Trapa natans L. Extract Attenuates Inflammation and Oxidative Damage in Cisplatin‐Induced Cardiotoxicity in Rats by Promoting M2 Macrophage Polarization DOI Creative Commons
Vesna Matović, Biljana Ljujić, Ivana D. Radojević

et al.

Mediators of Inflammation, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Background:Trapa natans L. fruits and leaf extracts have a broad range of immunomodulatory, anti-inflammatory, antioxidant effects; however, their effects on cardiac protection not been investigated. Objective: The study aims to test the biological activity Trapa extract (TNE) in cisplatin (CDDP)-induced cardiotoxicity. Methods: Wistar albino rats received single dose CDDP intraperitoneally TNE ones per day for 2 weeks orally. Cardiac inflammation, necrosis, fibrosis were determined by histological immunohistochemical analyses. Cytokines rat sera tissue detected enzyme-linked immunosorbent assay (ELISA) quantitative real-time (qRT)-PCR. Rat macrophages cultured presence 48 h harvested flow cytometry, while supernatants collected cytokine reactive oxygen species (ROS) measurement. Results: Application significantly attenuated induced cardiotoxicity as demonstrated biochemical histopathological analysis. Administration once daily 14 days decreased level proinflammatory (TNF-α, IFN-γ, IL-6) prooxidative parameters (NO2, O2, H2O2), increased immunosuppressive IL-10 antioxidative glutathione (GSH), catalase (CAT) uperoxide dismutase (SOD) systemic circulation. treatment resulted heart inflammation accompanied with reduced infiltration expression profibrotic genes CDDP-treated animals. In vitro lipopolysaccharide (LPS)-stimulated adopted phenotype characterized production cytokines mediators. Conclusion: Our provides evidence that ameliorates cisplatin-induced reducing oxidative stress via promoting M2 macrophage polarization.

Language: Английский

NF‐κB as a regulator of cancer metastasis and therapy response: A focus on epithelial–mesenchymal transition DOI
Sepideh Mirzaei,

Sam Saghari,

Farzaneh Bassiri

et al.

Journal of Cellular Physiology, Journal Year: 2022, Volume and Issue: 237(7), P. 2770 - 2795

Published: May 13, 2022

Metastasis of tumor cells is a complex challenge and significantly diminishes the overall survival prognosis cancer patients. The epithelial-to-mesenchymal transition (EMT) well-known mechanism responsible for invasiveness cells. A number molecular pathways can regulate EMT in nuclear factor-kappaB (NF-κB) one them. translocation NF-κB p65 induce transcription several genes involved induction. present review describes interaction their association progression. Due to oncogenic role signaling, its activation enhances metastasis via This has been confirmed various cancers including brain, breast, lung gastric cancers, among others. ZEB1/2, transforming growth factor-β, Slug as inducers undergo upregulation by promote After induction driven NF-κB, significant decrease occurs E-cadherin levels, while N-cadherin vimentin levels an increase. noncoding RNAs potentially also function upstream mediators modulate NF-κB/EMT axis cancers. Moreover, mediating drug resistance Thus, suppressing sensitivity chemotherapeutic agents.

Language: Английский

Citations

151
Curcumin and its derivatives in cancer therapy: Potentiating antitumor activity of cisplatin and reducing side effects DOI

Asal Jalal Abadi,

Sepideh Mirzaei, Mahmood Khaksary Mahabady

et al.

Phytotherapy Research, Journal Year: 2021, Volume and Issue: 36(1), P. 189 - 213

Published: Oct. 25, 2021

Abstract Curcumin is a phytochemical isolated from Curcuma longa with potent tumor‐suppressor activity, which has shown significant efficacy in pre‐clinical and clinical studies. stimulates cell death, triggers cycle arrest, suppresses oncogenic pathways, thereby suppressing cancer progression. Cisplatin (CP) DNA damage apoptosis chemotherapy. However, CP adverse effects on several organs of the body, drug resistance frequently observed. The purpose present review to show function curcumin decreasing CP's impacts improving its antitumor activity. administration reduces ROS levels prevent normal cells. Furthermore, can inhibit inflammation via down‐regulation NF‐κB maintain organs. nanoformulations reduce hepatoxicity, neurotoxicity, renal toxicity, ototoxicity, cardiotoxicity caused by CP. Notably, potentiates cytotoxicity mediating death arrest. Besides, STAT3 NF‐ĸB as tumor‐promoting enhance sensitivity resistance. targeted delivery tumor cells be mediated nanostructures. In addition, derivatives are also able CP‐mediated side effects, increase against various types.

Language: Английский

Citations

149
Caffeic acid and its derivatives as potential modulators of oncogenic molecular pathways: New hope in the fight against cancer DOI

Sepideh Mirzaei,

Mohammad Gholami, Amirhossein Zabolian

et al.

Pharmacological Research, Journal Year: 2021, Volume and Issue: 171, P. 105759 - 105759

Published: July 8, 2021

Language: Английский

Citations

137
Hyaluronic acid-based nanoplatforms for Doxorubicin: A review of stimuli-responsive carriers, co-delivery and resistance suppression DOI Creative Commons
Milad Ashrafizadeh, Sepideh Mirzaei, Mohammad Gholami

et al.

Carbohydrate Polymers, Journal Year: 2021, Volume and Issue: 272, P. 118491 - 118491

Published: July 27, 2021

An important motivation for the use of nanomaterials and nanoarchitectures in cancer therapy emanates from widespread emergence drug resistance. Although doxorubicin (DOX) induces cell cycle arrest DNA damage by suppressing topoisomerase activity, resistance to DOX has severely restricted its anti-cancer potential. Hyaluronic acid (HA) been extensively utilized synthesizing nanoparticles as it interacts with CD44 expressed on surface cells. Cancer cells can take up HA-modified through receptor-mediated endocytosis. Various types nanostructures such carbon nanomaterials, lipid polymeric nanocarriers have modified HA enhance delivery acid-based advanced materials provide a platform co-delivery genes drugs along efficacy overcome chemoresistance. In present review, potential methods application are discussed.

Language: Английский

Citations

137
Wnt/β-Catenin Signaling as a Driver of Hepatocellular Carcinoma Progression: An Emphasis on Molecular Pathways DOI Creative Commons
Mahshid Deldar Abad Paskeh,

Sepideh Mirzaei,

Milad Ashrafizadeh

et al.

Journal of Hepatocellular Carcinoma, Journal Year: 2021, Volume and Issue: Volume 8, P. 1415 - 1444

Published: Nov. 1, 2021

Abstract: Liver cancers cause a high rate of death worldwide and hepatocellular carcinoma (HCC) is considered as the most common primary liver cancer. HCC remains challenging disease to treat. Wnt/β-catenin signaling pathway tumor-promoting factor in various cancers; hence, present review focused on role Wnt HCC, its association with progression therapy response based pre-clinical clinical evidence. The nuclear translocation β-catenin enhances expression level genes such c-Myc MMPs increasing cancer progression. mutation CTNNB1 gene encoding overexpression can lead stem cell features promotes their growth rate. Furthermore, prevents apoptosis cells increases migration via triggering EMT upregulating MMP levels. It suggested that participates mediating drug resistance immuno-resistance HCC. Upstream mediators including ncRNAs regulate Anti-cancer agents inhibit mediate proteasomal degradation therapy. studies have revealed ( CTNBB1 ) Based these subjects, future experiments focus developing novel therapeutics targeting Keywords: cancer, resistance, immunotherapy, signaling, non-coding RNAs

Language: Английский

Citations

102
Ultrasound‐Augmented Nanocatalytic Ferroptosis Reverses Chemotherapeutic Resistance and Induces Synergistic Tumor Nanotherapy DOI
Yi Zheng, Xin Li, Caihong Dong

et al.

Advanced Functional Materials, Journal Year: 2021, Volume and Issue: 32(4)

Published: Oct. 10, 2021

Abstract Inducing ferroptosis has been acknowledged as an emerging strategy to kill drug‐resistant tumor cells, but how efficiently induce at the site and enhance its therapeutic efficacy are still highly challenging. In this work, ultrasound (US)‐augmented nanocatalytic is implemented by a GA‐Fe(II)‐based liposomal nanosystem, which simultaneously encapsulates doxorubicin hydrochloride (DOX), for reversing chemotherapeutic resistance inducing synergistic ferroptosis/apoptosis‐based nanotherapy. GA‐Fe(II), iron‐containing Fenton catalyst that catalyzes persistent conversion of H 2 O hydroxyl radicals, utilized deplete glutathione deliver excess iron into cells accumulating lipid peroxidation in DOX‐resistant MCF‐7/ADR cancer cells. US irradiation capable promoting cell phagocytosis nano‐agents, enhancing reaction, controlling drug release sites strengthen therapy. Transcriptomics analysis reveals US‐augmented reaction enables down‐regulation PGC‐1α Bcl‐2 expression, rendering susceptible DOX‐induced apoptosis. The distinct US‐responsive collaborating with chemotherapy substantially reverses achieves high tumor‐killing tumor‐bearing mice, suggesting such ferroptosis/apoptosis‐targeting instructive future design regimens against tumors.

Language: Английский

Citations

78
Chitosan‐based nanoscale systems for doxorubicin delivery: Exploring biomedical application in cancer therapy DOI
Milad Ashrafizadeh, Kiavash Hushmandi, Sepideh Mirzaei

et al.

Bioengineering & Translational Medicine, Journal Year: 2022, Volume and Issue: 8(1)

Published: Sept. 13, 2022

Green chemistry has been a growing multidisciplinary field in recent years showing great promise biomedical applications, especially for cancer therapy. Chitosan (CS) is an abundant biopolymer derived from chitin and present insects fungi. This polysaccharide favorable characteristics, including biocompatibility, biodegradability, ease of modification by enzymes chemicals. CS-based nanoparticles (CS-NPs) have shown potential the treatment other diseases, affording targeted delivery overcoming drug resistance. The current review emphasizes on application CS-NPs chemotherapeutic agent, doxorubicin (DOX), therapy as they promote internalization DOX cells prevent activity P-glycoprotein (P-gp) to reverse These nanoarchitectures can provide co-delivery with antitumor agents such curcumin cisplatin induce synergistic Furthermore, co-loading siRNA, shRNA, miRNA suppress tumor progression chemosensitivity. Various nanostructures, lipid-, carbon-, polymeric- metal-based nanoparticles, are modifiable CS delivery, while functionalization ligands hyaluronic acid promotes selectivity toward prevents demonstrate high encapsulation efficiency due protonation amine groups CS, pH-sensitive release occur. redox- light-responsive prepared treatment. Leveraging these characteristics view biocompatibility CS-NPs, we expect soon see significant progress towards clinical translation.

Language: Английский

Citations

62
Long noncoding RNAs (lncRNAs) in pancreatic cancer progression DOI
Milad Ashrafizadeh, Navid Rabiee, Alan Prem Kumar

et al.

Drug Discovery Today, Journal Year: 2022, Volume and Issue: 27(8), P. 2181 - 2198

Published: May 16, 2022

Language: Английский

Citations

56
Overcoming doxorubicin resistance in cancer: siRNA-loaded nanoarchitectures for cancer gene therapy DOI Creative Commons
Mahshid Deldar Abad Paskeh,

Hamidreza Saebfar,

Mahmood Khaksary Mahabady

et al.

Life Sciences, Journal Year: 2022, Volume and Issue: 298, P. 120463 - 120463

Published: March 7, 2022

Language: Английский

Citations

51
Resveratrol in breast cancer treatment: from cellular effects to molecular mechanisms of action DOI

Mitra Behroozaghdam,

Maryam Dehghani,

Amirhossein Zabolian

et al.

Cellular and Molecular Life Sciences, Journal Year: 2022, Volume and Issue: 79(11)

Published: Oct. 4, 2022

Language: Английский

Citations

40