Vagus Nerve Stimulation: A Personalized Therapeutic Approach for Crohn’s and Other Inflammatory Bowel Diseases DOI Creative Commons
Giovanni Cirillo, Flor Negrete-Diaz, Daniela Yucumá

et al.

Cells, Journal Year: 2022, Volume and Issue: 11(24), P. 4103 - 4103

Published: Dec. 17, 2022

Inflammatory bowel diseases, including Crohn’s disease and ulcerative colitis, are incurable autoimmune diseases characterized by chronic inflammation of the gastrointestinal tract. There is increasing evidence that inappropriate interaction between enteric nervous system central and/or low activity vagus nerve, which connects systems, could play a crucial role in their pathogenesis. Therefore, it has been suggested appropriate neuroprosthetic stimulation nerve lead to modulation tract consequent long-term control these diseases. In present paper, we provide comprehensive overview (1) cellular molecular bases immune system, (2) way systems interact contribute responses, (3) pathogenesis inflammatory disease, (4) therapeutic use stimulation, particular, transcutaneous auricular branch nerve. Then, expose working hypotheses for processes responsible intestinal develop personalized devices procedures favor patients.

Language: Английский

The microbiota-gut-brain-immune interface in the pathogenesis of neuroinflammatory diseases: a narrative review of the emerging literature DOI Creative Commons
Alison Warren, Yvonne Nyavor,

Nikkia Zarabian

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: May 16, 2024

Importance Research is beginning to elucidate the sophisticated mechanisms underlying microbiota-gut-brain-immune interface, moving from primarily animal models human studies. Findings support dynamic relationships between gut microbiota as an ecosystem (microbiome) within (host) and its intersection with host immune nervous systems. Adding this effects on epigenetic regulation of gene expression further complicates strengthens response. At heart inflammation, which manifests in a variety pathologies including neurodegenerative diseases such Alzheimer’s disease, Parkinson’s Multiple Sclerosis (MS). Observations Generally, research date limited has focused bacteria, likely due simplicity cost-effectiveness 16s rRNA sequencing, despite lower resolution inability determine functional ability/alterations. However, omits all other fungi, viruses, phages, are emerging key members microbiome. Much been done pre-clinical and/or small studies more developed parts world. The observed promising but cannot be considered reliable or generalizable at time. Specifically, causal determined currently. More followed by then little MS. data for MS encouraging this. Conclusions relevance While still nascent, interface may missing link, hampered our progress understanding, let alone preventing, managing, putting into remission diseases. Relationships must first established humans, have shown poorly translate complex physiology environments, especially when investigating microbiome where often overly simplistic. Only can robust conducted humans using mechanistic model

Language: Английский

Citations

9
The vagus nerve: An old but new player in brain–body communication DOI Creative Commons
Li Ma,

Hanbing Wang,

Kenji Hashimoto

et al.

Brain Behavior and Immunity, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

Citations

9
Therapeutic potential of Pranlukast against cuprizone-induced inflammatory demyelination and sensory impairment in mice: comparison with Fingolimod. DOI
Gabriel Natan Pires,

Renata Pereira Laurindo,

Luiza dos Santos Heringer

et al.

NeuroToxicology, Journal Year: 2025, Volume and Issue: 107, P. 37 - 52

Published: Jan. 31, 2025

Language: Английский

Citations

1
Fecal microbiota transplantation from patients with rheumatoid arthritis causes depression-like behaviors in mice through abnormal T cells activation DOI Creative Commons
Yaoyu Pu, Qiuping Zhang, Zhigang Tang

et al.

Translational Psychiatry, Journal Year: 2022, Volume and Issue: 12(1)

Published: June 1, 2022

Abstract Depression is common in patients with rheumatoid arthritis (RA); however, the precise mechanisms underlying a link between depression and RA remain unclear. Accumulating evidence suggests role of gut–microbiota–brain axis depression. In this study, we investigated whether collagen-induced (CIA) mice produce depression-like behaviors abnormal composition gut microbiota. Furthermore, fecal microbiota transplantation (FMT) from causes phenotypes antibiotic cocktail (ABX)-treated mice. CIA displayed behaviors, increased blood levels pro-inflammatory cytokine interleukin-6 (IL-6), decreased expression synaptic proteins prefrontal cortex (PFC), FMT caused phenotypes, alterations composition, IL-6 tumor necrosis factor-α (TNF-α), downregulation PFC compared to healthy controls. There were correlations relative abundance plasma cytokines, or behaviors. Interestingly, induced T cells differentiation Peyer’s patches spleen. Reduced percentage Treg an increase Th1/Th2 index was observed after patients. These findings suggest that exhibit systemic inflammation, microbiota, produces ABX-treated via differentiation. Therefore, abnormalities may contribute axis.

Language: Английский

Citations

38
A role of microRNA-149 in the prefrontal cortex for prophylactic actions of (R)-ketamine in inflammation model DOI
Li Ma, Long Wang, Lijia Chang

et al.

Neuropharmacology, Journal Year: 2022, Volume and Issue: 219, P. 109250 - 109250

Published: Sept. 9, 2022

Language: Английский

Citations

36
Key role of the gut–microbiota–brain axis via the subdiaphragmatic vagus nerve in demyelination of the cuprizone-treated mouse brain DOI Creative Commons

Xingming Wang,

Akifumi Eguchi, Yong Yang

et al.

Neurobiology of Disease, Journal Year: 2022, Volume and Issue: 176, P. 105951 - 105951

Published: Dec. 6, 2022

Multiple sclerosis (MS) is the most common demyelinating disease that attacks central nervous system. Dietary intake of cuprizone (CPZ) produces demyelination resembling patients with MS. Given role vagus nerve in gut-microbiota-brain axis development MS, we performed this study to investigate whether subdiaphragmatic vagotomy (SDV) affects CPZ-treated mice. SDV significantly ameliorated and microglial activation brain compared sham-operated Furthermore, 16S ribosomal RNA analysis revealed improved abnormal gut microbiota composition An untargeted metabolomic demonstrated blood levels metabolites mice Notably, there were correlations between or relative abundance several microbiome populations, suggesting a link brain. There also metabolites. Together, these data suggest CPZ through via nerve.

Language: Английский

Citations

35
Rapid antidepressant-like effect of non-hallucinogenic psychedelic analog lisuride, but not hallucinogenic psychedelic DOI, in lipopolysaccharide-treated mice DOI
Youge Qu, Lijia Chang, Li Ma

et al.

Pharmacology Biochemistry and Behavior, Journal Year: 2022, Volume and Issue: 222, P. 173500 - 173500

Published: Dec. 5, 2022

Language: Английский

Citations

32
Effects of spleen nerve denervation on depression–like phenotype, systemic inflammation, and abnormal composition of gut microbiota in mice after administration of lipopolysaccharide: A role of brain–spleen axis DOI
Li Ma, Jiancheng Zhang, Yūkō Fujita

et al.

Journal of Affective Disorders, Journal Year: 2022, Volume and Issue: 317, P. 156 - 165

Published: Aug. 26, 2022

Language: Английский

Citations

29
Role of the gut–brain axis via the subdiaphragmatic vagus nerve in stress resilience of 3,4-methylenedioxymethamphetamine in mice exposed to chronic restrain stress DOI Creative Commons
Youge Qu, Akifumi Eguchi, Li Ma

et al.

Neurobiology of Disease, Journal Year: 2023, Volume and Issue: 189, P. 106348 - 106348

Published: Nov. 11, 2023

3,4-Methylenedioxymethamphetamine (MDMA) is the most widely used illicit substance worldwide. Nevertheless, recent observational studies demonstrated that lifetime MDMA use among U.S. adults was associated with a lower risk of depression and suicide thoughts. We recently reported gut-brain axis may contribute to MDMA-induced stress resilience in mice. To further explore this, we investigated effects subdiaphragmatic vagotomy (SDV) modulating mice subjected chronic restrain (CRS). Pretreatment (10 mg/kg/day for 14 days) blocked anhedonia-like behavior reduced expression synaptic proteins brain-derived neurotrophic factor prefrontal cortex (PFC) CRS-exposed Interestingly, SDV beneficial on these alterations Analysis gut microbiome revealed four measures α-diversity between sham + CRS group group. Moreover, specific microbes differed vehicle group, differences microbial composition were observed all groups. Untargeted metabolomics analysis showed prevented increase plasma levels three compounds [lactic acid, 1-(2-hydroxyethyl)-2,2,6-tetramethyl-4-piperidinol, 8-acetyl-7-hydroxyvumaline] positive correlations found two abundance several across In conclusion, our data suggest via vagus nerve might MDMA.

Language: Английский

Citations

17
Exploring the multifaceted potential of (R)-ketamine beyond antidepressant applications DOI Creative Commons

Senbing Zhang,

Yanzhu Pu,

Jianning Liu

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: April 11, 2024

( R , S )- and )-ketamine have made significant progress in the treatment of treatment-resistant depression (TRD) become a research focus recent years. However, they both risks psychomimetic effects, dissociative abuse liability, which limit their clinical use. Recent preclinical studies shown that has more efficient lasting antidepressant effect with fewer side effects compared to )-ketamine. small-sample randomized controlled trial found although lower incidence adverse reactions adult TRD treatment, its efficacy is not superior placebo group, indicating advantage still needs further verification clarification. Moreover, an increasing body suggests might also applications prevention medical fields or diseases such as cognitive disorders, perioperative anesthesia, ischemic stroke, Parkinson’s disease, multiple sclerosis, osteoporosis, substance use inflammatory diseases, COVID-19, organophosphate poisoning. This article briefly reviews mechanism action on antidepressants related )-ketamine, fully revealing application potential development prospects, providing some references assistance for subsequent expanded research.

Language: Английский

Citations

7