Micromachines,
Journal Year:
2022,
Volume and Issue:
13(4), P. 631 - 631
Published: April 16, 2022
Metamaterial
biosensors
have
been
extensively
used
to
identify
cell
types
and
detect
concentrations
of
tumor
biomarkers.
However,
the
methods
for
in
situ
non-destruction
measurement
migration,
which
plays
a
key
role
progression
metastasis,
are
highly
desirable.
Therefore,
flexible
terahertz
metamaterial
biosensor
based
on
parylene
C
substrate
was
proposed
label-free
non-destructive
detection
breast
cancer
growth
migration.
The
maximum
resonance
peak
frequency
shift
achieved
183.2
GHz
when
MDA-MB-231
cultured
onto
surface
72
h.
A
designed
polydimethylsiloxane
(PDMS)
barrier
sheet
applied
rate
quantified
as
14.9
µm/h.
experimental
expressed
linear
relationship
with
covered
area
quadratic
distance,
consistent
simulation
results.
Additionally,
migration
indicated
that
transform
factor-β
(TGF-β)
promoted
shows
great
potential
investigation
biology
future.
Biosensors,
Journal Year:
2023,
Volume and Issue:
14(1), P. 3 - 3
Published: Dec. 21, 2023
In
recent
decades,
THz
metamaterials
have
emerged
as
a
promising
technology
for
biosensing
by
extracting
useful
information
(composition,
structure
and
dynamics)
of
biological
samples
from
the
interaction
between
wave
samples.
Advantages
with
include
label-free
non-invasive
detection
high
sensitivity.
this
review,
we
first
summarize
different
sensing
principles
modulated
metamaterial
bio-analyte
detection.
Then,
compare
various
resonance
modes
induced
in
range
enhancement.
addition,
non-conventional
materials
used
to
improve
performance
are
evaluated.
We
categorize
review
types
using
metamaterials.
Finally,
discuss
future
perspective
biosensing.
Materials & Design,
Journal Year:
2024,
Volume and Issue:
244, P. 113217 - 113217
Published: July 30, 2024
Metamaterials,
an
artificial
electromagnetic
(EM)
material,
have
exhibited
unique
characteristics,
enabling
innovations
in
terahertz
(THz)
wavefront
shaping,
polarization
modulation,
surface
wave
manipulation,
and
spectrum
modulation.
In
this
review,
we
focus
on
the
advancements
THz
metamaterials
for
emphasizing
their
structural
design,
special
materials,
applications.
The
review
discusses
various
designs,
including
metal-dielectric
composite
structures,
all-metal
all-dielectric
each
offering
distinct
advantages
Key
materials
such
as
graphene,
vanadium
dioxide
(VO2),
molybdenum
disulfide
(MoS2),
flexible
are
highlighted
significant
contributions
to
enhancing
performance
functionality
of
metamaterials.
applications
EM
stealth
sensing
thoroughly
introduced,
with
a
particular
biosensing,
pesticide
detection,
other
emphasizes
potential
developing
highly
sensitive
selective
sensors,
well
efficient
absorbers
filters.
Future
perspectives
include
continuous
development
novel
advanced
fabrication
technologies,
integration
multifunctional
capabilities
further
expand
efficiency
These
expected
drive
progress
technology,
impacting
fields
medical
diagnostics,
environmental
monitoring,
food
safety,
wireless
communication,
security.
Discover Nano,
Journal Year:
2023,
Volume and Issue:
18(1)
Published: April 15, 2023
Abstract
Based
on
the
extraordinary
electromagnetic
properties
of
terahertz
waves,
such
as
broadband,
low
energy,
high
permeability,
and
biometric
fingerprint
spectra,
sensors
show
great
application
prospects
in
biochemical
field.
However,
sensitivity
sensing
technology
is
increasingly
required
by
modern
demands.
With
development
functional
materials,
graphene-based
metasurface
with
advantages
sensitivity,
identification,
nondestructive
anti-interference
are
gradually
gaining
attention.
In
addition
to
providing
ideas
for
biosensors,
these
devices
have
attracted
in-depth
research
scientists.
An
overview
metasurfaces
their
applications
detection
molecules
presented.
This
includes
sensor
mechanism
research,
graphene
index
evaluation,
protein
nucleic
acid
sensors,
other
chemical
molecule
sensing.
A
comparative
analysis
graphene,
nanomaterials,
silicon,
metals
develop
material-integrated
metasurfaces.
Furthermore,
a
brief
summary
main
performance
results
this
class
presented,
along
suggestions
improvements
existing
shortcoming.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Oct. 8, 2024
Liquid
biopsy
is
a
minimally
invasive
method
that
uses
biofluid
samples
instead
of
tissue
for
cancer
diagnosis.
Exosomes
are
small
extracellular
vesicles
secreted
by
donor
cells
and
act
as
mediators
intercellular
communication
in
human
health
disease.
Due
to
their
important
roles,
exosomes
have
been
considered
promising
biomarkers
liquid
biopsy.
However,
traditional
methods
exosome
isolation
cargo
detection
time-consuming
inefficient,
limiting
practical
application.
In
the
past
decades,
many
new
strategies,
such
microfluidic
chips,
nanowire
arrays
electrochemical
biosensors,
proposed
achieve
rapid,
accurate
high-throughput
analysis
exosomes.
this
review,
we
discussed
about
advance
exosome-based
technology,
including
isolation,
enrichment,
approaches.
The
comparison
currently
available
also
included.
Finally,
summarized
advantages
limitations
present
strategies
further
gave
perspective
future
translational
use.
TrAC Trends in Analytical Chemistry,
Journal Year:
2024,
Volume and Issue:
175, P. 117715 - 117715
Published: April 16, 2024
To
comprehend
biological
processes
for
healthcare,
environmental,
food,
and
security
applications,
establishing
sensitive,
reliable,
rapid
techniques
detecting
biomolecular
substances
is
essential.
However,
conventional
labeling
methods
suffer
from
reliability
reproducibility
issues
because
they
influence
the
experimental
outcomes.
Therefore,
a
label-free
sensing
technique
required
to
overcome
these
limitations.
From
this
perspective,
terahertz
have
attracted
significant
attention
owing
their
unique
characteristics
of
low
photon
energy
ability
probe
overall
dielectric
responses
low-frequency
vibrational
modes
intermolecular
interactions.
In
review,
we
first
present
distinctive
waves
molecules
samples
through
comparison
with
spectroscopy.
Then,
challenges
opportunities
in
latest
technologies
metasurface-based
detection
are
introduced,
spanning
strategies
enhanced
absorption
cross-sections
emerging
frontiers
exploring
chirality
strongly
coupled
polaritons.
Analytical Chemistry,
Journal Year:
2024,
Volume and Issue:
96(10), P. 4322 - 4329
Published: Feb. 29, 2024
As
an
important
component
of
highly
heterogeneous
exosomes,
exosomal
microRNAs
(miRNAs)
have
great
potential
as
noninvasive
biomarkers
for
cancer
diagnosis.
Therefore,
a
sensitive
and
simple
sensor
is
the
key
its
clinical
application.
Herein,
we
designed
exponential
amplification
reaction
(EXPAR)
to
induce
reactivation
CRISPR-associated
protein
9/small
guide
RNA
(Cas9/sgRNA)
complex,
thus
achieving
visual
miRNAs-21
(miR-21)
fluorescence
sensing.
In
this
design,
inactivated
sgRNA
by
hybridizing
blocker
DNA.
Then,
used
trigger
DNA
hybridize
with
miR-21
produced
lot
activated
EXPAR.
Those
further
hybridized
released
free
form
Cas9/sgRNA
complex.
Based
on
quick
cleavage
reporter
labeled
SYBR
Green
I
was
from
surface
magnetic
nanoparticles
(MNPs)
into
supernatant,
sensitively
quantify
miRNAs
concentration
limit
detection
3
×
10
Analytical Chemistry,
Journal Year:
2022,
Volume and Issue:
94(10), P. 4513 - 4521
Published: March 2, 2022
MicroRNAs
are
potential
biomarkers
for
human
cancers
and
other
diseases
due
to
their
roles
as
post-transcriptional
regulators
gene
expression.
However,
the
detection
of
miRNAs
by
conventional
methods
such
RT-qPCR,
in
situ
hybridization,
northern
blot-based
platforms,
next-generation
sequencing
is
complicated
short
length,
low
abundance,
high
sequence
homology,
susceptibility
degradation
miRNAs.
In
this
study,
we
developed
a
nicking
endonuclease-mediated
interference
reduction
rolling
circle
amplification
(NEM-IR-RCA)
strategy
ultrasensitive
highly
specific
miRNA-21.
This
method
exploits
advantages
optical
properties
long-lived
iridium(III)
probes,
conjunction
with
time-resolved
emission
spectroscopy
(TRES)
exponential
(E-RCA).
Under
NEM-IR-RCA-based
signal
enhancement
processes,
limit
miRNA-21
was
down
0.0095
fM
linear
range
from
0.05
100
fM,
which
comparable
RT-qPCR.
Unlike
performed
at
lower
constant
temperature
without
heating/cooling
cycles
reverse
transcription.
The
could
clearly
discriminate
between
matched
mismatched
targets,
demonstrating
specificity.
Moreover,
application
demonstrated
cancer
cells
mouse
serum
samples,
showing
good
agreement
RT-qPCR
results.
Apart
detection,
platform
be
also
adapted
detecting
miRNAs,
let-7a
miRNA-22,
indicating
its
excellent
biomedical
research
clinical
diagnostics.
