Curcumin: Biological Activities and Modern Pharmaceutical Forms

Antibiotics, Journal Year: 2022, Volume and Issue: 11(2), P. 135 - 135

Published: Jan. 20, 2022

Curcumin (1,7-bis-(4-hydroxy-3-methoxyphenyl)-hepta-1,6-diene-3,5-dione) is a natural lipophilic polyphenol that exhibits significant pharmacological effects in vitro and vivo through various mechanisms of action. Numerous studies have identified characterised the pharmacokinetic, pharmacodynamic, clinical properties curcumin. has an anti-inflammatory, antioxidative, antinociceptive, antiparasitic, antimalarial effect, it used as wound-healing agent. However, poor curcumin absorption small intestine, fast metabolism, systemic elimination cause bioavailability human beings. In order to overcome these problems, number formulations been developed. The aim this paper provide overview recent research biological pharmaceutical aspects curcumin, methods sample preparation for its isolation (Soxhlet extraction, ultrasound pressurised fluid microwave enzyme-assisted aided extraction), analytical (FTIR, NIR, FT-Raman, UV-VIS, NMR, XRD, DSC, TLC, HPLC, HPTLC, LC-MS, UPLC/Q-TOF-MS) identification quantification different matrices, techniques developing formulations. optimal use appropriate method will significantly improve evaluation activity

Language: Английский

---

A review of therapeutic potentials of turmeric (Curcuma longa) and its active constituent, curcumin, on inflammatory disorders, pain, and their related patents

Phytotherapy Research, Journal Year: 2021, Volume and Issue: 35(12), P. 6489 - 6513

Published: July 26, 2021

Turmeric ( Curcuma longa ) and its constituent, curcumin, have been used for their therapeutic properties a long time. Most of the medicinal impacts turmeric curcumin might be attributed to anti‐inflammatory, antinociceptive, antioxidant effects. In present review, preventive potentials active on inflammatory disorders pain as well patents related analgesic anti‐inflammatory effects, summarized highlight value human health. A literature review was accomplished in Google Scholar, PubMed, Scopus, Patent, Patentscope, US Patent. Several documents disclosed significance apply several therapeutic, medicinal, pharmaceutical fields. These phytocompounds could applied supplementary therapy phytotherapy, such arthritis, bowel diseases, osteoarthritis, psoriasis, dermatitis, different types including neuropathic pain. However, because inadequate clinical trials, further high‐quality studies are needed firmly establish efficacy plant. Consistent with tendency usage rather than synthetic drugs, particular consideration must dedicated bond worth from basic sciences applications.

Language: Английский

---

Strategies for Improving Bioavailability, Bioactivity, and Physical-Chemical Behavior of Curcumin

Molecules, Journal Year: 2022, Volume and Issue: 27(20), P. 6854 - 6854

Published: Oct. 13, 2022

Curcumin (CCM) is one of the most frequently explored plant compounds with various biological actions such as antibacterial, antiviral, antifungal, antineoplastic, and antioxidant/anti-inflammatory properties. The laboratory data clinical trials have demonstrated that bioavailability bioactivity curcumin are influenced by feature molecular complex types. has a high capacity to form complexes proteins (such whey proteins, bovine serum albumin, β-lactoglobulin), carbohydrates, lipids, natural (e.g., resveratrol, piperine, quercetin). These increase curcumin. current review provides these derivatization strategies for in terms physico-chemical aspects strong focus on different type characterization methods, thermodynamic features protein–curcumin complexes, aim evaluating best performances. literature offers, taking into consideration effects CCM, whole approach CCM-biomolecules interactions CCM-proteins, CCM-nanomaterials, CCM-natural regarding improve well systems.

Language: Английский

---

Multiple health benefits of curcumin and its therapeutic potential

Environmental Science and Pollution Research, Journal Year: 2022, Volume and Issue: 29(29), P. 43732 - 43744

Published: April 20, 2022

Language: Английский

---

Potential of Nano-Antioxidants and Nanomedicine for Recovery from Neurological Disorders Linked to Long COVID Syndrome

Antioxidants, Journal Year: 2023, Volume and Issue: 12(2), P. 393 - 393

Published: Feb. 6, 2023

Long-term neurological complications, persisting in patients who cannot fully recover several months after severe SARS-CoV-2 coronavirus infection, are referred to as sequelae of the long COVID syndrome. Among numerous clinical post-acute COVID-19 symptoms, and psychiatric manifestations comprise prolonged fatigue, "brain fog", memory deficits, headache, ageusia, anosmia, myalgias, cognitive impairments, anxiety, depression lasting months. Considering that neurons highly vulnerable inflammatory oxidative stress damages following overproduction reactive oxygen species (ROS), neuroinflammation have been suggested dominate pathophysiological mechanisms It is emphasized mitochondrial dysfunction crucial for pathogenesis neurodegenerative disorders. Importantly, antioxidant therapies potential slow down prevent disease progression. However, many compounds display low bioavailability, instability, transport targeted tissues, limiting their applications. Various nanocarrier types, e.g., liposomes, cubosomes, solid lipid nanoparticles, micelles, dendrimers, carbon-based nanostructures, nanoceria, other inorganic can be employed enhance bioavailability. Here, we highlight phytochemical antioxidants neuroprotective agents (curcumin, quercetin, vitamins C, E D, melatonin, rosmarinic acid, N-acetylcysteine, Ginkgo Biloba derivatives) therapeutic strategies neuroregeneration. A particular focus given beneficial role nanoparticle-mediated drug-delivery systems addressing challenges managing preventing disorders factors sequelae.

Language: Английский

---

Curcumin and whey protein concentrate binding: Thermodynamic and structural approach

Food Hydrocolloids, Journal Year: 2023, Volume and Issue: 139, P. 108547 - 108547

Published: Feb. 7, 2023

The molecular interaction between curcumin (CCM), and whey protein concentrate (WPC), was studied by using fluorescence measurements. binding number (n), constant (KS) thermodynamic parameters (ΔG0, ΔH0 ΔS0) were determined at different temperatures various pH values. Thermodynamic approach revealed the highest stability of 1CCM-1WPC complex in acidic medium (e.g., stomach fluid 1.5), decreasing alkaline small intestine 7.4 to 8.0). CCM-WPC as spray-dried powder further investigated XRD, FTIR AFM imaging. X-ray diffractions show that due chemical CCM WPC a new amorphous compound is formed. spectra give strong evidence for with formation this complex. images nanostructure CCM, WPC, Docking studies hydrophobic interactions agreement entropic driven leading better understanding mechanism these components. Therefore, work confirmed promising carrier CCM. Lastly, development 35CCM-1WPC complex, characterized AFM, potentially natural safe functional foods through incorporation, distribution high bioactive compounds jointly enhancing their biological effects human health benefits.

Language: Английский

---

Innovative Delivery Systems for Curcumin: Exploring Nanosized and Conventional Formulations

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(5), P. 637 - 637

Published: May 9, 2024

Curcumin, a polyphenol with rich history spanning two centuries, has emerged as promising therapeutic agent targeting multiple signaling pathways and exhibiting cellular-level activities that contribute to its diverse health benefits. Extensive preclinical clinical studies have demonstrated ability enhance the potential of various bioactive compounds. While reported advantages are manifold, predominantly attributed antioxidant anti-inflammatory properties, efficacy is hindered by poor bioavailability stemming from inadequate absorption, rapid metabolism, elimination. To address this challenge, nanodelivery systems approach, offering enhanced solubility, biocompatibility, effects for curcumin. We analyzed knowledge on curcumin nanoencapsulation synergistic other compounds, extracted electronic databases. discuss pharmacokinetic profile curcumin, current advancements in techniques, combined agents across disorders. By unifying existing knowledge, analysis intends provide insights into technologies overcome constraints associated treatments, emphasizing importance combinatorial approaches improving efficacy. Finally, compilation study data aims inform inspire future research encapsulating drugs characteristics investigating innovative drug combinations improve outcomes.

Language: Английский

---

Cinnamon and its possible impact on COVID-19: The viewpoint of traditional and conventional medicine

Biomedicine & Pharmacotherapy, Journal Year: 2021, Volume and Issue: 143, P. 112221 - 112221

Published: Sept. 21, 2021

The COVID-19 global epidemic caused by coronavirus has affected the health and other aspects of life for more than one year. Despite current pharmacotherapies, there is still no specific treatment, studies are in progress to find a proper therapy with high efficacy low side effects. In this way, Traditional Persian Medicine (TPM), due its holistic view, can provide recommendations prevention treatment new diseases such as COVID-19. muco-obstruction airway, which occurs SARS-CoV-2, similar features TPM textbooks that lead us approaches. Based on pharmacological studies, Cinnamomum verum (Darchini)'s potential effective functions contribute SARS-CoV-2 infection been known be corona disease Public beliefs. From viewpoint theories, Cinnamon improvement through anti-obstructive, diuretic, tonic antidote addition, evidence anti-viral, anti-inflammatory, antioxidant, organ-o-protective anti-depression effects line therapeutic mentioned TPM.Overall, ingredients recommended SARS-CoV2 management multi-targeting therapies. This review provides basic information future drug's effectiveness preventing treating diseases.

Language: Английский

---

An updated and comprehensive review on the potential health effects of curcumin-encapsulated micro/nanoparticles

Critical Reviews in Food Science and Nutrition, Journal Year: 2022, Volume and Issue: 63(29), P. 9731 - 9751

Published: May 6, 2022

Curcumin (CUR) is a natural hydrophobic compound, which available in turmeric rhizome. It has several bioactivities including antioxidant, anti-obesity, anti-diabetic, cardioprotective, anti-inflammatory, antimicrobial, anticancer, and other activities. Despite its medical biological benefits, it using limitations because of hydrophobicity sensitivity. These unfavorable conditions further reduced the bioavailability (BA) efficacy CUR. This review summarizes stability BA free- encapsulated-CUR, as well comprehensively discusses potential activity CUR-loaded various micro-/nano-encapsulation systems. The CUR can be improved via loading different encapsulation systems, nanoemulsions, liposomes, niosomes, biopolymer-based nanoparticles, nano-hydrogel, others. Biopolymer-based nanoparticles (especially poly lactic-co-glycolic acid (PLGA), zein, chitosan) nano-gels are best carriers for encapsulating delivering Both delivery systems suitable their excellent functional properties such high efficiency, well-stability against conditions, coated Based on evidences, encapsulated-CUR exerted greater activities especially anticancer (breast cancer), antidiabetic, neuroprotective effects.

Language: Английский

---

Curcumin-Incorporated Biomaterials: In silico and in vitro evaluation of biological potentials

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 492, P. 215233 - 215233

Published: June 6, 2023

Language: Английский

---