Light patterning semiconductor nanoparticles by modulating surface charges DOI Creative Commons
Xiaoli He, Hongri Gu,

Yanmei Ma

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Nov. 13, 2024

Optical patterning of colloidal particles is a scalable and cost-effective approach for creating multiscale functional structures. Existing methods often use high-intensity light sources customized optical setups, making them less feasible large-scale microfabrication processes. Here, we report an method semiconductor nanoparticles by light-triggered modulation their surface charge. Rather than using as the primary energy source, this utilizes UV-induced cleavage ligands to modify charges, thereby facilitating self-assembly on charged substrate via electrostatic interactions. By citrate-treated ZnO nanoparticles, uniform patterns with variable thicknesses can be achieved. These multilayered are fabricated into UV detector on/off ratio exceeding 10

Language: Английский

Nano-bio interactions of 2D molybdenum disulfide DOI Creative Commons
Shounak Roy, Kaivalya A. Deo, Kanwar Abhay Singh

et al.

Advanced Drug Delivery Reviews, Journal Year: 2022, Volume and Issue: 187, P. 114361 - 114361

Published: May 27, 2022

Language: Английский

Citations

51
Laponite-Based Nanocomposite Hydrogels for Drug Delivery Applications DOI Creative Commons
Samuel Stealey, Akhilesh K. Gaharwar, Silviya P. Zustiak

et al.

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(6), P. 821 - 821

Published: May 31, 2023

Hydrogels are widely used for therapeutic delivery applications due to their biocompatibility, biodegradability, and ability control release kinetics by tuning swelling mechanical properties. However, clinical utility is hampered unfavorable pharmacokinetic properties, including high initial burst difficulty in achieving prolonged release, especially small molecules (<500 Da). The incorporation of nanomaterials within hydrogels has emerged as viable option a method trap therapeutics the hydrogel sustain kinetics. Specifically, two-dimensional nanosilicate particles offer plethora beneficial characteristics, dually charged surfaces, degradability, enhanced properties hydrogels. nanosilicate–hydrogel composite system offers benefits not obtainable just one component, highlighting need detail characterization these nanocomposite This review focuses on Laponite, disc-shaped with diameter 30 nm thickness 1 nm. using Laponite explored, well examples Laponite–hydrogel composites currently being investigated prolong macromolecules such proteins. Future work will further characterize interplay between nanosilicates, polymer, encapsulated therapeutics, how each components affect

Language: Английский

Citations

30
Poly(ethylene glycol)–Norbornene as a Photoclick Bioink for Digital Light Processing 3D Bioprinting DOI
Min Hee Kim, Chien‐Chi Lin

ACS Applied Materials & Interfaces, Journal Year: 2023, Volume and Issue: 15(2), P. 2737 - 2746

Published: Jan. 6, 2023

Digital light processing (DLP) bioprinting is an emerging technology for three-dimensional (3DBP) owing to its high printing fidelity, fast fabrication speed, and higher resolution. Low-viscosity bioinks such as poly(ethylene glycol) diacrylate (PEGDA) are commonly used DLP-based bioprinting. However, the cross-linking of PEGDA proceeds via chain-growth photopolymerization that displays significant heterogeneity in density. In contrast, step-growth thiol–norbornene not oxygen inhibited produces hydrogels with ideal network structure. The cytocompatibility rapid gelation have lent itself cell-laden but been extensively DLP this study, we explored eight-arm PEG–norbornene (PEG8NB) a bioink/resin visible light-initiated 3DBP. PEG8NB-based resin showed fidelity even without use any bioactive motifs initial stiffness. addition, demonstrated versatility PEGNB by solid structures cell culture devices, hollow channels endothelialization, microwells generating spheroids. This work only expands selection 3DBP also provides platform dynamic modification bioprinted constructs.

Language: Английский

Citations

26
3D-bioprinted human tissue and the path toward clinical translation DOI
Jacqueline M. Bliley, Daniel J. Shiwarski, Adam W. Feinberg

et al.

Science Translational Medicine, Journal Year: 2022, Volume and Issue: 14(666)

Published: Oct. 12, 2022

Three-dimensional (3D) bioprinting is a transformative technology for engineering tissues disease modeling and drug screening building organs repair, regeneration, replacement. In this Viewpoint, we discuss technological advances in 3D bioprinting, key remaining challenges, essential milestones toward clinical translation.

Language: Английский

Citations

34
Nanomaterials-Based Hybrid Bioink Platforms in Advancing 3D Bioprinting Technologies for Regenerative Medicine DOI
Dilip Kumar Chandra, Rui L. Reis, Subhas C. Kundu

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2024, Volume and Issue: 10(7), P. 4145 - 4174

Published: June 1, 2024

3D bioprinting is recognized as the ultimate additive biomanufacturing technology in tissue engineering and regeneration, augmented with intelligent bioinks bioprinters to construct tissues or organs, thereby eliminating stipulation for artificial organs. For of soft tissues, such kidneys, hearts, other human body parts, formulations bioink enhanced bioinspired rheological mechanical properties were essential. Nanomaterials-based hybrid have potential overcome above-mentioned problem require much attention among researchers. Natural synthetic nanomaterials carbon nanotubes, graphene oxides, titanium nanosilicates, nanoclay, nanocellulose, etc. their blended been used various benefitted bioprintability, biocompatibility, biodegradability. A limited number articles published, requirement pushed us write this review. We reviewed, explored, discussed nanocomposite-based technology, properties, natural, synthetic, nanomaterial-based bioinks, including applications challenges, limitations, ethical considerations, solution future perspective, technological advancement efficient cost-effective methods regeneration healthcare.

Language: Английский

Citations

7
Granular Biphasic Colloidal Hydrogels for 3D Bioprinting DOI Creative Commons
Kaivalya A. Deo, Aparna Murali, James J. Tronolone

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: May 15, 2024

Granular hydrogels composed of hydrogel microparticles are promising candidates for 3D bioprinting due to their ability protect encapsulated cells. However, achieve high print fidelity, need jam exhibit shear-thinning characteristics, which is crucial printing. Unfortunately, this overpacking can significantly impact cell viability, thereby negating the primary advantage using shield cells from shear forces. To overcome challenge, a novel solution: biphasic, granular colloidal bioink designed optimize viability and printing fidelity introduced. The biphasic ink consists cell-laden polyethylene glycol (PEG) embedded in continuous gelatin methacryloyl (GelMA)-nanosilicate network. Here, it demonstrated that offers outstanding rheological properties, structural stability. Furthermore, its utility engineering complex tissues with multiple types heterogeneous microenvironments demonstrated, by incorporating β-islet into PEG endothelial GelMA-nanosilicate Using approach, possible induce patterning, enhance vascularization, direct cellular function. proposed holds significant potential numerous emerging biomedical applications, including tissue disease modeling.

Language: Английский

Citations

5
Particle–polymer interactions for 3D printing material design DOI Open Access
Kellen Mitchell, Weijian Hua, Erick R. Bandala

et al.

Chemical Physics Reviews, Journal Year: 2024, Volume and Issue: 5(1)

Published: Jan. 31, 2024

Embedded ink writing (EIW) and direct (DIW) constitute the primary strategies for three-dimensional (3D) printing within realm of material extrusion. These methods enable rapid fabrication complex 3D structures, utilizing either yield-stress support baths or self-supporting inks. Both these have been extensively studied across a range fields, including biomedical, soft robotics, smart sensors, due to their outstanding print fidelity compatibility with diverse materials. Particle additives capable forming volume-filling networks are frequently incorporated into polymer solvents. This integration is crucial engineering requisite microstructures essential formulation successful bath The interplay between particle solvents critical achieving rheological tunability in various strategies, yet this area has not systematically reviewed. Therefore, review, we examined mechanisms particle–polymer interactions, resulting microstructures, subsequent impact on mechanical properties. Overall, work aims serve as foundational guideline design next-generation materials field extrusion additive manufacturing, specifically EIW DIW.

Language: Английский

Citations

4
Direct ink writing of bioceramic prosthetics and scaffolds: advances, challenges, and biomedical applications DOI

B. Latha,

Ayyappan Susila Praveen

Progress in Additive Manufacturing, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 8, 2025

Language: Английский

Citations

0
Injectable, Self‐healing, and 3D Printable Dynamic Hydrogels DOI
Hung Pang Lee, Kaivalya A. Deo, Jin‐Woo Jeong

et al.

Advanced Materials Interfaces, Journal Year: 2022, Volume and Issue: 9(23)

Published: July 13, 2022

Abstract Dynamic hydrogels are promising biomaterials for various biomedical and biotechnological applications due to their ability change physicochemical properties functions reversibly and/or sequentially in a time‐ or stimuli‐dependent manner. In this study, new class of dynamic that crosslinked by the situ redox reactions gold ions disulfide groups developed. Specifically, initiate hydrogel formation via gold‐thiol crosslinking, transforming from an injectable mechanically stable tough hydrogel. Moreover, nucleation growth nanoparticles within networks further enhance electrical conductivity. The current work demonstrates utility these 3D printing drug delivery.

Language: Английский

Citations

18
Laponite nanoclays for the sustained delivery of therapeutic proteins DOI Creative Commons
Ainhoa Gonzalez‐Pujana, Manoli Igartúa, Rosa Marı́a Hernández

et al.

European Journal of Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: 201, P. 106858 - 106858

Published: July 20, 2024

Protein therapeutics hold immense promise for treating a wide array of diseases. However, their efficacy is often compromised by rapid degradation and clearance. The synthetic smectite clay Laponite emerges as promising candidate sustained delivery. Despite its unique properties allow to load release proteins mitigating burst extending effects, precise control over Laponite-protein interactions remains challenging since it depends on complex interplay factors whose implication not fully understood yet. aim this review article shed light issue, providing comprehensive discussion the influencing protein loading release, including physicochemical nanoclay proteins, pH, dispersion buffer, clay/protein concentration degradation. Furthermore, we thoroughly revise bioactive that have been delivered from formulations containing nanoclay, highlighting Laponite-polymer nanocomposite hydrogels, avenue currently under extensive investigation.

Language: Английский

Citations

3