Harnessing Natural Polymers for Nano-Scaffolds in Bone Tissue Engineering: A Comprehensive Overview of Bone Disease Treatment

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(1), P. 585 - 611

Published: Jan. 5, 2024

Numerous surgeries are carried out to replace tissues that have been harmed by an illness or accident. Due various surgical interventions and the requirement of bone substitutes, emerging field tissue engineering attempts repair damaged with help scaffolds. These scaffolds act as template for regeneration controlling development new cells. For creation functional organs, there three elements play very crucial role: cells, signals achievement these aims, types natural polymers, like chitosan, chitin, cellulose, albumin silk fibroin, used preparation Scaffolds produced from polymers many advantages: they less immunogenic well being biodegradable, biocompatible, non-toxic cost effective. The hierarchal structure bone, microscale nanoscale, is mostly made up organic inorganic components nanohydroxyapatite collagen components. This review paper summarizes knowledge updates information about use scaffolds, their application in recent research trends area (BTE). article extensively explores related analyze advancement nanotechnology treatment bone-related diseases repair.

Language: Английский

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Self‐Assembled Nanocomposite Hydrogels as Carriers for Demineralized Bone Matrix Particles and Enhanced Bone Repair

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(10)

Published: Jan. 26, 2024

Demineralized bone matrix (DBM) has been widely used as an allogeneic alternative to autologous graft for repair. However, more extensive use of DBM is limited due its particulate nature after demineralization and rapid particle dispersion following irrigation, resulting in unpredictable osteoinductivity. Here, a new design injectable hydrogel carriers that combine self-healing ability osteogenic properties based on the self-assembly guanidinylated hyaluronic acid silica-rich nanoclays reported. The serve reversible linkages form dynamic network with guanidine moieties polymer chains. Gelation kinetics mechanical can be controlled by altering nanoclay content hydrogel. exerts crosslinks well retains overall performance high loading. exhibits great cytocompatibility effects mediated nanoclays. In vivo delivery using nanocomposite further demonstrates robust regeneration mouse calvarial defect model comparison delivered aqueous HA. This work suggests promising platform many applications including therapeutic tissue engineering.

Language: Английский

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Hybrid Nanoparticle–Hydrogel Systems for Drug Delivery Depots and Other Biomedical Applications

ACS Nano, Journal Year: 2024, Volume and Issue: 18(34), P. 22780 - 22792

Published: Aug. 14, 2024

Hydrogel-based depots typically tend to remain where injected and have excellent biocompatibility but are relatively poor at controlling drug release. Nanoparticles (NPs) the opposite properties. The smaller NPs are, more likely they leave site of injection. Their is variable depending on material can be poor. However, good In these other properties, combining hydrogels leverage their advantages negate disadvantages. This review highlights rationale for hybrid NP-hydrogel systems in delivery, basic methods producing them, examples two addressed specific problems.

Language: Английский

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Atomistic modelling and experimental study of tensile strength of nanocomposite hydrogel

International Journal of Mechanical Sciences, Journal Year: 2024, Volume and Issue: 277, P. 109397 - 109397

Published: May 17, 2024

Language: Английский

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3D-printed Laponite/Alginate hydrogel-based suppositories for versatile drug loading and release

Drug Delivery and Translational Research, Journal Year: 2024, Volume and Issue: 14(12), P. 3385 - 3403

Published: Jan. 7, 2024

Traditional approaches to solid rectal therapies have halted progress, leading a continual decline in the use of conventional suppositories. Additive manufacturing techniques been recently explored as suitable innovative tool for suppository fabrication. However, little advancement has made composition materials 3D-printed (3DPS) and still, vehicles are often used construct fabrication, hindering growth field. As novelty, this study unveils ground-breaking Laponite-alginate hydrogel-based 3DPS. Interestingly, proposes novel approach loading drugs into 3DPS employing first time post-printing loading. Thus, passive strategy molecular models is developed, demonstrating versatility capacity load molecules different charges sizes within matrix systems. This allows adapting wide range single ink, which simplifies speeds up technological development process with physico-chemical properties. Additionally, research, displacement three-dimensional Laponite matrices developed order enhance drug release through their disintegration capacity, resulting significant improvement diffusion hydrogel rapid Finally, our demonstrates that obtained vivo behavior, being non-obstructive allowing normal motility rats intestine.

Language: Английский

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Laponite®—From Dispersion to Gel—Structure, Properties, and Applications

Molecules, Journal Year: 2024, Volume and Issue: 29(12), P. 2823 - 2823

Published: June 13, 2024

Laponite® (LAP) is an intensively studied synthetic clay due to the versatility given by its layered structure, which makes it usable in various applications. This review describes multifaceted properties and applications of LAP aqueous dispersions gel systems. The first sections discuss structure interactions between discs medium under different conditions (such as ionic strength, pH, temperature, addition polymers) order understand function tailoring designed material. Additionally, explores aging phenomenon characteristic well development shake-gels incorporating LAP. second part shows most recent studies on materials containing with possible applicability drilling industry, cosmetics or care products biomedical fields. By elucidating remarkable ease integration into matrices, this underscores significance a key ingredient for creation next-generation tailored functionalities.

Language: Английский

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Novel pH-sensitive of organic composite (kc-g-poly(AAc-co-AAm)/bentonite), synthesis and characterization candidate as a carrier for controlled release system in vitro to some drugs

Carbon letters, Journal Year: 2024, Volume and Issue: 34(1), P. 505 - 517

Published: Jan. 1, 2024

Language: Английский

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Nanobioactive blood-derived shear-thinning biomaterial for tissue engineering applications

Applied Materials Today, Journal Year: 2024, Volume and Issue: 38, P. 102250 - 102250

Published: May 25, 2024

Language: Английский

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Fabrication and Characterization of Injectable Nanocomposite Hydrogel Containing PEG-PCL-PEG Copolymer/Montmorillonite Nanoparticles for Bone Tissue Regeneration

Arabian Journal for Science and Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 16, 2025

Language: Английский

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A predictive model for calculating the electrostatic intercalation efficiency of methotrexate-loaded laponite dependent on clay concentration and pH built from binding constants

Applied Clay Science, Journal Year: 2025, Volume and Issue: 270, P. 107781 - 107781

Published: March 15, 2025

Language: Английский

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