Natural Product Research,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 7
Published: April 17, 2024
Icariin
is
the
most
bioactive
ingredient
of
Epimedium
L.
and
a
quality
marker
Herba
Epimedii.
Conventional
methods
for
production
are
known
to
be
inefficient,
resulting
in
low
yields
significant
environmental
pollution.
This
study
aimed
develop
sustainable
effective
biphasic
enzymatic
hydrolysis
system
efficient
conversion
epimedin
C
icariin.
The
was
created
using
butyl
acetate
phosphate
buffer
(pH
4.5)
at
ratio
3:1
(V/V)
along
with
α-L-rhamnosidase/epimedin
(2
U/1
mg)
50
°C
12
h.
Consequently,
98.21%
hydrolysed
icariin,
95.62%
product
being
transferred
organic
phase.
Even
after
four
cycles
use,
remained
high
75.28%.
Furthermore,
this
novel
strategy
also
used
brevicornu
Maxim.
extracts.
represents
method
icariin
production,
offering
potential
benefits
industrial
applications.
Journal of Pharmaceutical Analysis,
Journal Year:
2022,
Volume and Issue:
13(3), P. 239 - 254
Published: Dec. 30, 2022
Flavonoids
such
as
baohuoside
I
and
icaritin
are
the
major
active
compounds
in
Epimedii
Folium
(EF)
possess
excellent
therapeutic
effects
on
various
diseases.
Encouragingly,
2022,
soft
capsules
were
approved
to
reach
market
for
treatment
of
hepatocellular
carcinoma
(HCC)
by
National
Medical
Products
Administration
(NMPA)
China.
Moreover,
recent
studies
demonstrate
that
can
serve
immune-modulating
agent
exert
anti-tumor
effects.
Nonetheless,
both
production
efficiency
clinical
applications
epimedium
flavonoids
have
been
restrained
because
their
low
content,
poor
bioavailability,
unfavorable
vivo
delivery
efficiency.
Recently,
strategies,
including
enzyme
engineering
nanotechnology,
developed
increase
productivity
activity,
improve
efficiency,
enhance
flavonoids.
In
this
review,
structure-activity
relationship
is
described.
Then,
enzymatic
strategies
increasing
highly
discussed.
The
nanomedicines
overcoming
barriers
improving
diseases
summarized.
Finally,
challenges
an
outlook
translation
proposed.
Journal of Functional Biomaterials,
Journal Year:
2023,
Volume and Issue:
14(1), P. 44 - 44
Published: Jan. 12, 2023
Among
scaffolds
used
in
tissue
engineering,
natural
biomaterials
such
as
plant-based
materials
show
a
crucial
role
cellular
function
due
to
their
biocompatibility
and
chemical
indicators.
Because
of
environmentally
friendly
behavior
safety,
green
methods
are
so
important
designing
scaffolds.
A
key
bioactive
flavonoid
the
Epimedium
plant,
Icariin
(ICRN),
has
broad
range
applications
improving
constant
non-immunogenic
material,
stimulating
cell
growth,
differentiation
chondrocytes
well
embryonic
stem
cells
towards
cardiomyocytes.
Moreover,
fusion
ICRN
into
hydrogel
or
crosslinking
can
enhance
secretion
collagen
matrix
proteoglycan
bone
cartilage
engineering.
To
scrutinize,
various
types
cancer
cells,
plays
decisive
through
increasing
cytochrome
c
secretion,
Bax/Bcl2
ratio,
poly
(ADP-ribose)
polymerase
caspase
stimulations.
Surprisingly,
induce
apoptosis,
reduce
viability
inhibit
proliferation
repress
tumorigenesis
metastasis.
no
longer
grow
by
halting
cycle
at
two
checkpoints,
G0/G1
G2/M,
inhibition
NF-κB
ICRN.
Besides,
nephrotoxicity
occurring
cisplatin
inhibiting
multidrug
resistance
other
this
biomaterial.
Chemistry & Biodiversity,
Journal Year:
2023,
Volume and Issue:
20(9)
Published: Aug. 7, 2023
With
the
increasing
prevalence
of
cancer
and
toxic
side
effects
synthetic
drugs,
natural
products
are
being
developed
as
promising
therapeutic
approaches.
Gracillin
is
a
naturally
occurring
triterpenoid
steroidal
saponin
with
several
activities.
It
obtained
major
compound
from
different
Dioscorea
species.
This
review
was
designated
to
summarize
research
progress
on
anti-cancer
activities
gracillin
focusing
underlying
cellular
molecular
mechanisms,
well
its
pharmacokinetic
features.
The
data
were
collected
(up
date
May
1,
2023)
various
reliable
authentic
literatures
comprising
PubMed,
Springer
Link,
Scopus,
Wiley
Online,
Web
Science,
ScienceDirect,
Google
Scholar.
findings
demonstrated
that
displays
anticancer
through
including
anti-inflammatory
effects,
apoptotic
cell
death,
induction
oxidative
stress,
cytotoxicity,
genotoxicity,
cycle
arrest,
anti-proliferative
effect,
autophagy,
inhibition
glycolysis,
blocking
migration.
Additionally,
this
highlighted
features
gracillin,
indicating
lower
oral
bioavailability.
As
conclusion,
it
can
be
proposed
could
serve
hopeful
chemotherapeutic
agent.
However,
further
extensive
clinical
recommended
establish
safety,
efficacy,
potential
in
treatment.
Journal of Advanced Research,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Feb. 1, 2024
Lipid
metabolism
has
been
implicated
in
a
variety
of
normal
cellular
processes
and
strongly
related
to
the
development
multiple
diseases,
including
tumor.
Tumor-associated
macrophage
(TAM)
emerged
as
crucial
regulator
tumorigenesis
promising
target
for
tumor
treatment.
Phytomedicine Plus,
Journal Year:
2024,
Volume and Issue:
4(2), P. 100540 - 100540
Published: Feb. 21, 2024
cancer
is
one
of
the
foremost
life-threatening
diseases
and
managed
by
various
strategies
like
surgery,
radiotherapy,
chemotherapy.
Among
all,
chemotherapy
most
preferential
strategy
for
management
but
faces
certain
limitations.
Phytochemicals
(PCs)
have
been
considered
potential
chemotherapeutics
chemopreventive
agents
their
clinical
application
can
be
questionable
because
poor
bioavailability
stability.
phytosomes
are
promising
carriers
to
deliver
anticancer
PCs
target
site
with
improved
stability
owing
unique
properties.
This
comprehensive
review
discusses
recent
advances
in
loaded
(covering
period
2013-December
2023)
overcome
limitations
PCs.
initially,
this
covers
that
under
trials
along
FDA-approved
(especially
management).
Here,
we
excluded
a)
an
experimental/preclinical
or
investigational
stage;
b)
possess
activity
other
than
anticancer;
c)
exhibit
combination
drugs;
d)
PC-based
drugs
anticancer.
Further,
article
mainly
emphasizes
Additionally,
cancer,
challenges,
future
directions
also
discussed.
versatile
alternatives
boost
PCs'
therapeutic
efficacy,
bioavailability,
specific
targeting
distinctive
structural
composition,
which
similar
composition
cell
membranes
enabling
them
close
physiological
systems.
Moreover,
these
vesicular
systems
increase
oral
polar
PCs,
protect
from
physical
chemical
degradation,
facilitate
efficiency
through
stimuli-responsive
sustained
release
Therefore,
will
help
researchers
develop
a
phytochemical-based
drug
delivery
system
successful
cancer.
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(2), P. 260 - 260
Published: Feb. 9, 2024
The
use
of
data-driven
high-throughput
analytical
techniques,
which
has
given
rise
to
computational
oncology,
is
undisputed.
widespread
machine
learning
(ML)
and
mathematical
modeling
(MM)-based
techniques
widely
acknowledged.
These
two
approaches
have
fueled
the
advancement
in
cancer
research
eventually
led
uptake
telemedicine
care.
For
diagnostic,
prognostic,
treatment
purposes
concerning
different
types
research,
vast
databases
varied
information
with
manifold
dimensions
are
required,
indeed,
all
this
can
only
be
managed
by
an
automated
system
developed
utilizing
ML
MM.
In
addition,
MM
being
used
probe
relationship
between
pharmacokinetics
pharmacodynamics
(PK/PD
interactions)
anti-cancer
substances
improve
treatment,
also
refine
quality
existing
models
incorporated
at
steps
development
related
routine
patient
This
review
will
serve
as
a
consolidation
benefits
special
focus
on
area
prognosis
anticancer
therapy,
leading
identification
challenges
(data
quantity,
ethical
consideration,
data
privacy)
yet
fully
addressed
current
studies.
Frontiers in Pharmacology,
Journal Year:
2023,
Volume and Issue:
14
Published: June 30, 2023
Numerous
chemical
compounds
used
in
cancer
treatment
have
been
isolated
from
natural
herbs
to
address
the
ever-increasing
incidence
worldwide.
Therein
is
icariin,
which
has
extensively
studied
for
its
therapeutic
potential
due
anti-inflammatory,
antioxidant,
antidepressant,
and
aphrodisiac
properties.
However,
there
a
lack
of
comprehensive
detailed
review
studies
on
icariin
treatment.
Given
this,
this
study
reviews
examines
relevant
literature
chemopreventive
potentials
describes
mechanism
action.
The
shows
that
property
inhibiting
progression
reversing
drug
resistance.
Therefore,
may
be
valuable
agent
prevention
various
cancers
origin,
safety,
low
cost
compared
conventional
anticancer
drugs,
while
further
research
needed.
Cancer Cell International,
Journal Year:
2024,
Volume and Issue:
24(1)
Published: Feb. 14, 2024
Breast
cancer
is
the
most
prevalent
female
tumor,
of
which
triple-negative
breast
(TNBC)
accounts
for
about
15%.
Characterized
by
its
aggressive
nature
and
limited
treatment
options,
TNBC
currently
stands
as
a
significant
clinical
challenge.
This
study
aimed
to
investigate
effects
icariin
(ICA)
on
explore
underlying
molecular
mechanism.
Cell
viability
was
assessed
using
CCK-8
assay,
whereas
impact
ICA
cell
proliferation
determined
colony
formation
assay
detection
proliferating
nuclear
antigen
protein.
Wound
healing
transwell
assays
were
used
evaluate
migration
invasion,
respectively.
Flow
cytometry
analyze
cycle
distribution
apoptosis.
Transmission
electron
microscopy
monodansylcaverine
staining
performed
detect
induction
autophagy,
docking
conducted
predict
potential
targets
associated
with
autophagy.
The
in
vivo
anti-tumor
evaluated
4T1
xenograft
mouse
model.
Protein
expression
levels
examined
immunoblotting
immunohistochemistry.
In
vitro,
effectively
suppressed
viability,
proliferation,
migration,
invasion
cells
induced
G0/G1
phase
arrest,
apoptosis,
autophagy
regulating
adenosine
monophosphate-activated
protein
kinase
(AMPK)/mammalian
target
rapamycin
(mTOR)/Unc-51-like
1
(ULK1)
signaling
pathway.
knockdown
AMPK
inhibition
3-methyladenine
reversed
ICA,
highlighting
importance
anti-cancer
mechanism
ICA.
vivo,
significantly
inhibited
growth,
promoted
regulated
AMPK/mTOR/ULK1
Our
findings
demonstrated
that
exerts
against
mechanisms.
will
help
facilitate
further
preclinical
investigations
TNBC.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(12), P. 10402 - 10402
Published: June 20, 2023
Inflammasomes
are
multiprotein
complexes
that
activate
inflammatory
responses
by
inducing
pyroptosis
and
secretion
of
pro-inflammatory
cytokines.
Along
with
many
previous
studies
on
diseases
induced
canonical
inflammasomes,
an
increasing
number
have
demonstrated
non-canonical
such
as
mouse
caspase-11
human
caspase-4
emerging
key
players
in
various
diseases.
Flavonoids
natural
bioactive
compounds
found
plants,
fruits,
vegetables,
teas
pharmacological
properties
a
wide
range
Many
successfully
flavonoids
play
anti-inflammatory
role
ameliorate
inhibiting
inflammasomes.
Others
the
roles
diseases,
new
mechanism
which
inhibit
This
review
discusses
recent
investigated
inflammasomes
further
provides
insight
into
developing
flavonoid-based
therapeutics
potential
nutraceuticals
against
