Endophytic fungal species Nigrospora oryzae and Alternaria alternata exhibit antimicrobial activity against gram-positive and gram-negative multi-drug resistant clinical bacterial isolates DOI Creative Commons

Asiphe Fanele,

Sizwe I. Ndlovu

BMC Complementary Medicine and Therapies, Journal Year: 2023, Volume and Issue: 23(1)

Published: Sept. 15, 2023

The emergence of multidrug-resistant pathogens and the lack new antimicrobial drugs is a major public health concern that needs urgent innovative solutions. Endophytic fungi living in unique niches such as endosymbiosis with plants are increasingly drawing attention alternative sources novel chemically diverse compounds mechanisms action.In present study, ten endophytic isolated from medicinal plant, Sclerocarya birrea were screened for bioactivity against panel indicator bacteria. Three bioactive (strains P02PL2, P02MS1, P02MS2A) selected identified through ITS-rDNA sequencing. whole broth extracts three isolates further contemporary drug-resistant bacterial pathogens. This was followed by partial purification solid phase extraction GC-MS analysis fractions.The Alternaria alternata species P02PL2 P02MS1) Nigrospora oryzae (strain P02MS2A). N. P02MS2A exhibited MIC one μg/mL 16 gram-negative, MDR Pseudomonas 5625574 gram-positive MRSA 25775 clinical isolates, respectively. After extract A. alternaria PO2MS1, 2-fluorobenzoic acid heptadecyl putatively active compound fraction C this extract. also E B P02MS1 P02MS2A, interestingly, all these fractions retained activity two isolates.The putative identification showing broad-spectrum activity, more especially gram-negative highly encouraging initiative at developing to combat multi-drug resistance.

Language: Английский

Fungal Endophytes as Mitigators against Biotic and Abiotic Stresses in Crop Plants DOI Creative Commons

Hittanahallikoppal Gajendramurthy Gowtham,

P. Hema,

M. Murali

et al.

Journal of Fungi, Journal Year: 2024, Volume and Issue: 10(2), P. 116 - 116

Published: Jan. 30, 2024

The escalating global food demand driven by a gradually expanding human population necessitates strategies to improve agricultural productivity favorably and mitigate crop yield loss caused various stressors (biotic abiotic). Biotic stresses are phytopathogens, pests, nematodes, along with abiotic like salt, heat, drought, heavy metals, which pose serious risks security productivity. Presently, the traditional methods relying on synthetic chemicals have led ecological damage through unintended impacts non-target organisms emergence of microbes that resistant them. Therefore, addressing these challenges is essential for economic, environmental, public health concerns. present review supports sustainable alternatives, emphasizing possible application fungal endophytes as innovative eco-friendly tools in plant stress management. Fungal demonstrate capabilities managing plants against biotic via direct or indirect enhancement plants’ innate immunity. Moreover, they contribute elevated photosynthesis rates, stimulate growth, facilitate nutrient mineralization, produce bioactive compounds, hormones, enzymes, ultimately improving overall resistance. In conclusion, harnessing potentiality represents promising approach toward sustainability practices, offering effective alternative solutions reduce reliance chemical treatments address posed stresses. This ensures long-term promotes environmental economic viability agriculture.

Language: Английский

Citations

30
Bioorganic compounds in quorum sensing disruption: strategies, Mechanisms, and future prospects DOI
Tarunkarthick Subramani, Harish Saravanan, Helma David

et al.

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 108192 - 108192

Published: Jan. 1, 2025

Language: Английский

Citations

3
The Multifunctions and Future Prospects of Endophytes and Their Metabolites in Plant Disease Management DOI Creative Commons
Yandong Xia, Junang Liu,

Cang Chen

et al.

Microorganisms, Journal Year: 2022, Volume and Issue: 10(5), P. 1072 - 1072

Published: May 23, 2022

Endophytes represent a ubiquitous and magical world in plants. Almost all plant species studied by different researchers have been found to harbor one or more endophytes, which protect host plants from pathogen invasion adverse environmental conditions. They produce various metabolites that can directly inhibit the growth of pathogens even promote development In this review, we focus on biological control diseases, aiming elucidate contribution key roles endophytes their field with latest research information. Metabolites synthesized are part disease management, application endophyte induce resistance is very promising. Furthermore, multi-omics should be fully utilized plant-microbe research, especially mining novel bioactive metabolites. We believe utilization for management meaningful promising direction lead new breakthroughs effective ecosystem-friendly insecticides fungicides modern agriculture.

Language: Английский

Citations

70
Towards further understanding the applications of endophytes: enriched source of bioactive compounds and bio factories for nanoparticles DOI Creative Commons
Nisha Choudhary, Naveen Dhingra, Amel Gacem

et al.

Frontiers in Plant Science, Journal Year: 2023, Volume and Issue: 14

Published: July 10, 2023

The most significant issues that humans face today include a growing population, an altering climate, reliance on pesticides, the appearance of novel infectious agents, and accumulation industrial waste. production agricultural goods has also been subject to great number shifts, often known as revolutions, which have influenced by progression civilization, technology, general human advancement. Sustainable measures can be applied in agriculture, environment, medicine, industry are needed lessen harmful effects aforementioned problems. Endophytes, might bacterial or fungal, could successful solution. They protect plants promote growth producing phytohormones providing biotic abiotic stress tolerance. Endophytes produce diverse type bioactive compounds such alkaloids, saponins, flavonoids, tannins, terpenoids, quinones, chinones, phenolic acids etc. for various therapeutic advantages anticancer, antitumor, antidiabetic, antifungal, antiviral, antimicrobial, antimalarial, antioxidant activity. Proteases, pectinases, amylases, cellulases, xylanases, laccases, lipases, other types enzymes vital many different industries produced endophytes. Due presence all these endophytes, they preferred sources green synthesis nanoparticles. This review aims comprehend contributions uses endophytes medicinal, sectors bio-nanotechnology with their mechanism action.

Language: Английский

Citations

25
Endophytic Fungi for Crops Adaptation to Abiotic Stresses DOI Creative Commons

Adan Topiltzin Morales-Vargas,

Varinia López-Ramírez, César Álvarez-Mejía

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(7), P. 1357 - 1357

Published: July 2, 2024

Endophytic fungi (EFs) have emerged as promising modulators of plant growth and stress tolerance in agricultural ecosystems. This review synthesizes the current knowledge on role EFs enhancing adaptation crops to abiotic stress. Abiotic stresses, such drought, salinity, extreme temperatures, pose significant challenges crop productivity worldwide. shown remarkable potential alleviating adverse effects these stresses. Through various mechanisms, including synthesis osmolytes, production stress-related enzymes, induction defense enhance resilience stressors. Moreover, promote nutrient uptake modulate hormonal balance plants, further plants. Recent advancements molecular techniques facilitated identification characterization stress-tolerant EF strains, paving way for their utilization practices. Furthermore, symbiotic relationship between plants offers ecological benefits, improved soil health a reduced dependence chemical inputs. However, remain understanding complex interactions host well scaling up application diverse systems. Future research should focus elucidating mechanisms underlying endophytic-fungal-mediated developing sustainable strategies harnessing production.

Language: Английский

Citations

15
Exploring the antioxidant potential of endophytic fungi: a review on methods for extraction and quantification of total antioxidant capacity (TAC) DOI Creative Commons
Rita Onyekachukwu Asomadu, Timothy Prince Chidike Ezeorba, Tobechukwu Christian Ezike

et al.

3 Biotech, Journal Year: 2024, Volume and Issue: 14(5)

Published: April 5, 2024

Abstract Endophytic fungi have emerged as a significant source of natural products with remarkable bioactivities. Recent research has identified numerous antioxidant molecules among the secondary metabolites endophytic fungi. These organisms, whether unicellular or micro-multicellular, offer potential for genetic manipulation to enhance production these valuable compounds, which hold promise promoting health, vitality, and various biotechnological applications. In this study, we provide critical review methods extracting, purifying, characterizing, estimating total capacity (TAC) metabolites. While many endophytes produce similar those found in plants established symbiotic associations, also highlight existence novel scientific interest. Additionally, discuss how advancements nanotechnology opened new avenues exploring nanoformulations future studies, offering opportunities diverse biological industrial

Language: Английский

Citations

13
Enhancing dendrobine production in Dendrobium nobile through mono-culturing of endophytic fungi, Trichoderma longibrachiatum (MD33) in a temporary immersion bioreactor system DOI Creative Commons
Surendra Sarsaiya, Archana Jain,

Fuxing Shu

et al.

Frontiers in Plant Science, Journal Year: 2024, Volume and Issue: 15

Published: Jan. 29, 2024

Dendrobine, a valuable alkaloid found in

Language: Английский

Citations

12
Unveiling the cytotoxic and anti-proliferative potential of green-synthesized silver nanoparticles mediated by Colletotrichum gloeosporioides DOI Creative Commons
Priyamvada Gupta, Swati Singh, Nilesh Rai

et al.

RSC Advances, Journal Year: 2024, Volume and Issue: 14(6), P. 4074 - 4088

Published: Jan. 1, 2024

Fungal endophytes are a putative source of bioactive metabolites that have found significant applications in nanomedicine due to their metabolic versatility. In the present study, an aqueous extract fungal endophyte,

Language: Английский

Citations

12
Health-Promoting Effects of Bioactive Compounds from Plant Endophytic Fungi DOI Creative Commons
Tharuka Wijesekara, Baojun Xu

Journal of Fungi, Journal Year: 2023, Volume and Issue: 9(10), P. 997 - 997

Published: Oct. 8, 2023

The study examines the intricate relationship between plants and endophytic fungi inhabiting their tissues. These harmoniously coexist with plants, forming a distinct symbiotic connection that has caught scientific attention due to its potential implications for plant health growth. diverse range of bioactive compounds produced by these holds significant promise human health. review covers various aspects this topic, starting introducing microorganisms, explaining colonization different parts, illuminating roles in enhancing defense against diseases promoting emphasizes widespread occurrence diversity microorganisms among species while highlighting complexities significance isolating extracting from them. It focuses on benefits compounds, including capacity exhibit antioxidant, anti-inflammatory, antimicrobial, anticancer effects. delves into mechanisms behind health-promoting effects, spotlighting how interact cellular receptors, signaling pathways, gene expression. In conclusion, provides comprehensive overview fungi. outlines multifaceted impact, applications, future research avenues medicine.

Language: Английский

Citations

20
Genome sequencing and molecular networking analysis of the wild fungus Anthostomella pinea reveal its ability to produce a diverse range of secondary metabolites DOI Creative Commons
Roberto Iacovelli, Tao He, Julian L. Allen

et al.

Fungal Biology and Biotechnology, Journal Year: 2024, Volume and Issue: 11(1)

Published: Jan. 3, 2024

Abstract Background Filamentous fungi are prolific producers of bioactive molecules and enzymes with important applications in industry. Yet, the vast majority fungal species remain undiscovered or uncharacterized. Here we focus our attention to a wild isolate that identified as Anthostomella pinea . The fungus belongs complex polyphyletic genus family Xylariaceae , which is known comprise endophytic pathogenic produce plethora interesting secondary metabolites. Despite that, largely understudied only two have been fully sequenced characterized at genomic level. Results In this work, used long-read sequencing obtain complete 53.7 Mb genome sequence including full mitochondrial DNA. We performed extensive structural functional annotation coding sequences, genes encoding potential biotechnology. Among others, found A. encodes 91 biosynthetic gene clusters, more than 600 CAZymes, 164 P450s. Furthermore, untargeted metabolomics molecular networking analysis cultivation extracts revealed rich metabolism, particular an abundance sesquiterpenoids sesquiterpene lactones. also polyketide antibiotic xanthoepocin, attribute anti–Gram-positive effect observed antibacterial plate assays. Conclusions Taken together, results provide first glimpse into Anthstomella new biocatalysts will facilitate future research these valuable

Language: Английский

Citations

8