It
is
known
that
stress
powerfully
alters
pain,
but
its
underlying
mechanisms
remain
elusive.
Here,
we
identified
a
circuit,
locus
coeruleus
descending
noradrenergic
neurons
projecting
to
the
spinal
dorsal
horn
(LC
→SDH
-NA
neurons),
activated
by
acute
exposure
restraint
and
required
for
stress-induced
mechanical
pain
hypersensitivity
in
mice.
Interestingly,
primary
target
of
NA
released
from
LC
-NAergic
terminals
causing
was
α
1A
-adrenaline
receptors
(α
Rs)
Hes5-positive
(Hes5
+
)
astrocytes
located
SDH,
an
astrocyte
subset
has
ability
induce
sensitization.
Furthermore,
activation
Hes5
reduced
activity
SDH-inhibitory
(SDH-INs)
have
inhibitory
role
processing.
This
astrocytic
reduction
IN
canceled
A
1
-adenosine
receptor
(A
R)-knockdown
SDH-INs,
R-knockdown
suppressed
caused
stress.
Therefore,
our
findings
suggest
neuronal
signaling
SDH
subsequent
SDH-IN
are
essential
facilitation
Norepinephrine
(NE)
neurons
in
the
locus
coeruleus
(LC)
make
long-range
projections
throughout
central
nervous
system,
playing
critical
roles
arousal
and
mood,
as
well
various
components
of
cognition
including
attention,
learning,
memory.
The
LC-NE
system
is
also
implicated
multiple
neurological
neuropsychiatric
disorders.
Importantly,
are
highly
sensitive
to
degeneration
both
Alzheimer’s
Parkinson’s
disease.
Despite
clinical
importance
brain
region
prominent
role
a
variety
behavioral
functions,
detailed
molecular
characterization
LC
lacking.
Here,
we
used
combination
spatially-resolved
transcriptomics
single-nucleus
RNA-sequencing
characterize
landscape
transcriptomic
profile
human
brain.
We
provide
freely
accessible
resource
these
data
web-accessible
downloadable
formats.
Journal of Oral Rehabilitation,
Journal Year:
2023,
Volume and Issue:
50(11), P. 1279 - 1315
Published: June 19, 2023
Some
studies
have
shown
burning
mouth
syndrome
(BMS)
as
comorbid
psychosocial
and
psychiatric
disorders,
well,
pointed
at
stress
a
major
risk
factor.The
aim
of
this
meta-analysis
was
to
answer
the
following
question:
'Is
there
an
association
between
BMS
stress,
compared
healthy
controls?'Two
reviewers
searched
for
effect
in
published
on
five
main
databases
three
from
grey
literature.
Various
questionnaires
biomarkers
were
analysed.
Of
2489
selected
articles,
30
met
inclusion
criteria.
Studies
englobed
questionnaires,
such
Perceived
Stress
Questionnaire,
Lipp
Symptoms
Inventory,
Holmes-Rahe
scale,
Depression,
Anxiety,
Scale
(DASS-21),
Recent
Experience
Test;
various
biomarkers,
cortisol,
opiorphin,
IgA,
α-amylase
interleukins.In
all
with
significantly
increased
group
vs.
control.
Patients
presented
25.73%
higher
cortisol
levels,
28.17%
IgA
levels
40.62%
than
controls.
Meta-analysis
found
that
subjects
3.01
nmoL/L
[0.53;
5.50]
84.35
kU/L
[15.00;
153.71]
29.25
mg/mL
[9.86;
48.64]
258.59
pg/mL
[59.24;
457.94]
IL-8
No
differences
opiorphin
concentration
ng/mL
[-0.96;
2.53].
For
interleukins,
no
founded
IL-1
β,
IL-2,
IL-4,
IL-6,
IL-8,
IL-10
TNF-α.Based
available
evidence,
suggests
more
factors
questionnaire-based
studies,
α-amylase,
Neurobiology of Disease,
Journal Year:
2024,
Volume and Issue:
193, P. 106443 - 106443
Published: Feb. 21, 2024
The
coexistence
of
chronic
pain
and
depression
in
clinical
practice
places
a
substantial
social
burden
profoundly
impacts
patients.
Although
clear
correlation
exists,
the
underlying
mechanism
comorbidity
between
remains
elusive.
Research
conducted
recent
decades
has
uncovered
that
soluble
epoxide
hydrolase,
pivotal
enzyme
metabolism
polyunsaturated
fatty
acids,
plays
crucial
role
inflammation.
Interestingly,
this
is
intricately
linked
to
development
both
depression.
With
understanding,
review
aims
summarize
roles
hydrolase
pain,
depression,
their
comorbidity.
Simultaneously,
we
will
also
explore
mechanisms,
providing
guidance
for
future
research
drug
development.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: June 8, 2024
Selective
manipulation
of
neural
circuits
using
optogenetics
and
chemogenetics
holds
great
translational
potential
but
requires
genetic
access
to
neurons.
Here,
we
demonstrate
a
general
framework
for
identifying
tool-independent,
pharmacological
strategies
circuit-selective
modulation.
We
developed
an
economically
accessible
calcium
imaging-based
approach
large-scale
scans
endogenous
receptor-mediated
activity.
As
testbed
this
approach,
used
the
mouse
locus
coeruleus
due
combination
its
widespread,
modular
efferent
circuitry
wide
variety
endogenously
expressed
GPCRs.
Using
machine
learning-based
action
deconvolution
retrograde
tracing,
identified
agonist
cocktail
that
selectively
inhibits
medial
prefrontal
cortex-projecting
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(1), P. 402 - 402
Published: Jan. 5, 2025
Diffuse
noxious
inhibitory
control
(DNIC),
also
known
as
conditioned
pain
modulation
(CPM)
in
humans,
is
a
paradigm
wherein
the
heterotopic
application
of
stimulus
results
attenuation
another
spatially
distant
input.
The
pre-clinical
and
clinical
studies
show
involvement
several
neurochemical
systems
DNIC/CPM
point
to
major
contribution
noradrenergic,
serotonergic,
opioidergic
systems.
Here,
we
thoroughly
review
latest
data
on
monoaminergic
studies,
focusing
particularly
models
chronic
pain.
We
conduct
an
in-depth
analysis
these
by
integrating
available
with
descending
modulatory
circuits
therein
bring
light
mechanisms
involved
regulation
DNIC.
most
recent
suggest
that
DNIC
may
have
dual
outcome
encompassing
not
only
analgesic
effects
but
hyperalgesic
effects.
This
duality
might
be
explained
underlying
circuitry
receptor
subtypes
therein.
Acknowledging
this
contribute
validating
prognostic
nature
paradigm.
Additionally,
serve
robust
predictive
value
for
guiding
treatment
through
more
effective
targeting
modulation.
