerged a means for treatment different diseases due targeting properties, biocompatibility functionalities. Moreover, possess characteristics that overcome defects traditional immunotherapy, large drug loading capacity, precise easy modification, thus leading wide application immunotherapy. There are two main classes novel nanoparticles mentioned this review: organic (polymeric nanomaterials, liposomes lipid nanoparticles) inorganic (non-metallic metallic nanomaterials). Besides, fabrication method nanoparticles, Nanoemulsions, was also introduced. In summary, review article mainly discussed research progress based on past few years offers theoretical basis exploring strategies future.

Language: Английский

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Engineered extracellular vesicles and their mimetics for cancer immunotherapy

Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 349, P. 679 - 698

Published: July 28, 2022

Language: Английский

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Extracellular vesicles: a rising star for therapeutics and drug delivery

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: July 20, 2023

Abstract Extracellular vesicles (EVs) are nano-sized, natural, cell-derived that contain the same nucleic acids, proteins, and lipids as their source cells. Thus, they can serve natural carriers for therapeutic agents drugs, have many advantages over conventional nanocarriers, including low immunogenicity, good biocompatibility, blood – brain barrier penetration, capacity gene delivery. This review first introduces classification of EVs then discusses several currently popular methods isolating purifying EVs, EVs-mediated drug delivery, functionalization carriers. Thereby, it provides new avenues development EVs-based strategies in different fields medicine. Finally, highlights some challenges future perspectives with regard to clinical application EVs. Graphical

Language: Английский

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Mesenchymal stem cell-derived extracellular vesicles in skin wound healing: roles, opportunities and challenges

Military Medical Research, Journal Year: 2023, Volume and Issue: 10(1)

Published: Aug. 17, 2023

Abstract Skin wounds are characterized by injury to the skin due trauma, tearing, cuts, or contusions. As such injuries common all human groups, they may at times represent a serious socioeconomic burden. Currently, increasing numbers of studies have focused on role mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) in wound repair. cell-free therapy, MSC-derived EVs shown significant application potential field repair as more stable and safer option than conventional therapy. Treatment based can significantly promote damaged substructures, including regeneration vessels, nerves, hair follicles. In addition, inhibit scar formation affecting angiogenesis-related antifibrotic pathways promoting macrophage polarization, angiogenesis, proliferation, migration, inhibiting excessive matrix production. Additionally, these structures serve scaffold for components used repair, be developed into bioengineered support trauma Through formulation standardized culture, isolation, purification, drug delivery strategies, exploration detailed mechanism will allow them clinical treatments conclusion, EVs-based therapies important prospects Here we provide comprehensive overview their current status, potential, associated drawbacks.

Language: Английский

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Cell-derived nanovesicle-mediated drug delivery to the brain: Principles and strategies for vesicle engineering

Molecular Therapy, Journal Year: 2022, Volume and Issue: 31(5), P. 1207 - 1224

Published: Oct. 17, 2022

Developing strategies toward safe and effective drug delivery into the central nervous system (CNS) with improved targeting abilities reduced off-target effects is crucial. CNS-targeted carriers made of synthetic molecules raise concerns about their biodegradation, clearance, immune responses, neurotoxicity. Cell-derived nanovesicles (CDNs) have recently been applied in delivery, because intrinsic stability, biocompatibility, inherent homing capability, ability to penetrate through biological barriers, including blood-brain barrier. Among these CDNs, extracellular vesicles exosomes are most studied surface can be engineered modified cater brain targeting. In this review, we focus on application CDNs brain-targeted treat neurological diseases. We cover developed methods exosome derivation engineering, exosome-like particles, hybrid exosomes, exosome-associated adeno-associated viruses, envelope protein nanocages. Finally, discuss limitations project future development CDN-based systems, conclude that hold great potential treatment

Language: Английский

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