NF‐κB as a regulator of cancer metastasis and therapy response: A focus on epithelial–mesenchymal transition

Journal of Cellular Physiology, Journal Year: 2022, Volume and Issue: 237(7), P. 2770 - 2795

Published: May 13, 2022

Metastasis of tumor cells is a complex challenge and significantly diminishes the overall survival prognosis cancer patients. The epithelial-to-mesenchymal transition (EMT) well-known mechanism responsible for invasiveness cells. A number molecular pathways can regulate EMT in nuclear factor-kappaB (NF-κB) one them. translocation NF-κB p65 induce transcription several genes involved induction. present review describes interaction their association progression. Due to oncogenic role signaling, its activation enhances metastasis via This has been confirmed various cancers including brain, breast, lung gastric cancers, among others. ZEB1/2, transforming growth factor-β, Slug as inducers undergo upregulation by promote After induction driven NF-κB, significant decrease occurs E-cadherin levels, while N-cadherin vimentin levels an increase. noncoding RNAs potentially also function upstream mediators modulate NF-κB/EMT axis cancers. Moreover, mediating drug resistance Thus, suppressing sensitivity chemotherapeutic agents.

Language: Английский

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Curcumin and its derivatives in cancer therapy: Potentiating antitumor activity of cisplatin and reducing side effects

Phytotherapy Research, Journal Year: 2021, Volume and Issue: 36(1), P. 189 - 213

Published: Oct. 25, 2021

Abstract Curcumin is a phytochemical isolated from Curcuma longa with potent tumor‐suppressor activity, which has shown significant efficacy in pre‐clinical and clinical studies. stimulates cell death, triggers cycle arrest, suppresses oncogenic pathways, thereby suppressing cancer progression. Cisplatin (CP) DNA damage apoptosis chemotherapy. However, CP adverse effects on several organs of the body, drug resistance frequently observed. The purpose present review to show function curcumin decreasing CP's impacts improving its antitumor activity. administration reduces ROS levels prevent normal cells. Furthermore, can inhibit inflammation via down‐regulation NF‐κB maintain organs. nanoformulations reduce hepatoxicity, neurotoxicity, renal toxicity, ototoxicity, cardiotoxicity caused by CP. Notably, potentiates cytotoxicity mediating death arrest. Besides, STAT3 NF‐ĸB as tumor‐promoting enhance sensitivity resistance. targeted delivery tumor cells be mediated nanostructures. In addition, derivatives are also able CP‐mediated side effects, increase against various types.

Language: Английский

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Nrf2 signaling pathway in cisplatin chemotherapy: Potential involvement in organ protection and chemoresistance

Pharmacological Research, Journal Year: 2021, Volume and Issue: 167, P. 105575 - 105575

Published: March 24, 2021

Language: Английский

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Curcumin and chemokines: mechanism of action and therapeutic potential in inflammatory diseases

Inflammopharmacology, Journal Year: 2023, Volume and Issue: 31(3), P. 1069 - 1093

Published: March 30, 2023

Language: Английский

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Targeting oxidative stress as a preventive and therapeutic approach for cardiovascular disease

Journal of Translational Medicine, Journal Year: 2023, Volume and Issue: 21(1)

Published: Aug. 2, 2023

Abstract Cardiovascular diseases (CVDs) continue to exert a significant impact on global mortality rates, encompassing conditions like pulmonary arterial hypertension (PAH), atherosclerosis (AS), and myocardial infarction (MI). Oxidative stress (OS) plays crucial role in the pathogenesis advancement of CVDs, highlighting its significance as contributing factor. Maintaining an equilibrium between reactive oxygen species (ROS) antioxidant systems not only aids mitigating oxidative but also confers protective benefits cardiac health. Herbal monomers can inhibit OS CVDs by activating multiple signaling pathways, such increasing activity endogenous decreasing level ROS expression. Given actions herbal significantly protect normal function heart reduce damage caused organism. Hence, it is imperative recognize prospective therapeutic interventions for CVDs. This paper aims comprehensively review origins mechanisms underlying OS, elucidate intricate association explore potential treatment utilizing monomers. Furthermore, particular emphasis will be placed examining cardioprotective effects evaluating their pathways subsequent treatment. Graphical

Language: Английский

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Neuroprotective Effects of Curcumin in Neurodegenerative Diseases

Foods, Journal Year: 2024, Volume and Issue: 13(11), P. 1774 - 1774

Published: June 5, 2024

Curcumin, a hydrophobic polyphenol extracted from the rhizome of Curcuma longa, is now considered candidate drug for treatment neurological diseases, including Parkinson’s Disease (PD), Alzheimer’s (AD), Huntington’s (HD), Multiple Sclerosis (MS), Amyotrophic Lateral (ALS), and prion disease, due to its potent anti-inflammatory, antioxidant potential, anticancerous, immunomodulatory, neuroprotective, antiproliferative, antibacterial activities. Traditionally, curcumin has been used medicinal dietary purposes in Asia, India, China. However, low water solubility, poor stability blood, high rate metabolism, limited bioavailability, little capability cross blood–brain barrier (BBB) have clinical application curcumin, despite important pharmacological activities this drug. A variety nanocarriers, liposomes, micelles, dendrimers, cubosome nanoparticles, polymer solid lipid nanoparticles developed with great success effectively deliver active brain cells. Functionalization on surface brain-specific ligands makes them target-specific, which should significantly improve bioavailability reduce harmful effects. The aim review summarize studies and/or containing most common neurodegenerative highlighting neuroprotective potential nutraceutical.

Language: Английский

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Biomimetic Platelet‐Cloaked Nanoparticles for the Delivery of Anti‐Inflammatory Curcumin in the Treatment of Atherosclerosis

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(15)

Published: March 19, 2024

Atherosclerosis still represents a major driver of cardiovascular diseases worldwide. Together with accumulation lipids in the plaque, inflammation is recognized as one key players formation and development atherosclerotic plaque. Systemic anti-inflammatory treatments are successful reducing disease burden, but correlated severe side effects, underlining need for targeted formulations. In this work, curcumin chosen payload model further loaded lignin-based nanoparticles (NPs). The NPs then coated tannic acid (TA)- Fe (III) complex cloaked fragments derived from platelet cell membrane, yielding homogenous size. two coatings increase interaction between cells, both endothelial macrophages, steady state or inflamed status. Furthermore, cytocompatible toward endothelial, smooth muscle immune while not inducing activation. efficacy demonstrated cells by real-time quantitative polymerase chain reaction ELISA assay where curcumin-loaded decrease expression Nf-κb, TGF-β1, IL-6, IL-1β lipopolysaccharide-inflamed cells. Overall, due to cell-NP interactions efficacy, these represent potential candidates treatment atherosclerosis.

Language: Английский

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Therapeutic detoxification of quercetin for aflatoxin B1-related toxicity: Roles of oxidative stress, inflammation, and metabolic enzymes

Environmental Pollution, Journal Year: 2024, Volume and Issue: 345, P. 123474 - 123474

Published: Feb. 1, 2024

Language: Английский

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Elucidating Role of Reactive Oxygen Species (ROS) in Cisplatin Chemotherapy: A Focus on Molecular Pathways and Possible Therapeutic Strategies

Molecules, Journal Year: 2021, Volume and Issue: 26(8), P. 2382 - 2382

Published: April 19, 2021

The failure of chemotherapy is a major challenge nowadays, and in order to ensure effective treatment cancer patients, it great importance reveal the molecular pathways mechanisms involved chemoresistance. Cisplatin (CP) platinum-containing drug with anti-tumor activity against different cancers both pre-clinical clinical studies. However, resistance has restricted its potential patients. CP can promote levels free radicals, particularly reactive oxygen species (ROS) induce cell death. Due double-edged sword role ROS as pro-survival or pro-death mechanism, result resistance. In present review, association sensitivity/resistance discussed, particular, how pathways, upstream downstream targets, affect response cells chemotherapy. Furthermore, compounds, such curcumin, emodin, chloroquine that regulate related increasing sensitivity are described. Nanoparticles provide co-delivery agents by mediating photodynamic therapy, overgeneration trigger sensitivity. Genetic tools, small interfering RNA (siRNA) down-regulate HIF-1α Nrf2 levels, leading Considering relationship between chemotherapy, translating these findings clinic pave way for

Language: Английский

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An Overview of NO Signaling Pathways in Aging

Molecules, Journal Year: 2021, Volume and Issue: 26(15), P. 4533 - 4533

Published: July 27, 2021

Nitric Oxide (NO) is a potent signaling molecule involved in the regulation of various cellular mechanisms and pathways under normal pathological conditions. NO production, its effects, efficacy, are extremely sensitive to aging-related changes cells. Herein, we review cardiovascular system, central nervous system (CNS), reproduction as well effects on skin, kidneys, thyroid, muscles, immune during aging. The decline levels bioavailability also discussed this review. decreased production by endothelial nitric oxide synthase (eNOS) was revealed aged system. In CNS, neuronal (n)NOS related impairment memory, sleep, cognition. played an important role aging oocytes aged-induced erectile dysfunction. Aging downregulated cells resulting kidney, muscle disorders. Putative therapeutic agents (natural/synthetic) affecting process present study. summary, all studies reviewed demonstrate that plays crucial processes.

Language: Английский

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