Stimuli‐Responsive Antibacterial Materials: Molecular Structures, Design Principles, and Biomedical Applications

Advanced Science, Journal Year: 2022, Volume and Issue: 9(13)

Published: Feb. 27, 2022

Infections are regarded as the most severe complication associated with human health, which urgent to be solved. Stimuli-responsive materials appealing therapeutic platforms for antibacterial treatments, provide great potential accurate theranostics. In this review, advantages, response mechanisms, and key design principles of stimuli-responsive highlighted. The biomedical applications, current challenges, future directions also discussed. First, categories comprehensively itemized based on different sources stimuli, including external physical environmental stimuli (e.g., temperature, light, electricity, salt, etc.) bacterial metabolites acid, enzyme, redox, etc.). Second, structural characteristics, principles, applications responsive discussed, underlying interrelationships revealed. molecular structures closely related stimuli. Finally, challenging issues proposed. This review will scientific guidance promote clinical materials.

Language: Английский

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Bacteria-responsive programmed self-activating antibacterial hydrogel to remodel regeneration microenvironment for infected wound healing

National Science Review, Journal Year: 2024, Volume and Issue: 11(4)

Published: Jan. 29, 2024

ABSTRACT There is still an urgent need to develop hydrogels with intelligent antibacterial ability achieve on-demand treatment of infected wounds and accelerate wound healing by improving the regeneration microenvironment. We proposed a strategy hydrogel dressing bacteria-responsive self-activating property multiple nanozyme activities remodel microenvironment in order significantly promote healing. Specifically, pH-responsive H2O2 self-supplying composite (MSCO) pH/enzyme-sensitive triblock micelles encapsulated lactate oxidase (PPEL) were prepared composed L-arginine-modified chitosan (CA) phenylboronic acid-modified oxidized dextran (ODP) form cascade platform. The respond multifactorial changes bacterial metabolic biofilm eradication through transformation metabolites, chemodynamic therapy enhanced activity conjunction self-driven nitric oxide (NO) release. showed ‘self-diagnostic’ for Through infection stage self-adaptive oxidative stress relief angiogenesis post-infection stage, it promotes closure, accelerates collagen deposition angiogenesis, completely improves regeneration, which provides new method design dressings.

Language: Английский

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Lactose azocalixarene drug delivery system for the treatment of multidrug-resistant pseudomonas aeruginosa infected diabetic ulcer

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Oct. 21, 2022

Abstract Diabetic wound is one of the most intractable chronic wounds that prone to bacterial infection. Hypoxia an important feature in its microenvironment. However, it challenging for antimicrobial therapy directly apply existing hypoxia-responsive drug delivery systems due active targeting deficiency and biofilm obstacle. Herein, we customizes a carrier, lactose-modified azocalix[4]arene (LacAC4A) with ability actively target inhibit biofilm. By loading ciprofloxacin (Cip), resultant supramolecular nanoformulation Cip@LacAC4A demonstrates enhanced antibacterial efficacy resulting from both increased accumulation controlled release at site When applied on diabetic together multidrug-resistant Pseudomonas aeruginosa infection vivo, induces definitely less inflammatory infiltration than free Cip, which translates into high healing performance. Importantly, such design principle provides direction developing systems.

Language: Английский

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Stimuli responsive nanosonosensitizers for sonodynamic therapy

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 361, P. 547 - 567

Published: Aug. 15, 2023

Language: Английский

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Tailoring the Surface and Composition of Nanozymes for Enhanced Bacterial Binding and Antibacterial Activity

Small, Journal Year: 2023, Volume and Issue: 19(42)

Published: June 15, 2023

With the advantages of diverse structures, tunable enzymatic activity, and high stability, nanozymes are widely used in medicine, chemistry, food, environment, other fields. As an alternative to traditional antibiotics, attract more attention from scientific researchers recent years. Developing nanozymes-based antibacterial materials opens up a new avenue for bacterial disinfection sterilization. In this review, classification their mechanisms discussed. The surface composition critical efficacy, which can be tailored enhance both binding activity. On one hand, modification enables targeting bacteria that improves performance including biochemical recognition, charge, topography. modulated achieve enhanced single nanozyme-mediated synergistic multiple nanozymes-mediated cascade catalytic applications. addition, current challenges future prospects tailoring applications This review provide insights into design treatments.

Language: Английский

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Advances in preparation and application of antibacterial hydrogels

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: Aug. 26, 2023

Bacterial infections, especially those caused by drug-resistant bacteria, have seriously threatened human life and health. There is urgent to develop new antibacterial agents reduce the problem of antibiotics. Biomedical materials with good antimicrobial properties been widely used in applications. Among them, hydrogels become focus research field biomedical due their unique three-dimensional network structure, high hydrophilicity, biocompatibility. In this review, latest progresses about recent years were summarized, mainly including preparation methods According different mechanisms, several representative introduced, such as antibiotics loaded hydrogels, antibiotic-free metal-based peptide polymers, stimuli-responsive smart light-mediated hydrogels. addition, we also discussed applications challenges biomedicine, which are expected provide directions ideas for application clinical therapy.

Language: Английский

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Flourishing Antibacterial Strategies for Osteomyelitis Therapy

Advanced Science, Journal Year: 2023, Volume and Issue: 10(11)

Published: Jan. 30, 2023

Abstract Osteomyelitis is a destructive disease of bone tissue caused by infection with pathogenic microorganisms. Because the complex and long‐term abnormal conditions, osteomyelitis one refractory diseases in orthopedics. Currently, anti‐infective therapy primary modality for addition to thorough surgical debridement. However, bacterial resistance has gradually reduced benefits traditional antibiotics, development advanced antibacterial agents received growing attention. This review introduces main targets treating osteomyelitis, including cell wall, membrane, intracellular macromolecules, energy metabolism, focuses on their mechanisms, predicts prospects clinical applications.

Language: Английский

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Emerging nanosonosensitizers augment sonodynamic-mediated antimicrobial therapies

Materials Today Bio, Journal Year: 2023, Volume and Issue: 19, P. 100559 - 100559

Published: Jan. 21, 2023

With the widespread prevalence of drug-resistant pathogens, traditional antibiotics have limited effectiveness and do not yield desired outcomes. Recently, alternative antibacterial therapies based on ultrasound (US) been explored to overcome crisis bacterial pathogens. Antimicrobial sonodynamic therapy (aSDT) offers an excellent solution that relies US irradiation produce reactive oxygen species (ROS) achieve antibiotic-free mediated antimicrobial effects. In addition, aSDT possesses advantage superior tissue penetrability compared light irradiation, demonstrating great feasibility in treating deep infections. Although existing conventional sonosensitizers can ROS for activity, some limitations, such as low penetration rate, nonspecific distribution poor production under hypoxic conditions, result suboptimal sterilization aSDT. emerging nanosonosensitizers enormous advantages high-performance agents aSDT, which deficiencies described above. Thus, nanosonosensitizer-mediated has a bright future management This review classifies current available provides overview mechanisms, biomedical applications, recent advances perspectives

Language: Английский

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AIEgens for microorganism‐related visualization and therapy

Deleted Journal, Journal Year: 2023, Volume and Issue: 1(2)

Published: Jan. 21, 2023

Abstract Humans and bacteria have always been closely related. However, pathogenic drug‐resistant pose a certain threat to human life health. On the other hand, probiotics, such as intestinal flora, also affect our daily life. Understanding microstructure of microorganisms is important for effective treatment bacterial infections. Luminogens with aggregation‐induced emission properties are now recognized potent fluorescent agents diagnosis microorganisms. In this review, we summarized most recent developments AIEgen‐based biomaterials discussed advantages AIE probes imaging. Their applications rapid imaging bacteria, differentiation Gram‐ negative positive specific intracellular fungi presented. The monitoring bacteria‐cell interaction was introduced. Finally, design strategy engineered bacteria‐AIEgen hybrid system their role in anti‐cancer discussed.

Language: Английский

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Specific Chemiluminescence Imaging and Enhanced Photodynamic Therapy of Bacterial Infections by Hemin‐Modified Carbon Dots

Small, Journal Year: 2023, Volume and Issue: 19(31)

Published: March 25, 2023

Abstract Antibacterial photodynamic therapy (aPDT) is a promising antibiotics‐alternative strategy for bacterial infectious diseases, which features broad‐spectrum antibacterial activity with low risk of inducing resistance. However, clinical applications aPDT are still hindered by the hydrophobicity‐caused inadequate conventional photosensitizers and hypoxic microenvironment infections. To address these problems, herein, developed to achieve specific chemiluminescence (CL) imaging enhanced PDT infections using hemin‐modified carbon dots (H‐CDs). The H‐CDs can be facilely prepared exhibit favorable water solubility, augmented activity, unique peroxidase‐mimicking capacity. Compared free CDs, efficacy significantly due increased electron–hole separation efficiency. Moreover, peroxidase catalytic performance enables not only infection identification via microenvironment‐responsive CL but also oxygen self‐supplied hypoxia‐relief‐enhanced bacteria inactivation effects. Finally, efficiencies validated in both vivo abscess infected wound models. This work may provide an effective platform selective imaging‐guided treatment

Language: Английский

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