Piezoelectric Metal–Organic Frameworks Based Sonosensitizer for Enhanced Nanozyme Catalytic and Sonodynamic Therapies

ACS Nano, Год журнала: 2023, Номер 17(8), С. 7901 - 7910

Опубликована: Апрель 13, 2023

The regulation of electrostatic electric fields through electrical stimulation is an efficient method to increase the catalytic activity nanozymes and improve therapeutic effect nanozyme therapy. Piezoelectric materials, which are capable generating a built-in field under ultrasound (US), not only but also enable piezoelectric sonodynamic therapy (SDT). In this study, sonosensitizer based on Hf-based metal–organic framework (UIO-66) Au nanoparticles (NPs) was produced. Under US irradiation, UIO-66 can generate inside promotes electron–hole separation produces reactive oxygen species (ROS). introduction NPs facilitated electron transfer, inhibited recombination pairs improved properties UIO-66. value constant (d33) increased from 71 122 pmV–1 after deposition NPs. addition, intrinsic catalase peroxidase activities were 2-fold induced exposure. vivo in vitro experiments revealed that proposed kill cancer cells inhibit tumor growth mice enhanced SDT sensitizer work proved be candidate used for multiple modalities

Язык: Английский

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Sodium Bicarbonate Nanoparticles for Amplified Cancer Immunotherapy by Inducing Pyroptosis and Regulating Lactic Acid Metabolism

Angewandte Chemie International Edition, Год журнала: 2023, Номер 62(40)

Опубликована: Авг. 17, 2023

Abstract Although immunotherapy has a broad clinical application prospect, it is still hindered by low immune responses and immunosuppressive tumor microenvironment. Herein, simple drug‐free inorganic nanomaterial, alkalescent sodium bicarbonate nanoparticles (NaHCO 3 NPs), prepared via fast microemulsion method for amplified cancer immunotherapy. The obtained NaHCO regulates lactic acid metabolism through acid‐base neutralization so as to reverse the mildly acidic environment. Additionally, can further release high amounts of Na + ions inside cells induce surge in intracellular osmolarity, thus activate pyroptosis pathway immunogenic cell death (ICD), damage‐associated molecular patterns (DAMPs) inflammatory factors, improve responses. Collectively, NPs observably inhibit primary/distal growth metastasis remitted immunosuppression induced activation, showing an enhanced antitumor immunity efficiency. This work provides new paradigm mediated treatment, which potential

Язык: Английский

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The promising role of tumor-associated macrophages in the treatment of cancer

Drug Resistance Updates, Год журнала: 2024, Номер 73, С. 101041 - 101041

Опубликована: Янв. 3, 2024

Язык: Английский

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Engineered nanoparticles for precise targeted drug delivery and enhanced therapeutic efficacy in cancer immunotherapy

Acta Pharmaceutica Sinica B, Год журнала: 2024, Номер 14(8), С. 3432 - 3456

Опубликована: Май 13, 2024

The advent of cancer immunotherapy has imparted a transformative impact on treatment paradigms by harnessing the power immune system. However, challenge practical and precise targeting malignant cells persists. To address this, engineered nanoparticles (NPs) have emerged as promising solution for enhancing targeted drug delivery in immunotherapeutic interventions, owing to their small size, low immunogenicity, ease surface modification. This comprehensive review delves into contemporary research at nexus NP engineering immunotherapy, encompassing an extensive spectrum morphologies strategies tailored toward optimizing tumor augmenting therapeutic effectiveness. Moreover, it underscores mechanisms that NPs leverage bypass numerous obstacles encountered regimens probes combined potential when co-administered with both established novel modalities. Finally, evaluates existing limitations platforms which could shape path future advancements this field.

Язык: Английский

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Biomimetic copper-doped polypyrrole nanoparticles induce glutamine metabolism inhibition to enhance breast cancer cuproptosis and immunotherapy

Journal of Controlled Release, Год журнала: 2024, Номер 371, С. 204 - 215

Опубликована: Май 31, 2024

Язык: Английский

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Immunological nanomaterials to combat cancer metastasis

Chemical Society Reviews, Год журнала: 2024, Номер 53(12), С. 6399 - 6444

Опубликована: Янв. 1, 2024

This review highlights recent advances in immunological nanomaterials against metastasis and summarizes various nanomaterial-mediated immunotherapy strategies.

Язык: Английский

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Peptide‐Appended Nanosonosensitizers Targeting Tumor Glycolysis for Synergistic Sonodynamic–Immunometabolic Therapy of Spinal‐Metastasized Tumors

Advanced Materials, Год журнала: 2023, Номер 35(42)

Опубликована: Июль 18, 2023

Despite recent advancements in cancer immunotherapy, challenges have yet to be surmounted achieve two major goals of magnifying antitumor immunity and remodeling the immunosuppressive tumor microenvironment. Here, a nanosystem (ODM-R) that integrates oxygen-deficient molybdenum oxide (ODM) nanosonosensitizers R7 peptides with metabolism regulation effects is designed fabricated for synergistic sonodynamic-immunometabolic therapy spinal-metastasized tumors. The ODM generates reactive oxygen species upon ultrasound irradiation implement sonodynamic (SDT), inducing cell apoptosis immunogenic death. attached on markedly inhibits uptake glucose excretion lactic acid cells by perturbing glycolysis process. combination SDT obstruction ODM-R guarantees satisfactory efficacy synergizing PD-L1 antibody eradicate tumors, achieving concurrent sonodynamic-triggered immune activation microenvironment remodeling. This work provides proof-of-concept boosting immunotherapy metabolic regulation.

Язык: Английский

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Photothermal and Acid-Responsive Fucoidan-CuS Bubble Pump Microneedles for Combined CDT/PTT/CT Treatment of Melanoma

ACS Applied Materials & Interfaces, Год журнала: 2023, Номер 15(34), С. 40267 - 40279

Опубликована: Авг. 18, 2023

Transdermal cancer therapy faces great challenges in clinical practice due to the low drug transdermal efficiency and unsatisfactory effect of monotherapy. Herein, we develop a novel bubble pump microneedle system (BPMN-CuS/DOX) by embedding sodium bicarbonate (NaHCO3) into hyaluronic acid microneedles (MNs) loaded with fucoidan-based copper sulfide nanoparticles (Fuc-CuS NPs) doxorubicin (DOX). BPMN-CuS/DOX can generate CO2 bubbles triggered an acidic tumor microenvironment for deep rapid intradermal delivery. Fuc-CuS NPs exhibit excellent photothermal Fenton-like catalytic activity, producing more reactive oxygen species (ROS) (PTT) chemodynamic (CDT), which enhances antitumor efficacy DOX reduces dosage its chemotherapy (CT). Simultaneously, increases intracellular hydrogen peroxide (H2O2) supplementation promotes sustained production ROS. significantly inhibits melanoma both vitro vivo combination CDT, PTT, CT. In short, our study effectiveness delivery constructing BPMNs provides promising strategy treatment multiple therapies.

Язык: Английский

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Recent Advances in Reprogramming Strategy of Tumor Microenvironment for Rejuvenating Photosensitizers‐Mediated Photodynamic Therapy

Small, Год журнала: 2023, Номер 20(16)

Опубликована: Ноя. 28, 2023

Abstract Photodynamic therapy (PDT) has recently been considered a potential tumor due to its time‐space specificity and non‐invasive advantages. PDT can not only directly kill cells by using cytotoxic reactive oxygen species but also induce an anti‐tumor immune response causing immunogenic cell death of cells. Although it exhibits promising prospect in treating tumors, there are still many problems be solved practical application. Tumor hypoxia immunosuppressive microenvironment seriously affect the efficacy PDT. The hypoxic is mainly abnormal vascular matrix around tumor, metabolism, influence various immunosuppressive‐related their expressed molecules. Thus, reprogramming (TME) great significance for rejuvenating This article reviews latest strategies PDT, from regulating matrix, interfering with related factors reverse microenvironment. These provide valuable information better understanding TME guide development next‐generation multifunctional nanoplatforms

Язык: Английский

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Photothermal Fe3O4 nanoparticles induced immunogenic ferroptosis for synergistic colorectal cancer therapy

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Окт. 16, 2024

Photothermal therapy (PTT) is a promising non-invasive treatment that has shown great potential in eliminating tumors. It not only induces apoptosis of cancer cells but also triggers immunogenic cell death (ICD) which could activate the immune system against cancer. However, immunosuppressive tumor microenvironment (TIME) poses challenge to triggering strong responses with single treatment, thus limiting therapeutic effect immunotherapy. In this study, dual-targeted nano delivery (GOx@FeNPs) combined αPD-L1 checkpoint blocker inhibit colorectal (CRC) progression by mediating PTT, ferroptosis and anti-tumor response. Briefly, specific was achieved cyclic arginine glycyl aspartate (cRGD) peptide anisamide (AA) GOx@FeNPs had good photothermal realize PTT induce ICD, deplete glutathione (GSH) catalyze production reactive oxygen species (ROS) from endogenous H

Язык: Английский

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