Planta, Journal Year: 2023, Volume and Issue: 257(4)
Published: March 1, 2023
Language: Английский
Journal of Fungi, Journal Year: 2022, Volume and Issue: 8(2), P. 205 - 205
Published: Feb. 20, 2022
Plant-associated fungi (endophytic fungi) are a biodiversity-rich group of microorganisms that normally found asymptomatically within plant tissues or in the intercellular spaces. Endophytic promote growth host plants by directly producing secondary metabolites, which enhances plant’s resistance to biotic and abiotic stresses. Additionally, they capable biosynthesizing medically important “phytochemicals” were initially thought be produced only plant. In this review, we summarized some compounds from endophyte with novel structures diverse biological activities published between 2011 2021, focus on origin endophytic fungi, structural activity produce, special attention paid exploration pharmacological mechanisms action certain compounds. This review revealed had high potential harnessed as an alternative source metabolites for studies.
Language: Английский
Citations
171
Journal of Applied Microbiology, Journal Year: 2021, Volume and Issue: 131(5), P. 2161 - 2177
Published: April 24, 2021
Plants associate with communities of microbes (bacteria and fungi) that play critical roles in plant development, nutrient acquisition oxidative stress tolerance. The major share microbiota is endophytes which inhabit tissues help them various capacities. In this article, we have reviewed what presently known regard to how endophytic interact plants modulate root branching, hair formation their implications overall development. Endophytic link the interactions plants, rhizospheric soil promote solubilization further vectoring these nutrients roots making soil-plant-microbe continuum. Further, internalize oxidatively extract from rhizophagy cycle. between result by are also instrumental tolerance plants. It evident actively cultivate internally, on surfaces soils acquire nutrients, development improve health. Understanding continuum could be greater significance connecting hidden half can harnessed applied terms enhance through favourable system architecture for sustainable production under conditions.
Language: Английский
Citations
139
Journal of Fungi, Journal Year: 2021, Volume and Issue: 7(2), P. 147 - 147
Published: Feb. 17, 2021
Endophytic microbes are microorganisms that colonize the intracellular spaces within plant tissues without exerting any adverse or pathological effects. Currently, world population is facing devastating chronic diseases affect humans. The resistance of pathogens to commercial antibiotics increasing, thus limiting therapeutic potential and effectiveness antibiotics. Consequently, need search for novel, affordable nontoxic natural bioactive compounds from endophytic fungi in developing new drugs with multifunction mechanisms meet human needs essential. Fungal endophytes produce invaluable metabolic beneficial humans antimicrobial, anticancer, antidiabetic, anti-inflammatory, antitumor properties, etc. Some these include pestacin, taxol, camptothecin, ergoflavin, podophyllotoxin, benzopyran, isopestacin, phloroglucinol, tetrahydroxy-1-methylxanthone, salidroside, borneol, dibenzofurane, methyl peniphenone, lipopeptide, peniphenone Despite aforementioned importance fungal metabolites, less information available on their exploration pharmacological importance. Therefore, this review, we shall elucidate metabolites medicinal plants potential.
Language: Английский
Citations
130
Molecules, Journal Year: 2021, Volume and Issue: 26(4), P. 1142 - 1142
Published: Feb. 20, 2021
Oxidative stress originates from an elevated intracellular level of free oxygen radicals that cause lipid peroxidation, protein denaturation, DNA hydroxylation, and apoptosis, ultimately impairing cell viability. Antioxidants scavenge reduce oxidative stress, which further helps to prevent cellular damage. Medicinal plants, fruits, spices are the primary sources antioxidants time immemorial. In contrast microorganisms can be used as a source with advantage fast growth under controlled conditions. Further, microbe-based nontoxic, noncarcinogenic, biodegradable compared synthetic antioxidants. The present review aims summarize current state research on antioxidant activity including actinomycetes, bacteria, fungi, protozoa, microalgae, yeast, produce variety compounds, i.e., carotenoids, polyphenols, vitamins, sterol, etc. Special emphasis is given mechanisms signaling pathways followed by Reactive Oxygen Species (ROS), especially for those compounds have been scarcely investigated so far.
Language: Английский
Citations
119
Microbial Cell Factories, Journal Year: 2023, Volume and Issue: 22(1)
Published: June 6, 2023
Abstract Human life has been significantly impacted by the creation and spread of novel species antibiotic-resistant bacteria virus strains that are difficult to manage. Scientists researchers have recently motivated seek out alternatives other sources safe ecologically friendly active chemicals a powerful effective effect against wide variety pathogenic as result all these hazards problems. In this review, endophytic fungi their bioactive compounds biomedical applications were discussed. Endophytes, new category microbial source can produce biological components, major values for study broad prospects development. Recently, received much attention compounds. addition, natural generated endophytes is due close relationship between host plants. The separated from usually classified steroids, xanthones, terpenoids, isocoumarins, phenols, tetralones, benzopyranones enniatines. Moreover, review discusses enhancement methods secondary metabolites production fungal which include optimization methods, co-culture method, chemical epigenetic modification molecular-based approaches. Furthermore, deals with different medical such antimicrobial, antiviral, antioxidant anticancer activities in last 3 years.
Language: Английский
Citations
115
Mycology: An International Journal on Fungal Biology, Journal Year: 2021, Volume and Issue: 12(3), P. 139 - 159
Published: Jan. 27, 2021
Endophytes are a potent source of bioactive compounds that mimic plant-based metabolites. The relationship host plant and endophyte is significantly associated with alteration in fungal colonisation the extraction endophyte-derived compounds. Screening endophytes their plants essential for isolation Numerous antioxidant, antimicrobial, anticancer, immunomodulatory properties known to be derived from endophytes. Bioinformatics tools along latest techniques such as metabolomics, next-generation sequencing, metagenomics multilocus sequence typing can potentially fill gaps research. current review article focuses on plant-associated pharmacological importance. We conclude challenges opportunities research area
Language: Английский
Citations
109
Frontiers in Plant Science, Journal Year: 2022, Volume and Issue: 13
Published: July 5, 2022
The agricultural sustainability concept considers higher food production combating biotic and abiotic stresses, socio-economic well-being, environmental conservation. On the contrary, global warming-led climatic changes have appalling consequences on agriculture, generating shifting rainfall patterns, high temperature, CO2, drought, etc., prompting stress conditions for plants. Such stresses abandon plants to thrive, demoting productivity ultimately hampering security. Though issues are natural cannot be regulated, can still enabled endure these abnormal conditions, reinforcing resilience in an eco-friendly fashion by incorporating fungal endophytes. Endophytic fungi a group of subtle, non-pathogenic microorganisms establishing mutualistic association with diverse plant species. Their varied host under dynamic environments boosts endogenic tolerance mechanism against various via overall modulations local systemic mechanisms accompanied antioxidants secretion, ample enough scavenge Reactive Oxygen Species (ROS) hence, coping over-expression defensive redox regulatory system as aversion stressed condition. They also reported ameliorate toward mitigation elevate phytohormone levels forging them worthy used biocontrol agents biofertilizers pathogens, promoting crop improvement soil improvement, respectively. This review summarizes present-day conception endophytic fungi, their diversity crops, molecular behind resistance climate-resilient aided sustainable agriculture.
Language: Английский
Citations
102
Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14
Published: July 11, 2023
Endophytic fungi comprise host-associated fungal communities which thrive within the tissues of host plants and produce a diverse range secondary metabolites with various bioactive attributes. The such as phenols, polyketides, saponins, alkaloids help to mitigate biotic abiotic stresses, fight against pathogen attacks enhance plant immune system. We present an overview association endophytic discuss molecular mechanisms induced during their symbiotic interaction. focuses on (especially those terpenoid nature) secreted by respective function. recent advancement in multi-omics approaches paved way for identification these characterization via comparative analysis extensive omics datasets. This study also elaborates role associated key agricultural crops hence important sustainability agriculture.
Language: Английский
Citations
65
Journal of Fungi, Journal Year: 2024, Volume and Issue: 10(2), P. 116 - 116
Published: Jan. 30, 2024
The escalating global food demand driven by a gradually expanding human population necessitates strategies to improve agricultural productivity favorably and mitigate crop yield loss caused various stressors (biotic abiotic). Biotic stresses are phytopathogens, pests, nematodes, along with abiotic like salt, heat, drought, heavy metals, which pose serious risks security productivity. Presently, the traditional methods relying on synthetic chemicals have led ecological damage through unintended impacts non-target organisms emergence of microbes that resistant them. Therefore, addressing these challenges is essential for economic, environmental, public health concerns. present review supports sustainable alternatives, emphasizing possible application fungal endophytes as innovative eco-friendly tools in plant stress management. Fungal demonstrate capabilities managing plants against biotic via direct or indirect enhancement plants’ innate immunity. Moreover, they contribute elevated photosynthesis rates, stimulate growth, facilitate nutrient mineralization, produce bioactive compounds, hormones, enzymes, ultimately improving overall resistance. In conclusion, harnessing potentiality represents promising approach toward sustainability practices, offering effective alternative solutions reduce reliance chemical treatments address posed stresses. This ensures long-term promotes environmental economic viability agriculture.
Language: Английский
Citations
30
South African Journal of Botany, Journal Year: 2020, Volume and Issue: 134, P. 126 - 134
Published: July 24, 2020
Endophytes are microbial symbionts of plants which dwell within the internal tissues healthy without manifestation any infection symptoms on their hosts. In addition to being vital growth and development host, endophytes also assist medicinal plant host species in accumulating some highly coveted secondary metabolites under various abiotic stress conditions. The type quantity accumulated by rely age developmental phase as well taxonomic groupings both symbionts. Medicinal during life cycle become vulnerable different types tissue-damaging factors that hamper survival productivity. These stressors connected an appreciable build-up reactive oxygen (ROS) tissues. ROS a group chemicals interact with several cellular molecules, thus prompting irreversible metabolic anomalies cell necrosis. Reactive serve signals ensure survival; these produce antioxidants (both enzymatic non-enzymatic) maintain integrity system. Some are, however, produced result symbiotic relationship between endophytes. this review, we aim examine interaction stress.
Language: Английский
Citations
107