Serving up health: How phytochemicals transform food into medicine in the battle against cancer DOI Creative Commons
Eshita Sharma, Manju Tewari,

Priyanka Sati

et al.

Food Frontiers, Journal Year: 2024, Volume and Issue: 5(5), P. 1866 - 1908

Published: July 7, 2024

Abstract The escalating global cancer burden underscores the urgent need for more effective therapeutic strategies. Phytochemicals, naturally occurring compounds in plants, have garnered attention their potential chemoprevention and chemotherapy. Their ability to modulate molecular mechanisms influence cell signaling pathways offers a promising avenue management. This review aims synthesize current knowledge on phytochemicals’ chemopreventive chemotherapeutic potential, focusing of action impacts involved cancer. A systematic literature search was conducted across major databases, including PubMed/Medline, Web Science, Scopus, Google Scholar. strategy uses Medical Subject Headings (MeSH) free‐text terms using Boolean operators capture relevant studies. Inclusion criteria targeted original research reviews effects phytochemicals cancer, with specific focus mechanisms. flavonoids, polyphenols, terpenoids, demonstrated significant anticancer properties by inducing cycle arrest, apoptosis, autophagy. They critical pathways, such as cyclooxygenase‐2, nuclear factor kappa B, various growth factor‐related rectify epigenetic alterations, contributing effects. Phytochemicals represent valuable resource developing novel prevention treatment strategies; actions underscore combat. Further is warranted translate these findings into clinical applications, optimizing phytochemical‐based interventions

Language: Английский

Curcumin and analogues against head and neck cancer: From drug delivery to molecular mechanisms DOI
Chengzhi Zhao, Xueer Zhou,

Zhiwei Cao

et al.

Phytomedicine, Journal Year: 2023, Volume and Issue: 119, P. 154986 - 154986

Published: July 21, 2023

Language: Английский

Citations

19
Armeniacae semen amarum: a review on its botany, phytochemistry, pharmacology, clinical application, toxicology and pharmacokinetics DOI Creative Commons
Shun Tang, Minmin Wang, Yu‐Hui Peng

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Jan. 23, 2024

Armeniacae semen amarum —seeds of Prunus armeniaca L. (Rosaceae) (ASA), also known as Kuxingren in Chinese, is a traditional Chinese herbal drug commonly used for lung disease and intestinal disorders. It has long been to treat coughs asthma, well lubricate the colon reduce constipation. ASA refers dried ripe seed diverse species Rosaceae contains variety phytochemical components, including glycosides, organic acids, amino flavonoids, terpenes, phytosterols, phenylpropanoids, other components. Extensive data shows that exhibits various pharmacological activities, such anticancer activity, anti-oxidation, antimicrobial anti-inflammation, protection cardiovascular, neural, respiratory digestive systems, antidiabetic effects, liver kidney, activities. In clinical practice, can be single or combination with medicines, forming ASA-containing formulas, afflictions. However, it important consider potential adverse reactions pharmacokinetic properties during its use. Overall, bioactive diversified actions potent efficacies, promising merits in-depth study on functional mechanisms facilitate application.

Language: Английский

Citations

8
Application of natural products in regulating ferroptosis in human diseases DOI

Liyan Deng,

Wen Tian, Lianxiang Luo

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 128, P. 155384 - 155384

Published: Jan. 28, 2024

Language: Английский

Citations

8
Curcumin affects apoptosis of colorectal cancer cells through ATF6‐mediated endoplasmic reticulum stress DOI
Wei Xu,

Yu Shen

Chemical Biology & Drug Design, Journal Year: 2024, Volume and Issue: 103(1)

Published: Jan. 1, 2024

Abstract Colorectal cancer (CRC) is the main cause of cancer‐associated death. Herein, we treated SW620 and HT‐29 CRC cells with different curcumin concentrations, followed by treatment half maximal inhibitory concentration (IC50) curcumin/endoplasmic reticulum stress (ERS) inhibitor 4‐phenyl butyric acid (4‐PBA)/activating transcription factor 6 (ATF6) interference plasmid (si‐ATF6). We detected cell proliferation/apoptosis, ATF6 cellular localization/nuclear translocation, ion concentration, protein/apoptotic protein (Bax/Bcl‐2/Cleaved Caspase‐3) levels, ERS‐related proteins (glucose‐regulated 78 [Grp78]/C/EBP homologous [CHOP]). discovered inhibited proliferation/growth, enhanced apoptosis/(Bax/Bcl‐2) ratio/Cleaved Caspase‐3 levels/Ca 2+ in cytoplasm/ERS‐related (Grp78/CHOP) activated ERS following IC50 curcumin. 4‐PBA partially reversed effect on restraining ERS. Curcumin stimulated expression its nuclear translocation to activate silencing partly annulled cells. Our study explored molecular mechanism affecting apoptosis through ATF6.

Language: Английский

Citations

7
Curcumin synergistically enhances the efficacy of gemcitabine against gemcitabine-resistant cholangiocarcinoma via the targeting LAT2/glutamine pathway DOI Creative Commons
Phonpilas Thongpon, Kitti Intuyod,

Sasitorn Chomwong

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: July 11, 2024

Cholangiocarcinoma (CCA) is often diagnosed late, leading to incomplete tumor removal, drug resistance and reduced chemotherapy efficacy. Curcumin has the potential for anti-cancer activity through various therapeutic properties can improve efficacy of chemotherapy. We aimed investigate synergistic effect a combination curcumin gemcitabine against CCA, targeting LAT2/glutamine pathway. This synergistically suppressed proliferation in gemcitabine-resistant CCA cells (KKU-213B

Language: Английский

Citations

7
Targeting DNA methyltransferases for cancer therapy DOI
Kaiyue Wang,

Zhangxu He,

Gang Jin

et al.

Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 151, P. 107652 - 107652

Published: July 15, 2024

Language: Английский

Citations

6
The Bright Side of Curcumin: A Narrative Review of Its Therapeutic Potential in Cancer Management DOI Open Access
Andrea Amaroli, Isabella Panfoli, Matteo Bozzo

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(14), P. 2580 - 2580

Published: July 18, 2024

Curcumin, a polyphenolic compound derived from Curcuma longa, exhibits significant therapeutic potential in cancer management. This review explores curcumin’s mechanisms of action, the challenges related to its bioavailability, and enhancement through modern technology approaches. Curcumin demonstrates strong antioxidant anti-inflammatory properties, contributing ability neutralize free radicals inhibit inflammatory mediators. Its anticancer effects are mediated by inducing apoptosis, inhibiting cell proliferation, interfering with tumor growth pathways various colon, pancreatic, breast cancers. However, clinical application is limited poor bioavailability due rapid metabolism low absorption. Novel delivery systems, such as curcumin-loaded hydrogels nanoparticles, have shown promise improving curcumin efficacy. Additionally, photodynamic therapy has emerged complementary approach, where light exposure enhances modulating molecular crucial for survival. Studies highlight that combining concentrations visible irradiation significantly boosts antitumor efficacy compared alone. The interaction cytochromes or drug transporters may play role altering pharmacokinetics conventional medications, which necessitates careful consideration settings. Future research should focus on optimizing understanding fully harness treatment.

Language: Английский

Citations

6
Curcumin attenuates lupus nephritis by inhibiting neutrophil migration via PI3K/AKT/NF-κB signalling pathway DOI Creative Commons
Hui Yang,

Haiwei Zhang,

Lili Tian

et al.

Lupus Science & Medicine, Journal Year: 2024, Volume and Issue: 11(2), P. e001220 - e001220

Published: July 1, 2024

Objective To investigate the role of curcumin in treatment lupus nephritis (LN) by inhibiting migration neutrophils and underlying mechanism involved. Methods Two mouse models, MRL/lpr mice R848-treated mice, were treated with 50 mg/kg intraperitoneal injection. H&E Masson staining used to estimate histopathological changes kidney. Immunofluorescence was assess deposition immune complexes. The expression inflammatory factors detected enzyme-linked immunosorbent assay (ELISA) real-time reverse transcription polymerase reaction (RT-PCR), protein western blotting. Results We revealed remarkable potential improving conditions both R848-induced mice. Curcumin effectively decelerates progression inflammation diminishes infiltration their release pivotal factors, thereby reducing renal tissues. Mechanistically, significantly inhibits p-PI3K, p-AKT p-NF-κB, which are upregulated interleukin-8 induce neutrophil inflammation, factors. Conclusion recruitment proinflammatory kidney PI3K/AKT/NF-κB signalling pathway, providing new therapeutic targets medication strategies for LN.

Language: Английский

Citations

6
Ultraviolet (UV) radiation: a double-edged sword in cancer development and therapy DOI Creative Commons

Zhen-wei Yu,

Min Zheng,

Hua‐yang Fan

et al.

Molecular Biomedicine, Journal Year: 2024, Volume and Issue: 5(1)

Published: Oct. 17, 2024

It has long been widely acknowledged that ultraviolet (UV) light is an environment risk factor can lead to cancer, particularly skin cancer. However, it worth noting UV radiation holds potential for cancer treatment as a relatively high-energy electromagnetic wave. With the help of nanomaterials, role caught increasing attention in treatment. In this review, we briefly summarized types UV-induced cancers, including malignant melanoma, squamous cell carcinoma, basal Merkel carcinoma. Importantly, discussed primary mechanisms underlying carcinogenesis, mutations by DNA damage, immunosuppression, inflammation and epigenetic alterations. Historically limited its shallow penetration depth, introduction nanomaterials dramatically transformed utilization The direct effect itself generally leads suppression growth initiation apoptosis ferroptosis. also be utilized activate photosensitizers reactive oxygen species (ROS) production, sensitize radiotherapy achieve controlled drug release. Finally, comprehensively weigh significant risks limitations associated with therapeutic use radiation. And contradictory exposure promoting inhibiting tumor discussed. This review provides clues clinical therapy well future study directions field. precise delivery control or wavelength dose effects are needed thorough understanding

Language: Английский

Citations

6
Research progress on the mechanism of curcumin in cerebral ischemia/reperfusion injury: a narrative review DOI
Liyuan Zhang, Yibo Han, Xuelan Wu

et al.

APOPTOSIS, Journal Year: 2023, Volume and Issue: 28(9-10), P. 1285 - 1303

Published: June 26, 2023

Language: Английский

Citations

15