miR-223: a key regulator of pulmonary inflammation DOI Creative Commons
Mingyu Shi, Qianying Lu, Yanmei Zhao

et al.

Frontiers in Medicine, Journal Year: 2023, Volume and Issue: 10

Published: July 3, 2023

Small noncoding RNAs, known as microRNAs (miRNAs), are vital for the regulation of diverse biological processes. miR-223, an evolutionarily conserved anti-inflammatory miRNA expressed in cells myeloid lineage, has been implicated monocyte–macrophage differentiation, proinflammatory responses, and recruitment neutrophils. The functions this gene regulated by its expression levels or tissues. In review, we first outline regulatory role miR-223 granulocytes, macrophages, endothelial cells, epithelial dendritic (DCs). Then, summarize possible chronic obstructive pulmonary disease (COPD), acute lung injury (ALI), coronavirus 2019 (COVID-19) other inflammatory diseases to better understand molecular networks diseases.

Language: Английский

Targeting miRNA by CRISPR/Cas in cancer: advantages and challenges DOI Creative Commons
Bashdar Mahmud Hussen, Mohammed Fatih Rasul, Snur Rasool Abdullah

et al.

Military Medical Research, Journal Year: 2023, Volume and Issue: 10(1)

Published: July 17, 2023

Clustered regulatory interspaced short palindromic repeats (CRISPR) has changed biomedical research and provided entirely new models to analyze every aspect of sciences during the last decade. In study cancer, CRISPR/CRISPR-associated protein (Cas) system opens avenues into issues that were once unknown in our knowledge noncoding genome, tumor heterogeneity, precision medicines. CRISPR/Cas-based gene-editing technology now allows for precise permanent targeting mutations provides an opportunity target small non-coding RNAs such as microRNAs (miRNAs). However, development effective safe cancer gene editing therapy is highly dependent on proper design be innocuous normal cells prevent introducing other abnormalities. This aims highlight cutting-edge approaches cancer-gene based CRISPR/Cas miRNAs therapy. Furthermore, we potential challenges CRISPR/Cas-mediated miRNA offer advanced strategies overcome them.

Language: Английский

Citations

56
Epigenetic modifications: Key players in cancer heterogeneity and drug resistance DOI Creative Commons
Hana Q. Sadida,

Alanoud Abdulla,

Sara Al Marzooqi

et al.

Translational Oncology, Journal Year: 2023, Volume and Issue: 39, P. 101821 - 101821

Published: Nov. 4, 2023

Cancer heterogeneity and drug resistance remain pivotal obstacles in effective cancer treatment management. One major contributor to these challenges is epigenetic modifications - gene regulation that does not involve changes the DNA sequence itself but significantly impacts expression. As we elucidate phenomena, underscore role of regulating expression, contributing cellular diversity, driving adaptive can instigate therapeutic resistance. This review dissects essential methylation, histone modifications, chromatin remodeling illustrating their significant yet complex contributions biology. While offer potential avenues for intervention due reversible nature, interplay genetic cells presents unique must be addressed harness full potential. By critically analyzing current research landscape, identify knowledge gaps propose future directions, exploring therapies discussing translating concepts into treatments. comprehensive aims stimulate further aid developing innovative, patient-centered therapies. Understanding critical scientific advancement paves way towards improving patient outcomes fight against this formidable disease.

Language: Английский

Citations

48
Unraveling the impact of miR-21 on apoptosis regulation in glioblastoma DOI
Mohammad Arshad Javed Shaikh, Abdulmalik Saleh Alfawaz Altamimi, Muhammad Afzal

et al.

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 254, P. 155121 - 155121

Published: Jan. 10, 2024

Language: Английский

Citations

21
Circulating microRNAs in Medicine DOI Open Access

Tetiana Pozniak,

Dzmitry Shcharbin, Maria Bryszewska

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(7), P. 3996 - 3996

Published: April 3, 2022

Circulating microRNAs (c-microRNAs, c-miRNAs), which are present in almost all biological fluids, promising sensitive biomarkers for various diseases (oncological and cardiovascular diseases, neurodegenerative pathologies, etc.), their signatures accurately reflect the state of body. Studies expression microRNA markers show that they can enable a wide range to be diagnosed before clinical symptoms manifested, help assess patient’s response therapy order correct personalize treatments. This review discusses latest trends uses miRNAs diagnosing treating viral non-viral. It is concluded exogenous used as high-precision therapeutic agents these purposes.

Language: Английский

Citations

67
MiRNA-93: a novel signature in human disorders and drug resistance DOI Creative Commons
Bashdar Mahmud Hussen, Snur Rasool Abdullah, Mohammed Fatih Rasul

et al.

Cell Communication and Signaling, Journal Year: 2023, Volume and Issue: 21(1)

Published: April 19, 2023

miRNA-93 is a member of the miR-106b-25 family and encoded by gene on chromosome 7q22.1. They play role in etiology various diseases, including cancer, Parkinson's disease, hepatic injury, osteoarthritis, acute myocardial infarction, atherosclerosis, rheumatoid arthritis, chronic kidney disease. Different studies have found that this miRNA has opposing roles context cancer. Recently, been downregulated breast gastric colorectal pancreatic bladder cervical renal However, up-regulated wide variety malignancies, such as lung, colorectal, glioma, prostate, osteosarcoma, hepatocellular carcinoma. The aim current review to provide an overview miRNA-93's function cancer disorder progression non-cancer disorders, with focus dysregulated signaling pathways. We also give miRNA's biomarker prognosis emphasize how it contributes drug resistance based vivo, vitro, human studies. Video Abstract.

Language: Английский

Citations

27
MiRNA in cervical cancer: Diagnosis to therapy: Systematic review DOI Creative Commons
Hiwot Tezera Endale,

Yitbarek Fantahun Mariye,

Habtu Kifle Negash

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(3), P. e24398 - e24398

Published: Jan. 12, 2024

Cancers are one of the most public health problems worldwide. Among them, cervical cancer (CC) is fourth prevalent with 604 000 new cases and 342 deaths. Mostly, it associated Human papillomavirus (HPV). It has been caused by aggregation genetic epigenetic modifications in epithelial cells. Although mutations given great attention for carcinogenesis CC, changes have emerged as a hotspot area CC biomarkers research implications early diagnosis, prognosis, treatment response prediction disease. Recently, there several studies focused on miRNAs cancer. However, precise function development not still completely understood, particularly when comes to unconventional sampling materials like mucus plasma serum. Hence, this review article will give summary profiles that emerge at different stages progression their downstream effects target genes signaling pathways. Finally, these results may provide insight into use or diagnosis miRNA-based therapeutics against

Language: Английский

Citations

13
A versatile upconversion-based multimode lateral flow platform for rapid and ultrasensitive detection of microRNA towards health monitoring DOI
Cong Chen,

Songtao Hu,

Lulu Tian

et al.

Biosensors and Bioelectronics, Journal Year: 2024, Volume and Issue: 252, P. 116135 - 116135

Published: Feb. 16, 2024

Language: Английский

Citations

11
Dual Roles of miR-10a-5p and miR-10b-5p as Tumor Suppressors and Oncogenes in Diverse Cancers DOI Open Access
Rajan Singh, Se Eun Ha, Tae Yang Yu

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(1), P. 415 - 415

Published: Jan. 6, 2025

Cancer is a complex genetic disorder characterized by abnormalities in both coding and regulatory non-coding RNAs. microRNAs (miRNAs) are key RNAs that modulate cancer development, functioning as tumor suppressors oncogenes. miRNAs play critical roles progression, influencing processes such initiation, promotion, metastasis. They exert their effects targeting suppressor genes, thereby facilitating while also inhibiting oncogenes to prevent further disease advancement. The miR-10 family, particularly miR-10a-5p miR-10b-5p (miR-10a/b-5p), notably involved progression. Intriguingly, functions can differ across different cancers, sometimes promoting at other times suppressing growth depending on the type target genes. This review explores dual of miR-10a/b-5p tumor-suppressive (TSmiRs) or oncogenic (oncomiRs) various cancers examining molecular cellular mechanisms impact microenvironment. Furthermore, we discuss potential therapeutic targets, emphasizing miRNA-based strategies for treatment. insights discussed this aim advance our understanding miR-10a/b-5p’s biology application developing innovative therapies.

Language: Английский

Citations

1
Identification of a six‐microRNA signature as a potential diagnostic biomarker in breast cancer tissues DOI Creative Commons

Mojdeh Mahmoudian,

Ehsan Razmara, Bashdar Mahmud Hussen

et al.

Journal of Clinical Laboratory Analysis, Journal Year: 2021, Volume and Issue: 35(11)

Published: Sept. 15, 2021

Abstract Background Breast cancer (BC) is by far the most common malignancy among women. Epigenetic modulators, microRNAs in particular, may set stages for BC development and its progression. Herein, we aimed to assess diagnostic potentiality of a signature six miRNAs (i.e., hsa‐miR‐25‐3p, ‐29a‐5p, ‐105‐3p, ‐181b1‐5p, ‐335‐5p, ‐339‐5p) adjacent non‐tumor tissues. Methods A pair 50 tumor samples were taken from patients. The expression each candidate miRNA was measured using quantitative reverse transcription PCR. To investigate possible roles their impressions on prognosis, silico tools used. Receiver operating characteristic (ROC) curves performed determine accuracy association with clinicopathological characteristics analyzed. Results Our findings showed upregulation downregulation hsa‐miR‐335‐5p ‐339‐5p compared corresponding Except hsa‐miR‐339‐5p, up‐/down‐regulation associated TNM stages. hsa‐miR‐105‐3p, correlated HER‐2 status. ROC curve analysis that six‐miRNA potential biomarker distinguishing between breast tissue samples. Conclusion We dysregulation novel can be used as diagnosis.

Language: Английский

Citations

44
Cervical Cancer, Papillomavirus, and miRNA Dysfunction DOI Creative Commons

Evelyn Gabriela Bañuelos-Villegas,

María Fernanda Pérez-yPérez,

Luis Marat Álvarez-Salas

et al.

Frontiers in Molecular Biosciences, Journal Year: 2021, Volume and Issue: 8

Published: Dec. 10, 2021

Cervical cancer is the leading cause of death by in women from developing countries. Persistent infection with high-risk human papillomavirus (HPV) types 16 and 18 a major risk factor for cervical carcinogenesis. Nevertheless, only few morphologic expression HPV progress into invasive disease suggesting involvement other factors MicroRNAs (miRNAs) are conserved small non-coding RNAs that negatively regulate gene including genes involved fundamental biological processes cancer. Dysregulation miRNAs has been widely reported This work focuses on reviewing affected during process, as well relevant contribute to development maintenance malignant tumor cells. Finally, we recapitulate may be used distinguish between healthy individuals patients precancerous lesions or tumors.

Language: Английский

Citations

41