Ferroptosis: a novel mechanism of cell death in ophthalmic conditions

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: June 27, 2024

Ferroptosis, a new type of programmed cell death proposed in recent years, is characterized mainly by reactive oxygen species and iron-mediated lipid peroxidation differs from death, such as apoptosis, necrosis, autophagy. Ferroptosis associated with variety physiological pathophysiological processes. Recent studies have shown that ferroptosis can aggravate or reduce the occurrence development diseases targeting metabolic pathways signaling tumors, ischemic organ damage, other degenerative related to peroxidation. Increasing evidence suggests closely linked onset progression various ophthalmic conditions, including corneal injury, glaucoma, age-related macular degeneration, diabetic retinopathy, retinal detachment, retinoblastoma. Our review current research on reveals significant advancements our understanding pathogenesis, aetiology, treatment these conditions.

Language: Английский

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Disulfidptosis: a novel cell death modality induced by actin cytoskeleton collapse and a promising target for cancer therapeutics

Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)

Published: Oct. 11, 2024

Disulfidptosis is a novel discovered form of programmed cell death (PCD) that diverges from apoptosis, necroptosis, ferroptosis, and cuproptosis, stemming disulfide stress-induced cytoskeletal collapse. In cancer cells exhibiting heightened expression the solute carrier family 7 member 11 (SLC7A11), excessive cystine importation reduction will deplete nicotinamide adenine dinucleotide phosphate (NADPH) under glucose deprivation, followed by an increase in intracellular stress aberrant bond formation within actin networks, ultimately culminating collapse disulfidptosis. involves crucial physiological processes eukaryotic cells, such as uptake, NADPH metabolism, dynamics. The Rac1-WRC pathway-mediated polymerization also implicated this due to its contribution formation. However, precise mechanisms underlying disulfidptosis role tumors are not well understood. This probably multifaceted functionalities SLC7A11 complexities downstream pathways driving review describes critical roles summarizes recent research advancements potential Moreover, less-studied aspects newly process highlighted stimulate further investigations field.

Language: Английский

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Natural products and ferroptosis: A novel approach for heart failure management

Phytomedicine, Journal Year: 2025, Volume and Issue: 142, P. 156783 - 156783

Published: April 18, 2025

Language: Английский

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Pathological mechanisms and crosstalk among various cell death pathways in cardiac involvement of systemic lupus erythematosus

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 5, 2024

Systemic lupus erythematosus (SLE) is a prevalent autoimmune disease primarily characterized by the involvement of multiple systems and organs. Cardiovascular primary cause mortality in patients with SLE, though mechanisms underlying increased cardiovascular risk SLE remain unclear. Recent studies indicate that abnormal activation programmed cell death (PCD) signaling crosstalk among various forms are critical immunopathogenesis SLE. Furthermore, apoptosis, necroptosis, pyroptosis, NETosis, ferroptosis recognized as key cellular processes pathogenesis closely linked to cardiac involvement. This review uniquely explores intricate between other pathways, discussing their roles interactions Investigating interplay PCD understanding disease's offers opportunities for new therapeutic interventions. The integration precision medicine innovative strategies targeting these complex pathways holds promise enhancing treatment prospects

Language: Английский

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