Biomimetic nanocarriers: integrating natural functions for advanced therapeutic applications DOI Creative Commons
Hugo Félix Perini, Beatriz Sodré Matos, Carlo José Freire Oliveira

et al.

Beilstein Journal of Nanotechnology, Journal Year: 2024, Volume and Issue: 15, P. 1619 - 1626

Published: Dec. 16, 2024

Biomimetic nanocarriers, engineered to mimic the characteristics of native cells, offer a revolutionary approach in treatment various complex human diseases. This strategy enhances drug delivery by leveraging innate properties cellular components, thereby improving biocompatibility and targeting specificity. nanocarriers demonstrate significant advancements systems against cancer therapy, Alzheimer's disease, autoimmune diseases, viral infections such as COVID-19. Here, we address therapeutic applications biomimetic their promising for personalized medicine.

Language: Английский

Rational Design of Nanozymes for Engineered Cascade Catalytic Cancer Therapy DOI

Xiuna Jia,

Erkang Wang, Jin Wang

et al.

Chemical Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

Nanozymes have shown significant potential in cancer catalytic therapy by strategically catalyzing tumor-associated substances and metabolites into toxic reactive oxygen species (ROS) situ, thereby inducing oxidative stress promoting cell death. However, within the complex tumor microenvironment (TME), rational design of nanozymes factors like activity, reaction substrates, TME itself significantly influence efficiency ROS generation. To address these limitations, recent research has focused on exploring that affect activity developing nanozyme-based cascade systems, which can trigger two or more processes tumors, producing therapeutic achieving efficient stable with minimal side effects. This area remarkable progress. Perspective provides a comprehensive overview nanozymes, covering their classification fundamentals. The regulation nanozyme strategies are discussed detail. Furthermore, representative paradigms for successful construction systems treatment summarized focus revealing underlying mechanisms. Finally, we current challenges future prospects development biomedical applications.

Language: Английский

Citations

3
Targeted apoptosis in breast cancer cells via niosome-mediated delivery of cyclophosphamide and sodium oxamate DOI

Mahsa Fakeri,

Mehdi Haghi, Rana Jahanban‐Esfahlan

et al.

Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)

Published: Jan. 18, 2025

Language: Английский

Citations

2
For and against tumor microenvironment: Nanoparticle-based strategies for active cancer therapy DOI Creative Commons

Soroush Karimi,

Roksana Bakhshali,

Soheil Bolandi

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101626 - 101626

Published: March 1, 2025

Cancer treatment is challenged by the tumor microenvironment (TME), which promotes drug resistance and cancer cell growth. This review offers a comprehensive innovative perspective on how nanomedicine can modify TME to enhance therapy. Strategies include using nanoparticles improve oxygenation, adjust acidity, alter extracellular matrix, making treatments more effective. Additionally, immune responses activating cells reducing suppression within tumors. By integrating these approaches with existing therapies, such as chemotherapy radiotherapy, show promise in overcoming traditional barriers. The discusses changes effectiveness of itself, creating reciprocal relationship that boosts overall efficacy. We also highlight novel strategies aimed at exploiting TME, leveraging nanoparticle-based for targeted therapy through precise modulation.

Language: Английский

Citations

2
Nanomaterial-based regulation of redox metabolism for enhancing cancer therapy DOI

Xiaodan Jia,

Yue Wang, Yue Qiao

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

This review provides a comprehensive summary of the dysregulation redox metabolism in cancer cells and advantages latest advances nanomaterial-assisted metabolic regulation therapy.

Language: Английский

Citations

9
N-Amidothiourea fluorescence sensor for sensitive detection of Zn2+ ions and cell imaging: A tool for plasma membrane analysis DOI

Kaitlin Ricks,

Mubeena Akhtar,

Sergio Mendez

et al.

Inorganica Chimica Acta, Journal Year: 2025, Volume and Issue: unknown, P. 122551 - 122551

Published: Jan. 1, 2025

Language: Английский

Citations

0
Emerging strategies in lymph node-targeted nano-delivery systems for tumor immunotherapy DOI Creative Commons
Yang Zhao, Man Tian, Xin Tong

et al.

Essays in Biochemistry, Journal Year: 2025, Volume and Issue: 69(02)

Published: March 28, 2025

The emergence of immunotherapy has led to the clinical approval several related drugs. However, their efficacy against solid tumors remains limited. As hub immune activation, lymph nodes (LNs) play a critical role in tumor by initiating and amplifying responses. Nevertheless, intricate physiological structure barriers within LNs, combined with immunosuppressive microenvironment induced cells, significantly impede therapeutic immunotherapy. Engineered nanoparticles (NPs) have shown great potential overcoming these challenges facilitating targeted drug transport LNs directly or indirectly activating T cells. This review systematically examines structural features key factors influencing targeting efficiency NPs, current strategies for remodeling LNs. Additionally, it discusses future opportunities optimizing NPs enhance immunotherapy, addressing translation safety evaluation.

Language: Английский

Citations

0
Current nano drug delivery systems for targeting head and neck squamous cell carcinoma microenvironment: a narrative review DOI
Aref Faraji-Barhagh, Samaneh Jahandar-Lashaki, Rana Jahanban‐Esfahlan

et al.

Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)

Published: April 8, 2025

Language: Английский

Citations

0
Smart materials in pharmacological drug development: Neutrophils and its constituents for drug delivery and consequent antitumor effects DOI

Shengjie Cai,

Xuehan Wei,

Qian Li

et al.

Molecular Immunology, Journal Year: 2025, Volume and Issue: 183, P. 18 - 32

Published: May 2, 2025

Language: Английский

Citations

0
Dual-stage Acting Dendrimeric Nanoparticle for Deepened Chemotherapeutic Drug Delivery to Tumor Cells DOI Creative Commons
Mohammad Shahpouri,

Mohammad Amin Adili-Aghdam,

Hossein Mahmudi

et al.

Advanced Pharmaceutical Bulletin, Journal Year: 2024, Volume and Issue: 14(3), P. 634 - 645

Published: June 29, 2024

Purpose: We report on the design of hypoxia-induced dual-stage acting dendrimeric nanoparticles (NPs) for selective delivery two chemotherapeutic model drugs doxorubicin (DOX) and tirapazamin (TPZ) deepened drug into hypoxic tumors in vitro. Methods: PAMAM G5 dendrimers were crosslinked with a azo linker, attached to mPEG form detachable corona dendrimer surface (PAP NPs). NPs characterized by Zeta sizer, transmission electron microscope (TEM), Fourier transforms infrared (FTIR) release kinetics. The anti-cancer performance PAPs was evaluated numerous tests 2D 3D cultured MDA-MB-231 breast cancer cells. Results: MTT assay showed significant difference between PAP PAMAMG5 terms biocompatibility, effect PAP@DOX significantly greater than free DOX conditions. results DAPI Annexin V-FITC/PI cell staining also confirmed uniform penetration as validated induction 90% apoptosis spheroids high level PAP@DOX-induced ROS generation under hypoxia Mechanistically, reduced expression mTOR, Notch1, while Bax Caspase3 considerably unregulated, compared controls. Importantly, hypoxia-responsive disintegration activation HAP synergized promote deep homogenous distribution whole microtumor regions efficiently eliminate residual tumor Conclusion: Our indicate safety therapeutic potential system targeted chemotherapeutics particular HAPs which show maximum activity against solid tumors.

Language: Английский

Citations

3
Aripiprazole-loaded niosome/chitosan-gold nanoparticles for breast cancer chemo-photo therapy DOI Creative Commons
Sajjad Alimohammadvand, Masoumeh Kaveh Zenjanab, Parvin Samadi Pakchin

et al.

BMC Biotechnology, Journal Year: 2024, Volume and Issue: 24(1)

Published: Dec. 24, 2024

Breast cancer, a formidable global health challenge for women, necessitates innovative therapeutic strategies with enhanced efficacy and minimal side effects. Aripiprazole (ARI), widely used schizophrenia medication, exhibits promising potential in the treatment of breast cancer. As cancer therapy evolves towards combination approach, multimodal nano-based delivery systems, such as ARI-loaded niosomes (NIOs) combined Chitosan-Au nanoparticles chemo-photothermal therapy, show promise over traditional chemotherapy alone by enhancing targeted minimizing In this study, niosomal formulation was designed, incorporating ARI chitosan-coated AuNPs (i.e. NIOs/AuNPs-CS/ARI), to study synergistic effect photothermal/chemotherapy cells. The nanosystems were characterized using UV-Vis spectroscopy Fourier-transform infrared (FT-IR), confirming successful synthesis steps. hydrodynamic diameter NIOs/AuNPs-CS determined be 44.62 nm zeta -0.836. Also, Transmission Electron Microscopy (TEM) Field-Emission Scanning Microscopical (FE-SEM) analysis performed assess size morphology NPs. loading efficiency NIOs NIOs/AuNPs–CS 75% 88%, respectively. Furthermore, release rate drug from is higher than blank at two pH values (5.8 7.4). cellular uptake AuNPs-CS-encapsulated considerably that NIOs. Annexin V/PI staining assay showed apoptosis/necrosis high NIOs/AuNPs-CS/ARI (46%) NIOs/ARI (36%) 48 h. results MTT assessments demonstrated cytotoxicity viability MCF-7 cells treated reduced 60% 50% 40% 20%, respectively, after 24 h upon laser irradiation. experiment remarkable effectiveness treatment, owing their unique properties, including PTT capability sensitivity.

Language: Английский

Citations

1