Synergistic Effects of Probiotics and Lifestyle Interventions on Intestinal Microbiota Composition and Clinical Outcomes in Obese Adults

Metabolites, Journal Year: 2025, Volume and Issue: 15(2), P. 70 - 70

Published: Jan. 23, 2025

Background and objective: Obesity is a growing global epidemic. The composition of the intestinal microbiota can be influenced by several factors. Studies highlight role bacteria in pathophysiology obesity. So, objective this study was to investigate whether use probiotics, together with healthy lifestyle habits, contributes weight reduction obese individuals analyzing profile. Methods: A prospective carried out 45 adults Participants underwent guidance on received probiotic component containing different microbiological strains were followed for 60 days. Clinical parameters, body composition, biochemical analysis, assessment performed before after treatment. After days, it observed that bacterial present patients’ microbiota. also showed improvements physical activity, sleep quality, anxiety management, as well changes some eating such consumption processed foods significant increase water intake. Results: BMI, fasting glucose, insulin, HOMA-IR, LDL cholesterol, triglycerides observed, addition an HDL improvement bowel movement frequency, stool consistency. Analysis revealed microbial diversity better balance between phyla Firmicutes Bacteroidetes. Conclusions: related improving microbiota, dietary increased reduced anxiety, quality have significantly contributed loss physiological parameters individuals.

Language: Английский

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Frozen Shoulder as a Metabolic and Immune Disorder: Potential Roles of Leptin Resistance, JAK-STAT Dysregulation, and Fibrosis

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(5), P. 1780 - 1780

Published: March 6, 2025

Frozen shoulder (FS) is a complex and multifactorial condition characterized by persistent inflammation, fibrosis, metabolic dysregulation. Despite extensive research, the underlying drivers of FS remain poorly understood. Recent findings indicate coexistence pro-inflammatory fibrosis-resolving macrophages within affected tissues, suggesting dysregulated immune response influenced neuroendocrine factors. This review proposes that leptin resistance, hallmark syndrome chronic may play central role in pathogenesis impairing macrophage polarization, perpetuating disrupting fibrosis resolution. The JAK-STAT signaling pathway, critically modulated further contribute to dysregulation sustaining inflammatory activation interfering with tissue remodeling. Additionally, shares pathogenic features fibrotic diseases driven TGF-β signaling, mitochondrial dysfunction, circadian disruption, linking systemic dysfunction localized pathology. Beyond regulation, alterations gut microbiota, bacterial translocation, psychosocial stress exacerbate inflammation imbalances, intensifying resistance. By examining intricate interplay between metabolism, function, remodeling, this highlights targeting sensitivity, modulation, restoration as novel therapeutic strategies for treatment. Future research should explore these interconnections develop integrative interventions address both FS, ultimately improving clinical outcomes.

Language: Английский

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Effects of bacteriophages on gut microbiome functionality

Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)

Published: March 31, 2025

The gut microbiome, composed of bacteria, fungi, and viruses, plays a crucial role in maintaining the delicate balance human health. Emerging evidence suggests that microbiome disruptions can have far-reaching implications, ranging from development inflammatory diseases cancer to metabolic disorders. Bacteriophages, or "phages", are viruses specifically infect bacterial cells, their interactions with receiving increased attention. Despite recently revived interest phageome, it is still considered "dark matter" gut, more than 80% viral genomes remaining uncharacterized. Today, research focused on understanding mechanisms by which phages influence microbiota potential applications. Bacteriophages may regulate relative abundance communities, affect functions various ways, modulate mammalian host immunity. This review explores how functionality, particularly commensals pathogens, emphasizing health disease.

Language: Английский

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The Role of Gut Microbiota and Leaky Gut in the Pathogenesis of Food Allergy

Nutrients, Journal Year: 2023, Volume and Issue: 16(1), P. 92 - 92

Published: Dec. 27, 2023

Food allergy (FA) is a growing public health concern, with an increasing prevalence in Western countries. Increasing evidence suggests that the balance of human gut microbiota and integrity our intestinal barrier may play roles development FA. Environmental factors, including industrialization consumption highly processed food, can contribute to altering barrier, susceptibility allergic sensitization. Compositional functional alterations microbiome have also been associated In addition, increased permeability allows translocation allergenic molecules, triggering Th2 immune responses. Preclinical clinical studies highlighted potential probiotics, prebiotics, postbiotics prevention treatment FA through enhancing function promoting restoration healthy microbiota. Finally, fecal transplantation (FMT) now being explored as promising therapeutic strategy prevent both experimental studies. this review article, we aim explore complex interplay between FA, well depict strategies.

Language: Английский

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Sustainability, nutrition, and scientific advances of functional foods under the new EU and global legislation initiatives

Journal of Functional Foods, Journal Year: 2023, Volume and Issue: 109, P. 105793 - 105793

Published: Sept. 14, 2023

The health of the general population is one various factors at stake in 2020′s generation: food security, safety, nutrition, and responsible, sustainable production consumption are also part priorities governments enterprises. Under that prism, new EU legislation (Green Deal – Farm to Fork) building on top UN’s Sustainable Development Goals groundwork has brought about a revamped focus sustainability industry, emphasising reducing production's environmental impact promoting systems. Here, an integrative approach between scientific technological advancement, policymakers, consumers, society, design sustainable, functional foods presented, focusing innovation for developing bioactive-rich ingredients tackling non-communicable diseases (NCD). We critically analyse how these findings fit within policy frameworks UN under common goal achieving global security growth.

Language: Английский

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Links between Diet, Intestinal Anaerobes, Microbial Metabolites and Health

Biomedicines, Journal Year: 2023, Volume and Issue: 11(5), P. 1338 - 1338

Published: May 1, 2023

A dense microbial community resides in the human colon, with considerable inter-individual variability composition, although some species are relatively dominant and widespread healthy individuals. In disease conditions, there is often a reduction diversity perturbations composition of microbiota. Dietary complex carbohydrates that reach large intestine important modulators microbiota their primary metabolic outputs. Specialist gut bacteria may also transform plant phenolics to form spectrum products possessing antioxidant anti-inflammatory activities. Consumption diets high animal protein fat lead formation potentially deleterious products, including nitroso compounds, hydrogen sulphide, trimethylamine. Gut anaerobes range secondary metabolites, polyketides possess antimicrobial activity thus contribute microbe–microbe interactions within colon. The overall outputs colonic microbes derived from an intricate network pathways interactions; however, much still needs be learnt about subtleties these networks. this review we consider multi-faceted relationships between variation, diet, health.

Language: Английский

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Population-specific differences in the human microbiome: Factors defining the diversity

Gene, Journal Year: 2024, Volume and Issue: 933, P. 148923 - 148923

Published: Sept. 6, 2024

Language: Английский

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How the Microbiota May Affect Celiac Disease and What We Can Do

Nutrients, Journal Year: 2024, Volume and Issue: 16(12), P. 1882 - 1882

Published: June 14, 2024

Celiac disease (CeD) is an autoimmune with a strong association human leukocyte antigen (HLA), characterized by the production of specific autoantibodies and immune-mediated enterocyte killing. CeD unique condition, as it only one in which environmental trigger known: gluten, storage protein present wheat, barley, rye. How when loss tolerance intestinal mucosa to gluten occurs still unknown. This event, through activation adaptive immune responses, enhances epithelial cell death, increases permeability barrier, induces secretion pro-inflammatory cytokines, resulting transition from genetic predisposition actual onset disease. While role gastrointestinal infections possible has been considered on basis mechanism mimicry, more likely alternative appears involve complex disruption microbiota ecosystem triggered infections, rather than effect single pathogen mucosal homeostasis. Several lines evidence show existence dysbiosis that precedes genetically at-risk subjects, protective bacterial elements both epigenetically functionally can influence response epithelium leading tolerance. We have conducted literature review order summarize current knowledge about part unraveled accompanies some exciting new data how this might be prevented and/or counteracted. The search was PubMed.gov time frame 2010 March 2024 utilizing terms "celiac microbiota", microbiome", probiotics" restricting following article types: Clinical Trials, Meta-Analysis, Review, Systematic Review. A total 364 papers were identified reviewed. main conclusions outlined follows: (1) quantitative qualitative changes gut clearly documented patients; (2) microbiota's extensive variable interactions enterocytes, viral pathogens even combine impact inflammatory tolerance, ultimately affecting pathogenesis, progression, clinical expression CeD; (3) gluten-free diet fails restore eubiosis digestive tract patients, also negatively affects microbial homeostasis; (4) tools allowing targeted therapy, such use probiotics (a good example being precision like novel strain B. vulgatus (20220303-A2) begin potential applications.

Language: Английский

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Fecal Microbiota Transplantation, a tool to transfer healthy longevity

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 103, P. 102585 - 102585

Published: Nov. 23, 2024

The complex gut microbiome influences host aging and plays an important role in the manifestation of age-related diseases. Restoring a healthy via Fecal Microbiota Transplantation (FMT) is receiving extensive consideration to therapeutically transfer longevity. Herein, we comprehensively review benefits microbial rejuvenation - FMT promote aging, with few studies documenting life length properties. This explores how preconditioning donors standard lifestyle pharmacological antiaging interventions reshape microbiome, resulting being also FMT-transferable. Finally, expose current clinical uses context therapy address challenges regulatory landscape, protocol standardization, health risks that require refinement effectively utilize elderly.

Language: Английский

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Shaping the future of gastrointestinal cancers through metabolic interactions with host gut microbiota

Heliyon, Journal Year: 2024, Volume and Issue: 10(15), P. e35336 - e35336

Published: July 27, 2024

Gastrointestinal (GI) cancers represent a significant global health challenge, driving relentless efforts to identify innovative diagnostic and therapeutic approaches. Recent strides in microbiome research have unveiled previously underestimated dimension of cancer progression that revolves around the intricate metabolic interplay between GI host's gut microbiota. This review aims provide comprehensive overview these emerging interactions their potential catalyze paradigm shift precision diagnosis breakthroughs cancers. The article underscores groundbreaking impact on oncology by delving into symbiotic connection host metabolism It offers valuable insights tailoring treatment strategies individual patients, thus moving beyond traditional one-size-fits-all approach. also sheds light novel methodologies could transform early detection cancers, potentially leading more favorable patient outcomes. In conclusion, exploring microbiota showcases promising frontier ongoing battle against formidable diseases. By comprehending harnessing microbiome's influence, future innovation for appears optimistic, opening doors tailored treatments enhanced precision.

Language: Английский

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