Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 5, 2024
Abstract
Reproductive
health
concerns
like
Mayer‐Rokitansky‐Küster‐Hauser
(MRKH)
syndrome
are
prevalent
in
today's
society.
MRKH
is
a
condition
that
severely
affects
women's
sexual
life,
fertility,
and
mental
has
high
prevalence
of
one
out
5000
female
births.
Vaginoplasty
the
primary
method
to
regain
patients’
reproductive
health.
However,
conventional
vaginoplasty
faces
various
challenges,
including
complex
non‐customized
treatment
procedures
causing
intense
pains
complications.
To
bring
new
advances
vaginoplasty,
3D‐printed
hydrogel
scaffold
developed
provide
satisfactory
mechanical
support
bioactivity
for
accelerating
defect
repair
after
surgery.
The
consisting
gelatin
methacryloyl
(gelMA)
carrageenan
(Car)
custom
using
an
ambient
temperature
printing
system.
Furthermore,
undergoes
dual‐crosslinking
through
chemical
crosslinking
gelMA
ionic
Car
with
magnesium
ions
(Mg
2+
).
This
strategy
substantially
improves
overall
properties
introduces
bioactive
Mg
.
sustained
release
plus
extracts
from
dual‐crosslinked
significantly
promotes
cell
proliferation,
migration
angiogenesis.
In
preclinical
rat
model
penetrating
genital
tract
defects
mimicking
implantation
repairs
wounds
near‐normal
levels
within
week,
showing
potential
as
alternative
better
regaining
Small,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 27, 2025
Abstract
3D
printing
has
greatly
improved
the
precision
of
cell
and
biomaterial
placement,
enabling
accurate
reproduction
tissue
models
with
sustainable
potential.
Various
techniques,
including
inkjet
printing,
extrusion‐based
vat
photopolymerization,
offer
unique
advantages
but
often
fail
to
replicate
full
complexity
native
tissues
because
material
scalability
limitations.
Hybrid
bioprinting,
combining
multiple
techniques
in
a
single
process,
shown
great
potential
creating
complex
multifunctional
capabilities,
ranging
from
patient‐specific
implant
fabrication
full‐scale
organ
development.
It
capitalizes
on
strengths
integration
sustainable,
renewable
biomaterials
at
varying
resolutions,
nano
microscale.
This
approach
addresses
both
biological
environmental
responsibility
by
minimizing
waste
enhancing
sustainability
engineering
processes.
Despite
progress,
substantial
gap
remains
between
current
technologies
bioengineering
requirements.
A
deep
understanding
hybrid
its
underlying
mechanisms
is
crucial.
Herein,
this
review
summarizes
discusses
recent
advancements
systems
for
fabricating
multiscale
hierarchical
models,
focusing
challenges
field.
aims
insights
identify
key
requirements
advancing
technology
toward
developing
functional,
biomimetic
constructs.
Macromolecular Bioscience,
Journal Year:
2022,
Volume and Issue:
23(1)
Published: Sept. 30, 2022
Abstract
The
conversion
of
liquid
resin
into
solid
structures
upon
exposure
to
light
a
specific
wavelength
is
known
as
photopolymerization.
In
recent
years,
photopolymerization‐based
3D
printing
has
gained
enormous
attention
for
constructing
complex
tissue‐specific
constructs.
Due
the
economic
and
environmental
benefits
biopolymers
employed,
photo‐curable
considered
an
alternative
method
replacing
damaged
tissues.
However,
lack
suitable
bio‐based
photopolymers,
their
characterization,
effective
crosslinking
strategies,
optimal
conditions
are
hindering
extensive
application
printed
materials
in
global
market.
This
review
highlights
present
status
various
synthesis,
optimization
parameters
biomedical
applications.
Moreover,
glimpse
photopolymerization
techniques
currently
employed
also
discussed.
Furthermore,
naturally
derived
nanomaterials
reinforced
polymerization
influence
on
printability
shape
fidelity
reviewed.
Finally,
ultimate
use
those
photopolymerized
hydrogel
scaffolds
tissue
engineering
Taken
together,
it
believed
that
great
future,
whereas
conventional
requires
considerable
sophistication,
this
can
provide
readers
with
comprehensive
approach
developing
light‐mediated
tissue‐engineering
ACS Applied Polymer Materials,
Journal Year:
2024,
Volume and Issue:
6(7), P. 4070 - 4077
Published: March 22, 2024
3D
printing
has
emerged
as
a
highly
accurate,
customizable,
and
low-cost
fabrication
method
to
realize
structures
with
designed
geometry.
However,
the
integral
of
complex
structures,
such
suspended
still
poses
significant
challenges
in
most
commonly
used
technology-fused
filament
(FFF).
Therefore,
designing
self-healing
material,
segmenting
finally
assembling
them
into
whole
by
capability
are
expected
resolve
this
issue.
In
research,
we
successfully
synthesized
polyurethane
(LNPU-3)
introduction
dynamic
oxime-urethane
bonds.
Specifically,
employed
polycaprolactone
diol
soft
segment,
2,4-pentanedione
dioxime
chain
extender,
4,4′-methylenebis(phenyl
isocyanate)
hard
segment.
LNPU-3
exhibited
outstanding
mechanical
properties,
tensile
stress
8.5
MPa
fracture
toughness
20.1
MJ/m3.
Even
after
cyclic
stretching
five
times
at
strain
30%,
specimen
could
recover
95%
its
original
value.
Furthermore,
be
fully
self-healed
room
temperature
(25
°C)
within
8
h,
healing
efficiency
92.9%.
Finally,
was
printed
using
FFF
samples
tested.
The
components
were
then
assembled
structure
that
difficult
print
whole.
summary,
is
an
ideal
demonstrating
potential
for
application
materials
advancement
technology.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(28)
Published: May 8, 2024
Abstract
3D‐printed
cell‐laden
hydrogels
as
tissue
constructs
show
great
promise
in
generating
living
tissues
for
medicine.
Currently,
the
maturation
of
into
remains
challenge,
since
commonly
used
struggle
to
provide
an
ideal
microenvironment
seeded
cells.
In
this
study,
a
cell‐adaptable
nanocolloidal
hydrogel
is
created
3D
printing
maturable
constructs.
The
composed
interconnected
nanoparticles,
which
prepared
by
self‐assembly
and
subsequent
photocrosslinking
gelatin
methacryloyl
solutions.
Cells
can
get
enough
space
grow
migrate
within
through
squeezing
flexible
networks.
Meanwhile,
nanostructure
promote
cells
proliferate
produce
matrix
proteins
mechanotransduction.
Using
digital
light
process‐based
technology,
it
rapidly
customize
cartilage
After
implantation,
these
efficiently
matured
articular
defect
repair
ear
reconstruction
vivo.
using
shows
potential
future
clinical
applications.
Materials Today Bio,
Journal Year:
2024,
Volume and Issue:
27, P. 101135 - 101135
Published: June 26, 2024
3D
bioprinting
technology,
a
subset
of
printing
is
currently
witnessing
widespread
utilization
in
tissue
repair
and
regeneration
endeavors.
In
particular,
light-based
technology
has
garnered
significant
interest
favor.
Central
to
its
successful
implementation
lies
the
judicious
selection
photosensitive
polymers.
Moreover,
by
fine-tuning
parameters
such
as
light
irradiation
time,
choice
photoinitiators
crosslinkers,
their
concentrations,
properties
scaffolds
can
be
tailored
suit
specific
requirements
targeted
sites.
this
comprehensive
review,
we
provide
an
overview
commonly
utilized
bio-inks
suitable
for
bioprinting,
delving
into
distinctive
characteristics
each
material.
Furthermore,
delineate
strategies
bio-ink
diverse
locations,
alongside
methods
optimizing
parameters.
Ultimately,
present
coherent
synthesis
aimed
at
enhancing
practical
application
engineering,
while
also
addressing
current
challenges
future
prospects.
Macromolecular Materials and Engineering,
Journal Year:
2024,
Volume and Issue:
309(6)
Published: April 18, 2024
Abstract
The
primary
request
nowadays
is
for
innovative
and
superior
scaffold
designs
that
mimic
the
characteristics
of
native
tissue
in
cartilage
engineering.
GelMA/Alginate
(G/A)
interpenetrating
polymer
network
(IPN)
has
become
a
popular
hydrogel
material
engineering
because
its
mechanical
biological
properties.
Here,
to
balance
properties,
composed
G/A
covalent
organic
frameworks
(COF)
nanoparticles
specially
designed.
In
this
study,
GelMA/Alginate/COF
(G/A/C)
with
improved
properties
such
as
pore
size,
swelling,
strength,
shear‐thinning
behavior,
biocompatibility
produced.
Furthermore,
G/A/C
facilitate
printing
complex
three
dimensional
(3D)
scaffolds.
test
result
demonstrates
addition
COF
up
1%
(w/w)
enhances
porosity
decreases
size
(0.2
times),
improves
compression
strength
(six
degradation
ratio
(0.05
times)
swelling
(0.3
compared
sample.
Besides,
cell
viability
confirms
growth
during
incubation
great
behavior
(more
than
98%).
suitable
performance
containing
shape
fidelity
injection
by
3D
printer
confirmed.
Nanocomposite
IPN
based
on
could
be
useful
applications.
Polymer Reviews,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 65
Published: Nov. 20, 2024
The
biomedical
industry
has
witnessed
a
transformative
evolution
with
the
advent
of
3D
printing
technology.
However,
inherent
limitations,
such
as
inability
to
produce
dynamic
human
tissues
due
absence
temporal
dimension,
have
persisted,
resulting
in
static
and
inanimate
printed
products.
To
address
this
challenge
enable
creation
living
constructs,
concept
4D
emerged,
marking
paradigm
shift
additive
manufacturing.
In
printing,
time
becomes
fourth
breathing
life
into
previously
creations.
This
review
paper
explores
journey
from
pivotal
role
manufacturing
process.
Specifically,
it
highlights
integration
time-dependent
responsive
materials,
focusing
on
stimuli-responsive
hydrogels,
cornerstone
advancements.
These
materials
exhibit
remarkable
ability
adapt
respond
various
stimuli,
encompassing
physical,
chemical,
biological
signals.
delves
recent
publications
synergy
between
these
stimuli
shedding
light
their
intricate
interactions
potential
applications.
One
primary
areas
interest
lies
medical
applications,
notably
tissue
engineering,
where
holds
immense
promise.
utilization
creating
biomimetic
scaffolds
that
can
dynamically
complex
environments.
Furthermore,
discusses
technical
considerations
prospects
technology,
emphasizing
its
revolutionize
landscape.
amalgamation
opens
new
avenues
for
personalized
medicine,
localized
drug
delivery,
regenerative
therapies,
bridging
gap
requirements
modern
healthcare.
present
offers
complete
examination
evolution,
challenges,
paving
way
innovations
field.
