Cell Biochemistry and Biophysics, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 21, 2024
Language: Английский
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: May 31, 2024
Rheumatoid arthritis is a chronic immunological disease leading to the progressive bone and joint destruction. Angiogenesis, accompanied by synovial hyperplasia inflammation underlies Delaying or even blocking angiogenesis has emerged as an important target of RA treatment. Natural medicines long history treating RA, numerous reports have suggested that natural strong inhibitory activity on angiogenesis, thereby improving progression RA. could regulate following signaling pathways: HIF/VEGF/ANG, PI3K/Akt pathway, MAPKs NF-κB PPARγ JAK2/STAT3 etc., inhibiting angiogenesis. Tripterygium wilfordii Hook. f. (TwHF), sinomenine, total glucoside Paeonia lactiflora Pall. Are currently most representative all products worthy development utilization. In this paper, main factors affecting were discussed different types inhibit systematically summarized. Their specific anti-angiogenesis mechanisms are also reviewed which aiming provide new perspective options for management targeting
Language: Английский
Citations
5
Phytomedicine, Journal Year: 2024, Volume and Issue: 135, P. 156121 - 156121
Published: Oct. 5, 2024
Language: Английский
Citations
5
Tissue Engineering Part B Reviews, Journal Year: 2024, Volume and Issue: 30(6), P. 607 - 630
Published: March 14, 2024
Regenerative medicine aims to restore the function of diseased or damaged tissues and organs by cell therapy, gene tissue engineering, along with adjunctive application bioactive molecules. Traditional molecules such as growth factors cytokines have shown great potential in regulation cellular behavior, but disadvantages limited source, high cost, short half-life, side effects. In recent years, herbal compounds extracted from natural plants/herbs gained increasing attention. This is not only because are easily obtained, inexpensive, mostly safe, reliable, also owing their excellent effects including anti-inflammatory, antibacterial, antioxidative, proangiogenic behavior ability promote stem differentiation. Such play important roles processes related regeneration. Furthermore, moieties can form physical chemical bonds scaffolds, which contributes improved mechanical strength stability scaffolds. Thus, incorporation biomaterials a promising direction for future regenerative applications. Herein, an overview on use combined different biomaterial scaffolds presented. We firstly introduce classification, structures, properties components then provide comprehensive survey engineer repair/regeneration skin, cartilage, bone, neural, heart tissues. Finally, we highlight challenges prospects development toward clinical translation. Overall, it believed that combination could be perspective next generation medicine.
Language: Английский
Citations
4
Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 17, 2024
Language: Английский
Citations
4
European Journal of Medicinal Chemistry Reports, Journal Year: 2025, Volume and Issue: unknown, P. 100251 - 100251
Published: Feb. 1, 2025
Language: Английский
Citations
0
Biomolecules, Journal Year: 2025, Volume and Issue: 15(3), P. 400 - 400
Published: March 11, 2025
Current gut microbiota studies often rely on relative quantitative sequencing. However, under certain circumstances, while the abundance of these bacteria may remain stable, absolute quantities specific can vary considerably. Since function is directly linked to their total numbers, quantification crucial. This study aims identify optimal method for microbiome analysis by comparing and Using ulcerative colitis, which closely associated with microbiota, as a disease model berberine (which affects microbiota) versus sodium butyrate does not) drugs, methods were used evaluate varying effects different drugs regulation in UC-affected animals. The regulatory BBR further synthesized identified earlier using an individual-based meta-analysis, we compared findings our sequencing results. results from more consistent actual microbial community, suggesting that measurements might not accurately reflect true species. Moreover, meta-analysis only partially sometimes opposed, analyses are prone misinterpretation incorrect correlation underscores importance representing counts sample evaluating modulatory microbiome, plays vital role microbiome.
Language: Английский
Citations
0
Kazan medical journal, Journal Year: 2025, Volume and Issue: unknown
Published: March 24, 2025
Malignant neoplasms remain one of the leading causes mortality worldwide, underscoring need for development novel and effective therapeutic strategies their treatment. In recent years, scientific community has actively pursued search pharmaceutical preparations with minimal adverse effects high efficacy, capable achieving complete remission in patients. this context, berberine, a natural phytochemical compound derived from various species Berberis, garnered increasing attention due to its diverse pharmacological properties. Berberine, recognized as nutraceutical, exhibits broad spectrum biological activities, including anti-inflammatory, antioxidant, antitumor effects. vitro vivo studies have demonstrated that berberine exerts inhibitory on several types cancer, breast, lung, liver, colorectal cancers. Its properties are associated key molecular mechanisms through which it targets tumor cells. review, we comprehensively examined pathways mediated. Specifically, activates caspase cascade, induction apoptosis cells, inhibits cell proliferation by blocking signaling such PI3K/Akt/mTOR. Additionally, modulates expression genes migration invasion, matrix metalloproteinases E-cadherin, making promising candidate approaches. It is also noteworthy anti-inflammatory properties, may contribute prevention carcinogenesis protecting cells oxidative stress inflammatory processes linked cancer development. These position agent further research clinical application, both monotherapy combination other anticancer drugs. Thus, represents an intriguing subject investigation action potential use oncology, could lead more safer patients malignant neoplasms.
Language: Английский
Citations
0
Pharmacological Research, Journal Year: 2025, Volume and Issue: unknown, P. 107742 - 107742
Published: April 1, 2025
Cancer continues to be among the most substantial health challenges globally. Among various natural compounds, berberine, an isoquinoline alkaloid obtained from Coptidis Rhizoma, has garnered considerable attention for its broad-spectrum biological activities, including anti-inflammatory, antioxidant, anti-diabetic, anti-obesity, and anti-microbial activities. Furthermore, berberine exhibits a broad spectrum of anti-cancer efficacy against malignancies, such as ovarian, breast, lung, gastric, hepatic, colorectal, cervical, prostate cancers. Its mechanisms are multifaceted, encompassing inhibition cancer cell proliferation, prevention metastasis, induction apoptosis, facilitation autophagy, modulation tumor microenvironment gut microbiota, enhancement conventional therapeutic strategies. This paper offers exhaustive overview cancer-fighting characteristics Rhizoma while also exploring recent developments in nanotechnology aimed at enhancing bioavailability berberine. side effects safety addressed well. The potential role artificial intelligence optimizing berberine's applications is highlighted. provides precious perspectives on prospective application management cancer.
Language: Английский
Citations
0
Phytomedicine, Journal Year: 2024, Volume and Issue: 132, P. 155779 - 155779
Published: May 31, 2024
QingChang-XiaoPi Decoction (QCXPY), a Chinese herbal prescription, has been employed in the treatment of ulcerative colitis (UC) China. However, its molecular mechanism action UC remains unclear.
Language: Английский
Citations
3
Journal of Molecular Recognition, Journal Year: 2024, Volume and Issue: 37(2)
Published: Jan. 8, 2024
Abstract The binding of four alkaloids with human serum albumin (HSA) was investigated by isothermal titration calorimetry (ITC), spectroscopy and molecular docking techniques. findings demonstrated that theophylline or caffeine can bind to HAS, respectively. number sites constants are obtained. mode is a static quenching process. effects steric hindrance, temperature, salt concentration buffer solution on the indicated HSA have higher affinity than caffeine. fluorescence ITC results showed interaction between an entropy‐driven spontaneous exothermic hydrophobic force primary driving factor. experimental were consistent data. Based structures alkaloids, hindrance might be major factor in these alkaloids. This study elucidates mechanism interactions HSA.
Language: Английский
Citations
2