BMC Oral Health, Journal Year: 2024, Volume and Issue: 24(1)
Published: Sept. 26, 2024
Language: Английский
International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 249, P. 125993 - 125993
Published: July 27, 2023
Language: Английский
Citations
31
Nutraceuticals, Journal Year: 2024, Volume and Issue: 4(4), P. 562 - 595
Published: Oct. 11, 2024
The major constituent of turmeric, curcumin, is a bioactive phenolic compound that has been studied for its potential health benefits and therapeutic properties. Within this article, the anti-inflammatory, antioxidant antithrombotic properties mechanisms action curcumin are thoroughly reviewed main focus shifted to associated health-promoting effects against inflammation-related chronic disorders. An overview cardio-protective, anti-tumor, anti-diabetic, anti-obesity, anti-microbial neuro–protective reviewed, while relative outcomes obtained from clinical trials also presented. Emphasis given wound-healing as presented by several studies trials, which further promote application ingredient in functional products, including foods, nutraceuticals, cosmetics drugs. Limitations future perspectives such uses bio-functional discussed.
Language: Английский
Citations
11
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(2), P. 177 - 177
Published: Jan. 26, 2024
Curcumin is a natural compound that has been widely investigated thanks to its various biological properties, including antiproliferative. This molecule acts on different cancers such as lung, breast, pancreatic, colorectal, etc. However, the bioactive actions of curcumin have limitations when physicochemical properties compromise pharmacological potential. As therapeutic strategy against cancer, associated with inorganic nanoparticles. These nanocarriers are capable delivering and offering synergistically enhance anticancer properties. review highlights types curcumin-based nanoparticles discusses their in vivo activity models cancer.
Language: Английский
Citations
9
Journal of drug targeting, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 28
Published: Jan. 3, 2025
Breast cancer (BC) is a substantial reason for cancer-related mortality among women across the globe. Anastrozole (ANS) an effective orally administered hormonal therapy estrogen+ (ER+) BC treatment. However, several side effects and pharmacokinetic limitations restricted its uses in Therefore, this study developed
Language: Английский
Citations
1
Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 14
Published: Jan. 14, 2025
Introduction This study utilized a injectable curcumin (Cur)-infused calcium phosphate silicate cement (CPSC) for addressing defects caused by bone cancer, and evaluated its promoting regeneration exerting cytotoxic effects on osteosarcoma cells. Methods The material’s physicochemical properties, biocompatibility with osteoblasts, cytotoxicity toward cells were rigorously analyzed. Results findings demonstrate that CPSC-Cur signicantly prolongs the setting time, which can be optimized adding silanized cellulose nanober (CNF-SH) to achieve balance between workability mechanical strength. Biological assessments reveal pronounced effect while maintaining minimal toxicity pre-osteoblasts, highlighting CPSC-Cur’s potential as promising material repairing following cancer removal. Conclusion lays groundwork future investigations into in vivo efficacy role clinical treatment of cancer.
Language: Английский
Citations
1
Communications Chemistry, Journal Year: 2024, Volume and Issue: 7(1)
Published: Aug. 13, 2024
Abstract Mitochondrial dysregulation plays a significant role in the carcinogenesis. On other hand, its destabilization strongly represses viability and metastatic potential of cancer cells. Photodynamic photothermal therapies (PDT PTT) target mitochondria effectively, providing innovative non-invasive anticancer therapeutic modalities. Cyanine dyes, with strong mitochondrial selectivity, show enhancing PDT PTT. The limitations cyanine dyes for PTT are discussed, along their applications combination therapies, theranostic techniques, optimal delivery systems. Additionally, novel approaches sonodynamic therapy using photoactive presented, highlighting advances treatment.
Language: Английский
Citations
8
Plants, Journal Year: 2023, Volume and Issue: 12(14), P. 2661 - 2661
Published: July 16, 2023
Transdermal delivery devices and wound dressing materials are constantly improved upgraded with the aim of enhancing their beneficial effects, biocompatibility, biodegradability, cost effectiveness. Therefore, researchers in field have shown an increasing interest using natural compounds as constituents for such systems. Plants, important source so-called “natural products” enormous variety structural diversity that still exceeds capacity present-day sciences to define or even discover them, been part medicine since ancient times. However, benefits just at beginning being fully exploited modern dermal transdermal Thus, plant-based primary compounds, without biological activity, contained gums mucilages, traditionally used gelling texturing agents food industry, now explored valuable cost-effective components biomedical field. Their non-toxicity compensate local availability compositional variations. Also, secondary metabolites, classified based on chemical structure, intensively investigated wide pharmacological toxicological effects. impact is highlighted detail through most recent reported studies. Innovative isolation purification techniques, new drug systems, advanced evaluation procedures presented.
Language: Английский
Citations
14
European Journal of Pharmaceutical Sciences, Journal Year: 2023, Volume and Issue: 191, P. 106586 - 106586
Published: Sept. 19, 2023
Cancer remains one of the leading causes mortality worldwide, presenting a significant healthcare challenge owing to limited efficacy current treatments. The application nanotechnology in cancer treatment leverages unique optical, magnetic, and electrical attributes nanomaterials engineer innovative, targeted therapies. Specifically, manipulating allows for enhanced drug loading efficiency, improved bioavailability, delivery systems, reducing non-specific cytotoxic effects characteristic conventional chemotherapies. Furthermore, recent advances have demonstrated encouraging results specifically targeting CSCs, key development considering role these cells disease recurrence resistance treatment. Despite breakthroughs, clinical approval rates nano-drugs not kept pace with research advances, pointing existing obstacles that must be addressed. In conclusion, presents novel, powerful tool fight against cancer, particularly elusive treatment-resistant CSCs. This comprehensive review delves into intricacies nanotherapy, explicitly stem cells, their markers, associated signaling pathways.
Language: Английский
Citations
14
Cancers, Journal Year: 2024, Volume and Issue: 16(14), P. 2580 - 2580
Published: July 18, 2024
Curcumin, a polyphenolic compound derived from Curcuma longa, exhibits significant therapeutic potential in cancer management. This review explores curcumin’s mechanisms of action, the challenges related to its bioavailability, and enhancement through modern technology approaches. Curcumin demonstrates strong antioxidant anti-inflammatory properties, contributing ability neutralize free radicals inhibit inflammatory mediators. Its anticancer effects are mediated by inducing apoptosis, inhibiting cell proliferation, interfering with tumor growth pathways various colon, pancreatic, breast cancers. However, clinical application is limited poor bioavailability due rapid metabolism low absorption. Novel delivery systems, such as curcumin-loaded hydrogels nanoparticles, have shown promise improving curcumin efficacy. Additionally, photodynamic therapy has emerged complementary approach, where light exposure enhances modulating molecular crucial for survival. Studies highlight that combining concentrations visible irradiation significantly boosts antitumor efficacy compared alone. The interaction cytochromes or drug transporters may play role altering pharmacokinetics conventional medications, which necessitates careful consideration settings. Future research should focus on optimizing understanding fully harness treatment.
Language: Английский
Citations
6
Biomedical Materials, Journal Year: 2024, Volume and Issue: 19(5), P. 052009 - 052009
Published: Aug. 27, 2024
Abstract Curcumin is a natural polyphenolic compound extracted from turmeric with antibacterial, antioxidant, antitumor, preventive and therapeutic neurological disorders variety of bioactivities, which widely used in the field food medicine. However, drawbacks curcumin such as poor aqueous solubility stability have limited practical application curcumin. To overcome these defects enhance its functional properties, various nanoscale systems (liposomes, polymer nanoparticles, protein solid lipid metal etc) been extensively employed for encapsulation delivery. Despite rapid development nanoformulations, there lack comprehensive reviews on their preparation properties. This review provides an overview construction nano-delivery systems, mechanisms action, nanocarrier methods applications nanocarriers pharmaceutical fields to provide theoretical basis technological support efficient bio-utilization, product early clinical
Language: Английский
Citations
6