Giant,
Journal Year:
2024,
Volume and Issue:
18, P. 100251 - 100251
Published: March 6, 2024
The
treatment
of
diabetic
wounds
is
a
major
challenge
faced
by
the
medical
system,
and
there
growing
interest
in
developing
innovative
therapies
to
accelerate
wound
healing.
Regenerative
medicine
with
cells
has
shown
promising
potential
skin
repair,
regenerative
properties
primarily
attributed
paracrine
effects
secreted
products,
including
exosomes.
Compared
cell-based
approaches,
using
exosomes
as
cell-free
therapy
for
chronic
several
advantages.
Exosomes
can
regulate
intercellular
communication
releasing
their
contents,
mRNA,
miRNA,
lipids,
proteins,
which
further
promote
are
well
explored
biomedical
application
owing
advantages
such
biocompatibility
low
immunogenicity.
However,
common
method
exosome
administration
through
injection,
but
due
rapid
clearance
rate
body,
maintaining
necessary
therapeutic
concentration
around
challenging.
Therefore,
it
develop
new
biocompatible
scaffold
carrier
extracellular
vesicles,
allowing
them
sustain
at
non-healing
sites
continuously
Engineered
kinds
modified
internal
treated
molecules,
surface
decoration
or
delivered
engineered
platform.
In
addition,
some
researchers
have
processed
exosomes,
known
decoration,
delivery
platforms.
regular
greater
promoting
this
review,
we
summarize
molecular
mechanisms
from
different
sources
varying
modifications
Advantages
limitations
repair
were
also
discussed.
Finally,
highlight
challenges
future
development
directions
translating
our
knowledge
into
clinical
practice.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(25)
Published: March 12, 2024
Abstract
Given
the
challenge
of
multidrug
resistance
in
antibiotics,
non‐antibiotic–dependent
antibacterial
strategies
show
promise
for
anti‐infective
therapy.
V
2
C
MXene‐based
nanomaterials
have
demonstrated
strong
biocompatibility
and
photothermal
conversion
efficiency
(PCE)
therapy
(PTT).
However,
limitation
MXene's
laser
irradiation
to
near‐infrared
region
I
(NIR‐I)
restricts
tissue
penetration,
making
it
difficult
achieve
complete
bacterial
eradication
with
single‐effect
therapeutic
strategies.
To
address
this,
Pt
nanoparticles
(Pt
NPs)
are
attached
C,
forming
artificial
nanoplatforms
(Pt@V
C).
Pt@V
exhibits
enhanced
PCE
(59.6%)
a
longer
(NIR‐II)
due
surface
plasmon
resonance
effect
NPs
C.
Notably,
displays
dual
enzyme‐like
activity
chemodynamic
(CDT)
NIR‐II
activity.
The
biocatalytic
mechanism
is
elucidated
using
density
functional
theory.
In
an
vivo
animal
model,
effectively
eliminates
methicillin‐resistant
Staphylococcus
aureus
from
deep‐seated
tissues
subcutaneous
abscesses
keratitis
environments,
accelerating
abscess
resolution
promoting
wound
cornea
healing
through
synergistic
effects
PTT/CDT.
Transcriptomic
analysis
reveals
that
targets
inflammatory
pathways,
providing
insight
into
its
mechanism.
This
study
presents
promising
approach
involving
hyperthermia‐amplified
biocatalysis
MXene
nanocomposites.
International Journal of Nanomedicine,
Journal Year:
2023,
Volume and Issue:
Volume 18, P. 7923 - 7940
Published: Dec. 1, 2023
Exosomes
are
nano-sized
membrane
vesicles
that
transfer
bioactive
molecules
between
cells
and
modulate
various
biological
processes
under
physiological
pathological
conditions.
By
applying
bioengineering
technologies,
exosomes
can
be
modified
to
express
specific
markers
or
carry
therapeutic
cargo
emerge
as
novel
platforms
for
the
treatment
of
cancer,
neurological,
cardiovascular,
immune,
infectious
diseases.
However,
there
many
challenges
uncertainties
in
clinical
translation
exosomes.
This
review
aims
provide
an
overview
recent
advances
engineered
exosomes,
with
a
special
focus
on
methods
strategies
loading
drugs
into
pros
cons
different
methods,
optimization
exosome
production
based
encapsulated.
Moreover,
we
also
summarize
current
applications
prospects
well
potential
risks
limitations
need
addressed
engineering,
including
standardization
preparation
engineering
protocols,
quality
quantity
control
drug
release,
immunogenicity
cytotoxicity
Overall,
represent
exciting
frontier
nanomedicine,
but
they
still
face
large-scale
production,
maintenance
storage
stability,
translation.
With
continuous
this
field,
exosome-based
formulation
could
offer
great
promise
targeted
human
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
unknown
Published: July 12, 2023
Abstract
Natural
living
materials
serving
as
biotherapeutics
exhibit
great
potential
for
treating
various
diseases
owing
to
their
immunoactivity,
tissue
targeting,
and
other
biological
activities.
In
this
review,
the
recent
developments
in
engineered
materials,
including
mammalian
cells,
bacteria,
viruses,
fungi,
microalgae,
plants,
active
derivatives
that
are
used
summarized.
Further,
future
perspectives
challenges
of
such
material‐based
discussed
provide
considerations
advances
biomedical
applications.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Jan. 28, 2024
Malignancy
is
a
major
public
health
problem
and
among
the
leading
lethal
diseases
worldwide.
Although
current
tumor
treatment
methods
have
therapeutic
effect
to
certain
extent,
they
still
some
shortcomings
such
as
poor
water
solubility,
short
half-life,
local
systemic
toxicity.
Therefore,
how
deliver
agent
so
realize
safe
effective
anti-tumor
therapy
become
urgently
be
solved
in
this
field.
As
medium
of
information
exchange
material
transport
between
cells,
exosomes
are
considered
promising
drug
delivery
carrier
due
their
nano-size,
good
biocompatibility,
natural
targeting,
easy
modification.
In
review,
we
summarize
recent
advances
isolation,
identification,
loading,
modification
carriers
for
alongside
application
therapy.
Basic
knowledge
exosomes,
biogenesis,
sources,
characterization
methods,
also
introduced
herein.
addition,
challenges
related
use
vehicles
discussed,
along
with
future
trends.
This
review
provides
scientific
basis
exosome
systems
oncological
Advanced Science,
Journal Year:
2023,
Volume and Issue:
10(32)
Published: Sept. 25, 2023
Extracellular
vesicles
(EVs),
involved
in
essential
physiological
and
pathological
processes
of
the
organism,
have
emerged
as
powerful
tools
for
disease
treatment
owing
to
their
unique
natural
biological
characteristics
artificially
acquired
advantages.
However,
limited
targeting
ability,
insufficient
production
yield,
low
drug-loading
capability
simplex
EVs
greatly
hindered
development
clinical
translation.
Therefore,
establishment
multifunctional
hybrid
membrane
nanovesicles
(HMNVs)
with
favorable
adaptability
flexibility
has
become
key
expanding
practical
application
EVs.
This
timely
review
summarizes
current
progress
HMNVs
biomedical
applications.
Different
preparation
strategies
including
physical,
chemical,
chimera
approaches
are
first
discussed.
then
individually
describes
diverse
types
based
on
homologous
or
heterologous
cell
substances,
a
fusion
liposome,
well
bacterial
membrane.
Subsequently,
specific
emphasis
is
placed
highlight
applications
toward
various
diseases
representative
examples.
Finally,
ongoing
challenges
prospects
currently
developed
translational
briefly
presented.
will
not
only
stimulate
broad
interest
among
researchers
from
disciplines
but
also
provide
valuable
insights
promising
nanoplatforms
precision
medicine.
Bioactive Materials,
Journal Year:
2023,
Volume and Issue:
32, P. 124 - 146
Published: Oct. 4, 2023
Due
to
its
multiple
features,
including
the
ability
orchestrate
remote
communication
between
different
tissues,
exosomes
are
extracellular
vesicles
arousing
highest
interest
in
scientific
community.
Their
size,
established
as
an
average
of
30-150
nm,
allows
them
be
easily
uptaken
by
most
cells.
According
type
cells-derived
exosomes,
they
may
carry
specific
biomolecular
cargoes
used
reprogram
cells
interacting
with.
In
certain
circumstances,
stimulate
immune
response
facilitating
or
amplifying
release
foreign
antigens-killing
cells,
inflammatory
factors,
antibodies
(immune
activation).
Meanwhile,
other
cases,
efficiently
malignant
elements
such
cancer
mislead
recognition
mechanism,
carrying
and
transferring
their
cancerous
distant
healthy
thus
contributing
antigenic
invasion
suppression).
Exosome
dichotomic
patterns
upon
system
regulation
present
broad
advantages
immunotherapy.
Its
perfect
comprehension,
from
early
biogenesis
interaction
with
recipient
will
promote
a
significant
enhancement
immunotherapy
employing
molecular
biology,
nanomedicine,
nanotechnology.
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 109 - 135
Published: Jan. 1, 2024
Abstract:
The
tumor
microenvironment
(TME)
plays
an
important
role
in
various
stages
of
generation,
metastasis,
and
evasion
immune
monitoring
treatment.
TME
targeted
therapy
is
based
on
components,
related
pathways
or
active
molecules
as
therapeutic
targets.
Therefore,
environmental
differences
between
normal
cells
has
been
widely
studied.
Biomimetic
nanocarriers
with
low
clearance,
immunogenicity,
high
targeting
have
enormous
potential
This
review
introduces
the
composition
characteristics
TME,
including
cancer‑associated
fibroblasts
(CAFs),
extracellular
matrix
(ECM),
blood
vessels,
non-tumor
cells,
latest
research
progress
biomimetic
nanoparticles
(NPs)
TME.
It
also
discusses
opportunities
challenges
clinical
transformation
nanoparticles.
Keywords:
nanoparticles,
delivery
system,
therapy,
cell
membrane-coating
Discover Nano,
Journal Year:
2024,
Volume and Issue:
19(1)
Published: March 7, 2024
Abstract
Breast
cancer
is
a
complex
and
heterogeneous
disease,
encompassing
various
subtypes
characterized
by
distinct
molecular
features,
clinical
behaviors,
treatment
responses.
Categorization
of
based
on
the
presence
or
absence
estrogen
receptor
(ER),
progesterone
(PR),
human
epidermal
growth
factor
2
(HER2),
leading
to
such
as
luminal
A,
B,
HER2-positive,
triple-negative
breast
(TNBC).
TNBC,
comprising
around
20%
all
cancers,
lacks
expression
ER,
PR,
HER2
receptors,
rendering
it
unresponsive
targeted
therapies
presenting
significant
challenges
in
treatment.
TNBC
associated
with
aggressive
behavior,
high
rates
recurrence,
resistance
chemotherapy.
Tumor
initiation,
progression,
are
attributed
stem
cells
(BCSCs),
which
possess
self-renewal,
differentiation,
tumorigenic
potential.
Surface
markers,
self-renewal
pathways
(Notch,
Wnt,
Hedgehog
signaling),
apoptotic
protein
(Bcl-2),
angiogenesis
inhibition
(VEGF
inhibitors),
immune
modulation
(cytokines,
checkpoint
inhibitors)
among
key
targets
discussed
this
review.
However,
targeting
BCSC
subpopulation
presents
challenges,
including
off-target
effects,
low
solubility,
bioavailability
anti-BCSC
agents.
Nanoparticle-based
offer
promising
approach
target
cellular
processes
implicated
survival
BSCS
TNBC.
In
review,
we
explore
nanocarrier-based
approaches
for
BCSCs
aiming
overcome
these
improve
outcomes
patients.
These
nanoparticle-based
therapeutic
strategies
hold
promise
addressing
gap
delivering
while
minimizing
systemic
toxicity
enhancing
efficacy.
Graphical
abstract
