Food Frontiers,
Journal Year:
2024,
Volume and Issue:
5(5), P. 1866 - 1908
Published: July 7, 2024
Abstract
The
escalating
global
cancer
burden
underscores
the
urgent
need
for
more
effective
therapeutic
strategies.
Phytochemicals,
naturally
occurring
compounds
in
plants,
have
garnered
attention
their
potential
chemoprevention
and
chemotherapy.
Their
ability
to
modulate
molecular
mechanisms
influence
cell
signaling
pathways
offers
a
promising
avenue
management.
This
review
aims
synthesize
current
knowledge
on
phytochemicals’
chemopreventive
chemotherapeutic
potential,
focusing
of
action
impacts
involved
cancer.
A
systematic
literature
search
was
conducted
across
major
databases,
including
PubMed/Medline,
Web
Science,
Scopus,
Google
Scholar.
strategy
uses
Medical
Subject
Headings
(MeSH)
free‐text
terms
using
Boolean
operators
capture
relevant
studies.
Inclusion
criteria
targeted
original
research
reviews
effects
phytochemicals
cancer,
with
specific
focus
mechanisms.
flavonoids,
polyphenols,
terpenoids,
demonstrated
significant
anticancer
properties
by
inducing
cycle
arrest,
apoptosis,
autophagy.
They
critical
pathways,
such
as
cyclooxygenase‐2,
nuclear
factor
kappa
B,
various
growth
factor‐related
rectify
epigenetic
alterations,
contributing
effects.
Phytochemicals
represent
valuable
resource
developing
novel
prevention
treatment
strategies;
actions
underscore
combat.
Further
is
warranted
translate
these
findings
into
clinical
applications,
optimizing
phytochemical‐based
interventions
Molecules,
Journal Year:
2023,
Volume and Issue:
28(4), P. 1845 - 1845
Published: Feb. 15, 2023
Phenolic
compounds
and
flavonoids
are
potential
substitutes
for
bioactive
agents
in
pharmaceutical
medicinal
sections
to
promote
human
health
prevent
cure
different
diseases.
The
most
common
found
nature
anthocyanins,
flavones,
flavanones,
flavonols,
flavanonols,
isoflavones,
other
sub-classes.
impacts
of
plant
phenolics
on
promoting
diseases
curing
preventing
antioxidant
effects,
antibacterial
impacts,
cardioprotective
anticancer
immune
system
promoting,
anti-inflammatory
skin
protective
effects
from
UV
radiation.
This
work
aims
provide
an
overview
phenolic
as
important
sources
medical
application
according
recently
published
studies,
well
some
interesting
directions
future
research.
keyword
searches
flavonoids,
phenolics,
tannins,
coumarins,
lignans,
quinones,
xanthones,
curcuminoids,
stilbenes,
cucurmin,
phenylethanoids,
secoiridoids
were
performed
by
using
Web
Science,
Scopus,
Google
scholar,
PubMed.
acids
contain
a
carboxylic
acid
group
addition
the
basic
structure
mainly
divided
into
hydroxybenzoic
hydroxycinnamic
acids.
Hydroxybenzoic
based
C6-C1
skeleton
often
bound
small
organic
acids,
glycosyl
moieties,
or
cell
structural
components.
Common
include
gallic,
syringic,
protocatechuic,
p-hydroxybenzoic,
vanillic,
gentistic,
salicylic
Hydroxycinnamic
C6-C3
also
molecules
such
quinic
glucose.
main
caffeic,
p-coumaric,
ferulic,
sinapic
Phytotherapy Research,
Journal Year:
2024,
Volume and Issue:
38(8), P. 3954 - 3972
Published: June 4, 2024
Driven
by
iron-dependent
lipid
peroxidation,
ferroptosis
is
regulated
p53
and
solute
carrier
family
7
member
11
(SLC7A11)/glutathione/glutathione
peroxidase
4
(GPX4)
axis
in
colorectal
cancer
(CRC).
This
study
aimed
to
investigate
the
influence
of
curcumin
(CUR)
on
CRC.
The
efficacies
CUR
malignant
phenotype
CRC
cells
were
determined
3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl
tetrazolium
bromide,
wound
healing,
clonogenic
assays.
effects
evaluated
transmission
electron
microscopy,
lactate
dehydrogenase
release
assay,
Fe
Drug Delivery and Translational Research,
Journal Year:
2024,
Volume and Issue:
14(10), P. 2845 - 2916
Published: July 13, 2024
Abstract
Several
efforts
have
been
extensively
accomplished
for
the
amelioration
of
cancer
treatments
using
different
types
new
drugs
and
less
invasives
therapies
in
comparison
with
traditional
therapeutic
modalities,
which
are
widely
associated
numerous
drawbacks,
such
as
drug
resistance,
non-selectivity
high
costs,
restraining
their
clinical
response.
The
application
natural
compounds
prevention
treatment
cells
has
attracted
significant
attention
from
pharmaceuticals
scientific
communities
over
past
decades.
Although
use
nanotechnology
therapy
is
still
preliminary
stages,
nanotherapeutics
demonstrated
to
decrease
various
limitations
related
compounds,
physical/chemical
instability,
poor
aqueous
solubility,
low
bioavailability.
Despite
emerged
a
promise
improve
bioavailability
there
limited
trials
performed
challenges
required
pre-clinical
trials,
production
at
an
industrial
level,
assurance
long-term
stability,
physiological
barriers
safety
regulatory
issues.
This
review
highlights
most
recent
advances
nanocarriers
secreted
plants,
bacteria,
fungi,
marine
organisms,
well
role
on
cell
signaling
pathways
anticancer
treatments.
Additionally,
status
main
regarding
loaded
applications
were
also
discussed.
Graphical
abstract
Molecules,
Journal Year:
2023,
Volume and Issue:
28(10), P. 4024 - 4024
Published: May 11, 2023
An
increase
in
life
expectancy
leads
to
a
greater
impact
of
chronic
non-communicable
diseases.
This
is
even
more
remarkable
elder
populations,
whom
these
become
main
determinants
health
status,
affecting
mental
and
physical
health,
quality
life,
autonomy.
Disease
appearance
closely
related
the
levels
cellular
oxidation,
pointing
out
importance
including
foods
one’s
diet
that
can
prevent
oxidative
stress.
Previous
studies
clinical
data
suggest
some
plant-based
products
slow
reduce
degradation
associated
with
aging
age-related
Many
plants
from
one
family
present
several
applications
range
food
pharmaceutical
industry
due
their
characteristic
flavor
scents.
The
Zingiberaceae
family,
which
includes
cardamom,
turmeric,
ginger,
has
bioactive
compounds
antioxidant
activities.
They
also
have
anti-inflammatory,
antimicrobial,
anticancer,
antiemetic
activities
properties
help
cardiovascular
neurodegenerative
These
are
abundant
sources
chemical
substances,
such
as
alkaloids,
carbohydrates,
proteins,
phenolic
acids,
flavonoids,
diarylheptanoids.
found
this
(cardamom,
ginger)
1,8-cineole,
α-terpinyl
acetate,
β-turmerone,
α-zingiberene.
review
gathers
evidence
surrounding
effects
dietary
intake
extracts
underlying
mechanisms
action.
could
be
an
adjuvant
treatment
for
oxidative-stress-related
pathologies.
However,
bioavailability
needs
optimized,
further
research
needed
determine
appropriate
concentrations
body.
Antioxidants,
Journal Year:
2023,
Volume and Issue:
12(6), P. 1212 - 1212
Published: June 3, 2023
Reactive
oxygen
species
(ROS)
are
important
second
messengers
in
many
metabolic
processes
and
signaling
pathways.
Disruption
of
the
balance
between
ROS
generation
antioxidant
defenses
results
overproduction
subsequent
oxidative
damage
to
biomolecules
cellular
components
that
disturb
function.
Oxidative
stress
contributes
initiation
progression
liver
pathologies
such
as
ischemia-reperfusion
injury
(LIRI),
non-alcoholic
fatty
disease
(NAFLD),
hepatocellular
carcinoma
(HCC).
Therefore,
controlling
production
is
an
attractive
therapeutic
strategy
relation
their
treatment.
In
recent
years,
increasing
evidence
has
supported
effects
polyphenols
on
via
regulation
levels.
current
review,
we
summarize
polyphenols,
quercetin,
resveratrol,
curcumin,
during
conditions
induce
injury,
LIRI,
NAFLD,
HCC.
Molecules,
Journal Year:
2025,
Volume and Issue:
30(2), P. 335 - 335
Published: Jan. 16, 2025
Epigenetic
abnormalities
play
a
critical
role
in
colon
carcinogenesis,
making
them
promising
target
for
therapeutic
interventions.
In
this
study,
we
demonstrated
that
curcumin
reduces
cancer
cell
survival
and
decrease
lysine
methylation
was
involved
such
an
effect.
This
correlated
with
the
downregulation
of
methyltransferases
EZH2,
MLL1,
G9a,
both
wild-type
p53
(wtp53)
HCT116
cells
mutant
(mutp53)
SW480
cells,
as
well
SET7/9
specifically
wtp53
cells.
The
effects
induced
by
were
more
pronounced
where
it
stronger
apoptosis
ferroptosis.
Interestingly,
also
reduced
mutp53
expression,
suggesting
could
enhance
efficacy
other
therapies,
particularly
overcoming
drug
resistance
mechanisms
associated
mutp53.
For
instance,
show
sensitized
to
inhibition
sinefungin,
further
supporting
its
potential
combinatorial
agent.
However,
although
lesser
extent,
impaired
HCT
116
null
molecular
pathways
or
factors,
beyond
p53,
may
be
curcumin-induced
cytotoxicity.
Discover Oncology,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: Feb. 28, 2025
Abstract
Objective
This
paper
aims
to
explore
the
research
hot
spot
and
development
trend
in
osteosarcoma
treatment
using
a
bibliometric
method
based
upon
Web
of
Science
Core
Collection
(WoSCC)
platform
over
last
decade.
Methods
The
literature
related
cure
which
were
published
from
January
2014
December
2023
retrieved
database
WoSCC
made
an
overall
analysis
for
papers
including
number
articles,
distribution
countries
institutions,
author
information,
keywords,
with
CiteSpace
6.2.R5.
Results
A
total
3131
retrieved,
2601
articles
530
reviews,
has
been
increasing
year
by
There
415
10,719
institutions
participating
into
study.
China’s
output
was
highest
relying
on
its
1490
published,
followed
United
States
(548
papers).
Shanghai
Jiaotong
university
had
largest
(121
papers)
Central
South
University
ranked
second
(82
16,816
authors
participated
Massimo
Serra
Rizzoli
Orthopaedics
Institute
(27
papers),
Dominique
Heymann
Sheffield
(20
visualization
keywords
software
showed
that
drug
resistance,
delivery,
tumor
tissue
engineering
gene
expression
have
become
hotspots
field
treatment.
Drug
resistance
significantly
limits
effectiveness
current
cancer
treatments.
delivery
technology
not
only
enhances
targeting
efficacy
drugs
but
also
helps
overcome
resistance.
stem
cells,
targeted
therapy,
microenvironment
represent
new
trends.
In
particular,
plays
key
role
development,
progression,
it
offers
numerous
potential
therapeutic
targets.
Conclusion
Our
investigation
identified
foci
treatment,
mechanisms,
innovations
technology,
cell
analysis,
novel
therapies,
clinical
translation
engineering.
International Journal of Dermatology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 10, 2025
ABSTRACT
The
concept
of
aging
has
evolved
from
being
primarily
attributed
to
genetic
factors
recognizing
the
critical
role
epigenetic
mechanisms.
Recent
advancements,
such
as
clocks,
have
provided
tools
assess
biological
age
and
offer
insights
into
processes
at
molecular
level.
In
aesthetic
dermatology,
understanding
these
allows
for
more
personalized,
effective
interventions
targeting
root
causes
skin
aging.
This
review
explores
interplay
changes,
aging,
potential
personalized
care
enhance
longevity
rejuvenation.
is
based
on
an
extensive
literature
search
conducted
across
PubMed
other
scientific
databases.
Studies
focused
mechanisms
DNA
methylation,
histone
modifications,
their
relationship
Particular
attention
was
given
recent
advancements
in
including
Horvath's
Clock
GrimAge,
implications
dermatological
treatments.
Epigenetic
Clock,
demonstrated
utility
assessing
through
methylation
markers,
revealing
actionable
processes.
Energy‐based
devices
like
fractional
lasers
radiofrequency
shown
promise
reversing
age‐related
promoting
collagen
synthesis,
reducing
age.
Additionally,
lifestyle
diet,
sleep,
circadian
rhythm
alignment
significantly
influence
health.
Integrating
dermatology
represents
a
paradigm
shift
rejuvenation,
allowing
treatments
that
address
visible
signs
underlying
Using
clocks
provides
framework
tailoring
individual
patient
needs,
optimizing
outcomes,
extending
results.
Future
research
should
focus
longitudinal
studies,
accessibility,
ethical
considerations
fully
harness
epigenetics
health
overall
well‐being.
