NLRP3 inflammasome and its role in autoimmune diseases: A promising therapeutic target

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 175, P. 116679 - 116679

Published: May 3, 2024

The NOD-like receptor protein 3 (NLRP3) inflammasome is a complex that regulates innate immune responses by activating caspase-1 and the inflammatory cytokines IL-1β IL-18. Numerous studies have highlighted its crucial role in pathogenesis development of bowel disease, rheumatoid arthritis, systemic lupus erythematosus, autoimmune thyroid diseases, other diseases. Therefore, investigating underlying mechanisms NLRP3 disease targeted drug therapies holds clinical significance. This review summarizes structure, assembly, activation inflammasome, focusing on involvement various also identifies where mechanism within same appears contradictory, as well differences NLRP3-related gene polymorphisms among different ethnic groups. Additionally, latest therapeutic advances targeting for diseases are outlined, novel perspectives discussed. Conclusively, this provides consolidated source information may guide future research efforts potential to positively impact patient outcomes.

Language: Английский

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Healing the diabetic wound: Unlocking the secrets of genes and pathways

European Journal of Pharmacology, Journal Year: 2024, Volume and Issue: 975, P. 176645 - 176645

Published: May 15, 2024

Language: Английский

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The Promising Potential of Cold Atmospheric Plasma Therapies

Plasma, Journal Year: 2024, Volume and Issue: 7(2), P. 465 - 497

Published: June 12, 2024

The outstanding properties and chemistry of cold atmospheric plasma (CAP) are not sufficiently understood due to their relatively complex systems transient properties. In this paper, we tried present a detailed review the applications CAP in modern medicine, highlighting biochemistry phenomenon. Due its unique characteristics, has emerged as promising tool various medical applications. CAP, partially—or fully ionized—gas-retaining state quasi-neutrality, contains many particles, such electrons, charged atoms, molecules displaying collective behaviour caused by Coulomb interactions. can be generated at pressure, making it suitable for settings. Cold plasma’s anti-microbial create an alternative method antibiotics when treating infections. It also enhances cell proliferation, migration, differentiation, leading accelerated tissue regeneration. powerful anti-tumour therapies, stem dental applications, disease treatment, e.g., neurology. is our belief that article contributes deeper understanding therapy potential medicine. objective study demonstrate novel approach treatment modality. By covering range biomedical fields, hope provide comprehensive overview multiple conditions. order gain further insight into subject, attempted gather crucial research evidence from studies, hopefully creating compelling argument favour therapy. Our aim highlight innovative aspects where traditional methods may have limitations. Through article, intend convenient reference source readers engaged examination CAP’s

Language: Английский

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16S rRNA seq-identified Corynebacterium promotes pyroptosis to aggravate diabetic foot ulcer

BMC Infectious Diseases, Journal Year: 2024, Volume and Issue: 24(1)

Published: April 1, 2024

Diabetic foot ulcer (DFU) is one of the main chronic complications caused by diabetes, leading to amputation in severe cases. Bacterial infection affects wound healing DFU.

Language: Английский

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Effective protective mechanisms of HO-1 in diabetic complications: a narrative review

Cell Death Discovery, Journal Year: 2024, Volume and Issue: 10(1)

Published: Oct. 10, 2024

Diabetes mellitus is a metabolic disorder with persistent hyperglycemia caused by variety of underlying factors. Chronic can lead to diverse serious consequences and diversified complications, which pose threat patients. Among the major complications are cardiovascular disease, kidney diabetic foot ulcers, retinopathy, neurological disorders. Heme oxygenase 1 (HO-1) protective enzyme antioxidant, anti-inflammatory anti-apoptotic effects, has been intensively studied plays an important role in complications. By inducing expression activity HO-1, it enhance anti-inflammatory, capacity tissues, thus reduce degree damage The present study aims review relationship between HO-1 pathogenesis diabetes its involved regulation macrophage polarization promotes M1 state (pro-inflammatory) towards M2 (anti-inflammatory). Induction dendritic cells inhibits them maturation secretion pro-inflammatory cytokines regulatory T cell (T

Language: Английский

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MicroRNA-122-5p is upregulated in diabetic foot ulcers and decelerates the transition from the inflammatory to the proliferative stage

World Journal of Diabetes, Journal Year: 2025, Volume and Issue: 16(4)

Published: Feb. 28, 2025

Shifting from the inflammatory to proliferative phase represents a pivotal step during managing diabetic foot ulcers (DFUs); however, existing medical interventions remain insufficient. MicroRNAs (miRs) highlight notable capacity for accelerating repair process of DFUs. Previous research has demonstrated which miR-122-5p regulates matrix metalloproteinases under conditions, thereby influencing extracellular dynamics. To investigate impact on transition stage in DFU. Analysis expression skin tissues ulcer patients and mice was analyzed using quantitative real-time polymerase chain reaction (qRT-PCR). A wound healing model induced by streptozotocin used, with receiving intradermal injections adeno-associated virus -DJ encoding empty vector or miR-122. Skin were retrieved at 3, 7, 14 days after injury gene analysis, histology, immunohistochemistry, network studies. The study explored miR-122-5p's role macrophage-fibroblast interactions its effect transitioning inflammation proliferation DFU healing. High-throughput sequencing revealed as crucial qRT-PCR showed significant upregulation within among individuals mice. Western blot, along immunohistochemical enzyme-linked immunosorbent assay, demonstrating mediators (hypoxia inducible factor-1α, metalloproteinase 9, tumor necrosis factor-α) reduced fibrosis markers (fibronectin 1, α-smooth muscle actin) targeting vascular endothelial growth factor. Fluorescence situ hybridization indicated localized epidermal keratinocytes fibroblasts Immunofluorescence enhanced increased presence M1 macrophages M2 polarization, highlighting inflammation. MiR-122-5p elevated cytokine levels while suppressing fibrotic activity exposed macrophage-derived media, regulating impedes cutaneous via enhancing inhibiting fibrosis, offering insights into miR roles human repair.

Language: Английский

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Atmospheric plasma control excessive inflammation and oxidative stress in burn wound healing in diabetes-induced rats

Journal of Tissue Viability, Journal Year: 2025, Volume and Issue: 34(3), P. 100918 - 100918

Published: April 15, 2025

Burns are the fourth most prevalent trauma worldwide, and their complications significantly exacerbated when associated with diabetes, leading to increased morbidity mortality. This study addresses urgent need for safe effective treatments by exploring therapeutic potential of atmospheric plasma (AP), an ionized gas produced at pressure, in enhancing healing burn wounds. We investigated effects AP on repair second-degree dorsal burns Wistar rats, induced diabetes alloxan (45 mg/kg). The animals were randomly assigned either sham group (plasma generator off) or (treated 1 min daily until 2nd, 7th, 14th 21st days). Our findings indicate that treatment reduced inflammatory cell accumulation, interleukin levels, controlled oxidative damage, stimulated antioxidant responses. Furthermore, promoted angiogenesis, fibroblast proliferation, collagen fiber organization. These results suggest accelerates tissue diabetic burns, making it a promising improving wound diabetes-induced conditions.

Language: Английский

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Medical gas plasma modifies Nrf2 signaling in diabetic wound healing

Journal of Advanced Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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Biomaterials and therapeutic strategies designed for tooth extraction socket healing.

Biomaterials, Journal Year: 2024, Volume and Issue: 316, P. 122975 - 122975

Published: Nov. 29, 2024

Language: Английский

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The Successful Treatment of Multi-Resistant Colonized Burns with Large-Area Atmospheric Cold Plasma Therapy and Dermis Substitute Matrix—A Case Report

European Burn Journal, Journal Year: 2024, Volume and Issue: 5(3), P. 271 - 282

Published: Aug. 26, 2024

The treatment of severe burn injuries, which occur particularly in the context armed conflicts, is based on a multimodal concept. In addition to complex intensive care therapy, surgical reconstruction options plastic surgery and typical antiseptic wound are main focuses. recent years, atmospheric cold plasma therapy (ACPT) has also become established for topical, optimization re-epithelialization. This case report shows successful extensive injuries using dermal skin substitute matrix topical with large-area device control multi-resistant pathogen colonization. illustrates importance ACPT surgery. However, larger series randomized controlled trials specialized centers needed assess its place future clinical practice.

Language: Английский

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