British Journal of Anaesthesia, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Journal of Clinical Anesthesia, Journal Year: 2024, Volume and Issue: 95, P. 111447 - 111447
Published: March 23, 2024
To investigate whether a single dosage of esketamine injection in the anesthesia period could improve postoperative negative emotions and early cognitive function patients undergoing non-cardiac thoracic surgery.
Language: Английский
Citations
17
Biomedicines, Journal Year: 2025, Volume and Issue: 13(1), P. 115 - 115
Published: Jan. 7, 2025
Postoperative neurocognitive dysfunction (PND) is a prevalent and debilitating complication in elderly surgical patients, characterized by persistent cognitive decline that negatively affects recovery quality of life. As the aging population grows, rising number patients has made PND an urgent clinical challenge. Despite increasing research efforts, pathophysiological mechanisms underlying remain inadequately characterized, underscoring need for more integrated framework to guide targeted interventions. To better understand molecular therapeutic targets PND, this narrative review synthesized evidence from peer-reviewed studies, identified through comprehensive searches PubMed, Embase, Cochrane Library, Web Science. Key findings highlight neuroinflammation, oxidative stress, mitochondrial dysfunction, neurotransmitter imbalances, microvascular changes, white matter lesions as central pathophysiology, with particular parallels encephalocele- sepsis-associated impairments. Among these, mediated pathways such NLRP3 inflammasome blood-brain barrier disruption, emerges pivotal driver, triggering cascades exacerbate neuronal injury. Oxidative stress synergistically amplify these effects, while imbalances alterations, including lesions, contribute synaptic decline. Anesthetic agents modulate interconnected pathways, exhibiting both protective detrimental effects. Propofol dexmedetomidine demonstrate neuroprotective properties suppressing neuroinflammation microglial activation, whereas inhalational anesthetics like sevoflurane intensify inflammatory responses. Ketamine, its anti-inflammatory potential, offers promise but requires further evaluation determine long-term safety efficacy. By bridging insights practice, highlights critical role personalized anesthetic strategies mitigating improving patients. It aims inform future decision-making address multifaceted
Language: Английский
Citations
2
Medicine, Journal Year: 2023, Volume and Issue: 102(8), P. e32991 - e32991
Published: Feb. 22, 2023
Postoperative delirium (POD) is an acute cognitive dysfunction that mainly characterized by memory impairment and disturbances in consciousness. POD can prolong the hospital stay increase 1-month mortality rate of patients. The overall incidence approximately 23%, its prevalence go up to 50% high-risk surgeries. Neuroinflammation important pathogenic mechanism mediates microglial activation leads synaptic remodeling. Neuroinflammation, as indispensable pathogenesis POD, occur due a variety factors, including aseptic inflammation caused surgery, effects anesthetic drugs, disruption blood-brain barrier, epigenetics. Understanding these factors avoiding occurrence risk may help prevent time. This review provides brief overview neuroinflammation summarizes various affecting development mediated neuroinflammation, which serve future targets for prevention treatment POD.
Language: Английский
Citations
38
Neuropharmacology, Journal Year: 2023, Volume and Issue: 237, P. 109646 - 109646
Published: June 24, 2023
Language: Английский
Citations
33
Annals of Neurology, Journal Year: 2023, Volume and Issue: 94(6), P. 1024 - 1035
Published: Aug. 24, 2023
Although animal models suggest a role for blood-brain barrier dysfunction in postoperative delirium-like behavior, its delirium and recovery humans is unclear. Thus, we evaluated the of hospital length stay among older surgery patients.
Language: Английский
Citations
31
Journal of Clinical Anesthesia, Journal Year: 2023, Volume and Issue: 88, P. 111125 - 111125
Published: April 19, 2023
Postoperative delirium (POD) is a common surgical complication associated with increased morbidity and mortality in elderly. Although the underlying mechanisms remain elusive, perioperative risk factors were reported to be closely related its development. This study was designed investigate association between duration of intraoperative hypotension POD incidence following thoracic orthopedic surgery
Language: Английский
Citations
25
Fluids and Barriers of the CNS, Journal Year: 2024, Volume and Issue: 21(1)
Published: Aug. 7, 2024
Cognitive decline covers a broad spectrum of disorders, not only resulting from brain diseases but also systemic diseases, which seriously influence the quality life and expectancy patients. As highly selective anatomical functional interface between circulation, blood-brain barrier (BBB) plays pivotal role in maintaining homeostasis normal function. The pathogenesis underlying cognitive may vary, nevertheless, accumulating evidences support BBB disruption as most prevalent contributing factor. This mainly be attributed to inflammation, metabolic dysfunction, cell senescence, oxidative/nitrosative stress excitotoxicity. However, direct evidence showing that causes is scarce, interestingly, manipulation opening alone exert beneficial or detrimental neurological effects. A overview present literature shows close relationship decline, risk factors disruption, well cellular molecular mechanisms disruption. Additionally, we discussed possible leading by potential therapeutic strategies prevent enhance repair. review aims foster more investigations on early diagnosis, effective therapeutics, rapid restoration against would yield better outcomes patients with dysregulated function, although their causative has yet been completely established.
Language: Английский
Citations
14
Current Osteoporosis Reports, Journal Year: 2024, Volume and Issue: 22(1), P. 152 - 164
Published: Feb. 1, 2024
Abstract Purpose of Review This comprehensive review delves into the intricate interplay between Alzheimer’s disease (AD) and osteoporosis, two prevalent conditions with significant implications for individuals’ quality life. The purpose is to explore their bidirectional association, underpinned by common pathological processes such as aging, genetic factors, inflammation, estrogen deficiency. Recent Findings advances have shown promise in treating both osteoporosis targeting disease-specific proteins bone metabolism regulators. Monoclonal antibodies against beta-amyloid tau AD, well RANKL sclerostin displayed therapeutic potential. Additionally, ongoing research has identified neuroinflammatory genes shared AD offering insight interconnected inflammatory mechanisms. knowledge opens avenues innovative dual-purpose therapies that could address conditions, potentially revolutionizing treatment approaches simultaneously. Summary underscores potential groundbreaking advancements early diagnosis unraveling connection health. It advocates a holistic, patient-centered approach medical care considers cognitive health, ultimately aiming enhance overall well-being individuals affected these conditions. article part series multiple manuscripts designed determine utility using artificial intelligence writing scientific reviews.
Language: Английский
Citations
10
British Journal of Anaesthesia, Journal Year: 2022, Volume and Issue: 130(2), P. e370 - e380
Published: June 29, 2022
Peripheral surgical trauma can trigger neuroinflammation and ensuing neurological complications, such as delirium. The mechanisms whereby surgery contributes to postoperative remain unclear without effective therapies. Here, we developed a microfluidic-assisted blood-brain barrier (BBB) device tested the effects of omega-3 fatty acids on neuroimmune interactions after orthopaedic surgery.A BBB was established using primary human cells. Tight junction proteins, vascular cell adhesion molecule 1 (VCAM-1), permeability, astrocytic networks were assessed stimulation with interleukin (IL)-1β in presence or absence clinically available acid emulsion (Omegaven®; Fresenius Kabi, Bad Homburg, Germany). Mice treated h before 10 μl g-1 body weight i.v. equal volumes saline. Changes pericytes, perivascular macrophages, opening, microglial activation, inattention evaluated.Omega-3 protected endothelial tight junctions, VCAM-1 exposure IL-1β model. In vivo studies confirmed that treatment inhibited surgery-induced impairment, delirium-like behaviour. We identified novel role for pericyte loss macrophage activation mice surgery, which rescued by prophylaxis acids.We present new approach study relevant perioperative recovery microphysiological platform. function, including dysregulation pericytes provide targets reduce
Language: Английский
Citations
29
Frontiers in Cell and Developmental Biology, Journal Year: 2023, Volume and Issue: 11
Published: April 10, 2023
The blood-brain barrier (BBB) is an important separating the central nervous system from periphery. composition includes endothelial cells, pericytes, astrocytes, synapses and tight junction proteins. During perioperative period, anesthesia surgical operations are also a kind of stress to body, which may be accompanied by damage brain metabolism dysfunction. Perioperative destruction closely associated with cognitive impairment increase risk postoperative mortality, not conducive enhanced recovery after surgery. However, potential pathophysiological process specific mechanism during period have been fully elucidated. Changes in permeability, inflammation neuroinflammation, oxidative stress, ferroptosis, intestinal dysbiosis involved damage. We aim review research progress its adverse effects molecular mechanisms, provide ideas for study homeostasis maintenance function precision anesthesia.
Language: Английский
Citations
19