3 Biotech, Journal Year: 2024, Volume and Issue: 15(1)
Published: Dec. 20, 2024
Language: Английский
Plants, Journal Year: 2023, Volume and Issue: 12(16), P. 2944 - 2944
Published: Aug. 14, 2023
The rising predominance of type 2 diabetes, combined with the poor medical effects seen commercially available anti-diabetic medications, has motivated development innovative treatment approaches for regulating postprandial glucose levels. Natural carbohydrate digestion enzyme inhibitors might be a viable option blocking dietary absorption fewer side than manufactured medicines. Alpha-amylase is metalloenzyme that facilitates by breaking down polysaccharides into smaller molecules such as maltose and maltotriose. It also contributes to elevated blood levels hyperglycemia. As result, scientists are being urged target α-amylase create can slow release from chains prolong its absorption, thereby resulting in lower plasma derived plants have gained popularity safe cost-effective alternatives. bioactive components responsible inhibitory actions various plant extracts been identified through phytochemical research, paving way further application. majority findings, however, based on vitro investigations. Only few animal experiments very human investigations confirmed these findings. Despite some promising results, additional investigation needed develop feasible drugs plant-derived pancreatic inhibitors. This review summarizes most recent findings research inhibitors, including compounds. Furthermore, it offers insights structural aspects crucial therapeutic target, α-amylases, addition their interactions
Language: Английский
Citations
59
Food Chemistry X, Journal Year: 2024, Volume and Issue: 22, P. 101376 - 101376
Published: April 10, 2024
The aim of this study was to investigate the effect Ganoderma lucidum fermentation on antioxidant and anti-glycemic activities Tartary buckwheat. Xylanase, total cellulase (CMCase FPase) β-glucosidase in fermented buckwheat (FB) increased significantly 242.06 U/g, 17.99 U/g 8.67 respectively. And polysaccharides, phenols, flavonoids triterpenoids, which is by 122.19%, 113.70%, 203.74%, 123.27%, Metabolite differences between non-fermented (NFB) FB pointed out that 445 metabolites were substantially different, involved related biological metabolic pathways. There a considerable rise concentrations hesperidin, xanthotoxol quercetin 3-O-malonylglucoside 240.21, 136.94 100.77 times (in Fold Change), results showed This demonstrates provides new idea enhance health-promoting components bioactivities
Language: Английский
Citations
12
Food Hydrocolloids for Health, Journal Year: 2024, Volume and Issue: 5, P. 100175 - 100175
Published: Jan. 1, 2024
Plant-derived hydrolysates are emerging as promising agents in the management of diverse ailments due to their ensuing functional and bioactive properties. This study investigated functional, antioxidant, anti-inflammatory, antidiabetic properties from Erythrina senegalensis Vigna subtenarrea seeds. Crude proteins were isolated via alkaline solubilization, followed by acid precipitation isoelectric point. Respective protein isolates hydrolyzed using trypsin pepsin at an enzyme-substrate ratio 1:8 (v/v) for 1 9 h. Pepsin after h elicited highest solubilities 95.54% 94.24% pH 13, while, E. digested displayed 1,1-diphenyl-2-picrylhydrazyl radical-scavenging (10-IC50 = 2.959 mg/mL) total antioxidant capacity (7.243 mgAAE/g), respectively. Correspondingly, 5 demonstrated most potent anti-inflammatory activities cogently inhibiting xanthine oxidase lipoxygenase with IC50 0.161±0.111 0.018±0.011 mg/mL, Trypsin V. subterranea potently inhibited α-amylase α-glucosidase respective 0.297±0.060 0.314±0.064 mg/mL. Overall, pronounced bioactivities relative hydrolysates. concludes that both seeds could serve unique matrices potential peptides prospects managing diabetes.
Language: Английский
Citations
7
Journal of Composites Science, Journal Year: 2023, Volume and Issue: 7(11), P. 453 - 453
Published: Nov. 1, 2023
The present study investigates the green synthesis of silver nanoparticles was carried out using a leaf extract Anoectochilus elatus (Ae-AgNPs). synthesised Ae-AgNPs were characterised different analytical techniques like UV-visible spectroscopy, X-ray diffraction (XRD), Fourier transform infrared (FTIR), and scanning electron microscopy (SEM) with energy-dispersive analysis (EDX). Additionally, in vitro activities investigated, they possess antioxidant, anti-inflammatory, antidiabetic, antimicrobial properties. UV-Vis spectra exhibited characteristic absorption peaks at approximately 480 nm. FTIR identified functional groups Ae-AgNPs. crystalline structure verified via XRD analysis. SEM studies revealed that spherical morphology. fabrication established by EDX spectrum, which prominent signals atoms. show potent antidiabetic activity compared to standard drugs. In addition, demonstrated most significant zone Inhibition. This affirms superior biological capability for target drug delivery their potential usage biomedical research therapeutics.
Language: Английский
Citations
13
Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 324, P. 117731 - 117731
Published: Jan. 11, 2024
Oxalis corniculata (O. corniculata) is a member of Oxalidaceae family, widely distributed in Asia, Europe, America, and Africa, used extensively as food its traditional folkloric uses include management epilepsy, gastric disorders, neurodegenerative diseases, together with use enhancing health. Numerous pharmacological benefits O. are linked to anti-inflammatory antioxidant abilities. One the most prevalent disorders Alzheimer's disease (AD) which neuroinflammation oxidative stress main pathogenic processes. Our research aimed study neuroprotective effect methanolic extract Linn. ME), compared selenium (Se) against AlCl3-induced AD. Forty male albino rats were allocated into four groups (Gps). Gp I control group, rest animals received AlCl3 (Gp II-Gp IV). Rats III IV treated Se ME, respectively. The chemical profile ME was studied using ultraperformance liquid chromatography-electrospray ionization-quadrupole time-of-flight mass spectrometry, allowing tentative identification sixty-six compounds, including organic acids, phenolics others, cinnamic acid derivatives, fatty flavonoids. showed deterioration short-term memory brain histological pictures. findings that helped combat produced by accumulation prophylaxis Thus, Selenium restored defense, via Nrf2/HO-1 hub, hampered neuroinflammation, TLR4/NF-κβ/NLRP3, along dampening apoptosis, Aβ generation, tau hyperphosphorylation, BACE1, ApoE4 LRP1 levels. Treatments also promoted autophagy modulated Wnt 3/β-catenin/GSK3β cue. It noted notable ameliorative on Nrf2/HO-1, APOE4/LRP1, 3/β-catenin/GSK-3β PERK axes.
Language: Английский
Citations
4
Food Chemistry Advances, Journal Year: 2025, Volume and Issue: unknown, P. 100912 - 100912
Published: Feb. 1, 2025
Language: Английский
Citations
0
Plants, Journal Year: 2025, Volume and Issue: 14(4), P. 578 - 578
Published: Feb. 14, 2025
Oxalis pes-caprae L., an invasive plant from South Africa, has developed into a severe ecological threat in many Mediterranean and temperate areas by replacing native flora modifying ecosystems. Although this species detrimental effects on the ecosystem, it unrealized potential as significant bioresource. Current research secondary metabolites found O. pes-caprae, such phenolic acids, oxalates, flavonoids, is summarized review, along with analysis of their biological pharmacological properties, which include antibacterial, antidiabetic, antioxidant activities. could be converted troublesome intruder financially ecologically advantageous bioresource natural products for pharmaceutical, nutraceutical, cosmetic, agricultural applications rethinking resource phytochemical extraction. This would offer novel approach to managing while promoting advancement green technologies sustainable practices.
Language: Английский
Citations
0
Food Chemistry Advances, Journal Year: 2023, Volume and Issue: 3, P. 100429 - 100429
Published: Sept. 7, 2023
Language: Английский
Citations
10
Fitoterapia, Journal Year: 2024, Volume and Issue: 174, P. 105873 - 105873
Published: Feb. 28, 2024
Language: Английский
Citations
3
Foods, Journal Year: 2024, Volume and Issue: 13(6), P. 858 - 858
Published: March 12, 2024
(1) Background: Oxalis pes-caprae L. is a plant considered within the group of so-called Wild Edible Plants (WEPs). The particularity these plants that they grow only with natural resources at their disposal. Unfortunately, types are undervalued, being regularly uprooted from fields. (2) Methods: Therefore, this study aimed to valorize plant, analyzing proximate composition (sugars, organic acids, minerals, amino acids profile, fatty content, and volatile profile) shoots (flower, leaves, stem) demonstrate full potential WEP. (3) Results: results showed can be source minerals; furthermore, 19 essential non-essential were found. Regarding acid flowers an important linoleic acid, leaves present high amount α-linolenic acid. (4) Conclusions: research provides new information reaffirms capacity (WEP) great future progression due its nutritional quality since it could used in food, nutritional, or pharmaceutical Further must conducted assay biomass production costs recommending farmers not destroy
Language: Английский
Citations
3