Nanomedicine,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 18
Published: Dec. 17, 2024
Biodegradable
controlled
delivery
systems
for
mesenchymal
stem
cells
(MSCs)
have
emerged
as
novel
advancements
in
the
field
of
regenerative
medicine,
particularly
accelerating
bone
fracture
healing.
This
detailed
study
emphasizes
importance
quick
and
adequate
treatment
limitations
existing
methods.
New
approaches
employing
biodegradable
scaffolds
can
be
placed
within
a
to
serve
mechanical
support
allow
release
situ
MSCs
bioactive
agents.
They
are
made
up
polymers
composites
which
degrade
over
time,
aiding
natural
tissue
regrowth.
The
fabrication
methods,
including
3D
printing,
electrospinning,
solvent
casting,
with
particulate
leaching
that
enable
precise
control
scaffold
architecture
properties,
discussed.
Progress
drug
encapsulation
techniques
kinetics
is
described,
highlighting
potential
such
strategies
maintain
therapeutic
benefits
prolonged
time
well
improving
outcomes
repair.
play
role
regeneration
through
differentiation
using
scaffolds,
paracrine
effects,
regulation
inflammation
focusing
on
Current
trends
future
directions
technology
MSC
delivery,
smart
growth
factor
incorporation
innovative
healing
also
Military Medical Research,
Journal Year:
2024,
Volume and Issue:
11(1)
Published: Oct. 21, 2024
Abstract
Severe
tissue
defects
present
formidable
challenges
to
human
health,
persisting
as
major
contributors
mortality
rates.
The
complex
pathological
microenvironment,
particularly
the
disrupted
immune
landscape
within
these
defects,
poses
substantial
hurdles
existing
regeneration
strategies.
However,
emergence
of
nanobiotechnology
has
opened
a
new
direction
in
immunomodulatory
nanomedicine,
providing
encouraging
prospects
for
and
restoration.
This
review
aims
gather
recent
advances
nanomedicine
foster
regeneration.
We
begin
by
elucidating
distinctive
features
local
microenvironment
defective
tissues
its
crucial
role
Subsequently,
we
explore
design
functional
properties
nanosystems.
Finally,
address
clinical
translation
development,
aiming
propose
potent
approach
enhance
through
synergistic
modulation
integration.
Bioactive Materials,
Journal Year:
2024,
Volume and Issue:
37, P. 424 - 438
Published: April 24, 2024
Bone
nonunion
poses
an
urgent
clinical
challenge
that
needs
to
be
addressed.
Recent
studies
have
revealed
the
metabolic
microenvironment
plays
a
vital
role
in
fracture
healing.
Macrophages
and
bone
marrow-derived
mesenchymal
stromal
cells
(BMSCs)
are
important
targets
for
therapeutic
interventions
fractures.
Itaconate
is
TCA
cycle
metabolite
has
emerged
as
potent
macrophage
immunomodulator
limits
inflammatory
response.
During
osteogenic
differentiation,
BMSCs
tend
undergo
aerobic
glycolysis
metabolize
glucose
lactate.
Copper
ion
(Cu2+)
essential
trace
element
participates
metabolism
may
stimulate
promote
osteogenesis.
In
this
study,
we
develop
4-octyl
itaconate
(4-OI)@Cu@Gel
nanocomposite
hydrogel
can
effectively
deliver
release
4-OI
Cu2+
modulate
improve
functions
of
involved
healing
process.
The
findings
reveal
burst
reduces
response,
promotes
M2
polarization,
alleviates
oxidative
stress,
while
sustained
stimulates
BMSC
differentiation
enhances
endothelial
cell
angiogenesis.
Consequently,
4-OI@Cu@Gel
system
achieves
rapid
mice.
Thus,
study
proposes
promising
regenerative
strategy
expedite
through
reprogramming
macrophages
BMSCs.
Molecular Medicine,
Journal Year:
2025,
Volume and Issue:
31(1)
Published: March 3, 2025
Abstract
As
an
emerging
technology,
organoids
are
promising
new
tools
for
basic
and
translational
research
in
disease.
Currently,
the
culture
of
relies
mainly
on
a
type
unknown
composition
scaffold,
namely
Matrigel,
which
may
pose
problems
studying
effect
mechanical
properties
organoids.
Hydrogels,
material
with
adjustable
properties,
can
adapt
to
current
studies.
In
this
review,
we
summarized
synthesis
recent
advance
developing
definite
hydrogel
scaffolds
organoid
identified
critical
parameters
regulating
properties.
addition,
classified
by
different
like
stiffness
viscoelasticity,
concluded
development
tumor
We
hope
review
enhances
understanding
hydrogels
provides
more
practical
approaches
investigating
them.
Stem Cell Research & Therapy,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: April 12, 2025
Mesenchymal
stem
cells
(MSCs)
play
a
crucial
role
in
bone
formation
and
remodeling.
Intrinsic
genetic
factors
extrinsic
environmental
cues
regulate
their
differentiation
into
osteoblasts.
Within
the
microenvironment,
complex
network
of
biochemical
biomechanical
signals
orchestrates
homeostasis
regeneration.
In
addition,
crosstalk
among
MSCs,
immune
cells,
neighboring
cells-mediated
by
extracellular
vesicles
non-coding
RNAs
(such
as
circular
micro
RNAs)
-profoundly
influences
osteogenic
Recent
studies
have
explored
specific
signaling
pathways
that
contribute
to
effective
regeneration,
highlighting
potential
manipulating
microenvironment
enhance
MSC
functionality.
The
integration
advanced
biomaterials,
gene
editing
techniques,
controlled
delivery
systems
is
paving
way
for
more
targeted
efficient
regenerative
therapies.
Furthermore,
artificial
intelligence
could
improve
tissue
engineering,
optimize
biomaterial
design,
enable
personalized
treatment
strategies.
This
review
explores
latest
advancements
emphasizing
intricate
interplay
molecules.
By
providing
comprehensive
overview
these
mechanisms
clinical
implications,
we
aim
shed
light
on
future
research
directions
this
rapidly
evolving
field.
