Advances in experimental medicine and biology, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Language: Английский
ACS Omega, Journal Year: 2025, Volume and Issue: 10(1), P. 1207 - 1225
Published: Jan. 3, 2025
Manufacturing bioactive materials for drug delivery involves developing that interact with biological tissues to release drugs in a controlled and targeted manner. The goal is optimize therapeutic efficacy reduce side effects by combining knowledge from engineering, biology, pharmacology. This study presents detailed bibliometric analysis, exploring the keywords "manufacturing," "bioactive materials," "drug delivery" identify highlight significant advancements field. From Web of Science, 36,504 articles were analyzed, 171 selected deeper identifying key journals, countries, institutions, authors. results field's interdisciplinary nature, grouped into four main themes, including regenerative medicine, scaffolds, three-dimensional (3D) printing, glass, tissue engineering. Future research this area will focus on more effective precise systems using technologies like 3D printing nanotechnology enhance customization control release, aiming efficient therapies.
Language: Английский
Citations
4
Journal of Biomaterials Science Polymer Edition, Journal Year: 2024, Volume and Issue: 35(5), P. 717 - 755
Published: Jan. 12, 2024
Corneal diseases are a major cause of vision loss worldwide. Traditional methods like corneal transplants from donors effective but face challenges limited donor availability and the risk graft rejection. Therefore, new treatment essential. This review examines growing field bioprinting biofabrication in tissue engineering. We begin by discussing various such as stereolithography, inkjet, extrusion printing, highlighting their strengths weaknesses for eye-related uses. also explore how biological tissues made suitable through process called decellularization, which can be achieved using chemical, physical, or methods. The then looks at natural materials, known bioinks, used bioprinting. focus on materials gelatin, collagen, fibrin, chitin, chitosan, silk fibroin, alginate, examining mechanical properties. importance hydrogel scaffolds, particularly those based collagen other is discussed context repairing tissue. Another key area we cover use stem cells regeneration. pay special attention to limbal epithelial mesenchymal stromal cells, roles this process. concludes with an overview latest advancements bioprinting, early techniques advanced delivering bioengineered materials. In summary, presents current state future potential creating functional tissues, developments ongoing view towards restoring vision.
Language: Английский
Citations
9
Progress in Retinal and Eye Research, Journal Year: 2024, Volume and Issue: 102, P. 101275 - 101275
Published: May 24, 2024
Language: Английский
Citations
7
Biomedicines, Journal Year: 2024, Volume and Issue: 12(6), P. 1303 - 1303
Published: June 12, 2024
Diabetes mellitus (DM) is a chronic metabolic disorder marked by hyperglycemia due to defects in insulin secretion, action, or both, with global prevalence that has tripled recent decades. This condition poses significant public health challenges, affecting individuals, healthcare systems, and economies worldwide. Among its numerous complications, ocular surface disease (OSD) concern, yet understanding pathophysiology, diagnosis, management remains challenging. review aims explore the epidemiology, clinical manifestations, diagnostic approaches, strategies of diabetes-related OSD. The surface, including cornea, conjunctiva, associated structures, vital for maintaining eye health, lacrimal functional unit (LFU) playing crucial role tear film regulation. In DM, changes glycosaminoglycan metabolism, collagen synthesis, oxygen consumption, LFU dysfunction contribute complications. Persistent leads expression cytokines, chemokines, cell adhesion molecules, resulting neuropathy, abnormalities, epithelial lesions. Recent advances molecular research therapeutic modalities, such as gene stem therapies, show promise managing diabetic Future should focus on pathogenetically oriented therapies neuropathy keratopathy, transitioning from animal models trials improve patient outcomes.
Language: Английский
Citations
6
Medical Hypotheses, Journal Year: 2024, Volume and Issue: 185, P. 111315 - 111315
Published: Feb. 29, 2024
Corneal diseases and injuries, with their substantial global prevalence adverse effects on quality of life, demographics, occupations, lifestyles, pose a pressing healthcare challenge worldwide. Limited treatment options are unable to halt the progression end-stage conditions, where transplantation is ideal solution. Unfortunately, high demand low supply corneal tissues, donor-recipient mismatches, host rejections leading graft failure limit this option. As result, there critical need for alternative interventions. This article aims establish bioengineered model generated from cadaveric decellularized extracellular matrix (dECM) that can repurpose discarded human tissues potentially increase transplantable tissues. Comparable studies have primarily focused reendothelialization re-epithelialization. Therefore, we hypothesize devising method support scaffold reinnervation emanating prominent nerve plexi spanning stroma epithelium in patient-centered manner, using peripheral blood mononuclear cells.
Language: Английский
Citations
5
Frontiers in Physiology, Journal Year: 2024, Volume and Issue: 15
Published: June 3, 2024
Methods: Herein, we obtained and characterized deltaN p63- adenosine triphosphate-binding cassette subfamily G member 2-expressing limbal stem cells (LSCs). Chitosan carboxymethyl chitosan (CTH) were cross-linked to be an in situ thermosensitive hydrogel (ACH), which was printed through four-dimensional (4D) printing obtain a porous carrier with uniform pore diameter (4D-CTH). Rabbits injected alloxan induce diabetes mellitus (DM). Following this, the LSC-carrying spread on surface of cornea diabetic rabbits cure corneal epithelium injury. Results: Compared control group (LSCs only), rapid wound healing observed treated 4D-CTH. Furthermore, test also showed better nerve repair ability. The results indicated potential 4D-CTH curing Conclusion: holds as useful tool for studying regenerative processes occurring during treatment various pathologies use cell-based technologies.
Language: Английский
Citations
4
Materials Today Bio, Journal Year: 2024, Volume and Issue: 29, P. 101342 - 101342
Published: Nov. 14, 2024
Hydrogels, that are crosslinked polymer networks, can absorb huge quantities of water and/or biological fluids. Their physical properties, such as elasticity and soft tissue, together with their biocompatibility biodegradability, closely resemble living tissues. The versatility hydrogels has fuelled application in various fields, agriculture, biomaterials, the food industry, drug delivery, tissue engineering, regenerative medicine. combination nanoparticles, specifically Mesoporous Silica Nanoparticles (MSNs), have elevated these composites to next level, since MSNs could improve hydrogel mechanical ability encapsulate controlled release great amounts different therapeutic agents, responsiveness a variety external internal stimuli. In this review, main features both introduced, followed by discussion hydrogels-MSNs structures an overview use applications, delivery technologies engineering.
Language: Английский
Citations
4
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 695 - 695
Published: Jan. 15, 2025
The World Health Organization estimates that approximately 285 million people suffer from visual impairments, around 5% of which are caused by corneal pathologies. Currently, the most common clinical treatment consists a transplant (keratoplasty) human donor. However, worldwide demand for donor corneas amply exceeds available supply. Lamellar keratoplasty (transplantation replacement only one three layers cornea) is partially solving problem cornea undersupply. Obviously, cell therapy applied to every these will expand current therapeutic options, reducing cost ophthalmological interventions and increasing effectiveness surgery. Mesenchymal stem cells (MSCs) adult with capacity self-renewal differentiation into different lineages. They can be obtained many tissues, such as bone marrow, umbilical cord, adipose tissue, dental pulp, skin, cornea. Their ease collection advantages over embryonic or induced pluripotent make them very practical source experimental potential applications. In this review, we focus on recent advances using MSCs sources replace damaged layers, at both preclinical levels specific diseases.
Language: Английский
Citations
0
Bioactive Materials, Journal Year: 2025, Volume and Issue: 48, P. 414 - 430
Published: Feb. 24, 2025
Language: Английский
Citations
0
Bulletin of Experimental Biology and Medicine, Journal Year: 2025, Volume and Issue: unknown
Published: March 28, 2025
Language: Английский
Citations
0