Inorganic Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 29, 2025
Metal-organic
framework
(MOF)-derived
carbon
materials
are
commonly
used
as
sensing
materials,
but
their
limited
accessibility
to
active
sites
and
specific
surface
area
restrict
applications.
In
this
study,
we
proposed
a
simple
method
involving
facile
tannic
acid
etching
calcination
create
NiCo-embedded
hollow
N-doped
nanocubes
(NiCo@HNC)
using
MOFs
sacrificial
templates.
The
resulting
NiCo@HNC
material
has
large
area,
improved
mass
transport
channels,
enhanced
exposure
of
electroactive
due
its
unique
structure
high
porosity,
leading
electrocatalytic
activity.
Moreover,
with
the
utilization
substrate
dopamine
functional
monomer,
ratiometric
molecularly
imprinted
electrochemical
sensor
was
developed
for
selective
sensitive
detection
carbendazim
(CBZ).
This
demonstrated
wide
linear
range
0.0003-10
μM
low
limit
0.1
nM.
addition,
utilized
accurate
quantification
CBZ
in
actual
carrot/strawberry
samples
recovery
96.0-103.0%,
indicating
potential
practical
application.
Small,
Journal Year:
2023,
Volume and Issue:
20(14)
Published: Nov. 20, 2023
Abstract
Nanozymes,
as
innovative
materials,
have
demonstrated
remarkable
potential
in
the
field
of
electrochemical
biosensors.
This
article
provides
an
overview
mechanisms
and
extensive
practical
applications
nanozymes
First,
definition
characteristics
are
introduced,
emphasizing
their
significant
role
constructing
efficient
sensors.
Subsequently,
several
common
categories
nanozyme
materials
delved
into,
including
metal‐based,
carbon‐based,
metal‐organic
framework,
layered
double
hydroxide
nanostructures,
discussing
Regarding
mechanisms,
two
key
roles
particularly
focused
biosensors:
selective
enhancement
signal
amplification,
which
crucially
support
sensor
performance.
In
terms
applications,
widespread
use
nanozyme‐based
biosensors
showcased
various
domains.
From
detecting
biomolecules,
pollutants,
nucleic
acids,
proteins,
to
cells,
providing
robust
means
for
high‐sensitivity
detection.
Furthermore,
insights
into
future
development
is
provided,
encompassing
improvements
optimizations
design
integration,
expansion
application
fields
through
interdisciplinary
collaboration.
conclusion,
this
systematically
presents
biosensors,
offering
valuable
references
prospects
research
field.
Deleted Journal,
Journal Year:
2023,
Volume and Issue:
1(4)
Published: Oct. 1, 2023
Abstract
Liquid
biopsy
has
emerged
as
a
promising
avenue
for
non‐invasive
and
rapid
retrieval
of
pathological
information
from
patient
body
fluids.
Over
the
years,
liquid
garnered
significant
attention
clinically
treating
cancer
by
selecting
appropriate
biomarkers
such
circulating
tumor
cells
(CTCs)
extracellular
vesicles
(EVs).
Further
integration
advanced
technologies
facilitated
efficient
capture
biopsy,
revolutionizing
clinical
decision‐making
in
multiple
processes
stages
patients.
Underscoring
intersection
different
disciplines,
this
review
provides
holistic
summary
recent
breakthroughs
specifically
designed
application
distinctive
to
blend
real‐world
with
material
science.
Firstly,
we
focus
on
main
principles
that
facilitate
release
(e.g.,
CTCs
EVs),
leveraging
their
physicochemical
properties.
Then,
applications
are
summarized,
highlighting
potential
providing
comprehensive
information.
Later,
incorporation
machine
learning
is
also
emphasized
enhancing
enabling
deeper
insights
design
next‐generation
platforms
specific
biomarker
isolation.
Finally,
future
opportunities
explored
combining
nanotechnologies
artificial
intelligence,
thereby
offering
inconceivable
possibilities
improving
care.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 13, 2024
Abstract
As
nanoscale
materials
with
the
function
of
catalyzing
substrates
through
enzymatic
kinetics,
nanozymes
are
regarded
as
potential
alternatives
to
natural
enzymes.
Compared
protein‐based
enzymes,
exhibit
attractive
characteristics
low
preparation
cost,
robust
activity,
flexible
performance
adjustment,
and
versatile
functionalization.
These
advantages
endow
them
wide
use
from
biochemical
sensing
environmental
remediation
medical
theranostics.
Especially
in
biomedical
diagnosis,
feature
catalytic
signal
amplification
provided
by
makes
emerging
labels
for
detection
biomarkers
diseases,
rapid
developments
observed
recent
years.
To
provide
a
comprehensive
overview
progress
made
this
dynamic
field,
here
an
diagnosis
enabled
is
provided.
This
review
first
summarizes
synthesis
nanozyme
then
discusses
main
strategies
applied
enhance
their
activity
specificity.
Subsequently,
representative
utilization
combined
biological
elements
disease
reviewed,
including
related
metabolic,
cardiovascular,
nervous,
digestive
diseases
well
cancers.
Finally,
some
development
trends
nanozyme‐enabled
highlighted,
corresponding
challenges
also
pointed
out,
aiming
inspire
future
efforts
further
advance
promising
field.
Analytical Chemistry,
Journal Year:
2024,
Volume and Issue:
96(11), P. 4479 - 4486
Published: March 8, 2024
Metal–organic
gels
(MOGs)
are
a
new
type
of
intelligent
soft
material,
which
bridged
by
metal
ions
and
organic
ligands
through
noncovalent
interactions.
In
this
paper,
we
prepared
highly
stable
P-MOGs,
using
the
classical
electrochemiluminescence
(ECL)
luminescence
meso-tetra(4-carboxyphenyl)porphine
as
ligand
Fe3+
ion.
Surprisingly,
P-MOGs
can
stably
output
ECL
signals
at
low
potential.
We
introduced
into
resonance
energy
transfer
strategy
(ECL-RET)
constructed
quenched
immunosensor
for
detection
SARS-CoV-2
nucleocapsid
protein
(SARS-CoV-2-N).
ECL-RET
system,
were
used
donors,
Au@Cu2O@Fe3O4
selected
acceptors.
The
ultraviolet-visible
spectrum
partially
overlaps
with
effectively
touch
off
behavior
between
donors
receptors.
Under
ideal
experimental
situation,
linear
range
SARS-CoV-2-N
concentration
was
10
fg/mL
to
100
ng/mL,
limit
1.5
fg/mL.
This
work
has
broad
application
prospects
porphyrin-MOGs
in
sensing.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: May 6, 2024
Abstract
Nanozyme,
characterized
by
outstanding
and
inherent
enzyme-mimicking
properties,
have
emerged
as
highly
promising
alternatives
to
natural
enzymes
owning
their
exceptional
attributes
such
regulation
of
oxidative
stress,
convenient
storage,
adjustable
catalytic
activities,
remarkable
stability,
effortless
scalability
for
large-scale
production.
Given
the
potent
regulatory
function
nanozymes
on
stress
coupled
with
fact
that
reactive
oxygen
species
(ROS)
play
a
vital
role
in
occurrence
exacerbation
metabolic
diseases,
nanozyme
offer
unique
perspective
therapy
through
multifunctional
achieving
essential
results
treatment
diseases
directly
scavenging
excess
ROS
or
regulating
pathologically
related
molecules.
The
rational
design
strategies,
nanozyme-enabled
therapeutic
mechanisms
at
cellular
level,
therapies
several
typical
underlying
are
discussed,
mainly
including
obesity,
diabetes,
cardiovascular
disease,
diabetic
wound
healing,
others.
Finally,
pharmacokinetics,
safety
analysis,
challenges,
outlooks
application
also
presented.
This
review
will
provide
some
instructive
perspectives
promote
development
strategies
disease
therapy.
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