Intelligent micro/nanorobots for improved tumor therapy

BMEMat, Journal Year: 2023, Volume and Issue: 1(2)

Published: Feb. 25, 2023

Abstract A major bottleneck underlying nanomaterial‐based tumor therapy lies in complex biological environment and physiological barriers. Micro/nanorobots with the features of self‐propulsion controllable navigation have gradually become a research hotspot therapeutic community, exhibiting their advantages efficient cargo loading, delivery, stimuli‐triggered release, deeper tissue penetration, enhanced accumulation tissue. In this review, are introduced as two properties micro/nanorobots, which micro/nanorobots propelled by chemical reactions, physical fields, systems could be navigated chemotaxis, remote magnetic guidance, light. Then, recent advances for chemotherapy, immunotherapy, photothermal therapy, photodynamic chemodynamic multimodal would discussed. Finally, perspective challenges also mentioned. It is expected that review gives an insight into intelligent improved aiming more extensive in‐depth investigations, final applications clinic.

Language: Английский

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Self-Propelled Janus Nanocatalytic Robots Guided by Magnetic Resonance Imaging for Enhanced Tumor Penetration and Therapy

Journal of the American Chemical Society, Journal Year: 2023, Volume and Issue: 145(20), P. 11019 - 11032

Published: May 16, 2023

Biomedical micro/nanorobots as active delivery systems with the features of self-propulsion and controllable navigation have made tremendous progress in disease therapy diagnosis, detection, biodetoxification. However, existing are still suffering from complex drug loading, physiological stability, uncontrollable release. To solve these problems, nanocatalytic medicine two independent research fields were integrated this study to achieve self-propulsion-induced deeper tumor penetration catalytic reaction-initiated vivo. We presented self-propelled Janus robots (JNCRs) guided by magnetic resonance imaging (MRI) for vivo enhanced therapy. These JNCRs exhibited movement H2O2 solution, their migration tissue could be tracked non-invasive MRI real time. Both increased temperature reactive oxygen species production induced near-infrared light irradiation iron-mediated Fenton reaction, showing great potential photothermal chemodynamic In comparison passive nanoparticles, enabled after intratumoral injection. Importantly, biocompatible components byproducts biosecurity mouse model. It is expected that our work promote combination medicine, resulting improved clinical transformations.

Language: Английский

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Intelligent micro/nanomotors: Fabrication, propulsion, and biomedical applications

Nano Today, Journal Year: 2024, Volume and Issue: 55, P. 102212 - 102212

Published: Feb. 26, 2024

Language: Английский

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Chemotaxis‐guided Self‐propelled Macrophage Motor for Targeted Treatment of Acute Pneumonia

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(20)

Published: March 11, 2023

Abstract Immune cells exhibit great potential as carriers of nanomedicine, attributed to their high tolerance internalized nanomaterials and targeted accumulation in inflammatory tissues. However, the premature efflux nanomedicine during systemic delivery slow infiltration into tissues have limited translational applications. Herein, a motorized cell platform carrier for highly efficient lungs effective treatment acute pneumonia are reported. β‐Cyclodextrin adamantane respectively modified manganese dioxide nanoparticles intracellularly self‐assembled large aggregates mediated via host‐guest interactions, effectively inhibit nanoparticles, catalytically consume/deplete H 2 O alleviate inflammation, generate propel macrophage movement rapid tissue infiltration. With curcumin loaded MnO macrophages carry intracellular nano‐assemblies rapidly chemotaxis‐guided, self‐propelled movement, immunoregulation induced by aggregates.

Language: Английский

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Covalent Organic Framework‐Based Nanomotor for Multimodal Cancer Photo‐Theranostics

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(30)

Published: Aug. 9, 2023

Developing efficient integrated diagnosis and treatment agents based on fuel-free self-movement nanomotors remains challenging in antitumor therapy. In this study, a covalent organic framework (COF)-based biomimetic nanomotor composed of polypyrrole (PPy) core, porphyrin-COF shell, HCT116 cancer cell membrane coating is reported. Under near-infrared (NIR) light irradiation, the obtained mPPy@COF-Por can overcome Brownian motion achieves directional through self-thermophoretic force generated from PPy core. The enables to selectively recognize source lines reduces bio-adhesion biological medium, endowing with NIR light-powered good mobility. More importantly, such multifunctional integration allows COF-based be powerful nanoagent for treatment, high infrared thermal imaging/photoacoustic imaging/fluorescence trimodal imaging-guided combined photothermal/photodynamic therapeutic effect tumor successfully achieved. results offer considerable promise development COF imaging/therapy modalities biomedical applications.

Language: Английский

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Dual‐Responsive Nanorobot‐Based Marsupial Robotic System for Intracranial Cross‐Scale Targeting Drug Delivery

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(9)

Published: Oct. 30, 2023

Nanorobots capable of active movement are an exciting technology for targeted therapeutic intervention. However, the extensive motion range and hindrance blood-brain barrier impeded their clinical translation in glioblastoma therapy. Here, a marsupial robotic system constructed by integrating chemical/magnetic hybrid nanorobots (child robots) with miniature magnetic continuum robot (mother robot) intracranial cross-scale targeting drug delivery is reported. For primary on macroscale, enters cranial cavity through minimally invasive channel (e.g., Ommaya device) skull transports to pathogenic regions. Upon circumventing barrier, released perform secondary microscale further enhance spatial resolution delivery. In vitro experiments against cells derived from different patients conducted personalized treatment guidance. The operation feasibility within organisms shown ex vivo swine brain experiments. biosafety suggested Owing hierarchical method, rate, accuracy, efficacy have improved greatly. offers novel local strategy constitutes key milestone development platforms.

Language: Английский

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Bimetallic Nanozymes‐Integrated Parachute‐Like Au₂Pt@PMO@ICG Janus Nanomotor with Dual Propulsion for Enhanced Tumor Penetration and Synergistic PTT/PDT/CDT Cancer Therapy

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(44)

Published: Aug. 12, 2024

Abstract Nanocatalytic therapeutic agents with triple synergistic treatment modes of chemodynamic therapy (CDT), photothermal (PTT) and photodynamic (PDT) are emerging nanomaterials in malignancy treatment. Nevertheless, the passive diffusion transport result poor permeability tumor lesions, severely affecting effectiveness therapy. Herein, a dual‐source‐driven parachute‐like Au 2 Pt@PMO@ICG Janus nanomotor (APIJNS) is prepared by an interfacial energy‐mediated anisotropic growth strategy for PTT‐mediated CDT/PDT cancer Such can realize self‐thermophoresis drive under trigger near‐infrared light, which effectively enhance active uptake APIJNS tissue, thus achieving efficient PTT/PDT/CDT effect. In addition, exhibits high‐efficiency catalase (CAT)‐like activity catalyze overexpressed H O microenvironment (TME) to generate oxygen (O ), not only alleviating hypoxia lesion, but also converting it into singlet ( 1 ) activate photosensitizer ICG, PDT. This work provides new ideas enhancing improving dual‐drive nanomotors based on dual noble metal nanozymes.

Language: Английский

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Swarming Multifunctional Heater–Thermometer Nanorobots for Precise Feedback Hyperthermia Delivery

ACS Nano, Journal Year: 2023, Volume and Issue: 17(17), P. 16731 - 16742

Published: Aug. 31, 2023

Micro-/nanorobots (MNRs) are envisioned to act as "motile-targeting" platforms for biomedical tasks due their ability propel and navigate in challenging, hard-to-reach biological environments. However, it remains a great challenge current swarming MNRs accurately report regulate therapeutic doses during disease treatment. Here we present the development of multifunctional heater-thermometer nanorobots (HT-NRs) application precise feedback photothermal hyperthermia delivery. The HT-NRs designed photothermal-responsive photonic nanochains consisting magnetic Fe3O4 nanoparticles arranged periodically one dimension encapsulated temperature-responsive hydrogel shell. exhibit energetic controllable motions under rotating field, while simultaneously functioning motile nanoheaters nanothermometers, utilizing conversion (photo)thermal-responsive structural color changes (photothermochromism). Consequently, can be quickly deployed remote target area (e.g., superficial tumor lesion) using collective motion selectively eliminate diseased cells specific targeted region by self-reporting photothermochromism visual precisely regulating external light irradiation. This work may inspire intelligent theranostic micro-/nanorobots practical applications

Language: Английский

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NIR-propelled Janus nanomotors for active photoacoustic imaging and synergistic photothermal/chemodynamic therapy

Journal of Colloid and Interface Science, Journal Year: 2023, Volume and Issue: 648, P. 457 - 472

Published: May 30, 2023

Language: Английский

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Biomimetic Dual‐Driven Heterojunction Nanomotors for Targeted Catalytic Immunotherapy of Glioblastoma

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 9, 2024

Abstract The existence of the blood–brain barrier (BBB) and characteristics immunosuppressive microenvironment in glioblastoma (GBM) present significant challenges for targeted GBM therapy. To address this, a biomimetic hybrid cell membrane‐modified dual‐driven heterojunction nanomotor (HM@MnO 2 ‐AuNR‐SiO ) is proposed treatment. These nanomotors are designed to bypass BBB target glioma regions by mimicking surface macrophage membranes. More importantly, MnO structure enables propulsion through near‐infrared‐II (NIR‐II) light oxygen bubbles, allowing effective treatment at deep tumor sites. Meanwhile, plasmonic AuNR‐MnO heterostructure facilitates separation electron–hole pairs generates reactive species (ROS), inducing immunogenic death under NIR‐II laser irradiation. Furthermore, reacts release Mn 2+ ions, activating cGAS‐STING pathway enhancing antitumor immunity. In vitro vivo experiments demonstrate that these achieve active targeting infiltration, promoting M1 polarization, dendritic maturation, effector T‐cell activation, thereby catalysis immunotherapy ROS production STING activation.

Language: Английский

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