Emerging Therapeutic Strategies in Sarcopenia: An Updated Review on Pathogenesis and Treatment Advances

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(8), P. 4300 - 4300

Published: April 12, 2024

Sarcopenia is a prevalent degenerative skeletal muscle condition in the elderly population, posing tremendous burden on diseased individuals and healthcare systems worldwide. Conventionally, sarcopenia currently managed through nutritional interventions, physical therapy, lifestyle modification, with no pharmaceutical agents being approved for specific use this disease. As pathogenesis of still poorly understood there treatment recognized as universally effective, recent research efforts have been directed at better comprehending illness diversifying strategies. In respect, paper overviews new advances correlation its underlying mechanisms. Specifically, review creates an updated framework sarcopenia, describing etiology, pathogenesis, risk factors, conventional treatments, further discussing emerging therapeutic approaches like drug formulations, delivery systems, stem cell therapies, tissue-engineered scaffolds more detail.

Language: Английский

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Restoration of epigenetic impairment in the skeletal muscle and chronic inflammation resolution as a therapeutic approach in sarcopenia

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 96, P. 102267 - 102267

Published: March 9, 2024

Language: Английский

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Gouqi-derived nanovesicles (GqDNVs) inhibited dexamethasone-induced muscle atrophy associating with AMPK/SIRT1/PGC1α signaling pathway

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: May 22, 2024

Abstract With the increasing trend of global aging, sarcopenia has become a significant public health issue. Goji berry, also known as “Gou qi zi” in China, is traditional Chinese herb that can enhance structure and function muscles bones. Otherwise, previous excellent publications illustrated plant-derived exosome-like nanoparticles exert good bioactive functions different aging or disease models. Thus, we issued hypothesis Gouqi-derived nanovesicles (GqDNVs) may have ability to improve skeletal muscle health, though effect its mechanism need be explored. Hence, extracted GqDNVs from fresh berries Lycium barbarum L. (goji) found contents are rich saccharides lipids. Based on pathway annotations predictions non-targeted metabolome analysis, tightly associated with pathways metabolism. In atrophy model mice, intramuscular injection improves cross-sectional area quadriceps muscle, grip strength AMPK/SIRT1/PGC1α expression. After separately inhibiting AMPK PGC1α C2C12 cells dexamethasone administration, activated plays chief role improving cell proliferation induced by GqDNVs. Furthermore, energy-targeted analysis demonstrates up-regulate metabolism amino sugar nucleotide sugar, autophagy oxidative phosphorylation process, which indicates activation regeneration. Besides, Spearman rank shows close associations between quality metabolites expression levels SIRT1. this study, provide new founding accompanying signaling pathway. Therefore, anti-aging potential adjuvant complementary method idea future therapy research. Graphical

Language: Английский

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The emerging role of exercise preconditioning in preventing skeletal muscle atrophy

Frontiers in Physiology, Journal Year: 2025, Volume and Issue: 16

Published: March 26, 2025

Skeletal muscle atrophy, characterized by the loss of mass and function, can result from disuse, aging, disease, drug. Exercise preconditioning—a form exercise training performed before these harmful threats—induces notable remodeling extensive biochemical adaptations in skeletal muscle, creating a protective phenotype fibers, thus serving as an effective intervention for preventing atrophy. Here, we review current understanding relating to how preconditioning protects damage caused inactivity, sarcopenia, or pharmacological intervention, with emphasis on cellular mechanisms involved. Key highlighted making significant contribution effects fibers include mitochondria; expression cytoprotective proteins such HSP72, SOD2, SESN2, PGC-1α AMPK; regulation oxidative stress. These findings underscore potential non-pharmacological preserving well muscular ultimately improving quality life at-risk populations.

Language: Английский

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SIRT1 signaling pathways in sarcopenia: Novel mechanisms and potential therapeutic targets

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 177, P. 116917 - 116917

Published: June 21, 2024

Sarcopenia is an aging-related skeletal disease characterized by decreased muscle mass, strength, and physical function, severely affecting the quality of life (QoL) elderly population. Sirtuin 1 (SIRT1), as a nicotinamide adenine dinucleotide (NAD+)-dependent histone deacetylases, has been reported to participate in various signaling pathways exert protective effect on many human diseases. SIRT1 functioned important role occurrence progression sarcopenia through regulating key related protein homeostasis, apoptosis, mitochondrial dysfunction, insulin resistance autophagy muscle, including SIRT1/Forkhead Box O (FoxO), AMP-activated kinase (AMPK)/SIRT1/nuclear factor κB (NF-κB), SIRT1/p53, AMPK/SIRT1/peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α), SIRT1/live B1 (LKB1)/AMPK pathways. However, specific mechanisms these processes have not fully illuminated. Currently, several SIRT1-mediated interventions preliminarily developed, such activator polyphenolic compounds, exercising calorie restriction. In this review, we summarized predominant involved therapeutic modalities targeting for prevention prognosis sarcopenia.

Language: Английский

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Emerging Targets and Treatments for Sarcopenia: A Narrative Review

Nutrients, Journal Year: 2024, Volume and Issue: 16(19), P. 3271 - 3271

Published: Sept. 27, 2024

Sarcopenia is characterized by the progressive loss of skeletal muscle mass, strength, and function, significantly impacting overall health quality life in older adults. This narrative review explores emerging targets potential treatments for sarcopenia, aiming to provide a comprehensive overview current prospective interventions.

Language: Английский

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Drug‐related sarcopenia as a secondary sarcopenia

Geriatrics and gerontology international/Geriatrics & gerontology international, Journal Year: 2023, Volume and Issue: 24(2), P. 195 - 203

Published: Dec. 29, 2023

Sarcopenia has a significant impact on falls, physical function, activities of daily living, and quality life in older adults, its prevention treatment are becoming increasingly important as the global population ages. In addition to primary age‐related sarcopenia, activity‐related disease‐related nutrition‐related sarcopenia have been proposed secondary sarcopenia. Polypharmacy potentially inappropriate medication based multiple diseases cause health problems patients. some cases, drugs used for therapeutic or preventive purposes act skeletal muscle adverse drug reactions induce Although caused by these may be more common patients, particular those taking many medications, drug‐related not yet received much attention. This review summarizes that emphasizes importance Geriatr Gerontol Int 2024; 24: 195–203 .

Language: Английский

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Effects of upper extremity blood flow restriction training on muscle strength and hypertrophy: a systematic review and meta-analysis

Frontiers in Physiology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 6, 2025

Low load resistance training with blood flow restriction (LL-BFRT) has been shown to improve muscle strength and hypertrophic function. The effect of LL-BFRT on lower extremity improvement widely discussed. However, no studies have discussed the this method upper muscles until now. This systematic review meta-analysis focused use in muscles. relevant literature was searched four major databases including Pubmed, Web science, Cochrane Library Embase from 10 June 2024. Collaboration's tool GRADE methodology were used assess risk bias quality included studies. a total 11 articles 220 participants. high (HLRT) produced similar effects improving (low certainty evidence, SMD: -0.35; 95%CI: -0.73 0.03; p: 0.07; I2: 2%) hypertrophy (moderate -0.36; 0.01; 0.05; 0%). Compared low (LLRT), showed greater advantages 0.67; 0.33 1.01; 0.0001; 0%) 0.37; 0.06 0.02; In general, can be as an alternative for HLRT hypertrophy. Our study shows that is limited by age region. It necessary formulate reasonable exercise programs according characteristics different demographic groups. https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42024555514.

Language: Английский

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Sarcopenic obesity and brain health: A critical appraisal of the current evidence

Nutrition Bulletin, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 12, 2025

Abstract Sarcopenic obesity (SO) is a body composition phenotype derived from the simultaneous presence in same individual of an increase fat mass and decrease skeletal muscle and/or function. Several protocols for diagnosis SO have been proposed last two decades making prevalence disease risk estimates heterogeneous challenging to interpret. Dementia complex neurological disorder that significantly impacts patients, carers healthcare systems. The identification factors early cognitive impairment dementia key mitigating forecasted trends 2‐fold case numbers over next worldwide. Excess adiposity sarcopenia both independently associated with dementia. Whether greater currently uncertain. This review critically appraises current evidence on association between outcomes risk. It also discusses some putative biological mechanisms may link alteration brain functions.

Language: Английский

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Physical and Mental Disability in People with Diabetes

Published: Jan. 1, 2025

Language: Английский

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