Recent progress of 3D printed vascularized tissues and organs

Smart Materials in Medicine, Journal Year: 2024, Volume and Issue: 5(2), P. 183 - 195

Published: Jan. 12, 2024

Since the need for vascular networks to supply oxygen and nutrients while expelling metabolic waste, most cells can only survive within 200 μm of blood vessels; thus, construction well-developed vessel is essential manufacture artificial tissues organs. Three-dimensional (denoted as 3D) printing a scalable, reproducible high-precision manufacturing technology. In past several years, there have been many breakthroughs in building various vascularized tissues, greatly promoting development biological tissue engineering. This paper highlights latest progress 3D printed organs, including heart, liver, lung, kidney, penis. We also discuss application status potential above prospect further requirement technology clinically useable tissues.

Language: Английский

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Advances in 3D skin bioprinting for wound healing and disease modeling

Regenerative Biomaterials, Journal Year: 2022, Volume and Issue: 10

Published: Dec. 19, 2022

Abstract Even with many advances in design strategies over the past three decades, an enormous gap remains between existing tissue engineering skin and natural skin. Currently available vitro models still cannot replicate three-dimensionality heterogeneity of dermal microenvironment sufficiently to recapitulate known characteristics disorder or disease vivo. Three-dimensional (3D) bioprinting enables precise control multiple compositions, spatial distributions architectural complexity, therefore offering hope for filling structure function artificial Our understanding wound healing process would thus be boosted by development that could more completely capture heterogeneous features biology. Here, we provide overview recent 3D bioprinting, as well concepts cells bioinks suitable process. We focus on applications this technology physiological pathological model, focusing specifically appendages vasculature. conclude current challenges technical perspective further bioprinting.

Language: Английский

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Embedded 3D bioprinting – An emerging strategy to fabricate biomimetic & large vascularized tissue constructs

Bioactive Materials, Journal Year: 2023, Volume and Issue: 32, P. 356 - 384

Published: Oct. 21, 2023

Three-dimensional bioprinting is an advanced tissue fabrication technique that allows printing complex structures with precise positioning of multiple cell types layer-by-layer. Compared to other methods, extrusion has several advantages print large-sized constructs and organ models due large build volume. Extrusion using sacrificial, support embedded strategies have been successfully employed facilitate hollow structures. Embedded a gel-in-gel approach developed overcome the gravitational overhanging limits micron-scale resolution. In bioprinting, deposition bioinks into microgel or granular bath will be facilitated by sol-gel transition through needle movement inside medium. This review outlines various polymers used in systems advantages, limitations, efficacy vascularized tissues Further, essential requirements like viscoelasticity, stability, transparency easy extraction human scale organs are discussed. Additionally, geometries vascular constructs, heart, bone, octopus jellyfish printed assisted methods their anatomical features elaborated. Finally, challenges clinical translation future scope these replace native envisaged.

Language: Английский

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(Bio)printing in Personalized Medicine—Opportunities and Potential Benefits

Bioengineering, Journal Year: 2023, Volume and Issue: 10(3), P. 287 - 287

Published: Feb. 23, 2023

The global development of technologies now enters areas related to human health, with a transition from conventional personalized medicine that is based significant extent on (bio)printing. goal this article review some the published scientific literature and highlight importance potential benefits using 3D (bio)printing techniques in contemporary also offer future perspectives research field. prepared according Preferred Reporting Items for Systematic Reviews Meta-Analyses (PRISMA) guidelines. Web Science, PubMed, Scopus, Google Scholar, ScienceDirect databases were used search. Six authors independently performed search, study selection, data extraction. This focuses bio(printing) provides classification several categories: overcoming shortage organs transplantation, elimination problems due difference between sexes organ reducing cases rejection transplanted organs, enhancing survival patients drug development, genetic/congenital defects tissues surgery planning medical training young doctors. In particular, we each applications included along associated reports recent literature. addition, present an overview challenges need be overcome bioprinting medicine. reviewed articles lead conclusion may adopted as revolution personalized, it has huge near become gold standard healthcare world.

Language: Английский

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Recent Developments of Silk-Based Scaffolds for Tissue Engineering and Regenerative Medicine Applications: A Special Focus on the Advancement of 3D Printing

Biomimetics, Journal Year: 2023, Volume and Issue: 8(1), P. 16 - 16

Published: Jan. 2, 2023

Regenerative medicine has received potential attention around the globe, with improving cell performances, one of necessary ideas for advancements regenerative medicine. It is crucial to enhance performances in physiological system drug release studies because variation environments between vitro and vivo develops a loop estimation. On other hand, tissue engineering path integrate cells scaffold biomaterials produce growth factors regenerate organs. Scaffold are prototype production perform vital functions engineering. Silk fibroin natural fibrous polymer significant usage growing interest leftovers silk Among various biopolymer-based biomaterials, fibroin-based have attracted due their outstanding mechanical properties, biocompatibility, hemocompatibility, biodegradability applications. This review article focused on highlighting recent 3D printing technologies

Language: Английский

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Nanomaterials-incorporated hydrogels for 3D bioprinting technology

Nano Convergence, Journal Year: 2023, Volume and Issue: 10(1)

Published: Nov. 15, 2023

Abstract In the field of tissue engineering and regenerative medicine, various hydrogels derived from extracellular matrix have been utilized for creating engineered tissues implantable scaffolds. While these hold immense promise in healthcare landscape, conventional bioinks based on ECM face several challenges, particularly terms lacking necessary mechanical properties required 3D bioprinting process. To address limitations, researchers are actively exploring novel nanomaterial-reinforced both functional aspects. this review, we focused discussing recent advancements fabrication monitoring systems using nanobioinks nanomaterials via technology. We highlighted synergistic benefits combining numerous into imposing geometrical effects by Furthermore, also elaborated critical issues remaining at moment, such as inhomogeneous dispersion consequent technical practical issues, complex structures with nanomaterials. Finally, plausible outlooks facilitating use biofabrication advancing function tissues.

Language: Английский

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Bioprinting and biomaterials for dental alveolar tissue regeneration

Frontiers in Bioengineering and Biotechnology, Journal Year: 2023, Volume and Issue: 11

Published: April 14, 2023

Three dimensional (3D) bioprinting is a powerful tool, that was recently applied to tissue engineering. This technique allows the precise deposition of cells encapsulated in supportive bioinks fabricate complex scaffolds, which are used repair targeted tissues. Here, we review recent developments application 3D dental These tissues, including teeth, periodontal ligament, alveolar bones, and pulp, present cell types mechanical properties with great heterogeneity, challenging reproduce vitro. After highlighting different methods regenerative dentistry, reviewed variety bioink formulations their effects on cells, have been established support development these We discussed advances achieved fabrication each provide an overview current state methods. conclude remaining challenges future needs.

Language: Английский

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3D bioprinting for organ and organoid models and disease modeling

Expert Opinion on Drug Discovery, Journal Year: 2023, Volume and Issue: 18(9), P. 1043 - 1059

Published: July 11, 2023

Introduction 3D printing, a versatile additive manufacturing technique, has diverse applications ranging from transportation, rapid prototyping, clean energy, and medical devices.Areas covered The authors focus on how printing technology can enhance the drug discovery process through automating tissue production that enables high-throughput screening of potential candidates. They also discuss bioprinting works what considerations to address when using this generate cell laden constructs for as well outputs such assays necessary determining efficacy been used cardiac, neural, testis models, focusing bio-printed organoids.Expert opinion next generation bioprinted organ model holds great promises field medicine. In terms discovery, incorporation smart culture systems biosensors into models could provide highly detailed functional screening. By addressing current challenges vascularization, electrophysiological control, scalability, researchers obtain more reliable accurate data development, reducing risk failures during clinical trials.

Language: Английский

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Silk fibroin-based inks for in situ 3D printing using a double crosslinking process

Bioactive Materials, Journal Year: 2024, Volume and Issue: 35, P. 122 - 134

Published: Jan. 25, 2024

The shortage of tissues and organs for transplantation is an urgent clinical concern.

Language: Английский

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Ultrasound-assisted tissue engineering

Nature Reviews Bioengineering, Journal Year: 2024, Volume and Issue: 2(6), P. 486 - 500

Published: April 2, 2024

Language: Английский

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