Journal of Cellular Physiology,
Journal Year:
2023,
Volume and Issue:
238(10), P. 2243 - 2252
Published: Sept. 24, 2023
Abstract
The
high
incidence,
low
healing
rate
and
huge
economic
burden
of
wounds
(especially
chronic
wounds)
worldwide
remain
a
great
challenge
for
clinical
staff
patients.
various
stages
wound
are
regulated
by
paracrine
or
autocrine
cytokines
growth
factors,
the
study
their
intrinsic
mechanisms
is
prerequisite
better
treatment.
Lactate,
end
product
glycolysis,
plays
role
in
all
healing,
recent
studies
have
identified
lactate
as
an
epigenetic
regulator
that
regulates
gene
expression
through
histone
lysine
lactylation
stimulates
posttranslational
modifications
to
regulate
related
expression,
thereby
causing
series
biological
functional
changes.
This
article
reviews
progress
research
on
during
diseases,
including
its
involvement
immune
regulation,
inflammation
control,
proliferative
remodeling,
finally
describes
prospects
therapy
regarding
healing.
ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(8), P. 7901 - 7910
Published: April 13, 2023
The
regulation
of
electrostatic
electric
fields
through
electrical
stimulation
is
an
efficient
method
to
increase
the
catalytic
activity
nanozymes
and
improve
therapeutic
effect
nanozyme
therapy.
Piezoelectric
materials,
which
are
capable
generating
a
built-in
field
under
ultrasound
(US),
not
only
but
also
enable
piezoelectric
sonodynamic
therapy
(SDT).
In
this
study,
sonosensitizer
based
on
Hf-based
metal–organic
framework
(UIO-66)
Au
nanoparticles
(NPs)
was
produced.
Under
US
irradiation,
UIO-66
can
generate
inside
promotes
electron–hole
separation
produces
reactive
oxygen
species
(ROS).
introduction
NPs
facilitated
electron
transfer,
inhibited
recombination
pairs
improved
properties
UIO-66.
value
constant
(d33)
increased
from
71
122
pmV–1
after
deposition
NPs.
addition,
intrinsic
catalase
peroxidase
activities
were
2-fold
induced
exposure.
vivo
in
vitro
experiments
revealed
that
proposed
kill
cancer
cells
inhibit
tumor
growth
mice
enhanced
SDT
sensitizer
work
proved
be
candidate
used
for
multiple
modalities
Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
62(40)
Published: Aug. 17, 2023
Abstract
Although
immunotherapy
has
a
broad
clinical
application
prospect,
it
is
still
hindered
by
low
immune
responses
and
immunosuppressive
tumor
microenvironment.
Herein,
simple
drug‐free
inorganic
nanomaterial,
alkalescent
sodium
bicarbonate
nanoparticles
(NaHCO
3
NPs),
prepared
via
fast
microemulsion
method
for
amplified
cancer
immunotherapy.
The
obtained
NaHCO
regulates
lactic
acid
metabolism
through
acid‐base
neutralization
so
as
to
reverse
the
mildly
acidic
environment.
Additionally,
can
further
release
high
amounts
of
Na
+
ions
inside
cells
induce
surge
in
intracellular
osmolarity,
thus
activate
pyroptosis
pathway
immunogenic
cell
death
(ICD),
damage‐associated
molecular
patterns
(DAMPs)
inflammatory
factors,
improve
responses.
Collectively,
NPs
observably
inhibit
primary/distal
growth
metastasis
remitted
immunosuppression
induced
activation,
showing
an
enhanced
antitumor
immunity
efficiency.
This
work
provides
new
paradigm
mediated
treatment,
which
potential
Acta Pharmaceutica Sinica B,
Journal Year:
2024,
Volume and Issue:
14(8), P. 3432 - 3456
Published: May 13, 2024
The
advent
of
cancer
immunotherapy
has
imparted
a
transformative
impact
on
treatment
paradigms
by
harnessing
the
power
immune
system.
However,
challenge
practical
and
precise
targeting
malignant
cells
persists.
To
address
this,
engineered
nanoparticles
(NPs)
have
emerged
as
promising
solution
for
enhancing
targeted
drug
delivery
in
immunotherapeutic
interventions,
owing
to
their
small
size,
low
immunogenicity,
ease
surface
modification.
This
comprehensive
review
delves
into
contemporary
research
at
nexus
NP
engineering
immunotherapy,
encompassing
an
extensive
spectrum
morphologies
strategies
tailored
toward
optimizing
tumor
augmenting
therapeutic
effectiveness.
Moreover,
it
underscores
mechanisms
that
NPs
leverage
bypass
numerous
obstacles
encountered
regimens
probes
combined
potential
when
co-administered
with
both
established
novel
modalities.
Finally,
evaluates
existing
limitations
platforms
which
could
shape
path
future
advancements
this
field.
Chemical Society Reviews,
Journal Year:
2024,
Volume and Issue:
53(12), P. 6399 - 6444
Published: Jan. 1, 2024
This
review
highlights
recent
advances
in
immunological
nanomaterials
against
metastasis
and
summarizes
various
nanomaterial-mediated
immunotherapy
strategies.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
35(42)
Published: July 18, 2023
Despite
recent
advancements
in
cancer
immunotherapy,
challenges
have
yet
to
be
surmounted
achieve
two
major
goals
of
magnifying
antitumor
immunity
and
remodeling
the
immunosuppressive
tumor
microenvironment.
Here,
a
nanosystem
(ODM-R)
that
integrates
oxygen-deficient
molybdenum
oxide
(ODM)
nanosonosensitizers
R7
peptides
with
metabolism
regulation
effects
is
designed
fabricated
for
synergistic
sonodynamic-immunometabolic
therapy
spinal-metastasized
tumors.
The
ODM
generates
reactive
oxygen
species
upon
ultrasound
irradiation
implement
sonodynamic
(SDT),
inducing
cell
apoptosis
immunogenic
death.
attached
on
markedly
inhibits
uptake
glucose
excretion
lactic
acid
cells
by
perturbing
glycolysis
process.
combination
SDT
obstruction
ODM-R
guarantees
satisfactory
efficacy
synergizing
PD-L1
antibody
eradicate
tumors,
achieving
concurrent
sonodynamic-triggered
immune
activation
microenvironment
remodeling.
This
work
provides
proof-of-concept
boosting
immunotherapy
metabolic
regulation.
ACS Applied Materials & Interfaces,
Journal Year:
2023,
Volume and Issue:
15(34), P. 40267 - 40279
Published: Aug. 18, 2023
Transdermal
cancer
therapy
faces
great
challenges
in
clinical
practice
due
to
the
low
drug
transdermal
efficiency
and
unsatisfactory
effect
of
monotherapy.
Herein,
we
develop
a
novel
bubble
pump
microneedle
system
(BPMN-CuS/DOX)
by
embedding
sodium
bicarbonate
(NaHCO3)
into
hyaluronic
acid
microneedles
(MNs)
loaded
with
fucoidan-based
copper
sulfide
nanoparticles
(Fuc-CuS
NPs)
doxorubicin
(DOX).
BPMN-CuS/DOX
can
generate
CO2
bubbles
triggered
an
acidic
tumor
microenvironment
for
deep
rapid
intradermal
delivery.
Fuc-CuS
NPs
exhibit
excellent
photothermal
Fenton-like
catalytic
activity,
producing
more
reactive
oxygen
species
(ROS)
(PTT)
chemodynamic
(CDT),
which
enhances
antitumor
efficacy
DOX
reduces
dosage
its
chemotherapy
(CT).
Simultaneously,
increases
intracellular
hydrogen
peroxide
(H2O2)
supplementation
promotes
sustained
production
ROS.
significantly
inhibits
melanoma
both
vitro
vivo
combination
CDT,
PTT,
CT.
In
short,
our
study
effectiveness
delivery
constructing
BPMNs
provides
promising
strategy
treatment
multiple
therapies.
Small,
Journal Year:
2023,
Volume and Issue:
20(16)
Published: Nov. 28, 2023
Abstract
Photodynamic
therapy
(PDT)
has
recently
been
considered
a
potential
tumor
due
to
its
time‐space
specificity
and
non‐invasive
advantages.
PDT
can
not
only
directly
kill
cells
by
using
cytotoxic
reactive
oxygen
species
but
also
induce
an
anti‐tumor
immune
response
causing
immunogenic
cell
death
of
cells.
Although
it
exhibits
promising
prospect
in
treating
tumors,
there
are
still
many
problems
be
solved
practical
application.
Tumor
hypoxia
immunosuppressive
microenvironment
seriously
affect
the
efficacy
PDT.
The
hypoxic
is
mainly
abnormal
vascular
matrix
around
tumor,
metabolism,
influence
various
immunosuppressive‐related
their
expressed
molecules.
Thus,
reprogramming
(TME)
great
significance
for
rejuvenating
This
article
reviews
latest
strategies
PDT,
from
regulating
matrix,
interfering
with
related
factors
reverse
microenvironment.
These
provide
valuable
information
better
understanding
TME
guide
development
next‐generation
multifunctional
nanoplatforms
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Oct. 16, 2024
Photothermal
therapy
(PTT)
is
a
promising
non-invasive
treatment
that
has
shown
great
potential
in
eliminating
tumors.
It
not
only
induces
apoptosis
of
cancer
cells
but
also
triggers
immunogenic
cell
death
(ICD)
which
could
activate
the
immune
system
against
cancer.
However,
immunosuppressive
tumor
microenvironment
(TIME)
poses
challenge
to
triggering
strong
responses
with
single
treatment,
thus
limiting
therapeutic
effect
immunotherapy.
In
this
study,
dual-targeted
nano
delivery
(GOx@FeNPs)
combined
αPD-L1
checkpoint
blocker
inhibit
colorectal
(CRC)
progression
by
mediating
PTT,
ferroptosis
and
anti-tumor
response.
Briefly,
specific
was
achieved
cyclic
arginine
glycyl
aspartate
(cRGD)
peptide
anisamide
(AA)
GOx@FeNPs
had
good
photothermal
realize
PTT
induce
ICD,
deplete
glutathione
(GSH)
catalyze
production
reactive
oxygen
species
(ROS)
from
endogenous
H
