NIR/glucose stimuli-responsive multifunctional smart hydrogel wound dressing with NO/O2 dual gas-releasing property promotes infected diabetic wound healing

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 492, P. 152249 - 152249

Published: May 15, 2024

Language: Английский

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Peroxide-Simulating and GSH-Depleting Nanozyme for Enhanced Chemodynamic/Photodynamic Therapy via Induction of Multisource ROS

ACS Applied Materials & Interfaces, Journal Year: 2023, Volume and Issue: 15(41), P. 47955 - 47968

Published: Oct. 9, 2023

Reactive oxygen species (ROS) generation, using photodynamic therapy (PDT) and chemodynamic (CDT), is a promising strategy for cancer treatment. However, the production of ROS in tumor cells often limited by hypoxia, insufficient substrates, high level scavengers microenvironment, which seriously affects efficacy ROS-related therapies. Herein, we report lipid-supported manganese oxide nanozyme, MLP@DHA&Ce6, decorating MnO2 nano-shell on liposome loaded with dihydroartemisinin (DHA) photosensitizer Ce6 generating multisource to enhance therapy. MLP@DHA&Ce6 can be accumulated tumors release active components, Mn2+ ions, O2. The conjugate generates via nanozyme-catalyzed CDT DHA as substrate, PDT through Ce6, Fenton reaction catalyzed ions. O2 from enhanced Ce6-mediated under near-infrared light irradiation. Meanwhile, showed prominent glutathione depletion, allowed retain activity cells. In addition, ions induced ferroptosis. This generation ferroptosis effect led therapeutic effects vivo.

Language: Английский

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Recent trends in nanozyme research and their potential therapeutic applications

Current Research in Biotechnology, Journal Year: 2024, Volume and Issue: 7, P. 100205 - 100205

Published: Jan. 1, 2024

Nanozymes are a class of nanoparticles that can mimic enzyme activity and be used for various applications in modern clinical therapy. It has recently been observed nanozymes have multi-enzyme mimicking activities, highly stable, versatile easily modified. Moreover, they high catalytic efficiency, recovery rates, improved substrate specificity suitable mass production. The mechanisms mainly include catalase, peroxidase, oxidase, hydrolase superoxide dismutase-like which enable to as potential therapeutics against plethora infectious lifestyle disorders. cancer, inflammatory diseases, neurodegenerative neurological disorders, bacterial, fungal viral infections, wounds diseases associated with Reactive Oxygen Species. purpose writing this review is provide comprehensive compilation novel research work taken place the last few years regarding use We compiled kinds elaborated on their anti-tumorigenic, antioxidant, anti-inflammatory, antibacterial, antifungal, antiviral, neuroprotective roles. Their modes action enzymatic targets also discussed. types synthesis summarized, along interactions nanozymes. Furthermore, strategies enhance compatibility between analyzed. Major focus laid therapeutic challenges future perspectives using therapy debated later sections.

Language: Английский

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MOFs‐Based Magnetic Nanozyme to Boost Cascade ROS Accumulation for Augmented Tumor Ferroptosis

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(20)

Published: March 26, 2024

The emerging cell death modality of ferroptosis has garnered increasing attention for antitumor treatment but still suffers from low therapeutic efficacy. A metal-organic frameworks (MOFs)-based magnetic nanozyme (PZFH) comprising porphyrin-based Zr-MOF (PCN) on zinc ferrite (ZF) nanoparticles modified with hyaluronic acid, delivering excellent magnetophotonic response efficient ferroptosis, is reported here. PZFH shows multienzyme-like cascade activity encompassing a photon-triggered oxidase-like catalysis to generate O

Language: Английский

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Tumor microenvironment activated mussel-inspired hollow mesoporous nanotheranostic for enhanced synergistic photodynamic/chemodynamic therapy

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 665, P. 188 - 203

Published: March 23, 2024

Language: Английский

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Nanozymes and their biomolecular conjugates as next-generation antibacterial agents: A comprehensive review

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 278, P. 134582 - 134582

Published: Aug. 8, 2024

Language: Английский

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Recent Development and Application of “Nanozyme” Artificial Enzymes—A Review

Biomimetics, Journal Year: 2023, Volume and Issue: 8(5), P. 446 - 446

Published: Sept. 21, 2023

Nanozymes represent a category of nano-biomaterial artificial enzymes distinguished by their remarkable catalytic potency, stability, cost-effectiveness, biocompatibility, and degradability. These attributes position them as premier biomaterials with extensive applicability across medical, industrial, technological, biological domains. Following the discovery ferromagnetic nanoparticles peroxidase-mimicking capabilities, research endeavors have been dedicated to advancing nanozyme utilization. Their capacity emulate functions natural has captivated researchers, prompting in-depth investigations into potential applications. This exploration yielded insights innovations in various areas, including detection mechanisms, biosensing techniques, device development. exhibit diverse compositions, sizes, forms, resembling molecular entities such proteins tissue-based glucose. rapid impact on body necessitates comprehensive understanding intricate interplay. As each day witnesses emergence novel methodologies technologies, integration nanozymes continues surge, promising enhanced comprehension times ahead. review centers expansive deployment advancement materials, encompassing biomedical, biotechnological, environmental contexts.

Language: Английский

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Inorganic-Nanomaterial-Composited Hydrogel Dressings for Wound Healing

Journal of Composites Science, Journal Year: 2024, Volume and Issue: 8(2), P. 46 - 46

Published: Jan. 26, 2024

Wound management heavily relies on the vital contribution of wound dressings, emphasizing significance finding an ideal dressing that can fulfill intricate requirements healing process with multiple functions. A promising strategy is combining several materials and therapies to create multifunctional dressings. Nanocomposite hydrogel dressings based nanomaterials, advantages nanomaterials hydrogels in treatment, significantly improve their respective performance compensate for shortcomings. variety nanocomposite diverse structures synergistic functions have been developed recent years, achieving results applications. In this review, functions, advantages, limitations as are first discussed. Additionally, application inorganic also elaborated on. Furthermore, we focused summarizing analyzing healing, which contain various including metals, metal oxides, sulfides, carbon-based silicon-based nanoparticles. Finally, prospects envisaged, providing insights further research management.

Language: Английский

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The potential use of nanozyme in aging and age‐related diseases

Biogerontology, Journal Year: 2024, Volume and Issue: 25(4), P. 583 - 613

Published: March 11, 2024

Language: Английский

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Nanozyme-based cancer theranostics: A scientometric analysis and comprehensive review

Nano Today, Journal Year: 2024, Volume and Issue: 57, P. 102386 - 102386

Published: July 13, 2024

Language: Английский

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